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Curriculum vitae
Overview
T hurs day, 0 3 - 1 1 - 2 0 1 4 :: 1 9 :1 1
A nabela C ordeiro Silva
E nd s es s ion
Overview
1. Personal data
Full Name
Anabela C ordeiro Silva
Name under which you publish
Anabela C ordeiro-da-Silva
Fiscal ID number
1780837734
ID document
7295884
Birth date
02-09-1966
National of
Portugal
Gender
F
Work address
IBMC e Faculdade de Farmácia da Universidade do Porto
Rua C ampo Alegre, 823
4150-180 Porto
Portugal
Residential A ddress
Rua Nova do Regado, 74, 4ºEsq
4250 325
Portugal
Work Phone
00351966125015
Email
[email protected]
Residential Phone
00351226074923/49
Fax
00351351 226 099 157
Cell phone
00351966125015
URL
www.ibmc.up.pt
2. Academic degrees
Year: 1989
Degree: LICENCIATURA
Final grade: 15 values
Degree granting institution Universidade do Porto
School/College/Campus Faculdade de Farmácia
Thesis title Degree in Pharmaceutical Sciences - Analysis Biological Chemistry
Supervisor:
Edit C V
Co-supervisor:
Scientific area Ciencias da Saude
Number of curricular years 6
Program title Degree in Pharmaceutical Sciences - Analysis Biological Chemistry
Year: 1992
Degree: MESTRADO
Final grade: Very good by unanimously
Degree granting institution Universidade do Porto
School/College/Campus Instituto de Ciências Biomédicas Abel Salazar
Thesis title Clonagem e sequenciação do cDNA que codifica
Supervisor: Maria de Sousa
Co-supervisor: André Capron
Scientific area Ciencias da Saude
Number of curricular years 1
Program title Immunology Master
Year: 1995
Degree: LICENCIATURA
Final grade: 14 values
Degree granting institution Universidade do Porto
School/College/Campus Faculdade de Farmácia
Thesis title Degree in Pharmaceutical Sciences - Pharmacy
Supervisor:
Co-supervisor:
Scientific area Ciencias da Saude
Number of curricular years 6
Program title Degree in Pharmaceutical Sciences - Pharmacy
Year: 1993
Degree: Post-graduation course "Molecular Biology of the Immune System"
Final grade: Approved
Degree granting institution Universidade do Porto
School/College/Campus Instituto de Ciências Biomédicas Abel Salazar
Thesis title
Supervisor:
Co-supervisor:
Scientific area
Number of curricular years 0
Program title
Year: 1992
Degree: Post-graduation course in Molecular Biology of the Immune System.
Final grade: Approved
Degree granting institution Universidade do Porto
School/College/Campus Instituto de Ciências Biomédicas Abel Salazar
Thesis title
Supervisor:
Co-supervisor:
Scientific area
Number of curricular years 0
Program title
Year: 1990
Degree: Post-graduation course in Medical Parasitology
Final grade: 15 values
Degree granting institution Universidade Nova de Lisboa
School/College/Campus Instituto de Higiene e Medicina Tropical
Thesis title
Supervisor:
Co-supervisor:
Scientific area
Number of curricular years 0
Program title
Year: 1990
Degree: Advanced course in Genetic Bacteriane
Final grade: Approved
Degree granting institution Universidade de Lisboa
School/College/Campus Faculdade de Farmácia
Thesis title
Supervisor:
Co-supervisor:
Scientific area
Number of curricular years 0
Program title
Year: 1989
Degree: Post-graduation course in Immunology
Final grade: Approved
Degree granting institution Universidade do Porto
School/College/Campus Instituto de Ciências Biomédicas Abel Salazar
Thesis title
Supervisor:
Co-supervisor:
Scientific area
Number of curricular years 0
Program title
Year: 1996
Degree: FEBS International Summer School on Immunology. The Immune System: Genes,
Receptors and Regulation
Final grade: Approved
Degree granting institution FEBS
School/College/Campus n/a
Thesis title
Supervisor:
Co-supervisor:
Scientific area
Number of curricular years 0
Program title
Year: 1994
Degree: Post-graduation - Biologie de la cellule : modeles cellulaires
Final grade: Approved
Degree granting institution École Doctorale du Museum, Universitée de Paris
School/College/Campus n/a
Thesis title
Supervisor:
Co-supervisor:
Scientific area
Number of curricular years 0
Program title
Year: 1994
Degree: Course of “Interrogation des bases de donnée sur CD-ROM”
Final grade: Approved
Degree granting institution Biblioteque Centrale de l’Institut Pasteur de Paris
School/College/Campus n/a
Thesis title
Supervisor:
Co-supervisor:
Scientific area
Number of curricular years 0
Program title
Year: 1993
Degree: Post-graduation in “Radioprotection et de Prévention des Risques Professionnels”
Final grade: Approved
Degree granting institution Secrétariat des Enseignements et des Stages de l’Institut Pasteur de
Paris
School/College/Campus n/a
Thesis title
Supervisor:
Co-supervisor:
Scientific area
Number of curricular years 0
Program title
Year: 1992
Degree: Post-graduation course in “Habilitation a l'utilisation du FACSCAN”
Final grade: Approved
Degree granting institution Instituto Pasteur de Paris
School/College/Campus n/a
Thesis title
Supervisor:
Co-supervisor:
Scientific area
Number of curricular years 0
Program title
Year: 2005
Degree: AGREGAÇÃO
Final grade: Approved unanimously
Degree granting institution Universidade do Porto
School/College/Campus Faculdade de Farmácia
Thesis title
Supervisor:
Co-supervisor:
Scientific area Aggregation in Immunology
Program title
Year: 1997
Degree: DOUTORAMENTO
Final grade: Approved unanimously
Degree granting institution Universidade do Porto
School/College/Campus Instituto de Ciências Biomédicas Abel Salazar
Thesis title Ratinhos Balb.Xid: modelo de estudo dos mecanismos de resistência à infecção por
Trypanosoma cruzi
Supervisor: Mário Arala Chaves
Co-supervisor: Paola Minoprio
Scientific area Imunologia
Program title Ciências Biomédicas - Immunologia
3. Previous activity and current status
Período
Cargo, categoria ou actividade
Instituição
01-72013 IBMC BSL-3 Faciliteis Director
a
IBMC
03-1Responsible scientific service of "C ell C ulture
2011
and Genotyping" in IBMC .
a
IBMC
17-6Deputy Director of the Unity of Infection and
2012
Immunity at IBMC
a
IBMC
a
Head of the group Parsaite' disease
Instituto de Biologia Molecular e C elular
a
Associated Professor
Faculdade de Farmácia da Universidade do Porto
a
Member of Scientific C ouncil
Institut de Recherche pour le Developpement,
Montpellier, France.
a
Responsable to the Animal facilities
Faculdade de Farmácia da Universidade do Porto
a
Investigator recognized to use animals for
experiment or scientific assays
Direcção de Serviços e Meios de Defesa da Saúde,
Bem Estar e Alimentação Animal Min. da Agricultura
a
Member of Scientific Societies
American Society for Microbiology, membership
number 55683510, division B
a
Member of Scientific Societies
Sociedade Portuguesa de C iências Farmacêuticas
a
Member of Scientific Societies
Sociedade Portuguesa de Bioquímica
a
Member of Scientific Societies
Société Francaise d’ Immunologie
a
Member of Scientific Society
Sociedade Portuguesa de Imunologia
a
Member of Scientific Societies, membership
number 2724SO
The British Society for Parasitology
a
Member of Profissional Societies
Ordem dos Farmacêuticos (Sociedade Farmacêutica
Lusitana)
a
Member of Scientific C ouncil
Faculdade de Farmácia da Universidade do Porto
a
Vice-President of Educational C ouncil
Faculdade de Farmácia, Universidade do Porto
a
Vice-President of Educational C ouncil
Faculdade de Farmácia da Universidade do Porto
a
Avaliator in Science Programme
Junta Nacional de Investigação C iêntífica. Lisboa
a
Moderator in Scientific Meeting
XXIX Annual meeting. Sociedade Portuguesa de
Imunologia. Porto
a
Participation in Scientific C omitée Meeting
VI Fórum Farmacêutico. Novas Terapias e Tecnologias
Farmacêuticas
a
Participation in Scientific C omitée Meeting 1º
Workshop de Bioquímica C línica
C upertino de Miranda Foundation, Porto
a
Participation to assess the fellowship of scientific Instituto de Biologia Molecular e C elular da
investigation
Universidade do Porto
a
President to assess fellowship of scientific
investigation
Unidade de Investigação de Stress em Animais do
Instituto de Biologia Molecular e C elular
a
Participation to assess Senior Researcher
Instituto de Biologia Molecular e C elular da
Universidade do Porto
a
Participation to assess fellowship of scientific
investigation
Instituto de Biologia Molecular e C elular da
Universidade do Porto
a
President to assess the fellowship scientific
investigation
Faculdade de Farmácia da Universidade do Porto
a
President to assess the fellowship in scientific
investigation
Instituto de Biologia Molecular e C elular da
Universidade do Porto
a
To assess a fellowship in scientific investigation
Instituto de Biologia Molecular e C elular da
Universidade do Porto
a
Participation to assess the definitive inscription
in PhD thesis of Isabel Alonso
Instituto de C iências Biomédicas Abel Salazar da
Universidade do Porto
a
Participation to assess the definitive inscription
in PhD thesis of Luisa Figueiredo
Instituto de C iências Biomédicas Abel Salazar da
Universidade do Porto
a
To assess Researcher project in collaboration of
Agência de Inovação
the Industry
a
To argue the PhD thesis “Etude
immunopathologique de la maladie de C hagas
chez la souris"
Université Pierre & Marie C urie, Paris
a
Fellowship
JNIC T - Programa C iência
a
Fellowship
SPI (Sociedade Portuguesa de Imunologia)
a
Fellowship
JNIC T - Programa Planeamento e Projectos no
Instituto Pasteur de Paris
a
Fellowship
Junta Nacional de Investigação C ientífica, Programa
de formação e mobilidade de recursos humanos
a
Fellowship
Programa de cooperaçäo JNIC T - Embaixada de
França (Processo nº: 45400AC ).
a
Fellowship
Fundação C alouste Gulbenkian
a
Fellowship
Junta Nacional de Investigação C ientífica e
Tecnologica
(JNIC T)/C entreNationaldeRechercheScientific
a
Fellowship
Fundação C alouste Gulbenkian
a
Teaching post-graduation course Immunology to C onfederação dos Farmacêuticos do Norte
the C hemists
(C OFANOR)
a
Talking in the meeting New Therapies and
Framaceutical Technologies T
Fundação Eng. António de Almeida
a
Teaching Post-graduation course in
Farmacotherapy with the theme Vaccines
Associação Nacional Farmácias, Porto.
a
Teaching Post-graduation: New vaccines in
Pediatrie
Associação Nacional Farmácias, Porto
a
Teaching Post-graduation in Laboratorial
Serviço de Microbiologia da Faculdade de Medicina do
Diagnosis inMedical Parasitology “Trypanosoma” Porto
a
Teaching in post-graduation education
Institut de Recherche pour le Développement,
Université de Montpellier I
a
Teaching in the module of “ The
Trypanosomatids:Biology and importance”
Post Graduated in Basic and Applied Biology of
Universidade do Porto
a
Teaching in C ontrol Quality Master
Faculdade de Farmácia da Universidade do Porto
a
Assistant Professor with definitive mention
Faculdade de Farmácia da Universidade do Porto
a
Assistant professor not definitive
Faculdade de Farmácia da Universidade do Porto
a
Assistant teacher in Immunology and Molecular
Genetic
Faculdade de Farmácia, Universidade do Porto
a
Student teacher assistant in Immunology and
Molecular Genetic
Faculdade de Farmácia, Universidade dom Porto
4. Area of scientific activity
Immunology: study of excretion / secretion trypanosomatids proteins involved in polyclonal activation of the
immune system responsible for infectivity of the body. Use of KO parasites, recombinant proteins, cDNA and
genes in dendritic cells as models of vaccines.
Molecular Biology: C loning and sequencing of genes encoding enzymes involved in drug targets and virulence
factors. Study of new drugs with anti-Leishmania. Using nanotechnology to increase the release of drugs and
the realization of new vaccine formulations.
Diagnosis: C reating new methods of leishmaniasis diagnosis using the tools generated in the laboratory,
namelly recombinant proteins.
5. Present research interest
Domain of specialization
Vaccines, Immunoparasitology, Drug target development.
Current research interests
Throughout the various ongoing projects, the key objective has been to find the components of the parasite
that are responsible for immune response. Molecules involved in parasite virulence factors as well as
searching for possible targets of drugs, polyamine derivatives, as well as the identification of molecules of the
parasite may be used as a marker of susceptibility or resistance to natural host (man or dog) for
leishmaniasis. We have studied various drugs, some promising as already described for the treatment of
leishmaniasis. We are also interested in the use of KO parasites, recombinant proteins and dendritic cells as a
promising model for vaccines. The use of nanotechnology in a controlled release of drugs or the use of new
vaccine formulations is an area of recent interest.
Other professional interests/activities
Nanotechnology use to drug delivery systems, Nanodiagnosisis developmet, Host parasite interactions
6. Experience as scientific adviser
C arrier Development
2013/2018 C arrier Development Joana Tavares. Trabalho intitulado: Dissecting the molecular basis of
Plasmodium sporozoites homing to the liver: a potential target to be considered in designing multi-antigenic
malaria vacines.
2008/2014 C iência 2008 Ricardo Silvestre. Trabalho intitulado: “Molecular mecha-nisms regulating apoptosis
of antigen presenting cells during visceral leishmaniasis: implication of sirtuin proteins”.
Post-Doc
2012/ Supervisor of the post-Doc of Nuno Santarem. The work entitled: “C ell communication by Leishmania
microvesicles”
2011 Supervisor of the post-Doc of Walter C oura Vital . The work entitled: Imuno diagnostic of visceral
leishmaniasis.Supported by Acções integradas Luso-Brasileiera, FC T-C APES.
2010/2013 Supervisor of the post-Doc of Susana Sousa. The work entitled: Devel-opment of a new
immunological method for detection of leishmaniasis using colloidal gold nanoparticles. Fellowship number
SFRH/BPD/65214/2009.
2009 Supervisor of the post-Doc of Sandra Isabel Gomes Pereira. The work entitled: “Infecção por
Leishmania infantum no modelo murino: influência do haplotipo H-2 na resposta imunológica celular”.
Fellowship number SFRH/BPD/44990/2008.
2009/2012 Supervisor of the post-Doc of Joana Tavares. The work entitled Studying the human skin stage of
protozoan parasites, implications to the disease outcome in co-supervision with Robert Menard, Unité de
Biologie et Génétique du Paludisme, Institut Pasteur, France. Fellowship number SFRH/BPD/48340/2008.
2008/2009 Supervisor of the post-Doc of Ricardo Silvestre. The work entitled: C haracterization of
HIV/Leishmania infantum co-infection in macrophage and dendritic cells: impact of apoptosis and immune
activation in the disease development. Fellowship number SFRH/BPD/41476/2007.
2008/2013 Supervisor of the post-Doc of Sofia C osta Lima. The work entitled: De-velopment of BNIP
polyamine drug delivery systems, liposome and nanoparticles, to tar-get specially Leishmania infected
macrophages and dendritic cells. Fellowship number BPD/37880/2007.
PhD
2013/….C o-supervisor of the PhD of Diana Raquel Bento Moreira, co-supervision with Ricardo Silvestre and
Jerome Estaquier. The work entitled: “Role of sirtuins in the con-text of host-pathogen interaction”in Parasite
Disease Group in Instituto de Biologia Molecular e C elular da Universidade do Porto and INSERM UMR 841 Equipe 16, Faculté de Medicine, 8, França. Fellow FC T ref. SFRH/BD/91543/2012.
2013/… Supervisor of the PhD of C arla Patrícia da Silva Lima.The work entitled: “C urrent control measures of
leishmaniasis rely on early diagnosis and chemotherapy of dog reservoir suffering from this disease” in
Parasite Disease Group in Instituto de Biologia Molecular e C elular da Universidade do Porto.
2013/… Supervisor of the PhD of Renata C ardoso Belo da C osta, in co-supervision of Maria do C armo Leitede Moraes no Hôpital Necker, France. The work entitled: “Implication of iNKT cells on allergic inflammatory
responses: role of microvesicles”. in Parasite Disease Group in Instituto de Biologia Molecular e C elular da
Universidade do Porto and Hôpi-tal Necker, France.
Universidade do Porto and Hôpi-tal Necker, France.
2012/ ….Supervisor of the PhD of Joana Raquel C orreia Faria, in co-supervision of Lúcio Júnior. The work
entitled: “ Ribose-5-Phosphate Isomerase and Asparagine Synthetase A targets specific small molecules to
control infections due to Trypanosomatids” is being developed in Portugal, in Parasite Disease Group in
Instituto de Biologia Molecular e C elular da Universidade do Porto and Pasteur Institut of South korea.
2012/ ….Supervisor of the PhD of Luís Filipe Silva Gaspar, in co-supervision of Lúcio Júnior. The work entitled:
“Targeting the Leishmania specific enzyme for the development of novel anti-parasitic strategies” is being
developed in Portugal, in Parasite Disease Group in Instituto de Biologia Molecular e C elular da Universidade
do Porto and Pasteur Institut of South korea.
2009/ ….Supervisor of the PhD of Vasco Rodrigues, in co-supervision of Ricardo Silvestre e Jerome Estaquier.
The work entitled: The role of sirtuins in the modulation of antigen presenting cell death during visceral
leishmaniasis ” is being developed in Portugal, in Parasite Disease Group in Instituto de Biologia Molecular e
C elular da Universidade do Porto and INSERM UMR 841 - Equipe 16, Faculté de Medicine, 8.
2009/ …. Supervisor of the PhD of Inês Loureiro, in co-supervision of Joana Tavares and Roy Nilanjan Roy.
The work entitled: Target specific small molecules to control infections due to Trypanosomatids and their
effects on the immune system” ” is being developed in Portugal, in Parasite Disease Group in Instituto de
Biologia Molecular e C elular da Universidade do Porto and Omics & C omputational Biology Laboratory,
National Institute of Pharmaceutical Education and Research, India.
2008/ …. Supervisor of the PhD of Joana C unha, in co-supervision of Javier Moreno, Spain. The work intitled
“Study of the immune response induced by a natural attenuated parasite compared to a virulent strain from
L. infantum in different animal models” is being developed in Portugal, in Parasdite Disease Group in Instituto
de Biologia Molecular e C elular da Universidade do Porto and C entro Nacional de Microbiologia- ISC III in
Majadahonda (Spain).
2007/2012 Supervisor of the PhD of Lúcia Teixeira, (fellowship of FC T, SFRH/BD/37178/2007 in cosupervision of Maria do C armo Leite-de Moraes in Hôpital Necker, France. The work intitled "Role and
mechanism of action of human immunoregulatory iNKT cells in Leishmania infection: new approaches for
vaccination?" is being developed in Portugal, in Parasdite Disease Group in Instituto de Biologia Molecular e
C elular da Universidade do Porto and Hôpital Necker, France. At present: Post-Doc at University of Minho,
Portugal.
