Process Improvement in health care units: Scenarios Planning with Discrete Event Simulation Model applied to a Nuclear Medicine Unit Miguel Amador Rosa Thesis to obtain the Master of Science Degree in Biomedical Engineering Examination Committee Chairperson: Professor João Pedro Estrela Rodrigues Conde Supervisor: Professor Mónica Duarte Correia de Oliveira Members of the Committee: Professor João Carlos da Cruz Lourenço Professor Fernando Godinho November 2012 If I have one hour to save the world I would spend fifty-five minutes defining the problem and only five minutes finding the solution Albert Einstein Acknowledgments First of all, I would like to thank Professor Mónica Oliveira for all the guidance, patience and critical thinking throughout this work, she always showed to me as my supervisor. I would like also wish the best to little Sofia, that was many times present, although not for her option. I would like also to thank Professor Fernando Godinho for letting me develop this work on the case of Atomedical, and for the long hours problem exploration, being always available to receive me. I also want to thank Professor Guilhermina Cantinho for all the support and insights of Atomedical. Without the collaboration of them, nothing of this would have been possible. To Joana Nunes and João Marques, I would like to let a huge "Obrigado" for having been all the time on my side during this journey. To Célia Cruz, for all comprehension and help, I will never forget. To all NEBM crew in the past year. It would not be possible without all the distractions, background talks and companion. Especially Pedro Afonso, for remembering all the times that one has to have priorities. To Vanessa Cunha, as promised, and to Anabela Reis for her support in the beginning. Finally, to my family. To my father for always asking when I finished my thesis, and for funding this work. To my mother for giving all her support , and always being there for me, and remembering that tomorrow is always a better day. iii Abstract Health care services are a highly competitive, complex and technology driven market. In the discussion of National Health Care Systems, a level of context uncertainty adds to the existing, intrinsically, within units examination operations. In this work, a novel combination of the methodology of Scenarios Planning with Discrete Event Simulation is developed and explored to addressed this problem in Atomedical, a private Nuclear Medicine practice unit, localized in Lisbon, Portugal. The objectives of the unit managers decision problem were focused in the examination operations performance (service quality and operating costs). The use of a Scenarios Planning methodology allowed to overcome the challenges of unit environment. It also guided the definition of scenarios that covered a wide range of problem context uncertainties. By using a new approach focused in operations, this methodology provided further understanding of Atomedical through a structured system analysis, with the identification of relevant variables within the problem. This gave support to the development of coherent scenarios and strategies for succeeding system study. Discrete Event Simulation was used to address the uncertainty regarding the procedure in operations. This simulation methodology allowed the evaluation, inside Scenarios Planning, of the drawn strategies and scenarios through complementary setups of an Atomedical unit model. Model and simulations were implemented using the SIMUL8 simulation software. The results of this methodology do not intend to provide unit managers with a solution for their problem, but rather a deeper understanding of it. The Scenarios Planning methodology was successful in systematically explore both operations system and environment context uncertainties of a multi-variable problem as in Atomedical, although it requires many technical choices. Learning how different contexts influence the unit, and the impact of different strategies, provides unit managers the tools to handle future realization of paths explored in scenarios. Keywords Scenarios Planning; Discrete Event Simulation (DES); Uncertainty; Nuclear Medicine; Scenarios; System Analysis; Operation Management; Scheduling v Resumo O mercado dos serviços de saúde é altamente tecnológico, competitivo e complexo. A discussão dos Sistemas de Saúde aumenta a incerteza, já existente intrinsecamente ao nível operacional. Neste trabalho, é desenvolvida e explorada uma nova combinação metodológica de Planeamento de Cenários com Simulação Discreta de Eventos, no sentido de abordar este problema na Atomedical, uma unidade privada de Diagnósticos de Medicina Nuclear, localizada em Lisboa, Portugal. Os objectivos do problema de decisão dos gestores estão focados no desempenho das operações da unidade (qualidade do serviço e custos operacionais). O uso de uma metodologia de Planeamento de Cenários permitiu ultrapassar os desafios do contexto ambiente. Esta guiou igualmente o processo de definição de cenários que cobrissem um vasto leque de contextos de incerteza do problema. Através do uso de uma nova abordagem, focada nas operações, esta metodologia permitiu um aprofundar do conhecimento da Atomedical. Usando uma estrutura para a análise de sistemas, identificou-se as variáveis relevantes para o problema. Estas deram suporte ao desenvolvimento de cenário e estratégias coerentes para a persecução do estudo. A Simulação Discreta de Eventos foi usada ao nível da incerteza dos procedimentos da unidade. Esta permitiu executar a avaliação das estratégias e cenários construídos, através um modelo da Atomedical. Para a simulação e implementação do modelo foi usado o software de simulação SIMUL8. Esta metodologia tenciona providenciar, aos gestores da unidade um superior conhecimento do problema, ao invés de uma solução. A metodologia de Planeamento de Cenários foi bem sucedida na exploração sistemática das incertezas ao nível das operações e contexto ambiente, num problema com múltiplas variáveis, como o da Atomedical. Apesar de, para tal, necessitar de diversas técnicas auxiliares. Uma ferramenta que permita o conhecimento dos impactos dos cenários e estratégias na unidade permitirá ao gestores estarem preparados para abordar qualquer evolução da unidade. Palavras Chave Planeamento de Cenários; Simulação de Eventos Discreta; Incerteza; Medicina Nuclear; Cenários; Análise de Sistemas; Gestão Operacional; Escalonamento vii Contents 1 Introduction 1 1.1 Motivation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.2 Original contributions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.3 Thesis outline . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2 Case Study: Atomedical 5 2.1 Atomedical . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 2.2 Nuclear Medicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2.3 Diagnostic health care services in Portugal . . . . . . . . . . . . . . . . . . . . . . . . . 12 2.4 Identifying the decision problem of Atomedical . . . . . . . . . . . . . . . . . . . . . . . 13 2.4.1 Context of the decision problem . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 2.4.2 Definition, objectives and scope of the decision problem . . . . . . . . . . . . . . 