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Envelhecimento cerebral. A batata roxa protege neurônios do cérebro
porque possui alto conteúdo em antocianinas
18/03/11
A batata roxa possui alta concentração de antocianinas. As antocianinas possuem efeito antioxidante, inibem o NF-kappaB induzido e
reparam e protegem a integridade do DNA genômico ao lado de estimular a AMPK e assim inibir o mTOR e o IGF-I. Também ativam a
via p38MPK e inibem a Akt. O extrato etanólico da Synadenium, rica em antocianinas,também possui forte efeito inibidor da
ciclooxigenase. Mais um presente da Natureza para o Homem sobreviver no Planeta.
José de Felippe Junior
Purple sweet potato color alleviates D-galactose-induced brain aging in old mice by promoting survival of neurons via PI3K
pathway and inhibiting cytochrome C-mediated apoptosis.
Lu J, Wu DM, Zheng YL, Hu B, Zhang ZF.
Brain Pathol. 2010 May;20(3):598-612.
Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Xuzhou Normal University, Xuzhou,
China.
Abstract
Purple sweet potato color (PSPC), a class of naturally occurring anthocyanins, protects brain function against oxidative stress induced
by D-galactose (D-gal) (Sigma-Aldrich, St. Louis, MO, USA). Our data showed that PSPC enhanced open-field activity, decreased
step-through latency, and improved spatial learning and memory ability in D-gal-treated old mice by decreasing advanced glycation
end-products' (AGEs) formation and the AGE receptor (RAGE) expression, and by elevating Cu,Zn-superoxide dismutase (Cu,Zn-SOD)
(Sigma-Aldrich) and catalase (CAT) expression and activity. Cleavage of caspase-3 and increased terminal deoxynucleotidyl transferase
(TdT)-mediated deoxyuridine triphosphate (dUTP) nick-end-labeling (TUNEL)-positive cells in D-gal-treated old mice were inhibited by
PSPC, which might be attributed to its antioxidant property. PSPC also suppressed the activation of c-Jun NH(2)-terminal kinase (JNK)
and the release of cytochrome c from mitochondria that counteracted the onset of neuronal apoptosis in D-gal-treated old mice.
Furthermore, it was demonstrated that phosphoinositide 3-kinase (PI3K) activation was required for PSPC to promote the neuronal
survival accompanied with phosphorylation and activation of Akt and p44/42 mitogen-activated protein kinase (MAPK) by using PI3K
inhibitor LY294002 (Cell Signaling Technology, Inc., Beverly, MA, USA), implicating a neuronal survival mechanism. The present results
suggest that neuronal survival promoted by PSPC may be a potentially effective method to enhance resistance of neurons to
age-related disease.
PMID: 19863544
30/9/2011 17:21