2007/2012 Supervisor of the PhD of Nuno Santarem(fellowship of FC T, SFRH/BD/37352/2007 in cosupervision of Marc Oullette in Laval University, Quebec, C anada. The work intitled "Study of the secretome
of Leishmania involved in infection" is being developed in Portugal, in Parasdite Disease Group in Instituto de
Biologia Molecular e C elular da Universidade do Porto and Laval University, C anada. At present: Post-Doc at
IBMC , Portugal.
2006/2012 Supervisor of the PhD of Marta Silva (fellowship of FC T, SFRH/BD/28316/2006 in co-supervision of
Grahm C oombs in University of Strathclyde, UK. The work intitled "The Leishmania TDR1 family-related gene:
functional studies and evaluated of TDR1 recombinant protein and knockout vaccine to protect against
leishmaniasis" is being developed in Portugal, in Parasdite Disease Group in Instituto de Biologia Molecular e
C elular da Universidade do Porto and University of Strathclyde, UK. At present: Post-Doc at IBMC , Portugal.
2005/2009 Supervisor of the PhD of Liliana Mâncio da Silva (fellow from FC T, SFRH/BD/11756/2003) in
conjunction with Artur Scherff, Instituto de Pasteur Paris, França. The work intitled “Epigenetic gene
regulation in the malária parasite P. falciparum” done in Portugal, in Serviço de Bioquímica da Faculdade de
Farmácia da Universidade do Porto and in Instituto de Biologia Molecular e C elular da Universidade do Porto
and in France, in Unit of “Interaction parasite hôte”, Institut Pasteur, Paris, France. At present: Post-Doc IMM,
Portugal.
2004/2008 Supervisor of the PhD of Joana Alexandra Pinto da C osta Tavares (bolseira da FC T,
SFRH/BD/18137/2004) in conjunction with Ali Ouaissi, do “Institut de Recherche pour le Développement,
Montpellier”, France. The work intitled “ANTI-LEISHMANIAL DRUGS: study the role of novel polyamine
derivative compounds for drug therapy and search for target specific SIR2 inhibitors” done in Portugal, in
Serviço de Bioquímica da Faculdade de Farmácia da Universidade do Porto and in France, in Institut de
Recherche pour le Développement, Montpellier. January 2005 to January 2008. At present: Researcher at
Pasteur Institute in Paris, France.
2004/2007 Supervisor of the PhD of Ricardo Leal Silvestre (fellow of FC T, SFRH/BD/13120/2003) in
conjunction with Ali Ouaissi, do “Institut de Recherche pour le Développement, Montpellier”, França. The work
intitled “Leishmania SIR2 family-related gene: immunological studies and evaluation of SIR2 recombinant
DNA and knockout vaccine to protect against Leishmaniasis”, done in Portugal, in Serviço de Bioquímica da
Faculdade de Farmácia da Universidade do Porto and in Instituto de Biologia Molecular e C elular da
Universidade do Porto and in France, in Institut de Recherche pour le Développement, Montpellier. January
2004 to January 2007. At present: Researcher C iencia 2008, at IBMC , Portugal.
2003/... C olaboration in the experimental orientation of PhD thesis of C armen Lisboa in Serviço de
Dermatologia do Hospital de São João, with work intitled: Male C andidiasis: more than just a sexually
transmitted disease. Study of superantigens of C andida albicans in the scloritic genital liquid, is being studied
in Serviço de Bioquímica da Faculdade de Farmácia and in Instituto de Biologia Molecular e C elular da
Universidade do Porto. At present: Medical Assistant at HGSJ, Portugal.
2003/2008 C olaboration in the experimental orientation of PhD thesis of Olga M. F. Borges Ribeiro, assistant
in Faculdade de Farmácia da Universidade de C oimbra, in Laboratório de Farmácia Galénica e Tecnologia
Farmacêutica, with the theme: C oated nanoparticles as transport system of vaccines through the nasal and
oral mucose. In particular, in co-supervision of the in vivo studies of the immunological responses in mice
after oral and nasal administration of coated nanoparticles transporter of the vaccine hepatitis B and in
assessment of cytotoxicity of the nanoparticles referred to. At present: Assistant Professor at FFUC , Portugal.
2002/2007 C olaboration in the experimental orientation of PhD thesis of Sofia C . C . Lima of Faculdade de
C iências da Universidade do Porto, with the work intitled Evaluation effect methal ion transition in drug
transpor by the P-glycoprotein, in the isolation of the glycoprotein Gp180 for use in liposomes as a drug
transporter. At present: Post-Doc at IBMC , Portugal.
1999/ 2003 Supervisor of the PhD of Margarida C outinho Borges in conjunction with Ali Ouaissi, in Institut de
Recherche pour le Développement, Montpellier, France. The work intitled C haracterization of minimal
functional domain of immunosupressor Tc52 protein of Trypanosoma cruzi with an eventual therapeutic
application, done in Portugal, in Serviço de Bioquímica da Faculdade de Farmácia da Universidade do Porto
and in Instituto de Biologia Molecular e C elular da Universidade do Porto and in France, in Institut de
Recherche pour le Développement, Montpellier. Defended in 6 October of 2003 in Faculdade de Farmácia da
Universidade do Porto. At present: Assistent professor FFUP, Portugal.
Master
Supervisor of the Pharmaceutical Sciences of Vanessa Duarte. Work intitled: Lipossomas como Vetores de
Fármacos, Faculdade de Farmácia, Universidade do Porto.
2013 Supervisor of the Pharmaceutical Sciences of Fernando Toca. Work intitled: Malá-ria: epidemiologia,
clinica e terapêutica. Mestrado de C iências Farmacêuticas, Faculdade de Farmácia, Universidade do Porto.
clinica e terapêutica. Mestrado de C iências Farmacêuticas, Faculdade de Farmácia, Universidade do Porto.
2012 Supervisor of the Pharmaceutical Sciences of Sílvia de C astro Morgado in co-supervision of C armo
Leite-de-Moraes, Faculté C NRS UMR 8147, Hôpital Necker, França. work intitled “Invariant NKT cells and
natural Th17 cells: Studies in pro-inflammatory conditions”. Faculdade de Farmácia, Universidade do Porto.
2012 Supervisor of the C ell Biology and Biotechnology master of Patrícia Varela Oliveira Martins. work intitled
“Drug screening of Bisnaphthalimidopropyl derivatives on Trypanosoma brucei”. Faculdade de C iências,
Universidade de Lisboa.
2012 Supervisor of the Biochemistry master of Daniela Filipa dos Santos Barros. The work intitled
“Mannosylated nanoparticles for targeted delivery of amphotericin B towards visceral leishmaniasis”.
Universidade do Porto.
2010/2013 Supervisor of Microbiology Master of Ana Luísa Robalo em co-tutela com Ricardo Sil-vestre. The
work intitled“Role of interleukin-12 cytokine family during visceral leishma-niasis”. Universidade C atólica.
2010 Supervisor of the Instrumental Analytical Sciences Master, The Robert Gordon University, Aberdeen, UK
of MARTA WOJTYNSKA. The work intitled “Nanotechnology approach in drug delivery systems for treatment of
leishaniasis” is being developed at Parasite Disease Group at IBMC .
2010 Supervisor of the Instrumental Analytical Sciences Master, The Robert Gordon University, Aberdeen, UK
of Tariq Hassam. The work intitled “Evaluation of the in vitro biological effects of novel bisnaphthalimidopropyl polyamine derivatives in Leishmania infantum” is being developed at Parasite Disease
Group at IBMC .
2010 Supervisor of the MSc Pharmaceutical Sciences of Daniel Anthony Gonçalves Bispo . The work intitled
“Phenotype of erythrocyte adhesion from Babesia divergens Bd37 protein” is being developed at Faculté de
Pharmacie, Université de Montpellier I”, France.
2010 Supervisor of the MSc Pharmaceutical Sciences of C arina Isabel Santos Alvané Gonçalves. The work
intitled “iNKT cells and regulatory T cells in lenalidomide-treated myelodysplastic syndrome and multiple
myeloma patients” is being developed at Faculté of Medicine, C NRS UMR 8147, Hôpital Necker, France.
2010 Supervisor of the MSc Pharmaceutical Sciences of Luís Tiago André C oelho Morais . The work intitled
“Selection and analysis of recombinant antibody from llama library against parasitic antigen” is being
developed at Faculté de Pharmacie, Université de Montpellier I”, France.
2009/2010 Supervisor of the Analitic Toxicology and Forense MsC of Maria Helena Azevedo Teixeira de
Andrade. The work intitled "Leishmania spp. Infection model optimization for drug discovery purposes" is
being developed at Institute Pasteur da C oreia do Sul.
2009/ Supervisor of the MSc Pharmaceutical Sciences. Adelina de Jesus da Gama dos Santos. The work
intitled “Sistema Imunológico: Autoimunidade” is being developed in Portugal, in FFUP da Universidade do
Porto.
2009/2010 Supervisor of the MSc Pharmaceutical Sciences. Ivete C onceiçãoi Filipe Fernandes de Lima. The
work intitled “C rioglobulinas: avaliação clínica e laboratorial”. is being developed in Portugal, in FFUP da
Universidade do Porto.
2008/2009 Supervisor of the MsC of Vânia Filipa Esteves Vilas Boas, in co-supervision of Fernando Remião,
Toxicology Departmente, FFUP. The work intitled “Determinação a expressão e actividade da glicoproteina-P
em linfócitos humanos” is being developed in Portugal, in Toxicology Department, FFUP da Universidade do
Porto
2009 Supervisor of the MsC of Inês da C onceição Aleixo Ribeiro, C linical Analysis Master, FFUP. The work
intitled “Avaliation of the comportment of the recombinant protein C PX2 as a diagnosis marker and
terapeuticalsucess in canin leishmaniasis”.
2009 Supervisor of the MsC Patricia Isabel Martins Gonçalves dos Santos, C linical Analysis Master, FFUP. The
work entitled “Avaliation of incidence from monoclonal gammapathy in patients from C entro Hospitalar
Tâmega e Sousa”.
2008/200 Supervision of Master in Biochemistry Universidade de Porto of Vasco Rodrigues . The work intitled
“Macrophage targeted delivery of anti- Leishmania compounds using mannose coated poly(d,l-lactide-coglycolide) nanoparticles ”, is being realized in Parasite Disease Group at Instituto de Biologia Molecular e
C elular da Universidade do Porto. October 2008 until now.
2007/2008 Supervision of Master in Biochemistry Universidade de Porto of Mariana Resende. The work
intitled “MODULATION OF DENDRITIC C ELLS FUNC TION BY LEISHMANIA EXC RETED/SEC RETED ANTIGENS”,
is being realized in Parasite Disease Group at Instituto de Biologia Molecular e C elular da Universidade do
Porto. Fevery 2007 to Dezember of 2005. Fellow integrated in a project.
2004/2006 Supervision of Master in Molecular Microbiology da Universidade de Aveiro of Joana Maciel. The
work intitled Study of the exreted/secreted parasite protein with immunological activity, is being realized in
Serviço de Bioquímica da Faculdade de Farmácia and in Instituto de Biologia Molecular e C elular da
Universidade do Porto. Fevery 2004 to September of 2005.
2004/2006 C o-supervision of Master in Molecular Microbiology da Universidade de Aveiro of Nuno Santarém.
The work intitled Isolation of molecules involved in high-affinity iron uptake systems amastigote formes of
Leishmania infantum, is being realized in Serviço de Bioquímica da Faculdade de Farmácia and in Instituto de
Biologia Molecular e C elular da Universidade do Porto. February of 2004 to September of 2005.
Orientation of fellowship holders of scientific investigation
Mariana Resende, fellowship in scientific investigation in the project "PTDC /C VT/65047/2006 The Leishmania
TDR1 family-related gene: functional studies and evaluated of TDR1 recombinant protein and knockout
vaccine to protect against leishmaniasis"
Marisa Silva, fellowship in scientific investigation in the project "PTDC /C VT/65047/2006 The Leishmania TDR1
family-related gene: functional studies and evaluated of TDR1 recombinant protein and knockout vaccine to
protect against leishmaniasis"
Inês Loureiro, fellowship in scientific investigation in the project “POC TI/SAU-C F/59837/2004 ANTILEISHMANIAL DRUGS: study the role of novel polyamine derivative compounds for drug therapy and search
for target specific SIR2 inhibitors”
Joana C unha, fellowship in scientific investigation in the project “POC TI/SAU-C F/59837/2004 ANTILEISHMANIAL DRUGS: study the role of novel polyamine derivative compounds for drug therapy and search
for target specific SIR2 inhibitors”
Joana C osta, fellowship in scientific investigation in the project "PTDC /C VT/65047/2006 The Leishmania TDR1
family-related gene: functional studies and evaluated of TDR1 recombinant protein and knockout vaccine to
family-related gene: functional studies and evaluated of TDR1 recombinant protein and knockout vaccine to
protect against leishmaniasis"
Augusta Sousa, fellowship in scientific investigation in the project "PTDC /SAU-FC F/67351/2006 ROLE OF
DENDRITIC C ELLS IN LEISHMANIASIS: intracellular signalling pathways activated by virulent and attenuated
parasite Leismania infantum.
Nuno Santarém, fellowship in scientific investigation in the project “ANTI-LEISHMANIAL DRUGS: study the role
of novel polyamine derivative compounds for drug therapy and search for target specific SIR2 inhibitors”.
Ana Marta Silva, fellowship in scientific investigation in the project “The Leishmania SIR2 family-related gene:
functional studies and evaluation of SIR2 recombinant DNA and knockout vaccine to protect against
Leishmaniasis”.
Joana Maciel and Ana Marta Silva, fellowship in scientific investigation in the project “ Study of excreted /
secreted proteins from Leishmania infantum with immunological activity".
Joana Tavares, fellowship in scientific investigation in the project nº14209;C linical and immunological effects
of aminosidine therapy in dogs experimentally infected with Leishmania infantum.
Bruno Filipe Marques da C osta, fellowship in scientific investigation in the project 55082;Validation of
Leishmania infantum proteins as a immunodiagnostic marker.
Daniela Filipa Martins Duarte, fellowship in scientific investigation in the project 39257;Study of
excretion/secretion of proteins induced by Leishmania infantum with immunological activity.
Ana C arvalho Figueiredo, fellowship in scientific investigation in the project 39257;Study of
excretion/secretion of proteins induced by Leishmania infantum with immunological activity.
Nuno Santarém, fellowship in scientific investigation in the project 55082;Validation of Leishmania infantum
proteins as a immunodiagnostic marker.
Natália da C osta Araújo, fellowship in scientific investigation in the Unit Stress in animals, in the Instituto de
Biologia Molecular e C elular da Universidade do Porto, in the investigation project intitled: Study of
immunological markers in Leishmaniasis treatment.
C arla Ferraz, fellowship in scientific investigation in the Unit Stress in animals, do Instituto de Biologia
Molecular e C elular da Universidade do Porto, in the investigation project intitled: Study of immunological
markers to the Leishmaniasis treatment.
Margarida C outinho Borges, fellowship in scientific investigation in the project Study of lymphocyte
populations involved in immunological response to ribosomal protein of 32 kDa of Leishmania major.
Raúl Bettencout, in his pós-graduate course in Biology, in C entro de C itologia Experimental, 22 of August of
1989 to 22 September of 1989.
7. Participation in R&D projects
Participação em projectos de investigação (coordenador/membro de equipas)
As a principal investigator:
Project (PTDC /BIA-MC /11866/2011) C ell communication by Leishmania microvesicles.FC T. 158 164€
NPP grant TRIC ONT, New INDIGO ERA NET: Science brings Europe and India closer, Target specific small
molecules to control infections due to Trypanosomatics.
Project (PTDC /SAU-FC F/101017/2008) Role and mechanism of action of immunoregulatory iNKT and DC cells
in Leishmania infection: new approaches for vaccination? FC T
Project (PTDC /SAU-FC F/67351/2006) intitled "The Role of dendritic cells in leishmaniasis: intracellular
signalling pathways activated by virulent parasite Leishmania infantum" grant from Fundação para a C iência e
Tecnologia (with assessment). 80.000euros
Project (PTDC /C VT/65047/2006) intitled "The Leishmania TDR1 family-related gene: functional studies and
evaluated of TDR1 recombinant protein and knockout vaccines against leishmaniasis" grant from Fundação
para a C iência e Tecnologia (with assessment). 168.241euros
Project (POC I/C VT//59840/2004) intitled “Leishmania SIR2 family-related gene: functional studies and
evaluation of SIR2 recombinant DNA and knockout vaccine to protect against Leishmaniasis” grant from
Fundação para a C iência e Tecnologia (with assessment). 90.367euros
Project (POC TI/SAU-FC F/59837/2004) intitled“Molecular and functional characterization of the Leishmania
cytosolic SIR2 deacetylase and search for target specific SIR2 inhibiors” grant from Fundação para a C iência
e Tecnologia (with assessment). 64.501euros
Project intitled New methods to diagnosis opportunist parasite (Leishmania) in immunodeficiency situations:
by flow cytometry and by PC R-ELISA, submitted at Reitoria da Universidade do Porto/Fundação Ilídeo Pinho
(without grant support). Project Ref. Nº: 55082 intitled Validation of Leishmania infantum proteins as a
immunodiagnosis marker, grant from Fundação C alouste Gulbenkian (with assessment).
Project (POC TI/C VT/14209/98/2001) intitled C linical and immunological effects of aminosidine therapy in
dogs experimentally infected with Leishmania infantum grant from Fundação para a C iência e Tecnologia
(with assessment). 25.000euros
Project (POC TI/C VT/39257/2001) intitled Study of excretion/secretion proteins from Leishmania infantum
with immunological activity, grant from Fundação para a C iência e Tecnologia (with assessment).
80.000euros
Project Role of a Leishmania infantum mithocondrial tryparedoxin peroxidase as a proeminant immunogen
submitted to Fundação para a C iência e Tecnologia (with assessment), not approved.
1999/2000. Project Study of lymphocyte populations involved in immunological response to ribosomal protein
of 32 kDa of Leishmania major, grant from Fundação C alouste Gulbenkian in Programa de Estímulo à
Iniciação C ientífica (with assessment). Project Study of immunological markers to the Leishmaniasis
treatment, grant from Programa Plurianual da Fundação para a C iência e Tecnologioa, in Unit of C ell
Adaptative Mechanisms, director Prof. Dr. Alexandre Quintanilha and co-director Prof. Dra. Natércia Teixeira
(with assessment).
As colaborator:
Project PTDC /SAU-FC F/100749/2008: “Implication of sirtuin proteins in the regulation of antigen presenting
cells apoptosis during leishmaniasis: a therapeutic approach”, PI:Ricardo Silvestre.
2007/2008 In the project intitled Development of remotely controlled multiparametric analytical systems REC OMAS. Universidade do Porto-aixaGeral de Depositos. Pluridisciplinar.
2004-2006 In the project intitled “The cytosolic pathway for peroxide detoxification in Leishmania infantum:
its importance for drug development and for parasite survival in macrophages” with Principal Investigator
Prof. Doutora Ana Tomás, grant from Fundação para a C iência e Tecnologia (with assessment).
