Imediata recorrência local e regional após excisão de melanoma polipoide : dormência
tumoral ou ativação tumoral?
Immediate local and regional recurrence after the excision of a
polypoid melanoma: tumor dormancy or tumor activation?
De Giorgi V1, Massi D, Gerlini G, Mannone F, Quercioli E, Carli P.
Dermatol Surg. 2003 Jun;29(6):664-7.
Author information
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1
Department of Dermatology, University of Florence, Florence, Italy. [email protected]
Abstract
Recurrent melanoma occurs in approximately one third of the patients who are treated for
cutaneous melanoma. Although the majority of recurrences occur within the first few years of
primary therapy, a significant number remain at risk beyond 10 years. Tumor dormancy
provides the conceptual framework to explain a prolonged quiescent state in which tumor cells
are present, but tumor progression is not clinically apparent. Surgery, or other perturbing
factors, might modulate the transition of dormant cancer cells to rapidly growing ones. These
may be due to a perturbation of the mechanisms of tumor regulation such as local immunity or
angiogenesis. Here, the case of a woman is discussed in whom the surgical removal of a
polypoid melanoma was followed, in less than a month, by local recurrence and locoregional
lymph nodal metastases, which were previously clinically absent.
PMID:12786716