13 2.4.3 Uncertainty as Atomedical decision problem . . . . . . . . . . . . . . . . . . . . 14 3 Literature review 15 3.1 Methodologies for system analysis in health care units . . . . . . . . . . . . . . . . . . . 16 3.1.1 System analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 3.1.2 Dealing with uncertainty . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 3.1.3 Appointment scheduling in health care units . . . . . . . . . . . . . . . . . . . . . 18 3.1.4 Discrete event simulation models . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 3.2 Scenarios Planning in Health Care . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 3.2.1 Scenarios Planning . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 3.2.2 Scenarios Planning methodologies . . . . . . . . . . . . . . . . . . . . . . . . . . 26 3.2.3 Dealing with Uncertainty in Scenarios Planning . . . . . . . . . . . . . . . . . . . 27 3.2.4 Using Scenarios Planning with other methodologies . . . . . . . . . . . . . . . . 28 3.2.5 Scenarios Planning in health care . . . . . . . . . . . . . . . . . . . . . . . . . . 29 3.3 A combination of Scenarios Planning with Simulation . . . . . . . . . . . . . . . . . . . . 30 4 Proposed methodology framework for Scenarios Planning 31 4.1 Scenarios Planning framework . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 4.2 Phase 1 - Analysis of the problem . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 4.2.1 Step One - Identify the focal issue, question or decision . . . . . . . . . . . . . . 33 ix 4.2.2 Step Two - Problem analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 4.2.3 Step Three - Identification of problem variables . . . . . . . . . . . . . . . . . . . 33 4.2.4 Step Four - Identification of Key Variables . . . . . . . . . . . . . . . . . . . . . . 34 4.2.5 Variables selection tools in Scenarios Planning . . . . . . . . . . . . . . . . . . . 35 4.3 Phase 2 - Scenarios and Strategies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 4.3.1 Step Five - Scenarios and Strategies construction . . . . . . . . . . . . . . . . . 40 4.4 Phase 3 - Study of Strategies and Scenarios . . . . . . . . . . . . . . . . . . . . . . . . 42 4.4.1 Step Six - Selection of leading indicators and signposts . . . . . . . . . . . . . . 42 4.4.2 Step Seven - Evaluation of Strategies under Scenarios . . . . . . . . . . . . . . . 42 5 Scenarios Planning Phase 1: Analysis of Atomedical problem 43 5.1 Step Two: Problem analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44 5.1.1 Analysis of the Atomedical unit operations . . . . . . . . . . . . . . . . . . . . . . 44 5.1.2 Identifying influential variables in problem objectives . . . . . . . . . . . . . . . . 48 5.2 Step Three: Variables in Atomedical problem . . . . . . . . . . . . . . . . . . . . . . . . 51 5.2.1 People . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 5.2.2 Equipment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 5.2.3 Materials and products . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 5.2.4 Methods and procedures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53 5.2.5 Unit environment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53 5.2.6 Unit performance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 54 5.3 Step Four: Systematization and classification of identified variables - key variables of the problem . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 54 5.3.1 Direct classification of variables - Dependency Structure Matrix using MICMAC . 55 5.3.2 Indirect classification of variables - Dependency Structure Matrix using MICMAC 57 5.3.3 Impact versus Uncertainty Analysis . . . . . . . . . . . . . . . . . . . . . . . . . 59 5.3.4 Key Variables . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62 6 Scenarios Planning Phase 2: Atomedical Scenarios and Strategies 63 6.1 Step Five: Scenarios constructions for the Atomedical problem . . . . . . . . . . . . . . 64 6.1.1 Subsystems Scenarios analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . 65 6.1.2 Scenarios . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 6.2 Step Five: Strategies in the Atomedical problem . . . . . . . . . . . . . . . . . . . . . . 68 6.2.1 Subsystems Strategies analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 6.2.2 Strategies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70 6.3 Step Six: Signposts for the Atomedical problem . . . . . . . . . . . . . . . . . . . . . . . 71 6.4 Scenarios and strategies in the Atomedical problem . . . . . . . . . . . . . . . . . . . . 72 x 7 Scenarios Planning Phase 3: Evaluation of Strategies and Scenarios - Discrete Event Simulation Model 73 7.1 Atomedical Simulation Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74 7.1.1 Simul8 Discrete Event Simulation (DES) Model Implementation . . . . . . . . . . 75 7.2 Atomedical DES Model Calibration and Validation . . . . . . . . . . . . . . . . . . . . . . 78 7.3 Implementation of Scenarios and Strategies into the Model . . . . . . . . . . . . . . . . 80 7.4 Simulation results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 7.4.1 Unit performance indicators . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 7.4.2 Service quality indicators . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83 7.4.3 Unit workload indicators . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86 7.4.4 Results Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88 8 Final remarks 89 Bibliography 93 Appendix A Literature review in the scheduling problem in health care units A-1 Appendix B Atomedical problem analysis B-1 xi List of Figures 2.1 Layout of Atomedical Facilities. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2.2 Cost Structure of Atomedical in 2010. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2.3 Representation of a Gamma Camera components. . . . . . . . . . . . . . . . . . . . . . 11 3.1 Generic architecture of a scenarios planning process. . . . . . . . . . . . . . . . . . . . 26 3.2 Illustration of multiplicity in possible futures, problem instances within a scenario. . . . . 28 4.1 Proposed Scenarios Planning Process. . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 4.2 Dependency Structure Matrix (DSM) and its graph representations. . . . . . . . . . . . . 36 4.3 Example of a DSM for a set of variables, in its original rearrangement and alternative rearrangement. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36 4.4 Variables influence versus dependence chart. . . . . . . . . . . . . . . . . . . . . . . . . 37 4.5 Shape of variables-points configuration as a way to determine the system stability. . . . 38 4.6 Scenarios and Strategies resulting in multiple test conditions. . . . . . . . . . . . . . . . 39 4.7 Scenarios resulting in relevant, coherent and plausible configurations of key variables possibilities. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 5.1 “Fishbone" cause-effect diagram for the operational costs. . . . . . . . . . . . . . . . . . 49 5.2 Process-type cause-effect diagram for the total patient waiting time . . . . . . . . . . . . 