2002/2004 In the project (POC TI/C VT/34206/99) intitled Functional analysis of two trypanoredoxin molecules
of Leishmania infantum and their validation as drug targets, with Principal Investigator Prof. Doutora Ana
Tomás, grant from Fundação para a C iência e Tecnologia (with assessment).
2003/2006 In the project (POC TI/ESP/41982/2001) intitled Isolation of molecules involved in high-affinity iron
uptake systems of Leishmania infantum, with Principal Investigator Prof. Doutora Ana Tomás, grant from
Fundação para a C iência e Tecnologia (with assessment).
2002/2004 In the project (POC TI/C TA/47583/2002)intitled Phylogenetic characterisation of the parasite
Perkinsus atlanticus by chromosome number and identification of conserved genes, with Principal Investigator
Prof. Doutor C arlos Azevedo, grant from Fundação para a C iência e Tecnologia (with assessment).
1999/2001 In the project (Praxis/SAL/10263) intitled A Leishmania infantum mitochondrial peroxiredoxin:
analysis of its role in parasite resistance to oxidative stress, with Principal Investigator Prof. Doutora Ana
Tomás, grant from Fundação para a C iência e Tecnologia (with assessment).
1999 In the project intitled A Leishmania infantum mitochondrial peroxiredoxin: analysis of its role in parasite
resistance to oxidative stress with Principal Investigator Prof. Doutora Ana Tomás, submitted to UNDP/World
Bank/WHO: Organização Mundial de Saúde (with assessment). Not approved.
1993 In the project intitled Identification, clonning and sequencing of immunosupressive/B mitogenic factors
of Trypanosoma cruzi with Principal Investigator Prof. Doutor Mário Arala-C haves, Laboratório de Imunologia,
Instituto de C iências Biomédicas Abel Salazar, Universidade do Porto, grant from Junta Nacional de
Investigação C ientífica, Programa Stride.
1990 In the project intitled Tuberculosis and immuno modulation with Principal Investigator Dr. Manuel
C asanovas, Serviço de Análises C línicas do Hospital Militar de Doenças Infecto-C ontagiosas, Lisboa. October
of 1989 to April of 1990.
1990 In the project intitled Screening of Fascioliasis in Benavente District with Principal Investigator Prof.
Doutora Palmira Rombert, Serviço de Helmintologia, Instituto de Higiene e Medicina Tropical, Universidade
nova de Lisboa. July of 1990.
1988/1989 In the project intitled Potential use of tritial in diets for Rainbow trout: effects of dietary levels and
incidence of cooking with Principal Investigator Prof. Doutor Emídio Gomes, Laboratório de Fisiologia Animal,
Instituto de C iências Biomédicas Abel Salazar Universidade do Porto.
International Responsible for the portuguese partner
2013-2016
“Kinetoplastid Drug Development: strengthening the preclinical pipeline”. HEALTH.2013.2.3.4-2: Drug
development for neglected parasitic diseases.
FP7- HEALTH-2013-INNOVATION-1
2014-2017
“New Medicines for Trypanosomatidic Infections”.
HEALTH.2013.2.3.4-2: Drug development for neglected parasitic diseases.
FP7- HEALTH-2013-INNOVATION-1
2014-2018
“C linical Studies on a Multivalent Vaccine for Human Visceral Leishmaniasis” HEALTH.2013.2.3.0-1: Innovation
in vaccines. FP7-HEALTH-2013-INNOVATION-1.
2010-2011
IMMUNONET: Immunotherapy network. SOE1/P1/E014. União Europeia FP7. begin: 01-09-2010 End: 01-092012.
2010-2011
NPP grant TRIC ONT, New INDIGO ERA NET: Science brings Europe and India closer, Target specific small
molecules to control infections due to Trypanosomatics. União Euro-peia FP7. begin: 01-09-2010 end: 01-092012.
2010 Project intitled: "Role and mechanism of action of human immunoregulatory iNKT cells in Leishmania
infection: new approaches for vaccination?" Programa Pessoa. Embaixada de França and EGIDE.
2009/2010 Project intitled: “Diagnóstico imunológico da leishmaniose visceral”. C ooperação C ientifica e
Tecnológica FC T/C APES – 2010-2011 (Proc.4.4.1.00 C APES).
2009 Project intitled: "Role and mechanism of action of human immunoregulatory iNKT cells in Leishmania
infection: new approaches for vaccination?" Programa Pessoa. Embaixada de França and EGIDE. 2400euros.
2008 Project intitled “The study into mode of action of novel polyamine derivatives /analogues as potential
antiparasitic therapeitics agents”. Acções Integradas Luso-Britânicas- 2008 NºB-10/08. 1500euros
2004/2005 Project intitled Role of protein SIR2 from Leishmania spp in the relationship parasite with host:
Search a potential vaccine Project nº 706 C 3 supported by the Programme GRIC E / Embaixada de França
(with assessment). Renovation for the second year.
2003/2004 Project intitled Role of protein SIR2 from Leishmania spp in the relationship parasite with host:
Search a potential vaccine Project nº 706 C 3 supported by the Programme GRIC E / Embaixada de França
(with assessment).
2002/...Project intitled The design, synthesis, mode of action and immunological study of novel antiparasitic
polyamine drugs in collaboration with Prof. Doutor Paul Kong, Gorden University, Aberdeen, UK.
1999 Project intitled C haracterization of domain functional immunosupressor of Tc52 protein from
Trypanosoma cruzi. Project grant from Programa C ientífico e Técnico Luso-Francesa IC C TI-INSERM (with
assessment).
Project intitled Immunological and molecular studies of the disease induced by Leishmania infantum and
Leishmania major: immunological and molecular characterization of immunosupressive parasite components,
cloning of the correspondent genes and assays of inactivation genes by the technic of genetic inverse. Project
grant from Programa C ientífico e Técnico Luso-Francesa IC C TI-INSERM (with assessment).
grant from Programa C ientífico e Técnico Luso-Francesa IC C TI-INSERM (with assessment).
As a collaborator
2003/2008 In the project intitled Mecanismes moléculaires et cellulaires de la pathogénie des
Trypanosomatidae: corollaires épidémiologiques, physiopathologiques et immunoprophylactiques with a
Principal Investigator Doutor Ali Ouaissi. Institut de Recherche pour le Développement, Montpellier, France.
1996 In the project intitled Role des populations cellulaires C D8+ dans la resistance à infection expermental
par Trypanosoma cruzi with the Principal Investigator Doutora Paola Minoprio.
1992/1995 In the project intitled Development of a rational therapy for C hagas´cardiomyopathy with
Principal Investigator Doutora Paola Minoprio, financiado pela C omunidade Europeia (ref. 921011),
Département Immunologie Unité Immunophysiopathologie Infectieuse, Institut Pasteur de Paris, France.
1992/1994 In the project intitled Mutation Xid: modele etude immunobiologique et moleculaire des antigens
induteures de la resistance a la pathologie experimental de C hagas with Principal Investigator Doutora Paola
Minoprio, grant from TDR-World Health Organization, ID 910289. Laboratoire Immunoparasitologie de l´
Institut Pasteur de Paris. 1 February of 1992 to 01 July of 1994.
1992/1993 In the project intitled Detection of profile Th1/Th2 in experimental infections with Trypanosoma
cruzi with Principal Investigator Doutora Paola Minoprio, Laboratoire Immunoparasitologie de l´ Institut
Pasteur de Paris. July of 1992 to October of 1993.
8. Prizes and awards received
Year
Name of the prize or award
Promoting entity
2003
Scientific prize APDF 2003
Associação Portuguesa de
Doutorados em França
1999
Gulbenkian Prize in the programme
stimulus of scientific researche
investigator
Fundação C alouste Gulbenkian
9. Published works
Teses
C ordeiro-da-Silva, A. Ratinhos Balb.Xid: modelo de estudo dos mecanismos de resistência à infecção por
Trypanosoma cruzi. PhD thesis in Biomedical Sciences. Instituo de C iências Biomédicas Abel Salazar,
Universidade do Porto. 1997.
C ordeiro-da-Silva. A. C lonagem e sequênciação do cDNA que codifica para uma proteína de 16 kDa de
Schistosoma mansoni. Master thesis in Immunology. Instituo de C iências Biomédicas Abel Salazar,
Universidade do Porto. 1992.
C ordeiro-da-Silva, A. Aggregation in Immunology. Faculdade de Farmácia, Universidade do Porto. 2005.
Capítulos de livros
Joana C unha, Eugenia C arrillo, Javier Moreno and Anabela C ordeiro-da-Silva.Book chapit
C an Attenuated Leishmania Induce Equally Effective Protection as Virulent Strains in Vis-ceral
Leishmaniasis?. C apítulo do livro “Leishmaniasis” (In press).
Silvestre, R. and C ordeiro da Silva, A. Imunologia da Infecção. C apítulo do livro Fundamentos em
Imunologia, 2ªedição, 2012.
C ordeiro da Silva, A. Vacinas e Imunoterapia. C apítulo do livro Microbiologia Médica (in press), 2013.
Silvestre R, Santarém N, Tavares J, Silva AM and C ordeiro-da-Silva A. Recognition of Leishmania Parasites
by Innate Immunity. Immun., Endoc. & Metab. Agents in Med. C hem., 9, 001-0010, 2009.
C ordeiro-da-Silva, A., Lesmere, J.L., Sereno, D. and Ouaissi, A. Leishmaniasis: from infection to
autoimmunity. Recent Research Developments in Immunology. 4:43-52. ISBN: 81-7736-142-2. 2002.
N. Santarém and A. C ordeiro-da-Silva. Diagnosis of visceral leishmaniasis. C ommunicating C urrent
Research and Educational Topics
and Trends in Applied Microbiology
- 2007 Edition Artigos em revistas de circulação internacional com arbitragem científica
Santarém N, C unha J, Silvestre R, Silva C , Moreira D, Ouellette M, C ordeiro-DA-Silva A. The impact of
distinct culture media in Leishmania infantum biology and infectivity. Parasitology. 2013 Sep 6:1-14.
Sousa S, C ardoso L, Reed SG, Reis AB, Martins-Filho OA, Silvestre R, C ordeiro da Silva A. Development of
a fluorescent based immunosensor for the serodiagnosis of canine leishmaniasis combining
immunomagnetic separation and flow cytometry. PLoS Negl Trop Dis. 2013 Aug 22;7(8):e2371. doi:
10.1371/journal.pntd.0002371.
Lopes AP, Sousa S, Dubey JP, Ribeiro AJ, Silvestre R, C otovio M, Schallig HD, C ardoso L, C ordeiro-da-Silva
A. Prevalence of antibodies to Leishmania infantum and Toxoplasma gondii in horses from the north of
Portugal. Parasit Vectors. 2013 Jun 17;6:178.
Resende M, Moreira D, Augusto J, C unha J, Neves B, C ruz MT, Estaquier J, C ordeiro-da-Silva A, Silvestre R.
Leishmania-infected MHC class IIhigh dendritic cells polarize C D4+ T cells toward a nonprotective T-bet+
IFN-?+ IL-10+ phenotype. J Immunol. 2013 Jul 1;191(1):262-73.
C unha J, C arrillo E, Sánchez C , C ruz I, Moreno J, C ordeiro-da-Silva A. C haracterization of the biology and
infectivity of Leishmania infantum viscerotropic and dermotropic strains isolated from HIV+ and HIVpatients in the murine model of visceral leishmaniasis. Parasit Vectors. 2013 Apr 26;6:122. doi:
10.1186/1756-3305-6-122.
Santarém N, Racine G, Silvestre R, C ordeiro-da-Silva A, Ouellette M. Exoproteome dy-namics in Leishmania
infantum. J Proteomics. 2013 Jun 12;84:106-18. doi: 10.1016/j.jprot.2013.03.012. Epub 2013 Apr 1.
Ribeiro R, Monteiro C , Silvestre R, C astela A, C outinho H, Fraga A, Príncipe P, Lobato C , C osta C , C ordeiroda-Silva A, Lopes JM, Lopes C , Medeiros R.Human periprostatic white adipose tissue is rich in stromal
progenitor cells and a potential source of prostate tumor stroma. Exp Biol Med (Maywood). 2012 Oct
1;237(10):1155-62.
C osta Lima SA, Resende M, Silvestre R, Tavares J, Ouaissi A, Lin PK, C ordeiro-da-Silva A.C haracterization
and evaluation of BNIPDaoct-loaded PLGA nanoparticles for visceral leishmaniasis: in vitro and in vivo
studies. Nanomedicine (Lond). 2012 Dec;7(12):1839-49.
Mehdi O, Françoise S, Sofia C L, Urs G, Kevin Z, Bernard S, Igor S, Anabela C D, Dominique L, Eric M, Ali O.
HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors
panobinostat (LBH589) and trichostatine (TSA). Pan-creatology. 2012 Mar;12(2):146-55.
Silva AM, Tavares J, Silvestre R, Ouaissi A, C oombs GH, C ordeiro-da-Silva A. C harac-terization of
Leishmania infantum thiol-dependent reductase 1 and evaluation of its poten-tial to induce immune
protection. Parasite Immunol. 2012 Jun;34(6):345-50.
C osta Lima S, Rodrigues V, Garrido J, Borges F, Kong Thoo Lin P, C ordeiro da Silva A. In vitro evaluation of
bisnaphthalimidopropyl derivatives loaded into pegylated nanoparti-cles against Leishmania infantum
protozoa. Int J Antimicrob Agents. 2012 May;39(5):424-30.
Moreira D, Santarém N, Loureiro I, Tavares J, Silva AM, Amorim AM, Ouaissi A, C ordeiro-da-Silva A,
Silvestre R. Impact of continuous axenic cultivation in Leishmania infantum virulence. PLoS Negl Trop Dis.
2012 Jan;6(1):e1469.
Silva AM, C ordeiro-da-Silva A, C oombs GH. Metabolic variation during development in culture of Leishmania
donovani promastigotes. PLoS Negl Trop Dis. 2011 Dec;5(12):e1451.
Moreira-Teixeira L, Resende M, Devergne O, Herbeuval JP, Hermine O, Schneider E, Dy M, C ordeiro-daSilva A, Leite-de-Moraes MC . Rapamycin combined with TGF-ß converts human invariant NKT cells into
suppressive Foxp3+ regulatory cells. J Immunol. 2012 Jan 15;188(2):624-31.
Tavares J, Ouaissi A, Silva AM, Lin PK, Roy N, C ordeiro-da-Silva A. Anti-leishmanial activity of the
bisnaphthalimidopropyl derivatives. Parasitol Int. 2012 Jun;61(2):360-3.
Vilas-Boas V, Silva R, Gaio AR, Martins AM, Lima SC , C ordeiro-da-Silva A, de Lourdes Bastos M, Remião F.
P-glycoprotein activity in human C aucasian male lymphocytes does not follow its increased expression
during aging. C ytometry A. 2011 Nov;79(11):912-9.
Sousa S, Lopes AP, C ardoso L, Silvestre R, Schallig H, Reed SG, C ordeiro da Silva A. Seroepidemiological
survey of Leishmania infantum infection in dogs from northeastern Portugal. Acta Trop. 2011 OctNov;120(1-2):82-7.
Moreira-Teixeira L, Resende M, C offre M, Devergne O, Herbeuval JP, Hermine O, Schneider E, Rogge L,
Ruemmele FM, Dy M, C ordeiro-da-Silva A, Leite-de-Moraes MC . Proinflammatory Environment Dictates the
IL-17-Producing C apacity of Human Invariant NKT C ells. J Immunol. 2011 May 15;186(10):5758-65.
Silva R, C armo H, Dinis-Oliveira R, C ordeiro-da-Silva A, Lima SC , C arvalho F, de Lourdes Bastos M,
Remião F. In vitro study of P-glycoprotein induction as an antidotal pathway to prevent cytotoxicity in C aco2 cells. Arch Toxicol. 2011 Apr;85(4):315-26.
Hoskins C , Ouaissi M, Lima SC , C heng WP, Loureirio I, Mas E, Lombardo D, C ordeiro-da-Silva A, Ouaissi A,
Kong Thoo Lin P. In vitro and in vivo anticancer activity of a novel nano-sized formulation based on selfassembling polymers against pancreatic cancer. Pharm Res. 2010 Dec;27(12):2694-703.
Neves BM, Silvestre R, Resende M, Ouaissi A, C unha J, Tavares J, Loureiro I, Santarém N, Silva AM, Lopes
MC , C ruz MT, C ordeiro da Silva A. Activation of hosphatidylinositol 3-kinase/Akt and impairment of nuclear
factor-kappaB: molecular mechanisms behind the arrested maturation/activation state of Leishmania
infantum-infected dendritic cells. Am J Pathol. 2010 Dec;177(6):2898-911.
Medhi Ouaissi, Sofia C abral, Joana Tavares, Anabela C ordeiro-da-Silva, F. Mathieu Daude, E. Mas, JP.
Bernard, B. Sastre, D. Lombard and Ali Ouaissi. Histone deacetylase (HDAC encoding gene expression in
pancreatic câncer cell lines and cell sensitivity to HADAC inhibitors. C âncer Biology and Therapy. 2010
7:4:523-531.
Santarém N, Silvestre R, C ardoso L, Schallig H, Reed SG, C ordeiro-da-Silva A. Application of an improved
enzyme-linked immunosorbent assay method for serological diagnosis of canine leishmaniasis. J C lin
Microbiol. 2010 May;48(5):1866-74. Epub 2010 Feb 17.
Tavares J, Ouaissi A, Kong Thoo Lin P, Loureiro I, Kaur S, Roy N, C ordeiro-da-Silva
A.Bisnaphthalimidopropyl derivatives as inhibitors of Leishmania SIR2 related protein 1. C hemMedC hem.
2010 Jan;5(1):140-7.
Silvestre R, Silva AM, C ordeiro-da-Silva A, Ouaissi A. The contribution of Toll-like receptor 2 to the innate
recognition of a Leishmania infantum silent information regulator 2 protein. Immunology. 2009
Dec;128(4):484-99.
Silvestre R, Santarém N, Teixeira L, C unha J, Schallig H, C ordeiro-da-Silva A. Evaluation of Leishmania
species reactivity in human serologic diagnosis of leishmaniasis. Am J Trop Med Hyg. 2009 Aug;81(2):2028.
Neves BM, C ruz MT, Francisco V, Garcia-Rodriguez C , Silvestre R, C ordeiro-da-Silva A, Dinis AM, Batista
MT, Duarte C B, Lopes MC .Differential roles of PI3-Kinase, MAPKs and NF-kappaB on the manipulation of
dendritic cell T(h)1/T(h)2 cytokine/chemokine polarizing profile. Mol Immunol. 2009 Aug;46(13):2481-92.
Nunes C , Sousa C , Ferreira H, Lucio M, Lima JL, Tavares J, C ordeiro-da-Silva A, Reis S.Substituted phenols
as pollutants that affect membrane fluidity. J Environ Biol. 2008 Sep;29(5):733-8.
Silvestre R, Santarém N, C unha J, C ardoso L, Nieto J, C arrillo E, Moreno J, C ordeiro-da-Silva A. Serological
evaluation of experimentally infected dogs by LicTXNPx-ELISA and amastigote-flow cytometry. Vet
Parasitol. 2008 Nov 25;158(1-2):23-30.
