SUN-264
www.ued-ham.org.br
SUN−336
HIGH PREVALENCE OF VITAMIN D DEFFICIENCY AND ITS ASSOCIATION
WITH METABOLIC SYNDROME IN ELDERLY MEN LIVING IN THE TROPICS
Marcelo Cabral, Juliana Maia, Manoel Soares Filho, Leonardo Bandeira, Francisco Bandeira
Division of Endocrinology, Diabetes and Bone Disease, Agamenon Magalhães Hospital, University of Pernambuco Medical School, Recife, Brazil
The aim of the present study was to determine the prevalence of
vitamin D deficiency among elderly men and its association with
metabolic syndrome in the city of Recife, Brazil (8oS).
In a univariate analysis, patients who had 25OHD <20ng/ml, had
mean sun index lower than those with >20ng/ml (4,46 ±3,69 vs
6,01 ±5.4; p=0.006) and this association was not statistically
significant using the cutoff of 30ng/ml (5,22 ±4,43 vs 6,12 ±6,14;
p=0.180). Patients with 25OHD <20ng/ml presented higher mean
BMI than those with >20ng/ml (25,91 ±4,73 vs 24,95 ±4,21;
p=0.045) and this was also true for those with 25OHD <30ng/ml
(26,12 ±4,92 vs 25,08 ±4,19; p=0.018).
After adjustment for possible confounders by multiple regression
analyses, sun index was independent and positively associated
with serum 25OHD levels (p=0,005); BMI and presence of MS
(NCEP) were independent and inversely associated with serum
25OHD levels (p=0,005 and p=0,007, respectively).
METHODS
CONCLUSION
INTRODUCTION
An inverse association between serum 25OHD levels and
metabolic syndrome (MS) has been proposed, but the data so
far are controversial especially related to the cut point used.
OBJECTIVE
We evaluated the serum levels of 25OHD, sun index and
metabolic risk factors in 284 men (age +-SD 69.44 yr ±6.49)
attending primary care clinics.
Figure 2 – Metabolic syndrome charge
Figure 3 - Prevalence of vitamin D deficiency in elderly men
according to MS charge
Our data suggest that regular sun exposure in the elderly
without protection in daily life doesn’t protect against 25OHD
levels less than 30ng/ml and that vitamin D deficiency was
independently associated with metabolic risk.
RESULTS
Mean serum 25OHD was 27.87±13.52 ng/ml, BMI 25.67 ±4.31
Kg/m2 and sun index (hours of sun exposure per week x fraction
of body surface area exposed) 5.49 ±5.05. The prevalence of
vitamin D deficiency was 31.5% (95% CI 26.2-36.8) and 66.7%
(95% CI 61.3-72.1) when cutoff of less than 20ng/ml and
30ng/ml were used, respectively. 70,5% had hypertension;
64,2% high fasting plasma glucose (≥ 100mg/dL); 42,3% had
high triglycerides (≥150 mg/dL); 47,4% low HDL-c (<40 mg/dL);
58,7% increased waist circumference according to IDF criteria
(>94cm) and 32,4% according to NCEP (> 102cm).
When evaluating the number of criteria for MS (NCEP) we found
that: 4,4% didn't have any; 17,6% had one; 23,4% had two;
30,8% had three; 19,8% had four and 4,0% had five. Among
patients with no MS criteria, 50% had 25OHD<30ng/mL and
24% < 20ng/mL. In contrast, for those with 5 MS criteria, 72,7%
had 25OHD <30ng/mL and 36,4% < 20ng/mL.
Figure 1 – Cardiovascular risk factors, vitamin D deficiency
and calcium intake of study patients
REFERENCES
1- Bandeira F, Griz L, Dreyer P et al. Vitamin D deficiency: a global
perspective. Arq Bras Endocrinol Metabol 2006; 50(4):640-646.
2- Cabral M, Borges C, Fontan D, Bandeira L, Chaves N, Bandeira F.
Prevalence of Vitamin D Deficiency and Its Relationship with Sun
Exposure and Skin Phototype in Enderly Men Living in the Tropics; J
Bone Miner Res 2011; 26 (Suppl 1): S-524
3-Thomas G, Hartaigh J, Bosch J et al. Vitamn D levels predict allcause and cardiovascular disease mortality In subjects with the metabolic
syndrome: The LURIC study. Diabetes Care 2012; 35:1158-1164.