50 5.3 Process-Type Cause-Effect Diagram for the Exam Quality . . . . . . . . . . . . . . . . . 51 5.4 Plan of direct influence versus dependence of Atomedical problem variables using MICMAC. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 5.5 Graph of direct influence of some Atomedical problem variables using MICMAC. . . . . 56 5.6 Compared classification of variables influence in direct and indirect classification using MICMAC. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 5.7 Plan of indirect influence versus dependence of Atomedical system variables using MICMAC. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58 5.8 Graph of indirect influence of some Atomedical system variables using MICMAC. . . . . 59 5.9 Plan of level of impact/importance versus level of certainty/control of Atomedical problem variables in a management vision of the unit. . . . . . . . . . . . . . . . . . . . . . . 60 5.10 Plan of level of impact/importance versus level of certainty/control of Atomedical problem variables in a operational vision of the unit. . . . . . . . . . . . . . . . . . . . . . . . 61 xiii 7.1 Systems and sub-systems of simulation model. . . . . . . . . . . . . . . . . . . . . . . . 74 7.2 Atomedical Simul8 Simulation model. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 76 B.1 Atomedical general examination process flow chart. . . . . . . . . . . . . . . . . . . . . B-2 xiv List of Tables 2.1 Evolution in the number of patients and exams per year from 2007 to 2011. . . . . . . . 8 3.1 Taxonomy of a framework for handling uncertainties and their effects. . . . . . . . . . . 17 3.2 Characterization of Foresight Techniques. . . . . . . . . . . . . . . . . . . . . . . . . . . 24 3.3 Example of Scenarios Planning methods used, steps and organizations origin. . . . . . 27 6.1 Key variables separation into Atomedical unit subsystems. . . . . . . . . . . . . . . . . . 64 6.2 Strategic key variables separation into Atomedical unit subsystems. . . . . . . . . . . . 68 7.1 Simulation Model Outputs and Signpost. . . . . . . . . . . . . . . . . . . . . . . . . . . . 78 7.2 Calibration Model Simulation Results. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 7.3 Unit performance results for Strategy 0 under the procurement scenarios. . . . . . . . . 82 7.4 Unit performance results for Strategy 0 under the operational scenarios. . . . . . . . . . 82 7.5 Unit performance results for Strategies 1 and 2 under the procurement scenarios. . . . 82 7.6 Unit performance results for Strategy 3 under the procurement scenarios. . . . . . . . . 83 7.7 Service quality results for Strategy 0 under the procurement scenarios. . . . . . . . . . 84 7.8 Service quality results for Strategy 0 under the operational scenarios. . . . . . . . . . . 84 7.9 Service quality results for Strategies 1 and 2 under the procurement scenarios. . . . . . 85 7.10 Service quality results for Strategy 3 under the procurement scenarios. . . . . . . . . . 86 7.11 Unit resources workload results for Strategy 0 under the procurement scenarios. . . . . 86 7.12 Unit resources workload results for Strategy 0 under the operational scenarios. . . . . . 87 7.13 Unit resources workload results for Strategies 1 and 2 under the procurement scenarios. 87 7.14 Unit resources workload results for Strategy 3 under the procurement scenarios. . . . . 87 A.1 Table of Literature in the Scheduling Problem in Health Care Units . . . . . . . . . . . . A-2 B.1 Atomedical Problem Variables and Analysis Results. . . . . . . . . . . . . . . . . . . . . B-3 xv Abbreviations DES Discrete Event Simulation RF Radiopharmaceutical NMT Nuclear Medicine Technician MPS Myocardial Perfusion Study MIBG Metaiodobenzylguanidine NM Doctor Nuclear Medicine Specialist Doctor NM Technician Nuclear Medicine Technician DSM Dependency Structure Matrix MDI Matrix of Direct Influences MII Matrix of Indirect Influences WT Waiting Time AVG Average NHS National Health Service CEO Chief Executive Officer xvii List of Symbols 67 Ga 99m 99 Radioactive Isotope of Gallium-67 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44 T c Metastable Nuclear Isomer of Technetium-99 . . . . . . . . . . . . . . . . . . . . . . 46 Mo Molybdenum-99 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46 xix 1 Introduction Contents 1.1 Motivation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.2 Original contributions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.3 Thesis outline . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2 3 1 1.1 Motivation Health care services are a highly competitive, complex and technology driven market. On one hand, the pressure in providing a quality service is tremendous, since dealing with the human life. On the other hand, services are asked to provide the same quality service at lower costs, as a result of limitation in the public funding. The complexity of health care systems resides in numerous stakeholders on the process that drive a multi variable uncertain environment context for unit operations. In such situation, problems that managers face are often complex, and the implications of options and context changes can only be solved with the aid of decision support tools [Ozcan, 2009]. This work addresses a problem in Atomedical, a private diagnostic unit of Nuclear Medicine. The field presents special operational complexity, mainly due to the dynamic of the used radionuclides. It justifies the difficulty to overcome uncertainties regarding its management without real experimentation of strategies. This type of uncertainty in Atomedical can be addressed using simulation models to study the result in quality indicators of different modification to the system. Azevedo [2010] previously studied Atomedical using a Discrete Event Simulation (DES) model. In this work, the author describes the development of the model and implementation in SIMUL8 simulation software, while characterizing and analyzing unit operations. However, even tough the developed model remains actual, the environment context has changed. Atomedical saw a reduction on the number of clients, as a result of national economic situation. Besides the operational complexity in Atomedical, the uncertainty of environment context arises as the main problem of management. The different strategies that impact in the system must also take into account different scenarios in the future of the unit. It is important to complement the DES methodology to provide a decision support tool to operations management decisions under those levels of uncertainty. 1.2 Original contributions To complement the study of the operational uncertainty of the problem with the DES, this work, Scenarios Planning methodology is explored as a way to systematically analyze the field of scenarios and strategies in the problem. It addresses the uncertainty at the level of the unit environment context. This method is often used in such complex problems through a more general and abstract perspective. However, this work explore the development of a new Scenarios Planning methodology approach that focus on the operational level of the problem and on the impacts of uncertainty in the unit operations system variables. This approach allows one the use of DES as part of Scenarios Planning methodology, in order to evaluate the impact of designing scenarios and strategies for several Atomedical unit system variables. This way both operations system and environment context uncertainties are being addressed in a multi-variable problem as a complex health care service. 