Borges O, Silva M, de Sousa A, Borchard G, Junginger HE, C ordeiro-da-Silva A.
Alginate coated chitosan nanoparticles are an effective subcutaneous adjuvant for hepatitis B surface
antigen. Int Immunopharmacol. 2008 Dec 20;8(13-14):1773-80. Epub 2008 Sep 16.
Kadam RU, Tavares J, Kiran VM, C ordeiro A, Ouaissi A, Roy N. Structure function analysis of Leishmania
sirtuin: an ensemble of in silico and biochemical studies. C hem Biol Drug Des. 2008 May;71(5):501-6. Epub
2008 Mar 27.
Lima SA, C ordeiro-da-Silva A, de C astro B, Gameiro P. Benzodiazepine-mediated structural changes in the
multidrug transporter P-glycoprotein: an intrinsic fluorescence quenching analysis.
J Membr Biol. 2008 Jun;223(3):117-25.
Tavares J, Ouaissi A, Santarém N, Sereno D, Vergnes B, Sampaio P, C ordeiro-da-Silva A. The Leishmania
infantum cytosolic SIR2-related protein 1 (LiSIR2RP1) is an NAD+ -dependent deacetylase and ADPribosyltransferase. Biochem J. 2008 Nov 1;415(3):377-86.
Silvestre R, C ordeiro-da-Silva A, Ouaissi A. Live attenuated Leishmania vaccines: a potential strategic
alternative. Arch Immunol Ther Exp (Warsz). 2008 Mar-Apr;56(2):123-6. Epub 2008 Mar 31. Review.
Borges O, C ordeiro-da-Silva A, Tavares J, Santarém N, de Sousa A, Borchard G, Junginger HE. Immune
response by nasal delivery of hepatitis B surface antigen and codelivery of a C pG ODN in alginate coated
chitosan nanoparticles. Eur J Pharm Biopharm. 2008 Jun;69(2):405-16. Epub 2008 Jan 31.
C abral SM, Silvestre RL, Santarém NM, Tavares JC , Silva AF, C ordeiro-da-Silva A.A Leishmania infantum
cytosolic tryparedoxin activates B cells to secrete interleukin-10 and specific immunoglobulin. Immunology.
2008 Apr;123(4):555-65. Epub 2007 Nov 17.
Sousa C , Nunes C , Lúcio M, Ferreira H, Lima JL, Tavares J, C ordeiro-da-Silva A, Reis S. Effect of
nonsteroidal anti-inflammatory drugs on the cellular membrane fluidity. J Pharm Sci. 2008 Aug;97(8):3195206.
Nunes C , Sousa C , Ferreira H, Lucio M, Lima JL, Tavares J, C ordeiro-da-Silva A, Reis S. Substituted phenols
as pollutants that affect membrane fluidity. J Environ Biol. 2008 Sep;29(5):733-8.
13. Borges O, Tavares J, de Sousa A, Borchard G, Junginger HE, C ordeiro-da-Silva A. Evaluation of the
immune response following a short oral vaccination schedule with hepatitis B antigen encapsulated into
alginate-coated chitosan nanoparticles. Eur J Pharm Sci. 2007 Dec;32(4-5):278-90.
Leonor Teles-Grilo M, Duarte SM, Tato-C osta J, Gaspar-Maia A, Oliveira C , Rocha AA, Marques A, C ordeiroda-Silva A, Azevedo C . Molecular karyotype analysis of Perkinsus atlanticus (Phylum Perkinsozoa) by
pulsed field gel electrophoresis. Eur J Protistol. 2007 Nov;43(4):315-8.
Santarém N, Silvestre R, Tavares J, Silva M, C abral S, Maciel J, C ordeiro-da-Silva A. Immune response
regulation by leishmania secreted and nonsecreted antigens. J Biomed Biotechnol. 2007;2007(6):85154.
Silvestre R, C ordeiro-Da-Silva A, Santarém N, Vergnes B, Sereno D, Ouaissi A. SIR2-deficient Leishmania
infantum induces a defined IFN-gamma/IL-10 pattern that correlates with protection. J Immunol. 2007 Sep
1;179(5):3161-70.
Oliveira J, Ralton L, Tavares J, C odeiro-da-Silva A, Bestwick C S, McPherson A, Thoo Lin PK. The synthesis
and the in vitro cytotoxicity studies of bisnaphthalimidopropyl polyamine derivatives against colon cancer
cells and parasite Leishmania infantum. Bioorg Med C hem. 2007 Jan 1;15(1):541-5. Epub 2006 Sep 28.
C ardoso L, Schallig HD, C ordeiro-da-Silva A, C abral M, Alunda JM, Rodrigues M. Anti-Leishmania humoral
and cellular immune responses in naturally infected symptomatic and asymptomatic dogs. Vet Immunol
Immunopathol. 2007 May 15;117(1-2):35-41. Epub 2007 Jan 31.
Olga Borges, Gerrit Borchard, Adriano de Sousa, Hans E. Junginger and Anabela C ordeiro-da-Silva.
Induction of lymphocytes activated marker C D69 following exposure to chitosan and alginate biopolymers.
Int J Pharm. 2007 Jun 7; 337(1-2):254-64.
Adriano MA, Vergnes B, Poncet J, Mathieu-Daude F, da Silva AC , Ouaissi A, Sereno D. Proof of interaction
between Leishmania SIR2RP1 deacetylase and chaperone HSP83. Parasitol Res. 2007 Mar;100(4):811-8.
Sereno D, C ordeiro da Silva A, Mathieu-Daude F, Ouaissi A. Advances and perspectives in Leishmania cell
based drug-screening procedures. Parasitol Int. . 2007 Mar;56(1):3-7. Epub 2006 Oct 31. Review.
Lima SA, C ordeiro-da-Silva A, de C astro B, Gameiro P. Sensitivity of P-glycoprotein tryptophan residues to
benzodiazepines and ATP interaction. Biophys C hem. 2007 Jan;125(1):143-50.
Sereno D, Vergnes B, Mathieu-Daude F, C ordeiro da Silva A, Ouaissi A. Looking for putative functions of the
Leishmania cytosolic SIR2 deacetylase. Parasitol Res. 2006 Dec;100(1):1-9.
Borges O, C ordeiro-da-Silva A, Romeijn SG, Amidi M, de Sousa A, Borchard G, Junginger HE. Uptake
studies in rat Peyer's patches, cytotoxicity and release studies of alginate coated chitosan nanoparticles for
mucosal vaccination. J C ontrol Release. 2006 Sep 12;114(3):348-58.
Silvestre R, C ordeiro-da-Silva A, Tavares J, Sereno D, Ouaissi A. Leishmania cytosolic silent information
regulatory protein 2 deacetylase induces murine B-cell differentiation and in vivo production of specific
antibodies. Immunology. 2006 Dec;119(4):529-40.
Borges M, C ordeiro-da-Silva A, Vergnes B, Sereno D, Ouaissi A. C onversion of Trypanosoma cruzi Tc52
released factor to a protein inducing apoptosis. Tissue C ell. 2005 Dec;37(6):469-78.
Vergnes B, Sereno D, Tavares J, C ordeiro-da-Silva A, Vanhile L, Madjidian-Sereno N, Depoix D, MonteAlegre A, Ouaissi A. Target disruption of cytosolic SIR2 deacetylase discloses its essential role in
Leishmania survival and proliferation. Gene. 19:85-96. 2005.
Lima, S.A., C ordeiro-da-Silva A., Gameiro, P. and C astro, B. A method for functional mouse MDR3 Pglycoprotein reconstitution in Escherichia coli lipids. Anal Biochem. 338: 350-353. 2005.
Ferreira, H., Lucio, M., Lima, J.L., C ordeiro-da-Silva, A., Tavares, J., Reis, S. Effect of anti-inflammatory
drugs on splenocyte membrane fluidity.
Anal Biochem. 339: 144-149. 2005.
Tavares, J., Ouaissi, A., Lin, P.K.T., Tomás, A. and C ordeiro-da-Silva, A. Differential effects of polyamine
derivative compounds against Leishmania infantum promastigotes and axenic amastigotes. Int. J.Parasitol.
35:637-646. 2005.
Santarém,N., Tomás,A., Ouaissi, A., Tavares, J., Ferreira, N., Manso, A., C ampino, L., C orreia, J. M. and
C ordeiro-da-Silva, A - Antibodies against a Leishmania infantum peroxiredoxin as a possible marker for
diagnosis of visceral leishmaniasis and for monitoring the efficacy of treatment. Immunology Letters, 2005,
101, 18-23.
Ouaissi, A., Ouaissi, M., Tavares, J. and C ordeiro-da-Silva, A. Host cell phenotypic variability induced by
Trypanosomatid parasite released immunomodulatory factors: physiopathological implications. J. Biomed.
Biotechnolog. 3: 167-174. 2004.
C astro, H., Sousa, C ., Novais, M., Santos, M., Budde, H., C ordeiro-da-Silva, A., Flohé, L. and Tomás, A.
Two close linked of Leishmania infantum encode tryparedoxins localized to the cytosol and to the
mitochondria. Mol. Biochem. Parasitol. 134: 137-147. 2004.
C ordeiro-da-Silva, A., Tavares, J., Santarém, N., Silvestre, R. and Ouaissi A. Antibodies against rLmS3a
enhance the Leishmania uptake by murine peritoneal macrophages. Immunology 2004, ISBN88-7587-069-
1: 25-30. 2004.
C ordeiro-da-Silva, A., Tavares, J., Araújo, N., C erqueira, F., Tomás, A., Thoo Lin, P.K. and Ouaissi A.
Immunological alterations induced by polyamine derivatives on murine splenocytes and human
mononuclear cells. International Immunopharmacology, 4 : 547-556. 2004.
C erqueira, F., C ordeiro-da-Silva, A., Gaspar, C ., Simões, F., Pinto, M.M.M. and Nascimento, M. S. J. Effect
of abietane diterpenes from Plectranthus grandilentatus on T- and B- lymphocyte proliferation. Bioorganic &
Medicinal C hemistry. 12: 217-223. 2004.
Garzon, E., Borges, M.C ., C ordeiro-da-Silva, A., Nacife, V., Meirelles, M.N., Guilvard, E., Bosseno, M.F.,
Guevara, A.G., Breiner, S.F., Ouaissi, A. Trypanosoma cruzi carrying a targeted deletion of a Tc52 proteinencoding allele elicits attenuated C hagas’ disease in mice. Immunol Lett. Oct 9;89(1):67-80. 2003.
C ordeiro-da-Silva, A.*, Borges, M., C ardoso, L., C astro, H., Tomás, A., Rodrigues, M., C abral, M. and
Ouaissi, A. Identification of antibodies to Leishmania silent information regulatory 2 (SIR2) protein
homologue during canine natural infections: pathological implications. Immunol Lett. 86: 155-162. 2003.
C erqueira, F., C ordeiro-da-Silva, A., C idade, H., Kijjoa, A. and Nascimento, M. S. J. Inhibition of
lymphocyte proliferation by prenylated flavones: Artelastin as a potent inhibitor. Life Science. 73: 23212334. 2003.
Borges, M., C ordeiro-da-Silva, A., Sereno, D. and Ouaissi, A. Peptide-based analysis of the amino acid
sequence important to the immunoregulatory function of Trypanosoma cruzi Tc52 virulence factor.
Immunology 109:147-155. 2003.
C ardoso, L., Santos, H., C ordeiro-da-Silva, A., Pratlong, F., Dedet J.P., Rodrigues, M.. Leishmania infantum
MON-98: infection in a dog from the Alto Douro, Portugal. Acta Trop. Jul; 83(1):83-5. 2002.
C astro, H., Sousa, C ., Santos, M., C ordeiro-da-Silva, A., Flohé, L. Tomás, A.M. C omplementary antioxidant
defence by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum. Free Radic Biol Med.
1;33(11):1552-62. 2002.
C ordeiro-da-Silva, A.*, Borges, M., Guilvard, E., and Ouaissi, A. Dual role of Leishmania major ribosomal
protein S3a homologue in the regulation of T and B cell activation. Infection & Immunity. 69: 6588-96.
2001.
Santos-Lima, E.C ., Vasconcellos, R., Reine-San-Martin, B., Fesel, C ., C ordeiro-da-Silva, A., Berneman, A.,
C osson, A., C outinho, A. and Minoprio, P. Significant association between the skewed natural antibody
repertoire of Xid mice and resistance to Trypanosoma cruzi infections. Eur. J. Immunol, Feb; 31 (2): 63445. 2001.
Borges, M., Guilvard, E., C ordeiro-da-Silva, A., Vergnes, B., Zemzoumi, K. and Ouaissi, A. Endogenous
Trypanosoma cruzi Tc52 protein expression up regulates the growth of murine macrophages and fibroblasts
and cytokine gene expression. Immunology Letters, 78:127-34. 2001.
Ouaissi, A., C ordeiro-da-Silva, A.*, Guevara, A., Borges, M. and Guilvard, E. Trypanosoma cruzi-induced
host immune system dysfunction: a rationable for parasite immunosuppressive factor(s) encoding gene
targeting. Journal of Biomedicine and Biotechnology, 1:11-17. 2001.
Guevara, A.G., Guilvard, E., Borges, M.M., C ordeiro-da-Silva, A., Ouaissi, A. N-Acetylcysteine and
glutathione modulate the behaviour of Trypanosoma cruzi experimental infection. Immunol Lett, 71(2):7983. 2000.
Reina-San-Martín, B., Degrave, W., Rougeot, C ., C osson, A., C hamond, N., C ordeiro-da-Silva, A., AralaC haves, M., C outinho, A. and Minoprio, P. A B-cell mitogen from a pathogenic trypanosome is a eukaryotic
proline racemase. Nature Medicine. 8: 890–897. 2000.
Zemzouni, K., Guilvard, E., Sereno, D., Preto, A., Benlemlih, M., C ordeiro-da-Silva, A., Lemesre, J.L. and
Ouaissi, A. C loning of a Leishmania major gene encoding for an antigen with extensive homology to
ribosomal protein S3a. Gene. 240 (1): 57-65. 1999.
C ordeiro-da-Silva, A., Guevara-Espinoza, A., Taibi, A. Ouaissi, A., and Minoprio, P. A 24 kDa Trypanosoma
cruzi specific antigen as a B cell activater. Immunology. 94: 189-196. 1998.
C ordeiro-da-Silva, A., Santos Lima, E. and Minoprio, P. V?6 bearing T cells are involved in resistance to
Trypanosoma cruzi infection in XID mice. International Immunology. 8: 1213-1219. 1996.
C ordeiro-da-Silva, A., Lepresle, T., C apron, A. and Pierce, R. Molecular cloning of a 16kDa C u/Zn
superoxide dismutase from Schistosoma mansoni. Mol. Biochem. Parasitol. 52:275-278.1992.
Artigos em revistas nacionais com arbitragem científica
1. C ordeiro-da-Silva A. Immune response in leishmaniasis induce s polyclonal activation. Review paper.
Revista da Sociedade de C iências Farmacêuticas. Submited
2. Santarém N, Fernandes F and C ordeiro-da-Silva A. Leishmaniasis diagnosis. Instituto de Biologia
Molecular e C elular News. 8. September. 2004.
3. Tavares J and C ordeiro-da-Silva A. The role of dendritic cells in Leishmania infection. Instituto de
Biologia Molecular e C elular News. 8. September. 2004.
4. Silvestre R and C ordeiro-da-Silva A. The role of dendritic cells in Leishmania vaccina-tion. Instituto de
Biologia Molecular e C elular News. 8. September. 2004.
5. C ordeiro-da-Silva A and Borges M. Leishmaniasis control by DNA vaccination. Insti-tuto de Biologia
Molecular e C elular News. 6. nº 8. September. 2002.
6. C ordeiro-da-Silva A. Leishmania spp induce infection or autoimmunity?. Instituto de Biologia Molecular e
C elular News. 5.nº 8. September. 2001.
7. C ordeiro-da-Silva A. Entrevista a Anabela C ordeiro da Silva. Artigo de divulgação científica. Revista da
Ordem dos Farmacêuticos. VII. Novembro/Dezembro. 58-59. 2000.
8. Zemzoumi K, Borges M, Guilvard E, C ordeiro-da-Silva A Ouaissi A. Determination of the minimal
functional immunosuppressive domain of Tc 52 protein from Trypanosoma cruzi. Revista da Sociedade
Portuguesa de Imunologia. 5, 57-58. 1999.
9. C ordeiro-da-Silva A. Estudo molecular e imunológico da infecção por Trypanosoma cruzi. Artigo de
revisão. Revista da Sociedade Portuguesa de Imunologia. 2, 11-35. 1997.
10. C ordeiro-da-Silva A, C arvalho F and Silveira I. Algumas notas sobre anti-depressivos Triciclicos. Rev.
Port. Farm. Vol. XXXVII. 4: 137-142. 1987.
Publicações em actas de encontros científicos
Anabela C ordeiro-da-Silva, Ana Marta Silva, Joana Tavares, Mariana Resende, Grahm C oombs. TDR1 elicits
a protective immune response in the contexto f infection for experimental leishmaniasis. International
Immunology, 2010, ISSN 0953-8178. PP-002-22.
Renata Silva, Anabela C ordeiro-da-Silva, Félix C arvalho, Maria de Lourdes Bastos, Helena C armo,
Fernando Remião. P-glycoprotein induction as a cellular protection tool against xenobiotics toxicity.
Toxicology Letters 189S (2009) S57–S273.
M. Resende, R.silvestre, N.Santarém, S. G. Pereira, A. C ordeiro-da-Silva "Leishmania infantum
excreted/secreted molecules modify dendritic cells activation status". European Journal of Immunology,
Supplement 1/09, ISSN 0014-2980, EJIMAF 39 (S1)-S808 (2009), Vol 39, No. S1, September 2009,
PA11/58.
Lúcia Teixeira, Odile Devergne, Jean-Philippe Herbeuval, Olivier Hermine, Michel Dy, Anabela C ordeiro-daSilva and Maria Leite-de-Moraes. Human invariant Natural Killer T cells: a new source of IL-17. 2009
European Journal of Immunology, 39, S1: 107, PA13/22.
Bruno Neves, Ricardo Silvestre, Joana C unha, Joana Tavares, Mariana Resende, Ali Ouaissi, Maria C eleste
Lopes, Maria Teresa C ruz and Anabela C ordeiro-da-Silva. Immunomodulation of dendritic cells by virulent
and attenuated Leishmana infantum strains. European Journal of Immunology, 39, S1: 365, PA1/60. 2009
Mariana Resende, Ricardo Silvestre, Nuno Santarém, Sandra Gomes Pereira and Anabela C ordeiro-daSilva. Leishmania infantum excreted / secreted molecules modify dendritc cells activation status. 2009
Journal of Immunology, 39, S1: 365, PA1/58.
Santarém N, Silvestre R, C ardoso L, C ordeiro-da-Silva A (2007). Evaluation of enzyme-linked
immunosorbent and flow cytometry assays for the serological diagnosis of visceral leishmaniasis using
crude and recombinant Leishmania proteins. Proceedings, International C onference of the World Association
for the Advancement of Veterinary Parasitology, Ghent, Belgium, p. 343.
