ECTP2014 - 20th European Conference on Thermophysical Properties
Poster P_130, 3 Sept. 15:30 – 19:00
Tânia M. T. Carvalho1; Luísa M. P. F. Amaral1; Victor M. F. Morais2; Maria D. M. C. Ribeiro da Silva1
Centro de Investigação em Química da Faculdade de Ciências da Universidade do Porto, Portugal;
de Investigação em Química da Faculdade de Ciências da Universidade do Porto; Instituto de Ciências Biomédicas
da Universidade do Porto, Portugal.
The large number of scientific publications in different areas of knowledge related with the indole derivatives is an
obvious acknowledgement of their importance. This happens since indole is a very important building block for naturally
occurring compounds and also as an intermediate in the manufacture of synthetic chemicals. Indole is also the sidechain chromophore of the amino acid tryptophan, and, therefore, it is important to understand its properties in the
excited-state in order to have an accurate interpretation about the luminescence and absorption spectra of the
mentioned amino acid. In the sequence of our previous study [1,2], we are involved in the study of influence of the
substituent (alkyl or aryl) in the position 2 on the 1-ethylindole structure (Figure 1). In this work, the standard (po =
0.1 MPa) molar energy of combustion, of 1-ethyl-2-methylindole, in the crystalline state, was determined, at T = 298.15
K, using a static bomb combustion calorimeter.The standard molar enthalpy of vaporization, at T = 298.15 K, was
determined by Calvet microcalorimetry. From the experimental results, the standard (po = 0.1 MPa) molar enthalpy of
formation of the compound, in the condensed and gaseous phases, at T = 298.15 K, were derived. The result obtained
for the gaseous enthalpy of formation has been compared with the previous one reported for 1-ethyl-2-phenylindole
Additionally, theoretical calculations was performed using density functional theory (DFT) with the hybrid functional
B3LYP together with the 6-31G(d) and the 6-311+G(2df,2p) basis sets.With the objective of assessing the quality of the
results, standard ab initio molecular orbital calculations at the G3(MP2) level were also performed. Enthalpies of
formation, obtained using appropriate working reactions, were calculated and compared with experimental data.
Figure 1: Structural formula of the compounds under study
Acknowledgments: Thanks are due to FCT, Lisbon, Portugal, and European Social Fund for financial support given to
CIQ-UP, strategic project PEst-C/QUI/UI0081/2013. LMPF Amaral holds a Ciência 2008 position of the Portuguese
Ministry of Science.
[1] Energetic study of 1-R-2-Phenylindole (R=H, CH3, C2H5), Carvalho, T. M. T.; Amaral, L. M. P. F.; Ribeiro da Silva,
M. D. M. C., 11º Encontro Nacional de Química-Física, Porto, Portugal, 9 -10 May 2013.
[2] Experimental and computational energetic study of 1-R-2-phenylindole (R=H, CH3, C2H5), T. M. T.; Amaral, L. M. P.
F.; Ribeiro da Silva, M. D. M. C., 4PYCHEM, Coimbra, Portugal, 29 April – 1 May 2014.

experimental and computational insights on the termochemistry of 1