2 1.3 Thesis outline In Chapter 2, this work starts with the characterization of the problem. In Chapter 3, it drives the literature review of analysis and uncertainty of systems, as well as the use of simulation methodologies, namely the DES, and Scenarios Planning. In Chapter 4, a methodology framework of Scenarios Planning is presented to Atomedical problem. In Chapter 5 and 6, the new framework is explored in Atomedical using: problem analysis; variables identification and classification; scenarios and strategies construction and signpost definition. In Chapter 7, the resulting scenarios and strategies are evaluated in an improved DES model of Atomedical operations in different simulations setups. The results of the signposts are used to perform an analysis of the uncertainty drivers, which provides unit managers further knowledge of their unit and options and consequently supporting future decisions. In Chapter 8, final remarks are presented regarding the results of addressing the uncertainty problem in Atomedical, suggesting further work and methodology improvements. 3 4 2 Case Study: Atomedical Contents 2.1 2.2 2.3 2.4 Atomedical . . . . . . . . . . . . . . . . . . . . . Nuclear Medicine . . . . . . . . . . . . . . . . . Diagnostic health care services in Portugal . . Identifying the decision problem of Atomedical . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 9 12 13 5 2.1 Atomedical Atomedical is a private Nuclear Medicine unit, located in Lisbon, Portugal. It has a strategic location, near city main public hospital, Hospital de Santa Maria, a medicine university Hospital, where the Administrator and the Clinical Director are faculty members in the Nuclear Medicine field. Atomedical unit is located near a wide range of public transports (including metro and train), and provides diagnostic services in the field of Nuclear Medicine, among some therapeutic services and echographies. It targets people from all the country, although the majority of the patients come mostly from the Metropolitan Area of Lisbon. Since August 2006, Atomedical is a public limited company with a shareholders’ equity amount of 500 000 e. Atomedical activity started in October 1987 with a single tomographic chamber equipment, having increased in infrastructures and number of equipments since then, in order to respond to the increment of patients numbers, being today the largest unit in the field, operating in Portugal, with four Gamma Cameras. Atomedical operations are described in detail in a previous work of a simulation model of the unit [Azevedo, 2010]. For the purpose of this work, will only be presented a broad view of the operations to sustain the proposed analysis of the current problem. Services: Atomedical provides mainly services in the field of Nuclear Medicine diagnosis [Azevedo, 2010]. Other services may be provided when is possible to order the needed Radiopharmaceutical (RF) and the needed equipment is available. However, there are three feature exams, as a result of a higher demand and major revenue generation: the Myocardial Perfusion Study, the All Body Bone Scintigraphy and the Thyroid Scintigraphy. Besides the Nuclear Medicine diagnosis studies, Atomedical makes use of the cope ability with radioactive products to also provide therapeutical services. Since the staff, namely the Clinical Director, is able to perform echographies, Atomedical provides also this type of service, in order to capitalize the in-house skills. Organizational Structure and Human Resources: Atomedical organizational structure consists in a Shareholders’ General Meeting who empowers the Administration Board or Executive Office, responsible by Atomedical management. The total workforce of Atomedical consists in 34 people: 2 Physicist (in which, Prof. Dr. Fernando Godinho is also Atomedical Administrator), 5 medical doctors (2 Nuclear Medicine Specialist Doctor (NM Doctor), being one the Clinical Director, 2 cardiologists and 1 specialist in internal medicine), 5 workers in administrative, management and consultative tasks, 10 Nuclear Medicine Technician (NMT), 7 secretaries (working in the reception and exam pick-up), 1 nurse, 1 pharmacist and 3 medical and cleaning auxiliaries. In Atomedical, the role of handling company stakeholders is a task of the Chief Executive Officer (CEO), Prof. Dr. Fernando Godinho. His role gives him the autonomy to implement the possible 6 structural and operational solutions of this work problem, as unit manager, being therefore, a Decision Maker. Drª. Guilhermina Cantinho, as unit Clinical Director, is also a unit manager, and therefore, a Decision Maker, as she has a major influence in the definition of unit operations, organization and procedures. In this case of study, Prof. Dr. Fernando Godinho and Drª. Guilhermina Cantinho are hence responsible by the definition of the decision problem and thereby considered unit managers. Facilities and Resources: In Figure 2.1, one can see the Atomedical plant, figuring the most important zones in the unit operations of examination. The plant identifies clearly the different zones and their functions that one can gather in self explanatory groups: Waiting Rooms, Administrative Facilities, Preparation Rooms, Examinations Rooms and Support Facilities. S.5 WC! P.2 RF! S.6 WC! P.1 Injections Room! W.2 Waiting Room! A.3 Telephonist! A.2 Reception Desk! E.4 GC Room! E.5 GC Room! W.6 Waiting Zone! E.2 Console Room! W.3 Waiting Room (Children)! E.1 Ultrasonography Room ! S.3! WC! E.3 GC Room! E.1 Console Room! W.4 Waiting Room (Stretchers)! W.5 Waiting Room! E.6 GC Room! P.3 RF! W.7 Waiting Zone! S.7 Store Room ! E.7 Strain Studies Room ! S.2 WC! A.4 Reports Room! S.1 WC! Legend: W.#! Wai%ng Rooms A.1 Reports Delivery! W.1 Waitting Room! Unit Entrance! Observa%on Windows Countertop A.#! Administra%ve Facili%es P.#! Prepara%on Rooms GC! Gamma Camera E.#! Examina%on Rooms RF! Prepara%on Room WC! Water Closet S.