Silvestre R, Santarém N, C ardoso L, Nieto J, Moreno J, A. C ordeiro-da-Silva A (2007). The potential of flow
cytometry as a diagnostic technique for canine leishmaniasis. Proceedings, X Iberian C ongress of
Parasitology, Madrid, Spain, DVD.
Tavares, J., Lin, P.K.T. and C ordeiro-da-Silva, A. New polyamine derivative compounds active against
Leishmania infantum induce apoptosis-like-death. Revista Portuguesa de Farmácia. ISSN 0484-811X Vol. LII
(n.º2) Suplemento. 61-62, 2005.
Tavares, J., Ouaissi, A., Thoo Lin,P.K. and C ordeiro da Silva, A.. New Polyamine Derivative C ompounds
Active Against Leishmania infantum Expressing Stable Luciferase Activity Induce Apoptosis-like Death.
Parassitologia. ISSN 0048-2951 Vol. 47, Suppl.1. 121, 2005.
Anabela C ordeiro-da-Silva, Joana PC Tavares, Nuno Santarém, Ricardo Silvestre and Ali Ouaissi. Antibodies
Against rLmS3arp Enhance the Leishmania Uptake by Murine Peritoneal Macrophages. C linical Investigative
Medicine. 2004. T45. 54.
Joana Tavares, Ali Ouaissi,Paul Kong Thoo Lin, Ana Tomás and Anabela C ordeiro-da-Silva. Apoptosis-like
death of Leishmania infantum induced by polyamine derivate compounds. C linical Investigative Medicine.
2004. M4.64.
Lima, S.A.C ., C ordeiro-da-Silva, A., Reis, S., Lima, J.L.F.C ., Gameiro, P. And C astro, B. Purificação da Pglicoproteína (MDR3) funcional a partir de células de Pichia pastoris. Revista Portuguesa de Farmácia. O-12,
ISSN 0484. Vol.LII (1). 2003.
Araújo, N., Tavares, J., Borges, N., Santarém, N., C ordeiro-da-Silva, A. Modification of different cell
populations during experimental Leishmania infantum infection. Revista Portuguesa de Farmácia. O-12,
ISSN 0484. Vol.LII (1). 2003.
Garzón, E., Borges, M., C ordeiro-da-Silva, A., Guilvara, E., Bosseno, M. F., Guevara, A. G., Breaiére, S. F.
and Ouaissi, A. Trypanosoma cruzi carrying a targeted deletion of a Tc52 protein-encoding allele elicits
attenuated C hagas’ disease in mice. Infectiom, Genetics and Evolution. 2: 235. 2003.
Garzón, E., Nacife, V.P., Monte-Alegro, A., C ordeiro-da-Silva, A., Guilvara, E., Bosseno, M. F., Meirelles, M.
N. L., Guevara, A. G., Borges, M., Breaiére, S. F. and Ouaissi, A. Trypanosoma cruzi carrying a targeted
deletion of a Tc52 protein-encoding allele elicits attenuated C hagas’ disease in mice. Rev. Inst. Med. Trop.
S. Paulo. 45: 134. 2003.
C astro, H., Lopes, R.B., C ordeiro-da-Silva, A., and Tomás, A. A mithocondrial H2O2 detoxification pathway
in Leishmania infantum. Eur. J. Biochem. 268:233. 2001.
C ordeiro-da-Silva, A., C outinho Borges, M. Guilvard, E. and Ouaissi, A. Leishmania major ribosomal protein
S3a induces a polyclonal B cell populations. Immunology Letters, vol. 73, nº2,3, 184. 2000.
Zemzoumi, K., Borges, M., Guilvard, E., C ordeiro-da-Silva, A. and Ouaissi, A. Determination of the
immunosupressive domain of Tc52 protein of Trypanosoma cruzi. Revista da Sociedade Portuguesa de
Imunologia. Ano 5. vol 1. 57. 1999.
Zemzoumi, K., Borges, M., Guilvard, E., C ordeiro-da-Silva, A. and Ouaissi, A. C aracterização funcional do
domínio imunossupressor da proteína Tc52 de Trypanosoma cruzi. Acta Parasitológica Portuguesa, vol. 5,
nº2. 1998.
C ordeiro-da-Silva, A., Guevara-Espinoza, A., Taibi, A. Ouaissi, A., and Minoprio, P. A 24 kDa Trypanosoma
cruzi specific antigen as a B cell activater. Revista da Sociedade Portuguesa de Imunologia. 4, C 22. 1996.
C ordeiro-da-Silva, A., Pena, M. R., Silero, A., Silero, M. and Teixeira, N. Diguanosine tetraphosphate
(Gp4G) activate a B cell population. Revista da Sociedade Portuguesa de Imunologia. 4,C 23. 1996.
C ordeiro-da-Silva, A., E. C ., Vicentelli, M. H. and Minoprio, P. - Papel das populações celulares C D8+ na
resistencia à infecção experimental pelo Trypanosoma cruzi. Revista da Sociedade Portuguesa de
Imunologia. 2, C 15. 1995.
C ordeiro da Silva, A., Santos Lima, E. C ., Vicentelli, M. H. and Minoprio, P. - The resistance of Balb.XID
mice to Trypanosoma cruzi infection is associated to presence of Vb6 bearing T cells. XX Annual Meeting on
Basic Research in C hagas´Disease. Memórias do Instituto Oswaldo C ruz. suppI.: 89, IM-023, 1994.
Parra, J., C ordeiro da Silva, A., C umano, A., Minoprio, P., Kourilsky P. and C outinho, A. - T cell repertoire
activated during acute phase of experimental T. cruzi infection. XX Annual Meeting on Basic Research in
C hagas´ Disease. Memórias do Instituto Oswaldo C ruz. suppl., 89, IM-015, 1994.
C ordeiro da Silva, A., Liegeard P., Arala C haves, M. and Minoprio, P. - Identificaçäo of immunossupressive
/ mitogenic factors of Trypanosoma cruzi. XX Annual Meeting on Basic Research in C hagas´Disease.
Memórias do Instituto Oswaldo C ruz. suppl., 88, IM-7, 1993.
C ordeiro da Silva, A., Liegeard P., Tavares, D., Arala C haves, M. and Minoprio, P. - Effect of P43
immunossupressive/ B mitogenic factor of C andida albicans in the immunomodulation of Trypanosoma cruzi
infection. XX Annual Meeting on Basic Research in C hagas´Disease. Memórias do Instituto Oswaldo C ruz.
suppl., 88, IM-8, 1993.
C ordeiro da Silva, A., Liegeard P. and Minoprio, P. - XID: mutation: immunobiological and molecular model
to study antigens which induce resistance to murine C hagas´ Disease. XX Annual Meeting on Basic
Research in C hagas´ Disease. Memórias do Instituto Oswaldo C ruz. suppl., 88, IM-6, 1993.
Santos Lima, E., C ordeiro-da-Silva, A., Liegeard, P. and Minoprio, P. gd C D3 and C D5B lymphocytes play a
consistent role in the mechanisms leading to C hagas´ Disease pathology. XX Annual Meeting on Basic
Research in C hagas´ Disease. Memórias do Instituto Oswaldo C ruz. suppl.: 88, C -6. 1993.
C ordeiro da Silva, A., Le Presle, T., C apron, A., and Pierce R. - C loning and characterization of a C u/Zn
superoxide dismutase from Schistosoma mansoni. Molecular and C ellular Biology of Host-parasite
interactions - Keyston Symposium. J. C ell. Biochem. Park C ity. January. 1992.
In Nacional Reviews
1. Lima, A.C ., C ordeiro-da-Silva, A., Reis, S., Lima, J.L.F.C ., Gameiro, P. And C astro, B. Purificação da Pglicoproteína (MDR3) funcional a partir de células de Pichia pastoris. Revista Portuguesa de Farmácia. O-12,
ISSN 0484. Vol.LII (1). 2003.
2. Araújo, N., Tavares, J., Borges, N., Santarém, N., C ordeiro-da-Silva, A. Modification of different cell
populations during experimental Leishmania infantum infection. Revista Portuguesa de Farmácia. O-12,
ISSN 0484. Vol.LII (1). 2003.
3. Zemzoumi, K., Borges, M., Guilvard, E., C ordeiro-da-Silva, A. and Ouaissi, A. C aracterização funcional
do domínio imunossupressor da proteína Tc52 de Trypanosoma cruzi. Acta Parasitológica Portuguesa, vol.
5, nº2. 1998.
4. Zemzoumi, K., Borges, M., Guilvard, E., C ordeiro-da-Silva, A. and Ouaissi, A. Determination of the
immunosupressive domain of Tc52 protein of Trypanosoma cruzi. Revista da Sociedade Portuguesa de
Imunologia. Ano 5. vol 1. 57. 1998.
5. C ordeiro-da-Silva, A., Guevara-Espinoza, A., Taibi, A. Ouaissi, A., and Minoprio, P. A 24 Kda
Trypanosoma cruzi specific antigen as a B cell activater. Revista da Sociedade Portuguesa de Imunologia.
4, C 22. 1996.
6. C ordeiro-da-Silva, A., Pena, M. R., Silero, A., Silero, M. and Teixeira, N. Diguanosine tetraphosphate
(Gp4G) activate a B cell population. Revista da Sociedade Portuguesa de Imunologia. 4,C 23. 1996.
7. C ordeiro-da-Silva, A., E. C ., Vicentelli, M. H. and Minoprio, P. - Papel das populações celulares C D8+ na
resistencia à infecção experimental pelo Trypanosoma cruzi. Revista da Sociedade Portuguesa de
Imunologia. 2, C 15. 1995.
Patentes
European Patent nº 03/12689 in co-owner and co-invention of Universidade do Porto and “Institut de
Recherche pour le Développement”. Title of invention: “Souches de protozoaires de virulence attenuée et
leur utilisation“ 29 October of 2003.
International Patent Nº: PC T/IB07/52311 in co-owner and co-invention of Universidade do Porto and The
Robert Gordon University, Aberdeen, UK. Title of invention: NEW DERIVATIVES OF
BISNAPHTHALIMIDOPROPYL, PROC ESS FOR ITS PREPARATION,PHARMAC EUTIC AL FORMULATION AND ITS
USE IN LEISHMANIASIS, TRYPANOSOMIASIS AND MALARIA.
10. Communications in scientific meetings
Comunicações orais por convite
Anabela C ordeiro da Silva e Ricardo Silvestre. ESC MID Postgraduate Technical Workshop "Technical
Workshop for Basic and C linical Parasitology. Leishmania: immunity. C IM – FMUP (C entro de Investigação
Médica Faculdade de Medicina da Uni-versidade do Porto).
Anabela C ordeiro da Silva. ESC MID Postgraduate Technical Workshop "Technical Workshop for Basic and
C linical Parasitology. Leishmania: diagnosis. C IM – FMUP (C entro de Investigação Médica Faculdade de
Medicina da Universidade do Porto).
C ordeiro-da-Silva, A. (invited speaker) Leishmania infection modify innate imune cells to regulate
adaptative immunity. How XXXVIII Annual Meeting of the Portuguese Society of Immunology. From
Immune Disorders to Immunotherapies. 25-27 November 2012.
C ordeiro-da-Silva, A. TRIC ONT: Target specific small molecules to control infections due to
Trypanosomatids. New INDIGO NPP during the EU-India S&T C ooperation Days 2011 in Vienna on 1-2
December 2011.
C ordeiro-da-Silva, A. Distinct immunological role of Leishmania infan-tum on infected and bystander
dendritic cells. 5th Meeting of the immunotherapy: New Trends in immunotherapy. Network (IMMUNONET).
Madrid, Spain, 20, May 2011.
C ordeiro-da-Silva A. C onvidada. “SIR2-deficient Leishmania in-fantum induces a cytokine profile that
correlates with protection”. BIT Life Sciences’ 3rd World C ongress of Vaccine: Infectious, Imunity and
Vaccinology. 23-25 Mars, Bei-jing. C hine. 2011.
C ordeiro-da-Silva A. “Effect of bisnaphthalimidopropyl polyamine derivatives against experimental
Leishmania infantum infection by cytosolic SIR2 related protein 1”. 22 de Mars, Instituto Pasteur da C oreia
do Sul, Seul. C oreia do Sul. 2011.
C ordeiro-da-Silva, A "Escape mechanisms devised by Parasites and Mycobacteria: possible interference"
C onferênces Jacques Monod. Aussois, França. 1994.
Outras comunicações orais
International meetings
Anabela C ordeiro-da-Silva. The role of bisnaphthalimidopropyl derivatives to control trypanosomatid
neglected infections. C OST AC TION C M0801 4th ANNUAL MEETING Kolymvari, C rete 10-21th September
2012.
C ordeiro-da-Silva, A. (invited speaker). How Leismania infection modify innate immune
cells to regulate adaptative immunity. SPI: From immune disorders to immunotherapies. 1-25-27 Novembro
2012. XXXVIII SPI Annual Meeting. Porto.
Resende, M, Moreira, D, C unha, J, Augusto, J, Neves B, C ruz, MT, Estaquier J, C ordeiro-da-Silva, A,
Silvestre, R. Leishmania – infected mature dendritic cells polarize C D4+T cells towards a non-protective Tbet+ INF-gamma+ IL-10+ phenotype. EMBO/EMBL Symposium. New Perspectives on Immunity to Infection. Heidelberg, Germany.19-22 May 2012.
C osta Lima S and C ordeiro-da-Silva A. The role of Amphotericin B in poly(lactic-co-glycolic acid) (PLGA)
nanoparticles against visceral leishmaniasis. Joint Expert Meeting between Working Groups 1 and 3 of the
C OST Action C M0801, Heidelberg, Holanda, 17-18 Mars. 2011.
Moreira-Teixeira L, Resende M, C offre M, Devergne O, Herbeuval JP, Hermine O, Schneider E, Rogge L,
Ruemmele FM, Dy M, C ordeiro-da-Silva A, Leite-de-Moraes M C . World Immune Regulation Meeeting –V
Innate and Adaptive Immune Response and Role of Tissues in Immune Regulation. 24-27 Mars, Davos,
Suiça.2011.
C osta Lima S, Roussaki M, Sampaio S, Detsi A, Kefalas P and nabela C ordeiro-da-Silva. Heterocyclic
scaffolds with anti - Leishmania infantum activity determined by flow cytometry. Joint Expert Meeting
between Working Groups 1 and 3 of the C OST Action C M0801, Siena, Italy, Mars. 2010.
C osta Lima S, Kong Thoo Lin P and C ordeiro da Silva A. Nanotechnology as a tool towards trypanosmiasis
and leishmaniasis chemotherapies. Joint Expert Meeting between Working Groups 1 and 3 of the C OST
Action C M0801, Siena, Italy, Mars. 2010.
C ordeiro da Silva A, Silvestre R, Santarem N, C unha J, C ardoso L, Nieto J, C arrillo E and Moreno J.
Serological evaluation of experimentally infected dogs by LicTXNPX-ELISA and amastigote-flow cytometry.
Joint Expert Meeting between Working Groups 1 and 3 of the C OST Action C M0801, Siena, Italy, Mars.
2010.
Kong Thoo Lin P, Tavares J, Ouaissi A,Loureiro I, Kaur S, Roy N and C ordeiro da Silva A. Novel
Bisnaphthalimidopropyl Derivatoves as Inhibitors of Leishmania SIR2 Re-lated Protein 1. Joint Expert
Meeting between Working Groups 1 and 3 of the C OST Ac-tion C M0801, Siena, Italy, Mars. 2010.
Lúcia MOREIRA-TEIXEIRA, Mariana RESENDE, Odile DEVERGNE, Jean-Philippe HERBEUVAL, Olivier
HERMINE, Elke SC HNEIDER, Michel DY, Anabela C ORDEIRO-DA-SILVA, and Maria C . LEITE-DE-MORAES.
Foxp3-expressing human invariant NKT cells”. 4ème journée Scientifique Miltenyi Biotec: "From
inflammation to immunomodulation in cancer", 24 June 2010, Paris - France.
Lúcia MOREIRA-TEIXEIRA, Mariana RESENDE, Odile DEVERGNE, Jean-Philippe HERBEUVAL, Olivier
HERMINE, Elke SC HNEIDER, Michel DY, Anabela C ORDEIRO-DA-SILVA, and Maria C . LEITE-DEMORAES.Foxp3-expressing human invariant NKT cells. 13e C olloque C ytokines du C rosic. French Society
for Immunology - Presqu'île du C roisic, France. 10-12 Mai 2010.
Renata Silva, Anabela C ordeiro-da-Silva, Félix C arvalho, Maria de Lourdes Bastos, Helena C armo,
Fernando Remião. P-glycoprotein induction as a cellular protection tool against xenobiotics toxicity.
EUROTOX: 26th C ongress of the European Societies of Toxicology. September, 13-16, 2009, Dresden,
Germany.
Joana Tavares, Sofia C osta Lima and Anabela C ordeiro da Silva. Effect of bisnaphthalimidopropyl
polyamine derivatives against experimental Leishmania infantum infection by cytosolic SIR2 related protein
1. Joint Expert Meeting between Working Groups 1 and 3 of the C OST Action C M0801, Sófia, Bulgária, Maio.
Joana Tavares, Ana Marta Silva, Ali Ouaissi, Paul Kong Thoo Lin, Nilanjan Roy and Anabela C ordeiro da
Silva. Antileishmanial activity of the bisnaphthalimidopropyl derivatives. 4th World C ongress on
Leishmaniasis 2009. 3rd to 7th February 2009, Lucknow, India.
Sofia.A.C . Lima, Paul Kong and Anabela C ordeiro da Silva.Encapsulation of bisnaphthalimidopropyl
derivatives, two novel anti-Leishmania drugs, in biodegradable PLA and PLGA nanoparticles. Nanomedicine
2008, Barcelona, Espanha, Setembro.
Ricardo Silvestre, Ali Ouaissi and C ordeiro-da-Silva, A. Leishmania cytosolic SIR2 deacetylase induces
selective murine B cell activation in vitro and in vivo. XI International C ongress of Parasitology. 6-11
August 2006. Glasgow,UK.
Silvestre R., C ordeiro-da-Silva A., Vergnes B., Sereno D. and Ouaissi A. Altered virulence of L. infantum
SIR2 single knockout-mutant: evaluation of its potential use as a vaccine candidate. 16th European
C ongress of Immunology, September 6-9, 2006, Paris, France.
Nuno Santarém; Sandra C arvalho; Susana Romão; Anabela C ordeiro-da-Silva; Vítor C osta, Ana M Tomás.
– Aquisição de Ferro em Amastigotas de Leishmania infantun, IX C ongresso Ibérico de Parasitologia.
C oimbra. 25 a 28 de Outubro de 2005.
Santarém, N; C ardoso, L.; Tomás, A.; C ordeiro-da-Silva, A. Flow C ytometry analysis as an alternative
diagnostic method to canine Leishmaniasis. 9º C ongresso da Sociedade Ibérica de C itometria. Porto. 19 a
21 de Maio de 2005.
Borges, M., C ordeiro-da-Silva, A., Vergnes, S., Sereno, D. And Ouaissi, A The role of TC 52 from
Trypanossoma cruzi: Apoptosis induction in cell populations. The first international conference. Mechanisms
of cell death and disease: Advance in therapeutic intervention. Sintra, Portugal. 8 November of 2002 to 11
November of 2002. C -2.
C astro, H., Sousa, C ., Santos, M., Budde, H., Lunsdorf, H., C ordeiro-da-Silva, A., Flohé, L. and Tomás, AM.
A mitochondrial peroxiredoxin in Leishmania infantum antioxidant defence. British Society for Parasitology
Trypanosomiasis and Leishmaniasis Seminar. Edinburgh, UK. 8 September of 2002 to 11 September of
2002. Pag.53.
Borges, M., C ordeiro-da-Silva, A Sereno, D. and Ouaissi, A T. cruzi Tc52 derived synthetic peptide
mediated suppression of IL-2 and IFN gamma production. Woods Hole Immunoparasitology Meeting.Woods
Hole, Massachusetts, USA. 28 April of 2002 to 29 April of 2002. Pag. 15 # 15.
C astro, H., Lopes, R.B., C ordeiro-da-Silva, A. and Tomás, AM. The mitochondrial H2O2 detoxification
system of Leishmania infantum. 4th C OST-B9 C ongress on Antiprotozoal C hemotherapy, Lisboa, Portugal, 6
to 9 May of 2001. Pag. 53.
C astro, H., C ordeiro-da-Silva, A., Flohé, L. and Tomás, AM. Functional characterization of a putative
mitochondrial peroxiredoxin from Leishmania infantum. 2nd International Meeting on C ellular Responses to
Oxidative and Osmotic Stress, Póvoa do Varzim, Portugal, 7 to 10 November of 2001. Pag.151.
C ordeiro-da-Silva, A., C outinho Borges, M., Guilvard, E. and Ouaissi, A. Leishmania major Ribosomal
Protein Induce a Polyclonal B C ell Populations.14th European immunology Meeting, Poznan, Polonia, 23 to
27 September of 2001.
Santos Lima, E., C osson, A., C ordeiro-da-Silva, A., Pereira da Silva, L. and Minoprio, P. La résistance à
Trypanosoma cruzi est dépendante de la regulation précoce d’INF-g et de TNF. Societe Francaise de
Parasitologie, Paris, France, 10 to 12 Mars of 1997.
Santos Lima, E., C ordeiro-da-Silva, A., Liegeard, P. and Minoprio, P. gd C D3 and C D5B lymphocytes play a
consistent role in the mechanisms leading to C hagas´ Disease pathology. XX Annual Meeting on Basic
Research in C hagas´ Disease. C axambu, Brasil, 9 to 11 November of 1993. C 6.
C ordeiro-da-Silva, A., Le Presle, T., C apron A. and Pierce R. - C loning and characterization of a C u/Zn
superoxide dismutase from Schistosoma mansoni. British Society for Parasitology. York, Inglaterra. April.
1992. C 12.
C astro, H, Sousa, C , Santos, M, Budde, H, Lunsdorf, H, C ordeiro da Silva, A, Flohé, L. & Tomás, AM. (2002).
“C ompartmented antioxidant defence by peroxiredoxins in Leishmania infantum”. 2nd International
Symposium on Antioxidants in Nutrition and Therapy: Mechanisms in Physiology-Pathology-Pharmacology,
Out. 2-4, Bali, Indonesia.
National meetings
Anabela C ordeiro da Silva. Imunologia e Infeção: Resposta imunológica na leishmaniose. VI C ongresso
C ientífico Anual NEF/AAC : Imunologia, Doenças Imunológicas e Imunote-rapias. C oimbra, 15 and 16
November 2012.
Ricardo Silvestre e Anabela C ordeiro da Silva (invited speakers). Imunopatologia da leishmaniose visceral:
conceitos e perspetivas futuras.Leishmaniose em Portugal no século XI. UTAD. 24 ofOctober 2011.
Santarem N, C ordeiro-da-Silva A, Ouellette M. Study of the exoproteome of Leishmania infantum. Second
I3S Scientific Retreat IBMC /INEB/IPATIMUP together in science. 6-7 May, Esposende, 2011.
Silva AM, Tavares J, Silvestre R, Ouaissi A, C oombs GH and C ordeiro-da-Silva A. Re-combinant Thiol
Dependent Reductase 1 from Leishmania infantum induces protection against Visceral Leishmaniasis.
Second I3S Scientific Retreat IBMC /INEB/IPATIMUP together in science. 6-7 May, Esposende, 2011.
Bruno Neves, Ricardo Silvestre, Mariana Resende, Joana C unha, Inês Loureiro, Joana Tavares, Ali Ouaissi,
Maria C eleste Lopes, Maria Teresa C ruz and Anabela C ordeiro Silva. PI3 kinase/AKT activation and
NF.kappa B impairment: a strategy used by Leishmabia parasites to impair DC function. XXXV Annual
Meeting of the Portuguese Society for Immunology, September, 28-30, 2009, Lisboa, Portugal.
Resende, M., Silvestre, R., Pereira, S and C ordeiro-da-Silva, A. Modulation of dendritic cells function by
leishmania excreted/secreted proteins. XXXIV Annual Meeting of the Portuguese Society for Immunology,
October, 26-28, 2008, Porto, Portugal.
Santarém N., Silvestre R., Tavares J., C abral S., Silva M., and C ordeiro-da-Silva, A. C omparative study of
the cytokine production in vitro and in vivo of three proteins involved in the trypanothione cascade. II
Simpósio Nacional de C itocinas, May 8, 2006, C oimbra, Portugal.
Silvestre R., C ordeiro-da-Silva A., Vergnes B., Sereno D. and Ouaissi A. Attenuated SIR2-deficient
Leishmania infantum as a vaccine candidate, XXXII Reunião Anual da Sociedade Portuguesa de Imunologia,
October 13-14, 2006, Braga, Portugal
Anabela C ordeiro-da-Silva. Parâmetros Imunológicos em Toxicologia- uma ciência, várias vertentes.
Fundação António de Almeida, Porto. 6 e 7 de Abril de 2005.
Santarém, N; C ardoso, L.; Tomás, A.; C ordeiro-da-Silva, A. Flow C ytometry analysis as an alternative
diagnostic method to canine Leishmaniasis. 9º C ongresso da Sociedade Ibérica de C itometria. Porto. 19th21st May. 2005.
Tavares, J., Araújo, N., Silvestre, R., Borges, M., Ouaissi, A., C ordeiro-da-Silva, A. Antibodies against
rLmS3arp enhance the Leishmania uptake by murine peritoneal macrophages. XXIX Annual meeting.
C hronic infections. Sociedade Portuguesa de Imunologia. Porto, Portugal, 9 to 11 October of 2003. C 1.3.
Borges, M., Garzón, E., C ordeiro-da-Silva, A., Guilvard, E. And Ouaissi, A. Trypanosoma cruzi Tc52+/mutant induced attenuated C hagas’ disease in mice. 2º Workshop C ell Adaptative Mechanisms. Ongoing
work and future perspectives. Vairão, Portugal, 12 June of 2003. Pag. 25.
Araújo, N., Tavares, J., Borges, M., Santarém, N. and C ordeiro-da-Silva, A. Modification of different cell
populations during experimental Leishmania infantum infection. 1º C ongresso da Sociedade Portuguesa de
C iências Farmacêuticas. Lisboa, 14 to 16 April of 2002. O-12.
C erqueira, F., C ordeiro-da-Silva, A., Gaspar, C ., Simões, F. and Nascimento, M.S.J. A. 7a-Acetoxi-6bhydroxyroyleanona: a potent inhibitor of T and B lymphocyte proliferation. XIII C ongresso Nacional de
Bioquímica. Lisboa, Portugal, 5 to 7 Dezember of 2002. P5.
Araújo, N., C erqueira, F., Tavares, J., Kong Thoon Lin, P. and C ordeiro-da-Silva, A. Polyamine derivate
compounds induce a immunossupressive effect on Leishmania host cells by an apoptotic mechanism.
XXVIII Reunião Annual da Sociedade Portuguesa de Imunologia. Transplantação, tolerância e inflamação.
C oimbra, 14 to 16 November of 2002. OP4.1.
Borges, M, Garzon, E., C ordeiro-da-Silva, A., Guilvard, E., Bosseno, MF, Guevara, AG, Breinere, S. And
Ouaissi, A Trypanosoma cruzi carrying a targeted deletion of a Tc52 protein encoding allele elicits
attenuated C hagas’ disease in mice. XXVIII Reunião Annual da Sociedade Portuguesa de Imunologia.
Transplantação, tolerância e inflamação. C oimbra, 14 to 16 November of 2002. OP2.4.
C erqueira, F, C ordeiro-da-Silva, A., Araújo, N., Gaspar, C ., Simões, F. And Nascimento, MSJ C oleon U a
potent inhibitor of T and B lymphocyte proliferation. XXVIII Reunião Annual da Sociedade Portuguesa de
Imunologia. Transplantação, tolerância e inflamação. C oimbra, 14 to 16 November of 2002.
Borges, M., Guilvard, E., C ordeiro-da-Silva, A., Vergnes, B., Zemzoumi, K. And Ouaissi, A. Endogenous
Trypanosoma cruzi Tc52 protein expression induces the up regulation of the growth of murine macrophages
and fibroblasts and cytokine gene expression. Instituto de Biologia Molecular e C elular da Universidade do
Porto. Porto, 29 January of 2002.
C ordeiro-da-Silva, A. Infecções Parasitárias Indutoras de Autoimunidade. Segundas Jornadas da Sociedade
Portuguesa de C iências Farmacêuticas. C entro C ultural de Belém, Lisboa, Portugal, 16 Mars of 2001.
Ferraz, C ., C avaleyra, M., C ordeiro-da-Silva, A. and Lemesre, J. Expression of excreted-secreted antigens
during in vitro Leishmania infantum life cycle. Sociedade Portuguesa de Imunologia. XXVII Annual Meeting.
“Infection and Immunity: Perspectives for vaccination”. Faculdade de Medicina Veterinária, Universidade de
Lisboa, 22 to 24 November of 2001. Pag. 40.
Santos, M.L., Kong, P., Tomás, A. and C ordeiro-da-Silva, A. The role of polyamine derivates in host cells
and Leishmania infantum parasites. Sociedade Portuguesa de Imunologia. XXVII Annual Meeting. “Infection
and Immunity: Perspectives for vaccination”. Faculdade de Medicina Veterinária. Universidade de Lisboa, 22
to 24 November of 2001. Pag. 25.
Borges, M., Guilvard, E., C ordeiro-da-Silva, A., Vergnes, B., Zemzoumi, K. and Ouaissi, A. Up regulation of
murine macrophages and fibroblasts growth and cytokine gene expression by endogenous Trypanosoma
cruzi Tc52 protein expression. Sociedade Portuguesa de Imunologia. XXVII Annual Meeting. “Infection and
Immunity: Perspectives for vaccination”. Faculdade de Medicina Veterinária, Universidade de Lisboa, 22 to
24 November of 2001. Pag.34.
C erqueira, F., C ordeiro-da-Silva, A., C idade, H., Kijjoa, A. and Nascimento, M.S.J. Artelastin: A potent
inhibitor of T and B lymphocyte proliferation. Sociedade Portuguesa de Imunologia. XXVII Annual Meeting.
“Infection and Immunity: Perspectives for vaccination”. Faculdade de Medicina Veterinária, Universidade de
Lisboa, 22 to 24 November of 2001. Pag. 39.
C ordeiro-da-Silva, A., C outinho Borges, M.Guilvard, E. and Ouaissi, A Leishmania major ribosomal protein
S3a induces a polyclonal B cell activation and autoantibody production. XXVI Reunião Annual da Sociedade
Portuguesa de Imunologia. Jornadas de Actualização em Imunologia. C asa do Médico, Porto, Portugal.
2000. C 17.
C outinho Borges, M., Zemzoumi, K., Ouaissi, A. and C ordeiro-da-Silva, A. Immunosupressive effect of 30
kDa Leishmania major ribosomal protein at lymphocyte cell populations. XXV Reunião Annual da Sociedade
Portuguesa de Imunologia. Jornadas de Actualização em Imunologia. C asa do Médico, Porto, Portugal.
1999.
C ordeiro-da-Silva, A. O sistema imune como agente terapêutico. Novas Terapias e Tecnologias
Farmacêuticas. VI Fórum Farmacêutico. Porto, Portugal, 3 to 4 November of 1999.
C ordeiro-da-Silva, A. 1º C iclo de conferências da Sociedade Portuguesa de C iências Farmacêuticas. Papel
das Populações Linfocitárias na Leishmaniose. Faculdade de Farmácia, Universidade de Lisboa, Lisboa,
Portugal. 1999.
Zemzoumi, K., Borges, M., Guilvard, E., C ordeiro-da-Silva, A. and Ouaissi, A. Determination of the
immunosupressive domain of Tc52 protein of Trypanosoma cruzi. V Reunião da Sociedade Portuguesa de
Parasitologia, Vila Real, Portugal e XXIV Reunião Annual da Sociedade Portuguesa de Imunologia. Jornadas
de Actualização em Imunologia. C asa do Médico, Porto, Portugal, 12 to 14 November of 1998.
C ordeiro-da-Silva, A. Estudo de marcadores Imunológicos na Patologia de C hagas. Instituto de Biologia
Molecular e C elular, Porto. 1998.
C ordeiro-da-Silva, A., Guevara-Espinoza, A., Taibi, A. Ouaissi, A., and Minoprio, P. A 24 Kda Trypanosoma
cruzi specific antigen as a B cell activater. XXII Reunião Annual da Sociedade Portuguesa de Imunologia.
Jornadas de Actualização em Imunologia. Imunoregulação e Terapêuticas Imunes. C uria, Portugal. 6 to 9
November of 1996. C 23.
C ordeiro-da-Silva, A., Pena, M. R., Silero, A., Silero, M. and Teixeira, N. The role of diguanosine
tetraphosphate (Gp4G) in B cell response. XXII Reunião Annual da Sociedade Portuguesa de Imunologia.
Jornadas de Actualização em Imunologia. Imunoregulação e Terapêuticas Imunes. C uria, Portugal. 6 to 9
November of 1996. C 22.
C ordeiro-da-Silva, A., E. C ., Vicentelli, M. H. and Minoprio, P. - Papel das populações celulares C D8+ na
resistência à infecção experimental pelo Trypanosoma cruzi. XXI Reunião Annual da Sociedade Portuguesa
de Imunologia. Avanços em imunologia clínica. Lisboa, Portugal. 9 to 11 November of 1995.
C ordeiro-da-Silva, A., Santos Lima, E. C ., Vicentelli, M. H. and Minoprio, P. - Vb6 bearing T cells are
involved in the mechanisms of resistance to Trypanosoma cruzi infection in the Xid experimental model of
C hagas disease. XX Reunião Annual da Sociedade Portuguesa de Imunologia. Lisboa, Portugal. 10 to 12
Novembro of 1994. C 1.
Parra, J., C ordeiro-da-Silva, A., C umano, A., Minoprio, P., Kourilsky, P., and C outinho, A. - T cell repertoire
activated during acute phase of experimental T. cruzi infection XX Reunião Annual da Sociedade Portuguesa
de Imunologia. Lisboa, Portugal. 10 to 12 November of 1994. C 2.
C ordeiro-da-Silva, A., Liegeard P., Arala C haves, M. and Minoprio, P. - Identification of immunossupressive/
mitogenic factors produced by of Trypanosoma cruzi. XIX Reunião Annual da Sociedade Portuguesa de
Imunologia. X Jornadas de Actualização em Imunologia. Da Fisiologia à terapêutica. Lisboa, Portugal. 25 to
27 November of 1993. C 17.
C ordeiro-da-Silva, A., Liegeard P., Tavares, D., Arala C haves, M. and Minoprio, P. - Effect of P43
immunossupressive/ B mitogenic factor of in the immunomodulation of Trypanosoma cruzi infection. XIX
Reunião Annual da Sociedade Portuguesa de Imunologia. 9ª Jornadas de Actualização em Imunologia. Da
Fisiologia do Sistema Imune às Terapêuticas Imunológicas. Lisboa, Portugal. 25 October. 1993. C 20
C ordeiro-da-Silva, A., Liegeard P. and Minoprio, P. - XID: mutation: immunobiological and molecular model
to study antigens which induce resistance to murine C hagas´ Disease. XIX Reunião Annual da Sociedade
Portuguesa de Imunologia.10ª Jornadas de Actualização em Imunologia. Da Fisiologia do Sistema Imune às
Terapêuticas Imunológicas. Lisboa, Portugal, 25 October of 1993. C 22
C ordeiro-da-Silva, A., C haves-Arala, M. and Minoprio, P. Efeito de uma substância imunossupressora e
mitogénica B na imunomodelação da resposta à infecção por Trypanosoma cruzi. XVIII Reunião Annual da
Sociedade Portuguesa de Imunologia. 9º Jornadas de Actualização em Imunologia. Imunobiologia da
infecção por retrovirus. Porto, Portugal, 19 to 21 November of 1992. C 10.
C ordeiro-da-Silva, A., Le Presle, T., C apron A. and Pierce R. - C loning and characterization of a C u/Zn
superoxide dismutase from Schistosoma mansoni. XVIII Reunião Annual da Sociedade Portuguesa de
Imunologia. 9º Jornadas de Actualização em Imunologia. Imunobiologia da infecção por retrovirus. Porto,
Portugal, 19 to 21 November of 1992. C 12.
C ordeiro-da-Silva, A. Silva, B.M., Gonçalves, J.R., Rodrigues, J.V., C asanovas, J.M. and Alfarroda, E.
C orrelação do perfil imunológico com o sucesso terapêutico. Reunião da Sociedade Portuguesa de Patologia
Respiratória. Viana do castelo, Portugal. 28 April of 1990.
Comunicações em painel ("poster")
C omunicações em forma de painel em Encontros internacionais
Moreira, D., Santarem, N, Loureiro, I, Tavares J, Silva AM, Amorim, AM, Ouaissi, A, C ordeiro-da-Silva, A.
Impacto f continuous axenic cultivation in Leishmania infantum virulence. EMBO/EMBL Symposium. New
Perspectives on Immunity to Infection. Heidelberg, Germany.19-22 May 2012.
M. Ouaïssi, F. Silvy, S. C osta lima, B. Sastre, I. Sielezneff, A. C ordeiro da Silva, D. lombardo, E. Mas, A.
Ouaïssi. HDAC gene expression in pancreatic tumor cell lines submitted to the probinostat or trichostatin
HDAC inhibitors. ESSR 2012 47th Annual C ongress. Lille from 6 to 9 June 2012.
Ouaissi M, Silvy F, C osta Lima S, Sastre B, Sielezneff I, C ordeiro Da Silva A, Lombardo D, Mas E, Ouaissi A.