#! Support Facili%es Radiopharmaceu%cals Figure 2.1: Layout of Atomedical Facilities. Based in [Azevedo, 2010] Unit operations focus in the Preparation and Examination Rooms. In Preparation Rooms, the patients are administrated with the RF for the following exam or just for a treatment. From the Preparations Rooms, the Radiopharmacy is the place where the Technetium Generator is located, and all the RF are prepared. In the Examination Rooms, the different tasks of the examinations are performed, namely images acquisition in the Gamma Cameras and the Strain Studies. Gamma Cameras are the core of Atomedical operations, so a more detailed description of the existing equipments is made. Atomedical has four Gamma Cameras with different functionalities and uses. Only one of the Gamma Cameras has 7 a CT (Computer Tomography) that is used in cases where is necessary anatomic information to complement the diagnostic information of the Nuclear Medicine exam, for instance in cardiology studies. That Gamma Camera is the only one that allows the use of radionuclides of low energy, like the Gallium and the Iodine. One of the Gamma Cameras, E.4, is an older and smaller equipment that is used in partial or static exams, which require less detail, such as renograms, thyroid or hands scintigraphy. All equipments must be daily calibrated and the quality control is assured by the Atomedical Physicist. Atomedical Activity: Although Atomedical provides several types of exams, unit operations are limited to few types of them. It depends on the procurement, which is influenced by the incidence of diseases in populations and the diagnostics exams used by practitioners. Table 2.1 provides information about the distribution of the exams performed at Atomedical, where is evident the relevance of few types of exams. The analysis of the evolution of exam type distribution, Table 2.1, allows to observe a higher decrease of certain exam types. For instance, the change in Renograms is justified by the reduction of children Nuclear Medicine exams. This is a result of non-radioactive alternatives for diagnostic exams. It is also possible to observe a reduction in the number of Bone Scintigraphy in the year 2011, that has no current direct explanation. Table 2.1: Evolution in the number of patients and number of exams per year from 2007 to 2011. 2007 2008 2009 2010 2011 Total Exams 32408 31749 32145 29775 21265 Bone Scintigraphy Myocardial Perfusion Thyroid Scintigraphy Renograms Other Exams 32,22% 37,43% 10,27% 6,79% 13,29% 31,39% 41,39% 9,65% 6,28% 11,29% 29,52% 47,64% 8,87% 3,44% 10,52% 27,55% 51,32% 9,61% 3,43% 8,1% Exam Distribution 32,01% 39,62% 10,19% 6,43% 11,74% Atomedical resources provides to the unit a capacity to perform certain number of exams. The unit capacity depends either on long term decisions, for instance, facilities and the number of existing equipments (usually irreversible), either on short/medium term decision, for instance, staff and consumables. While the number of exams are the driver of revenues, the unit capacity will determine the level of expenditures. The relation between both will result in the unit final profit. In Figure 2.2 is presented the structure of costs in 2010, where one can see significant weight of staff, equipment maintenance and exam consumables costs. These are the costs related to the short/medium term decisions that influence capacity. Since 2005, Atomedical has the current facilities and equipments, and therefore, the current capacity. The total exams per year, Table 2.1, shows that until 2009 Atomedical performed a steady number of exams, that was reported to represent the maximum unit capacity. Starting in 2010, the number of exams started to decrease, changing the context of unit operations. To avoid profit reduction or even loss, it is important to develop strategies that reduces the capacity and, consequently, the costs, which can be either long or short/medium term. 8 Other Costs" 28%" Consumables" 20%" Maintenance " 6%" Staff" 46%" Figure 2.2: Cost Structure of Atomedical in 2010. 2.2 Nuclear Medicine Nuclear Medicine is a technique that makes use of the administration of RF to obtain a diagnostic or a treatment [Webb, 2003]. Differently from other image techniques, as Nuclear Resonance or X-Ray, this technique does not provide a direct anatomic image, but rather an image of the spatial distribution of administrated radioactive compounds in the body. Radioactive chemical tracers emitting gamma rays or positrons can provide diagnostic information about a person’s internal anatomy and the functioning of specific organs or tissues, usually as a complement of other image techniques, as anatomic images from X-Rays. RF have specific biological and chemical affinities that, once administered to the patient, will be localized in specific organs or cellular receptors. This property of RF allows Nuclear Medicine the ability to image the extent of a disease process in the body, based on the chemical and biochemical changes and physiology, rather than relying only on physical changes in the tissue anatomy. In some diseases Nuclear Medicine studies can identify medical problems at an earlier stage than other diagnostic tests. Treatment of diseased tissue, based on metabolism, uptake or binding of a particular ligand, may also be accomplished, similar to other areas of pharmacology. However, the treatment effects of RF rely on the tissue-destructive power of short-range ionizing radiation [Webb, 2003]. RF are composed by a radioactive element, responsible for the emission of radioactivity to produce the image or to perform the treatment, and by a chemical substrate, that provides the binding specificity to specific tissues or organs and distribution along the body. Nuclear Medicine uses different compounds to study or treat different systems and functions. The radioactive element is an atom that presents an unstable nucleus, that releases radiation when decaying to a more stable isotope (radioactive decay) [Webb, 2003]. For the use in Nuclear Medicine, those radionuclides should be pure gamma radiation emitters. Gamma rays are high energy radiation, with high penetration power, due to their low interaction with tissues, that can easily exit the body and be detected. There are also used radionuclides, which emit positrons. A particle and its anti-particle, such as an electron and a positron, will undergo an annihilation process. This process produces neutral pions which quickly decay into two gamma-rays that exit the body in opposite directions. Radionuclides for Nuclear Medicine must 9 also have enough half-time 1 to the detection but in the minimum possible dose of radiation for the patient. From the few radionuclides that can then be used in Nuclear Medicine, Technetium (99m T c) is used in 90% of the exams since it can be produced on-site, which means that this nucleotide generator can be delivered at the hospitals and clinics where exams are performed. At the therapeutic level, one is looking for ionizing radiation, namely radionuclides that suffer a beta decay in order to interact with the tissues. For this purpose, the most used radionuclides are the Iodine 131, Samarium 153 and Strontium 89 [Webb, 2003], that are directly delivered to the units in individual doses, upon request. Technetium has a half-life time of about 6 hours and a HVL 2 of 4,6 cm in water, which makes it optimal to be handled securely in the exams performed. Technetium is generated from Molybdenum (99 M o) that decays with a half-life time of 66 hours, enough to be produced and be locally delivered, being the core resource of a Nuclear Medicine unit since it provides all the Technetium for the exams. In the generator, starting only with Molybdenum, the activity of the Technetium increases until a maximum value at the end of the second day. After that, the two radionuclides are in equilibrium, which means that both activities are similar and decrease according the decay of Molybdenum. Units in full operation need to order new generators in intervals of 2/3 days, with a maximum activity (defined by the initial amount of Molybdenum) that needs