Etude de l'efficacité Panobinostat LBH 589 sur l’inhibition de la croissance des lignées cellulaires
cancéreuses pancréatiques et la corrélation au niveau d’expression des HDAC . JFHOD 2012
Ouaissi M, Silvy F, C osta Lima S, Giger U, Zemmour K , Sastre B, IS, C ordeiro-da-Silva A, Lombardo D,
Mas E, Ouaissi A. C haracterization of the anti-pancreatic tumor cell effect induced by LBH589 and its
relation to HDAC encoding genes expression. XX Porto C ancer Meeting: Drug Resistance in cancer from
biology to molecular targets and drug. April 28-29, Porto, Portugal. 2011
Ouaissi M, C abral S, Tavares J, Sielezneff L, Dahan S, C ordeiro-da-Silva A, Lombardo D, Mas E, Bernard A
and Ouaissi A. Histone deacetylase (HDAC ) encoding gene expres-sion in pancreatic cancer cell lines and
cell sensitivity to HDAC inhibitors. ASC O: American Society of C linical Oncology. Mars 29, USA. 2011
L. Moreira-Teixeira, M. Resende, O. Devergenw, J. Herbeuva, O. Hermine, E. Schneider, M. Dy, A.
C ordeiro-da-Silva, and M- Leite-de-Moraes. "Foxp3 expressing human invariant NKT cells". 13e C olloque
C ytoquines du C roisic de la Société Française d'Immunologie. May 10-12, 2010. C roisic, France.
A. C ordeiro-da-Silva, A.M. Silva, J. Tavares, M. Resende and G.H. C oombs. “TDR1 elicits a protective
immune response in the context of Leishmania infection”. 14th International C ongress of Immunology, 2227 August 2010, Kobe, Japan.
AM Silva, L McC aig, S Müller, A C ordeiro-Da-Silva and GH C oombs. “C haracterization of Leishmania
donovani Thiol Dependent Reductase 1 knockout”. BSP Spring and Malaria Meeting , March 29 - April 1 ,
2010, C ardiff, UK
Anabela C ordeiro-da-Silva, Ana Marta Silva, Joana Tavares, Mariana Resende, Grahm C oombs. TDR1 elicits
a protective immune response in the contexto f infection for experimental leishmaniasis. International
Immunology, 2010, ISSN 0953-8178. PP-002-22.
M. Ouaïss, J. Tavares, A. C ordeiro da Silva, Kong Thoo Lin and Ali Ouaissi. Bisnaphthalimidopropyl
derivatives as new drug inhibitors of pancreatic cancer cells growth. Portuguese-British meeting on
Modulation of programmed cell deth and therapeutic targets in cancer and neurodegenerative diseases,
IPATIMUP, 2009. Porto.
Lúcia Teixeira, Odile Devergne, Jean-Philippe Herbeuval, Olivier Hermine, Michel Dy, Anabela C ordeiro-daSilva and Maria Leite-de-Moraes. Human invariant Natural Killer T cells: a new source of IL-17. 2nd
European C ongress of Immunology, September 13-16, 2009, Berlim, Germany.
Bruno Neves, Ricardo Silvestre, Joana C unha, Joana Tavares, Mariana Resende, Ali Ouaissi, Maria C eleste
Lopes, Maria Teresa C ruz and Anabela C ordeiro-da-Silva. Immunomodulation of dendritic cells by virulent
and attenuated Leishmana infantum strains. 2nd European C ongress of Immunology, September 13-16,
2009, Berlim, Germany.
Mariana Resende, Ricardo Silvestre, Nuno Santarém, Sandra Gomes Pereira and Anabela C ordeiro-daSilva. Leishmania infantum excreted / secreted molecules modify dendritc cells activation status. 2nd
European C ongress of Immunology, September 13-16, 2009, Berlim, Germany.
Ricardo Silvestre, Nuno Santarém, Joana C unha, Luís C ardoso, Javier Nieto, Eugenia C arrillo, Javier Moreno
and Anabela C ordeiro da Silva. Serological evaluation of experimental infected dogs by LIC TXNPXELISAand Amastigote-Flow cytometry. 4th World C ongress on Leishmaniasis 2009. 3rd to 7th February
2009, Lucknow, India
Ricardo Silvestre, Ana M. Silva, Anabela C ordeiro-da-Silva1 and Ali Ouaissi. The contribution of toll like
receptor 2 to the innate recognition of a Leishmania infantum sir2 protein. 4th World C ongress on
Leishmaniasis 2009. 3rd to 7th February 2009, Lucknow, India
Ricardo Silvestre, Nuno Santarém, Lúcia Teixeira, Joana C unha, Henk Shallig and Anabela C ordeiro da
Silva. Evaluation of Leishmania species reactivity in human serological diagnostic of leishnaniasis. 4th World
C ongress on Leishmaniasis 2009. 3rd to 7th February 2009, Lucknow, India
Medhi Ouaissi,Joana Tavares, Anabela C ordeiro da Silva, Paul Kong Thoo Lin and Ali Ouaissi.
Bisnaphalimidopropyl derivatives as new drug inhibitors of pancreatic câncer cells growth. PortugueseBritish Meeting on Modulation of programme cell death and therapeutic targets in cancer and
neurodegenerative disease. 2009, 23 January, IPATIMUP, Porto.
Tavares, J., Ouaissi, A., Santarém, N., Thoo Lin, PK., C ordeiro-Da-Silva , A.Enzymatic characterization of
the Leishmania infantum cytosolic SIR2 related protein 1 (LiSIR2RP1) and search for target specific
inhibitors. Woods Hole 21-25th of September, USA
Santarém,N., Silvestre, R., Tavares, J., Silva, M., C abral, S., Maciel, J., C ordeiro-da-Silva, A.
Immunological role of Leishmania secreted and nonsecreted antigens. BSP Spring, Trypanosomiasis /
Leishmaniasis and Malária meeting, March 30th-April 2nd2008. NewC astle, UK.
Silvestre R, Santarém N, C ardoso L, Nieto J, Moreno J, C ordeiro-da-Silva A. The potential of flow cytometry
as a diagnostic technique for canine leishmaniasis. X C ongreso Ibérico de Parasitología, July 15-20, 2007,
Madrid, Spain.
Joana Tavares, Ali Ouaissi, Marta Silva, Paul Kong Thoo Lin, Denis Sereno and Anabela C ordeiro-da-Silva.
The in vitro and in vivo effect of Bisnaphthalimidopropyl polyamine derivatives against experimental
Leishmania infantum infection. 4th C OST B22 C ongress on Drug Discovery and Development for Parasitic
Diseases. 10th to 13th of June, 2007 Dundee, Scotland, United Kingdom.
Joana Tavares, Ali Ouaissi, Nuno Santarém and Anabela C ordeiro-da-Silva. Enzymatic characterization of
the Leishmania infantum Silent Information Regulator 2 and its role in the parasite life cycle stages. Drug
development for parasitic disease: C OST B22 Annual C ongress in Dundee, UK, 10-13 June 2007
Silvestre R., C ordeiro-da-Silva A., Ouaissi A., Leishmania cytosolic SIR2 deacetylase induces murine B-cell
activation in vitro and in vivo and antibody specific immune response. ESF-EMBO Symposium on B cells
cross the divide from in silico to the whole person, May 13-18, 2006, Sant Feliu de Guixols, Spain
Sandra C arvalho; Nuno Santarém; Rosa Barreira da Silva; Susana Romão; Anabela C . Silva; Vítor C osta,
Ana M Tomás. – Iron acquisition in Leishmania amastigotes. Gordon Research C onference: Biology of HostParasite Interactions. 25th - 30th June, Newport, Rhode Island, USA. 2006.
Santarém N., Silvestre R., Tavares J., C abral S., Silva M., C astro H., Tomás A. and C ordeiro-da-Silva A.
C omparative study of the immunological profile induced by three Leishmania infantum proteins involved in
the trypanothione cascade. 11th International C ongress of Parasitology, IC OPA XI, August 6-11, 2006,
Glasgow, Scotland.
N. Santarém; S. C arvalho; S. Romão; A. C ordeiro-da-Silva; V. C osta and A. Tomás.- Iron acquisition in
Leishmania amastigotes. 11th International C ongress of Parasitology. 6th - 11th August. Glasgow, Scotland.
Santarém N., Silvestre R., Nieto J., Moreno J. and C ordeiro-da-Silva A. An excreted/secreted protein from
L. infantum as a diagnostic marker in experitmental canine infection. 16th European C ongress of
Immunology, September 6-9, 2006, Paris, France.
Sandra C arvalho, Nuno Santarém, Rosa Barreira da Silva, Susana Romão, Anabela Silva, Vítor C osta, Ana
Tomás. - Iron acquisition in Leishmania infantum amastigotes. Transporters 2006. Parma, Italy. 6th - 9th
September, 2006.
Santarém N., Silvestre R., Nieto J., Moreno J. and C ordeiro-da-Silva A. The use of leishmania recombinant
proteins as diagnostic markers in experimental canine infection. XXXII Reunião Anual da Sociedade
Portuguesa de Imunologia, October 13-14, 2006, Braga, Portugal.
Marta Silva, Joana Tavares, Joana Maciel, Graham H. C oombs, Anabela C ordeiro-da-Silva “Leishmania
major TDR1 protein induces a specific IgG1 antibody production”. 16th European C ongress of Immunology.
September 6-9, 2006, Paris, France.
Marta Silva, Joana Tavares, Joana Maciel, Ana Tomás, Anabela C ordeiro-da-Silva “C haracterization of a
new 50KDa Leishmania infantum protein”. 11th International C ongress of Parasitology. August 6-11, 2006,
Glasgow, United Kingdom.
Joana Tavares, Mehdi Ouaissi, Ali Ouaissi and Anabela C ordeiro da Silva. “The role of cisplatin as an
antileishmanial drug” 11th International C ongress of Parasitology. August 6-11, 2006, Glasgow, United
Kingdom.
Olga Borges, Anabela C . da Silva, Joana Tavares, Adriano de Sousa, Hans E. Junginger. “Immune response
to hepatitis B surface antigen encapsulated into coated chitosan nanoparticles following oral administration”,
C RS (32nd Annual meeting & Exposition of the C ontrolled Release Society), July 2006, Vienna, Austrian
Maciel, J., Silva, M., Tomás, A. and C ordeiro-da-Silva, A. “A new excreted/secreted protein from
Leishmania infantum induces a humoral immune response”. 5th International C ongress Pharmaceutical
Sciences C IFARP 2005. Brasil September 25 – 28, 2005.
Tavares, J., Lin, P.K.T. and C ordeiro-da-Silva, A. New polyamine derivative compounds active against
Leishmania infantum induce apoptosis-like-death. 2nd C ongress of the Portuguese Society of
Pharmaceutical Sciences and 6th C ongress of the Portuguese-Spanish C hapter of the C ontrolled Release
Society. C oimbra. 31st-2nd April. 2005. P-7.
Tavares, J., Ouaissi, A., Ouaissi, M. and C ordeiro-da-Silva, A. Antileishmanial activity using a classical
anticancer compound. 9º C ongresso da Sociedade Ibérica de C itometria de Fluxo. Porto. 19-21 de Maio de
2005. PO068-MIC . 2005.
Tavares, J., Ouaissi, A., Thoo Lin, P.K. and C ordeiro da Silva, A.. New Polyamine Derivative C ompounds
Active Against Leishmania infantum Expressing Stable Luciferase Activity Induce Apoptosis-like Death. 2nd
C OST B22 C ongress on Drug Discovery and Development for Parasitic Diseases. Siena. 29 September- 1
October 2005. P- 49. 2005.
Santarém, N; C ardoso, L.; Tomás, A.; C ordeiro-da-Silva,A. Flow C ytometry analysis as an alternative
diagnostic method to canine Leishmaniasis. 9º C ongresso da Sociedade Ibérica de C itometria. Porto. 19 a
21 de Maio de 2005.
R. Silvestre, A. C ordeiro-da-Silva, A. and A. Ouaissi – “A recombinant Leishmania antigen related to the
Silent Information Regulatory 2 (SIR2) protein family induces a B cell activation and antibody specific
immune response”. The Eighth Annual C onference on Vaccine Research., Baltimore, EUA, 9-11 Maio 2005,
P47
Maciel, J., Silva, R., Tomás, A. and C ordeiro-da-Silva, A. A new excreted/secreted protein from Leishmania
infantum induces a humoral immune response” 5th International C ongresso f Pharmaceutical Sciences.
Ribeirão Preto, Brasil, de 25 a 28 de Setembro de 2005.
Ferreira, H., L.F.C . Lima, J., C ordeiro-da-Silva, A., Tavares, J. and Reis, S. Antioxidant profile of NSAIDS in
splenocyte and membrane models by fluorescence measurements. MAF9 9th International C onference on
Methods and Applications of Fluorescence. Lisbon, Portugal, de 4 a 7 Setembro de 2005
O. Borges, G. Borchard, J.C . Verhoef, A. de Sousa, A. C . da Silva, H.E. Junginger. “The entrappment of the
hepatitis B antigen within a new nanoparticulate delivery system for mucosal vaccination”, C ongress
“Immunopotentiators in Modern Vaccines” - IMV 2005, Torrequebrada Hotel, Malaga, Spain, Mai 2005.
Tavares, J., Silva, M., Tomás, A. C ordeiro-da-Silva, A. A new excreted/secreted protein from Leishmania
infantum induces a humoral immune response. 5th International C ongress f Pharmaceutical Sciences.
Ribeirão Preto, Brasil, de 25 a 28 Setembro de 2005.
C ordeiro-da-Silva, A., Tavares, J., Santarém, N., Silvestre, R. and Ouaissi A. Antibodies Against rLmS3a
Enhance the Leishmania Uptake by Murine Peritoneal Macrophages. 12th International C ongress of
Immunology and 4th Annual C onference of FOC IS, Montréal, C anada, de 18 a 23 Julho de 2004.
Tavares, J., Ouaissi, A., Lin, P.K.T., Tomás, A. and C ordeiro-da-Silva, A. Apoptosis–Like Death of
Leishmania infantum Induced by Polyamine Derivative C ompounds. 12th International C ongress of
Immunology and 4th Annual C onference of FOC IS, Montréal, C anada, de 18 a 23 Julho de 2004.
Tavares, J., Borges, M., C ordeiro-da Silva, A, Kong Thoo Lin, P.. The role of polyamine derivative drugs in
the inhibition of parasite proliferation by an apoptotic mechanism. Gordon C onference, C onnecticut C ollege,
New London, C T, USA, 15 to 20 June of 2003.
C astro, H., Sousa, C ., Novais, M., Santarém, N., C ordeiro-da-Silva, A. and Tomás, A. Two distinct
hydroperoxide detoxification systems coexist in Leishmania infantum. 6º Portuguese C ongress on Free
Radical in C hemistry, Biology and Medicine. 1º Luso-Spanish C ongress on Free Radicals. C oimbra, Portugal.
4 to 6 Dezember of 2003. Poster 019.
Lima, S.A.C ., C ordeiro-da-Silva, A., Gameiro, P., Reis, S., Lima, J.L.F.C . and C astro, B. Reconstitution of
ATPase activity in proteolipossomes of mouse mdr3 p-glycoprotein. 17 EC IS - European C olloid and
Interface Society C onference Firenze. 21 to 26 September of 2003. P7/35, pag. 495.
Borges, M., C ordeiro-da-Silva, A, Sereno, D., Ouaissi, A T. cruzi Tc52 derived synthetic peptide mediated
suppression of IL-2 and IFN-gamma production. Woods Hole ImmunoParasitology Meeting 2002. Woods
Hole, Massachusetts, USA. 28 to 30 Apbril of 2002. #15.
Garzon, E, Borges, M., C ordeiro-da-Silva, A., Guilvard, E., Mosseno, MF, Guevara, A, Breniere, SF and
Ouaissi, A . Trypanosoma cruzi carrying a target deletion of a Tc52 proteion-encoding allele elicits
attenuated C hagas’ disease in mice. Molecular Epidemiology and Evolutionary Genetics of Infectious
Disease Society. Montpellier, France. 23 to 26 July of 2002.
C ordeiro-da-Silva, A., Ferraz, C ., C ardoso, L., Rodrigues, M., C astro, H., Tomás, A, C abral, M. And Ouaissi,
A Antibodies produced during Leishmania infantum natural infection recognise natural and exogenous
antigens. British Society for Parasitology Trypanosomiasis and Leishmaniasis Seminar. Edinburgh. 8 to 11
September of 2002. IM03.
Araujo, N., Borges, M., Ouaissi, A and C ordeiro-da-Silva, A The role of rLmS3arp in the parasitemia control
during acute phase of experimental Leishmania infantum infection. British Society for Parasitology
Trypanosomiasis and Leishmaniasis Seminar. Edinburgh. 8 to 11 September of 2002. IM04.
Borges, M., Guilvard, E., C ordeiro-da-Silva, A., Vergnes, B., Zemzoumi, K. and Ouaissi, A. Endogenous
Trypanosoma cruzi Tc52 protein expression up regulates the growth of murine macrophages and fibroblasts
and cytokine gene expression. C lube da Sociedade Francesa de Vacionologia. Institut Pasteur de Paris,
França, 16 to 17 October of 2001. Résumé 26.
Santos, M.L.N.C ., Ferraz, C .A.S., Kong, P., Tomás, A. and C ordeiro-da-Silva, A. Immunological effects of
polyamine drugs in host and parasite cells. A EURO C ONFERENC E. 2nd International Meeting on C ellular
Responses to oxidative and Osmotic Stress. Sensing, signalling and gene expression, Póvoa de Varzim,
Portugal, 7 to 10 November of 2001. Pag.148.
C astro, H., Lopes, R. B., C ordeiro-da-Silva, A. and Tomás, A A mithocondrial H2O2 detoxification pathway
in Leishmania infantum. 27th Meeting of the Federation of European Biochemical Societies. Lisboa, Portugal,
30 June to 5 July of 2001. PW9-041.
C astro, H., Lopes, R.B., C ordeiro-da-Silva, A. and Tomás, AM. The mitochondrial H2O2 detoxification
system of Leishmania infantum. 4th C OST-B9 C ongress on Antiprotozoal C hemotherapy, Lisboa, Portugal, 6
to 9 May of 2001. P06.
C outinho Borges, M., Guilvard, E., Ouaissi, A., C ordeiro-da-Silva, A. Immunossuppressive effect of 30kDa
Leishmania major ribosomal protein at linfocyte cell populations. 37. C ongrès Annuel de la Société
Française de Parasitologie, Montpellier, France, 1 to 3 Mars of 2000. Pag. 72.
Borges, M., Guilvard, E., C ordeiro-da-Silva, A and Ouaissi, A. Endogenous Trypanosoma cruzi Tc52 protein
expression up regulates the growth of murine macrophages and fibroblasts and cytokine gene expression.
C omité de avaliação INSERM: Montpellier, France, 14 September of 2000.
C astro, H., C ordeiro-da-Silva, A. and Tomás, A. A mitochondrial peroxiredoxin from Leishmania infantum:
analysis of its role in parasite protection to oxidants. Molecular Parasitology XI. Woods Hole, USA, 17 to 21
September of 2000. Pag. 265A.
C ordeiro da Silva, A., C outinho Borges, M., Guilvard, E. and Ouaissi, A. Leishmania major Ribosomal
Protein Induce a Polyclonal B C ell Populations.14th European immunology Meeting, Poznan, Polonia, 23 to
27 September of 2000. W-23, 448.
C outinho Borges, M., Guilvard, E., Ouaissi, A., C ordeiro-da-Silva, A. Immunossuppressive effect of 30kDa
Leishmania major ribosomal protein at linfocyte cell populations. 37. C ongrès Annuel de la Société
Française d’ Immunologie, Lille, France, 24 to 26 November of 1999. 37, pag. 72.
Parra, J., C ordeiro da Silva, A., C umano, A., Minoprio, P., Kourilsky P. and C outinho, A. - T cell repertoire
activated during acute phase of experimental T. cruzi infection. XXI Annual Meeting on Basic Research in
C hagas´ Disease. C axambu, Brasil, 9 to 11 November of 1994. IM-015.
C ordeiro da Silva, A., Santos Lima, E. C ., Vicentelli, M. H. and Minoprio, P. - The resistance of Balb.XID
mice to Trypanosoma cruzi infection is associated to presence of Vb6 bearing T cells. XX Annual Meeting on
Basic Research in C hagas´Disease. C axambu, Brasil, 9 to 11 November of 1993. IM-023
C ordeiro da Silva, A., Liegeard P., Arala C haves, M. and Minoprio, P. - Identification of immunossupressive
/ mitogenic factors of Trypanosoma cruzi. XX Annual Meeting on Basic Research in C hagas´Disease.
C axambu, Brasil, 9 to 11 November of 1993. IM-7.
C ordeiro da Silva, A., Liegeard P., Tavares, D., Arala C haves, M. and Minoprio, P. - Effect of P43
immunossupressive/ B mitogenic factor of C andida albicans in the immunomodulation of Trypanosoma cruzi
infection. XX Annual Meeting on Basic Research in C hagas´Disease. C axambu, Brasil, 9 to 11 November of
1993. IM-8
C ordeiro da Silva, A., Liegeard P. and Minoprio, P. - XID: mutation: immunobiological and molecular model
to study antigens which induce resistance to murine C hagas´ Disease. XX Annual Meeting on Basic
Research in C hagas´ Disease. C axambu, Brasil, 9 to 11 November of 1993. IM-6.
C ordeiro da Silva, A., Le Presle, T., C apron, A., and Pierce R. - C loning and characterization of a C u/Zn
superoxide dismutase from Schistosoma mansoni. Molecular and C ellular Biology of Host-parasite
interactions - Keyston Symposium. Park C ity, Utath, USA. 13 to 26 January of 1992.
C omunicações em painel em Encontros Nacionais
Barros D, C osta-Lima S, C ordeiro-da-Silva A. Immunotherapeutic of mannosylated nanoparticles. XXXVIII
Annual Meeting of the Portuguese Society of Immunology. 25-27 November 2012.
Ramos-Silva C , Silvestre R, Santarém N and C ordeiro-da-Silva. Impact of axenic culture conditions in
Leishmania infantum virulence. IJUP: Investigação Jovem na U.Porto. 17-19 February, Porto, 2011.
C osta Lima S, Roussaki M, Sampaio S, Detsi A, Kefalas P and C ordeiro-da-Silva A.. Leishmania infantum
activity of heterocyclic scaffolds determined by flow cytometry Se-cond I3S Scientific Retreat
IBMC /INEB/IPATIMUP together in science. 6-7 May, Esposende, 2011.
C osta Lima S, Rodrigues V, Garrido J, Borges F, Thoo Lin PK and C ordeiro-da-Silva A.. Pegylated
nanoparticles for encapsulation of bisnaphthalimidopropyl derivatives against Leishmania infantum. Second
I3S Scientific Retreat IBMC /INEB/IPATIMUP together in science. 6-7 May, Esposende, 2011.
Ramos-Silva C , Santarém N, C ordeiro-da-Silva A and Silvestre R. Modulatory activity of several defined
culture mediums on Leishmania infantum virulence. Second I3S Scien-tific Retreat IBMC /INEB/IPATIMUP
together in science. 6-7 May, Esposende, 2011.
Ribeiro D, Rodrigues V, C ordeiro-da-Silva A and Silvestre R. Manipulation of host cell cycle by Leishmania
parasites: a potential evasion mechanism. Second I3S Scientific Re-treat IBMC /INEB/IPATIMUP together in
science. 6-7 May, Esposende, 2011.
Moreira D, Santarém N, Loureiro I, Tavares J, Silva AM, Ouaissi A, Silvestre R and C ordeiro-da-Silva A.
Impact of axenic culture in Leishmania infantum virulence. Second I3S Scientific Retreat
IBMC /INEB/IPATIMUP together in science. 6-7 May, Espo-sende, 2011.
Loureiro I, Tavares J, C ordeiro-da-Silva A. Ribose 5-phosphate isomerase B, a common and potential
target against parasitic infections by members of the Trypanosomatidae family. Second I3S Scientific
Retreat IBMC /INEB/IPATIMUP together in science. 6-7 May, Esposende, 2011.
Resende R, Neves B, C unha J, C unha D, C ruz T, C ordeiro-da-Silva A and Silvestre R. Differential effect of
Leishmania infantum on infected and bystander dendritic cells. Se-cond I3S Scientific Retreat
IBMC /INEB/IPATIMUP together in science. 6-7 May, Esposende, 2011.
Resende M, C unha J, C osta Lima S, Moreira D, C ordeiro-da-Silva A and Silvestre R. Early stages of visceral
Leishmania infection. Second I3S Scientific Retreat IBMC /INEB/IPATIMUP together in science. 6-7 May,
Esposende, 2011.
Sousa S, Lopes AP, C ardoso L, Silvestre R, Schallig H, C ordeiro-da-Silva A. Seroepidemiological survey of
Leishmania infantum infection in dogs from northeastern Portugal. Second I3S Scientific Retreat
IBMC /INEB/IPATIMUP together in science. 6-7 May, Esposende, 2011.
Moreira-Teixeira L, Resende M, C offre M, Devergne O, Herbeuval JP, Hermine O, Schneider E, Rogge L,
Ruemmele FM, DY M, C ordeiro-da-Silva A & Leite-de-Moraes MC . Pro-inflammatory environment dictates
the IL-17-producing capacity of human invar-iant NKT cells. Second I3S Scientific Retreat
IBMC /INEB/IPATIMUP together in science. 6-7 May, Esposende, 2011.
C unha J, Moreno J, C ordeiro-da-Silva A. In vitro comparative study between naturally attenuated and
virulent strains of Leishmania infantum. Second I3S Scientific Retreat IBMC /INEB/IPATIMUP together in
science. 6-7 May, Esposende, 2011.
Sampaio S, C osta Lima S, Detsi A and C ordeiro-da-Silva. Bioactivity of flavonoids against Leishmania
infantum determined by flow cytometry. IJUP: Investigação Jovem na U.Porto. 17-19 February, Porto, 2010.
Lúcia MOREIRA-TEIXEIRA, Mariana RESENDE, Odile DEVERGNE, Jean-Philippe HERBEUVAL, Olivier
HERMINE, Elke SC HNEIDER, Michel DY, Anabela C ORDEIRO-DA-SILVA, and Maria C . LEITE-DE-MORAES.
Foxp3-expressing human invariant NKT cells. I3S Scientific Retreat 2010, 6-7 May, Povoa de Varzim –
Portugal.
AM Silva, GH C oombs, A C ordeiro-Da-Silva. “The Leishmania TDR1 as a DNA vaccine does not protect mice
against visceral leishmaniasis”. SPI. October 26-28, 2008 Porto, Portugal
C unha J, Moreno J C ordeiro-da-Silva A. C omparative study between naturally attenuated and virulent
strains of Leishmania infantum: culture conditions and infectiveness". XIV C ongresso Português de
Parasitologia 2010, Porto, Portugal, Poster P-31
Resende M, Silvestre R, Neves B, C unha J, C ruz MT & C ordeiro-da-Silva A. "Differential effect of
Leishmania infantum on infected and bystander dendritic cells". XXXVI Annual Meeting of the Portuguese
Society for Immunology, September 20-11, 2010, Braga, Portugal
Diana Moreira, Ricardo Silvestre, Inês Loureiro, Joana Tavares, Ali Ouaissi and Anabela C ordeiro-da-Silva;
Impact of axenic culture in Leishmania infantum virulence no XIV C ongresso Português de Parasitologia,
Porto 8-10 de Setembro de 2010Diana Moreira, Ricardo Silvestre, Inês Loureiro, Joana Tavares, Ali Ouaissi and Anabela C ordeiro-da-Silva.
Different sensitivity of the Leishmania strains in the complement resistance with time culture and parasite
form” presented I3S Scientific Retreat, 6 e 7 de Maio de 2010, no Hotel Axis Vermar, Póvoa de Varzim.
Sofia Lima and Anabela C ordeiro da Silva. 3º Encontro de Jovens Investigadores da Universidade do Porto,
Portugal, Fevereiro. “Bioactivity of flavonoids against Leishmania infantum determined by fow cytometry”.
2010.
Inês Loureiro, Joana Tavares, Ali Ouaissi and Anabela C ordeiro da Silva. Different sensitivities of
Leishmania strains to the complement mediated lysis. XXXV Annual Meeting of the Portuguese Society for
Immunology, Septemer, 28-30, 2009, Lisboa, Portugal.
Sandra Gomes Pereira and Anabela C ordeiro da Silva. Nramp-functionality affects dendritic cell function
during in vitro Leishmania infection. XXXV Annual Meeting of the Portuguese Society for Immunology,
Septemer, 28-30, 2009, Lisboa, Portugal.
Bruno Neves, Ricardo Silvestre, Mariana Resende, Joana C unha, Inês Loureiro, Joana Tavares, Ali Ouaissi,
Maria C eleste Lopes, Maria Teresa C ruz and Anabela C ordeiro Silva. PI3 kinase/AKT activation and
NF.kappa B impairment: a strategy used by Leishmabia parasites to impair DC function. XXXV Annual
Meeting of the Portuguese Society for Immunology, September, 28-30, 2009, Lisboa, Portugal.
Lúcia Teixeira, Odile Devergne, Jean-Philippe Herbeuval, Olivier Hermine, Michel Dy, Anabela C ordeiro-daSilva and Maria Leite-de-Moraes. Human invariant Natural Killer T cells: a new source of IL-17. XXXV
Annual Meeting of the Portuguese Society for Immunology, September, 28-30, 2009, Lisboa, Portugal.
Sofia Lima and C ordeiro-da-Silva, A. 8th Inorganic C hemistry C onference, C uria, Portugal, Setembro. “In
vitro evaluation of bisnaphthylimidopropul derivatives – loaded PLGA nanoparticles of Leishmania infected
cells”.
Silva, AM., C oombs, GH and C ordeiro-da-Silva, A. The Leishmania TDR1 as a DNA vaccine does not protect
mice against visceral leishmaniasis. XXXIV Annual Meeting of the Portuguese Society for Immunology,
October, 26-28, 2008, Porto, Portugal.
Neves, B., C ruz, MT., Francisco, V., Duarte, C , Garcia-Rodriguez, C ., Silvestre, R., C ordeiro-da-Silva, A and
Lopes, M.C . Differential roles of PI3 kinase, MAPKs and NF-KappaB on the maturation of skin dendritic cells.
XXXIV Annual Meeting of the Portuguese Society for Immunology, October, 26-28, 2008, Porto, Portugal.
Sofia A.C . Lima, Joana Tavares, Paula Gameiro, Baltazar de C astro and Anabela C ordeiro-da-Silva.
C ITOMETRIA DE FLUXO – UM MÉTODO PARA QUANTIFIC AR E IDENTIFIC AR INIBIDORES DA PGLIC OPROTEÍNA ”. 2007. 6º Encontro Nacional de Química Analítico. Sociedade Portuguesa de Química.
Instituto Superior Técnico.
Sofia Lima and Anabela C ordeiro-da-Silva. 45th Eurotox C ongress, Rodes, Grecia. “Effect of P-Glycoprotein
inducers on its expression and activity in C aco-2 cells”. (in collaboration with Requimte - Toxicology
Department, Faculty of Pharmacy, University of Porto). 2008.
Sofia Lima and Anabela C ordeiro-da-Silva. Nanomedicine 2008, Barcelona, Espanha, Setembro.
“Encapsulation of bisnaphthalimidopropyl derivatives, two novel anti-Leishmania drugs, in biodegradable
PLA and PLGA nanoparticles”.
Teixeira, L., Santarem, N., Silvestre, R., Schalling, H.D., C ordeiro-da Silva, A. (2007). Evaluation of the flow
cytometry potential for leishmaniasis diagnosis in humans. SPI. Lisboa.
Santarém N., Silvestre R., Tavares J., C abral S., Silva M., and C ordeiro-da-Silva A. C omparative study of
the cytokine production in vitro and in vivo of three proteins involved in the trypanothione cascade. II
Simpósio Nacional de C itocinas, May 8th, 2006, C oimbra, Portugal.
Marta Silva, Joana Tavares, Joana Maciel, Graham H. C oombs, Anabela C ordeiro-da-Silva “TDR1 induce a
Th2 profile antibody production”. Portuguese Society for Immunology XXXII Annual Meeting. October 13-14,
2006, Braga, Portugal
C abral S., Silvestre R., Santarém N., Silva M., Tavares J., Romão S., Tomás A., C ordeiro-da-Silva A.
“C haracterization of the immune response to an excreted/secreted Leishmania infantum tryparedoxin”.
Portuguese Society for Immunology XXXII Annual Meeting, “Innate and acquired immunity: Evolution and
regulation”. October 13-14, 2006, Braga, Portugal
Olga Borges, Joana Tavares, Gerrit Borchard, Adriano de Sousa, Hans E. Junginger and Anabela C . da
Silva. “Nanotechnology approach and the use of C pG ODN for an oral hepatitis B vaccine”, XXXII annual
Metting of SPI; 13-14th October 2006, University of Minho - Braga, Portugal.
Silvestre R., C ordeiro-da-Silva A., Vergnes B., Sereno D. and Ouaissi A. Attenuated SIR2-deficient
Leishmania infantum as a vaccine candidate, XXXII Reunião Anual da Sociedade Portuguesa de Imunologia,
October 13-14, 2006, Braga, Portugal.
Sena Esteves, F., Teixeira, N., Santos Silva, A., C ordeiro da silva, A., C astro, E., Elsa B., Marques, F.,
C orreia da Silva, G., Rebelo, I., Belo, L., Tavares, J. C epa, M., Silvestre, R., C atarina, R., Santos, R.,
C oimbra, S., Maciel, J., Silva, M., Santarém, N. “Research activities on inflammation, pregnancy and DNA
replication” integrado no simpósio “Os Farmacêuticos no Sistema de Saúde” Faculdade de Farmácia da
Universidade de Lisboa, nos dias 19 e 20 de Maio de 2005.
Lima, S.A.C ., C ordeiro-da-Silva, A., Gameiro, P. and C astro, B. Evaluation of the struture and function of
the reconstituted P-glycoprotein multidrug transporter. Requinte: rede de química e tecnologia. 3º encontro.
Fátima. 9 to 10 January of 2004. Pag. 39.
C ordeiro-da-Silva, A., Santarém, N., Tavares, J., Ferreira, N., Manso, A., Ouaissi, A. and Tomás, A. Use of
Leishmania recombinant proteins for diagnosis and monitoring cure of human Leishmaniasis. 1º Workshop
de Bioquímica C línica. Porto. 15 Dezember of 2003. Pag. 44.
Santarém, N., Ouaissi, A., Tomás, A., C ardoso, L., Rodrigues, M. and C ordeiro-da-Silva, A., Use of a
recombinant Leishmania protein antigens to monitor visceral leishmaniasis in dogs. XXIX Annual meeting.
C hronic infections. Sociedade Portuguesa de Imunologia. Porto. 9 to 11 October of 2003. P32.
Lima, A.C ., C ordeiro-da-Silva, A., Reis, S., Lima, J.L.F.C ., Gameiro, P. And C astro, B. Purificação da Pglicoproteína (MDR3) funcional a partir de células de Pichia pastoris. 1º C ongresso da Sociedade
Portuguesa de C iências Farmacêuticas. Lisboa. 14 to 16 April of 2003. P-35.
Tavares, J., Santos, ML, Araújo, N., Kong Thoo Lin, P., C astro, H., Tomás, A., C ordeiro-da-Silva, A.
Trypanothione: a target to polyamine derivates compounds in Leishmania infantum. Lisboa. XXX C ongresso
Nacional de Bioquimica. 5 to 7 Dezember of 2002. P9.
Borges, M., C ordeiro-da-Silva, A., Sereno, D. and Ouaissi, A T. cruzi Tc52 derived synthetic peptide
mediated suppression of IL-2 and IFN gamma production. Lisboa. XXX C ongresso Nacional de Bioquímica. 5
to 7 Dezember of 2002. P23.
C erqueira, F, C ordeiro-da-Silva, A., Araújo, N., Gaspar, C ., Simões, F. And Nascimento, MSJ 7a-Acetoxi-6bHydroxyleanona: A potent inhibitor of T and B lymphocyte proliferation. XXVIII Reunião Annual da
Sociedade Portuguesa de Imunologia. Transplantação, tolerância e inflamação. C oimbra. 14 to 16
November of 2002. PP07.
C astro, H., Lopes, R. B., C ordeiro-da-Silva, A., Tomas, A. M. A mitochondrial peroxiredoxin from
Leishmania infantum: analysis of its role in parasite protection to oxidative stress. XII C ongress Nacional de
Bioquímica. Povoa de Varzim. 28 to 30 September of 2000.
C ordeiro-da-Silva, A., C outinho Borges, M., Guilvard, E. and Ouaissi, A. A. Polyclonal B cell populations
induced by Leishmania major ribosomal protein. XII C ongresso Nacional de Bioquímica, Sociedade
Portugesa de Bioquímica. Póvoa do Varzim. 28 to 30 September of 2000. P 8.5.
Borges, M., Zemzoumi, K., Ouaissi, A. and C ordeiro-da-Silva, A. Immunosupressive effect of 30 kDa
Leishmania major ribosomal protein at lymphocyte cell populations. XXV Reunião Annual da Sociedade
Portuguesa de Imunologia. Jornadas de Actualização em Imunologia. Imunologia das infecções virais.
Lisboa. 25 to 27 November of 1999. P9.
Zemzoumi, K., Borges, M., Guilvard, E., C ordeiro-da-Silva, A. and Ouaissi, A. ”Determination of the minimal
functional immunosuppressive domain of Tc52 protein from Trypanosoma cruzi” V Reunião da Sociedade
Portuguesa de Parasitologia. Trás-os-Montes. 5 to 7 November of 1998. P14.
Zemzoumi, K., Borges, M., Guilvard, E., C ordeiro-da-Silva, A. and Ouaissi, A. ”C aracterização funcional do
domínio immunossupressor da proteína TC 52 de Trypanosoma cruzi” V Reunião da Sociedade Portuguesa
de Parasitologia, Vila Real. 5 to 7 November of 1998. D7.
C ordeiro da Silva, A., Pena, M. R., Silero, A., Silero, M. and Teixeira, N. The effect of diguanosine
tetraphosphate in B response. X C ongresso Nacional de Bioquímica. Universidade do Minho. Braga. 31
October to 2 e November of 1996. P8-11.
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