to be adjusted to the number and type of the exams performed from that generator. In Nuclear Medicine imaging, RF are administrated internally, for example intravenously or orally. Then, external detectors (Gamma Camera) capture and form images from the radiation emitted by the RF. This process is made after a waiting time from the RF administration that depends on its distribution in each person, on the target tissue and on the radionuclide properties. The administrated RF dose depends on the activity needed to the tissue in study, the patient size and the current activity of the radionuclide in use. The Gamma Camera detects the gamma rays, that are continuously emitted from inside the body, and process the detection signal in order to reconstruct the location of emission inside the body, providing so the diagnostic information. The resulting image is then evaluated by a NM Doctor that provides a detailed report. The Gamma Camera is constituted by a collimator, a gamma ray detector and photomultiplier tubes. The collimator only allows gamma rays that make an angle near 90 degrees to be detected. Unlike a lens, as used in visible light cameras, the collimator attenuates most (more than 99%) of incident photons and thus greatly limits the sensitivity of the camera system. Large amounts of radiation must be present in order to provide enough exposure for the camera system to detect sufficient scintillation dots to form a picture. In the detector, a crystal scintillates in response to incident gamma radiation. When a gamma photon leaves the patient it knocks an electron loose from an Iodine atom in the crystal, and a faint flash of light is produced when the dislocated electron again finds a minimal energy state. The initial phenomenon of the excited electron is similar to the photoelectric effect and 1 The half-life time of a radioactive element is the needed time to its decay activity be reduced to half of the initial activity. A material’s half-value layer (HVL), or half-value thickness, is the thickness of the material at which the intensity of radiation entering it is reduced by one half. 2 10 (particularly with gamma rays) to the Compton effect. After the production of the flash of light, it is detected. Photomultiplier tubes behind the crystal amplify the number of resulting photons, allowing the detection of the fluorescent flashes (events) as electrical pulses to a computer that sums the counts. The computer reconstructs and displays a two dimensional image of the relative spatial count density on a monitor. This reconstructed image reflects the distribution and relative concentration of radioactive tracer elements present in the organs and tissues imaged. Figure 2.3: Representation of a Gamma Camera components. Gamma Camera need to be highly maintained in order to sustain a performance that assure images quality. One of the Gamma Camera assessment of the equipment performance is the uniformity of the measurement. Basically, if it is exposed to a uniform flux of gamma radiation, the resulting image must present a uniform intensity. However, equipments present heterogeneities at this level, and consequently a daily calibration of the equipment is needed to correct the differences by using a reference source of radiation of the radionuclides to be used in the exams. During the exam, quality is guaranteed by assuring a statistical significance in the measurement, by which, a certain number of gamma rays must be detected. Therefore, an exam duration depends on the level of the activity dose administrated to the patients, since a higher activity would result in a quicker counting of detection until reaching the set statistical significance of the measurement. Statistical significance assures that the difference between the RF resulting measurement and the background is bigger than a detection limit defined for these methodologies. Nuclear Medicine is a very distinct technique inside diagnostic and treatment methods in health care. The use of radionuclides are center of this distinction, because of the need of special equipment and a strict resource management, the variability in the distribution of the administrated RF, the activity needed and the acquisition times of different exams and radionuclides. Since units need to deal with a resource that has a short life span, as radionuclides in a continuous decay, exam management has to take into account limitations of the resources, in order to maximize its use and provide a quality service. Any Nuclear Medicine unit presents strong constraints that result in complex systems, making difficult to predict its behavior. This operational uncertainty is very important in any consideration of the problem at Atomedical. 11 2.3 Diagnostic health care services in Portugal All residents in Portugal have access to health care provided by the National Health Service (NHS), financed mainly through taxation. Co-payments have been increasing over time, and the level of costsharing is highest for pharmaceutical products. Approximately one-fifth to a quarter of the population enjoys a second (or more) layer of health insurance coverage through health subsystems and voluntary health insurance. Health care delivery is based on both public and private providers. Public provision is predominant in primary care and hospital care, with a gatekeeping system in place for the former. Pharmaceutical products, diagnostic technologies and private practice by physicians constitute the bulk of private health care provision [Barros et al., 2011]. Planning and regulation take place largely at the central level in the Ministry of Health and its institutions. The management of the NHS takes place at the regional level. In each of the five regions, a health administration board that is accountable to the Ministry of Health is responsible for strategic management of population health, supervision and control of hospitals, management of primary care/NHS primary care centers and implementation of national health policy objectives. They are also responsible for contracting services with hospitals and private sector providers for NHS patients. Although in theory the regional health administrations have financial responsibilities, these are limited to primary care since hospital budgets are defined and allocated centrally. All hospitals belonging to the NHS are in the public sector, under the Ministry of Health jurisdiction. Private sector hospitals, both profit-making and non-profit-making, have their own management arrangements [Barros et al., 2011]. Atomedical operates in the field of private health care diagnostics units. However, it operates as a complement of the health care providers in the public sector, since most do not have a Nuclear Medicine unit available or its capacity do not fulfill the unit needs. This is reflected in the nature of the sector financing, mainly public. It has a higher importance in health care diagnostic units as Atomedical that have established a service and price agreement with the public sector. Therefore, most clients of such units reaches there forwarded by public hospitals and units that support the majority of the cost. Either by providing direct services to the Public Providers, or by providing cost support services directly to patients, diagnostic units only perform exams if prescribed by medical practitioners. Therefore, private diagnostic providers in Portugal are highly dependent on the National Health Care System regarding either funding, or exam requests [Deloitte, 2011]. In 2011, consultant firm Deloitte presented a report of the NHS in Portugal [Deloitte, 2011]. The report identified, in collaboration with different system stakeholders, the evolution of the NHS that drives the improvement of several Portuguese indicators of health. On the other hand, the report identifies the main challenges that the Portuguese health care sector faces nowadays, and that are important to a unit as Atomedical: • Financial instability of the Health Care System, due to the increasing costs of service, and to 12 the decrease of tax revenues in an aging population. • Lack of strategic planning of the services offer. • Deficiency in the evaluation and responsibility in the implementation of reforms and politics. • Lack of definition in the role of private institutions in the health care system. • Legislative instability. These challenges were exacerbated in the public debt crisis that put in the order of the day the costs with the NHS. Public Health providers are under pressure to reduce expenditure and the practitioners are pressured to only prescribe essential exams and treatments. As a result of an ongoing reform of the Portuguese Health Care System, it is unknown the evolution of the role of a public NHS in Portugal, as well as the impact of ongoing and future policies in the environment where Atomedical bases its operations. 2.4 2.4.1 Identifying the decision problem of Atomedical Context of the decision problem In the last 2 years, Atomedical has suffered with a decrease of the number of patients, as a result of the changes in health care administration policies and people economic power, as presented in Section 2.3. After facilities’ expansion in 2004, the unit is now working beneath the maximum capacity, and with no possible direct interference in the demand. In this environment context, unit managers have adjusted the complex exams schedule and workforce to the new reality, in order to maintain the unit final profit sustained in the high reputation of Atomedical. However, these adjustments were done empirically, based on the experience of the unit managers, mainly the Clinical Director, as the person in charge of the unit exams scheduling. Despite of the efforts, further adjustments need to be performed in order to sustain unit viability. Due to recent investment in facilities expansion and new equipment adjusting the capacity is limited to intervention in operations, as stated in Section 2.1. Section 2.3 showed how unit managers are on a leash by the external economic situation. Current health care policies and economic changes do not allow prediction of the evolution of the current situation. Therefore, unit managers need to be prepared to the possible switches of the current environment of unit operations, namely at the level of procurement. 2.4.2 Definition, objectives and scope of the decision problem Unit managers were supported in the definition of the Decision Problem. The methodology used in problem identification, helped them to set the problem and its structure, and sustain the following research and development. 13 The management of RFs perishable products, the diversity and number of exams, with procedure constraints, and significant workforce size, make managers believe that they can perform in a greater level of efficiency, adopting some organizational changes. The objective is to reduce operational costs, maintaining or even improving service quality (examination quality and patient waiting time). Since it is a risk to perform dramatic changes in the organizational structure of the unit, without a clear insight of the results, only small changes were performed. Given the context and the unit manager perceptions, the decision problems on the current situation were identified as problems regarding: 1. Exam scheduling weekly plan, increasing the efficiency of the use of resources, for the set objectives and radioactive products stock constraints. 2. Setting minimal staff for the proposed schedule and set objectives. 3. Predicting the effects of possible strategies in unit performance in uncertain operational and environment contexts. The scope of the problem is Atomedical unit operations, its performance regarding the influence multiple internal factors, and how external factors could play a role in determining the conditions in which the unit performs. The analysis of the unit performance is either at the financial level, or at the service quality level. Vicente et al. [2007] describes dimensions of quality from the part of the patient are the waiting list for an exam and the waiting time during it, being the last the one that they most valued. To guarantee a quality service, unit managers added also the importance of the quality of exam performed (therefore providing a good diagnostic report to patient medic). 2.4.3 Uncertainty as Atomedical decision problem As presented in Sections 2.2 and 2.3, unit managers face a context of uncertainty at two different unit levels: operations and environment. At the operations level, uncertainty resides in the behavior of the unit regarding either changes in procedures and context, or intrinsic uncertainty of procedures (for instance: exam durations or radionuclides activity) and inputs (for instance: number of patients). Previous work showed the usefulness of system simulation. This provides a tool to evaluate the current performance and impact of proposed changes, overcoming unit practical test limitations [Azevedo, 2010]. However, current Atomedical problem presents one a system with a high level of uncertainty regarding its current and future operations. This work must help General Managers not only to improve Atomedical service, but also to prepare them to possible futures of their working, economical, political and even technological contexts. Therefore, it is important to go further in the development of a decision support tool to the Atomedical problem. 14 3 Literature review Contents 3.1 Methodologies for system analysis in health care units . . . . . . . . . . . . . . . 3.2 Scenarios Planning in Health Care . . . . . . . . . . . . . . . . . . . . . . . . . . . 3.3 A combination of Scenarios Planning with Simulation . . . . . . . . . . . . . . . . 16 23 30 15 3.1 3.1.1 Methodologies for system analysis in health care units System analysis The development of a decision support tool needs to consider Atomedical operations as a system. A system can be viewed as a set of entities acting and interacting with each other in order to accomplish some logical end [Law and Kelton, 2007]. Therefore, in studying Atomedical as a system, one can focus only in the core entities related with the problem under analysis. The general types of processes that make part of a health care unit system are clinical, management and auxiliary. From those, the clinical processes are the most important, since they involve planning and controlling of resources used in the service provided to patients. The management processes deal with the tasks of managing resources, as equipments, supplies and staff, which support the clinical process. The auxiliary processes refer to all the resources, needed to the correct service of the health care unit [Vissers and Beech, 2005]. In Atomedical, one is between the clinical and management process, although the management is restricted to what directly influences the examination operations. In order to conduct a study of a system, one has two options: study the real system or study the system through using a model [Law and Kelton, 2007]. The first option is preferable as the final results present no doubt, however, the changes are, in most cases, irreversible, and it may be costly both in money and time. The second option offers the possibility to study a system using a model, which allows to overcome the difficulties that a real system study presents: studying several alternative changes, replication of the study and avoiding the risk of considering dangerous or even illegal changes [Pidd, 2003]. The use of a model of the system suits the problem of Atomedical as seen in Azevedo [2010]. Models tend to be close representations of the system to be studied. They can also represent changes whose effects are intended to be analyzed. A model can be either physical or mathematical. In management, the most frequently used are the mathematical models, since systems behavior can be, in most cases, easily described this way, allowing one more flexibility than a physical model [Pidd, 2003]. In cases where one is facing with a simple system, or a simpler model of the system, the relation between the entities and their behavior can be expressed with a logical and quantitative method, in order to obtain exact solutions, allowing one to optimize it. Therefore, the mathematical model can be studied analytically [Law and Kelton, 2007]. Many system configurations have received plenty of study, and can therefore be adapted to similar problems. For instance, system configuration used in production sites can be used in most common health care units. The usual solution methodologies applied in this type of mathematical problems can be divided in: traditional optimization methods, such as, dynamic programming, branch and bound or use of trade-off curves; integer programming formulations; and, more recent methods, such as, genetic algorithm, simulated annealing or tabu search. These system models are studied regarding their performance, and finally evaluate using a criteria or a multi-criteria methodology [Nagar et al., 16 1995]. However, Nuclear Medicine units were proved to be rather complex. The core problem in Atomedical corresponds to the scheduling of patients exams. However, there are other constraints that increases complexity. They are mainly related to the management of radiopharmaceuticals, different exams performed and the uncertainty around its environment inputs and procedures. Although analytical models can address uncertainty in the system components, the complexity of the system interactions limits the pratical use of analytical models to study Atomedical and similar problems. Problems focused in operations difficult the simplification of a model to a feasible level, due to multiple internal and external variables and related uncertainties. 3.1.2 Dealing with uncertainty In a system, different types of uncertainty may exist, depending on the problem, increase usually with its complexity. They are addressed by different tools and methodologies. In particular, this topic arises when one desires advanced systems characteristics, such as, robustness, flexibility and adaptability, although plagued by a terminology poorly defined [McManus and Hastings, 2006]. Uncertainties may be split into four categories. Uncertainties, leading to Risk or Opportunities, which are handled technically by Mitigations or Exploitations, leading hopefully to wanted Outcomes [McManus and Hastings, 2006]. These categories are then decomposed in different classes, in a taxonomy detailed Table 3.1. Table 3.1: Taxonomy of a framework for handling uncertainties and their effects. Uncertainties Risks/Opportunities Mitigations/Exploitations Outcomes Lack of Knowledge Disaster Margins Reliability Lack of Definition Failure Redundancy Robustness Statistically Characterized Variables Known Unknowns Degradation Design Choices Versatility Cost/Schedule (+/-) Verification and Test Flexibility Unknown Unknowns Market shifts (+/-) Generality Evolvability Need shifts (+/-) Upgradeability Interoperability Extra Capacity Modularity Emergent Capabilities Tradespace Exploration Portfolios and Real Options Source: McManus and Hastings [2006] An ideal method to deal with uncertainty would: acquire knowledge about all the uncertainties that a system faces; calculate all risks and opportunities inherent in them; model the effects of all mitigations and exploitations strategies; and achieve all the desired system attributes. In the current methods, quantitative methods, such as Risk Analysis, issue in quantifying known uncertainties and unsubtle risks. In engineering practices, straightforward techniques, as margins and redundancy, are used to mitigate less-characterized risks, due to a lack of knowledge or definition [McManus and Hastings, 2006]. 17 One of the emerging demands while dealing with uncertainty is to handle the “unknown unknowns”. If the effects of uncertainty on the performance of systems can be quantified, the associated risk may be quantified, and mitigations applied [McManus and Hastings, 2006]. If one focuses on the operational level of Atomedical, addressing the environment context uncertainty could be simplified through the study of system impact of variations on inputs. One central concept while dealing with uncertainty is how we express it, and the most widely used formalism for classifying uncertainty is probability. To ensure that a probability is meaningful, it must pass the clarity test, which means, an event or quantity must be well-specified for a meaningful probability distribution to be assessable [Morgan and Henrion, 1990]. One can define empirical quantities as measurable properties of the real world. Other variables or quantities can also be defined, such as: decision variables (a controllable input variable), value parameters (aspects of the preferences of the decision maker), index variables (e.g. time and space), model domain parameters (e.g. model index variables increments) and outcome criteria (variables used to rank or measure the desirability of possible outcomes). All possibly represent an uncertainty [Morgan and Henrion, 1990], that may have multiple sources [McManus and Hastings, 2006; Morgan and Henrion, 1990]: Statistical variation, Systematic error and subjective judgment, Linguistic imprecision, Variability, Randomness, Disagreement, Approximations and Model structure. Wittenberg [2009] surveyed senior executives in the practice of risk management. They identified the tools currently employed or that should be employed to address the risk or uncertain situations, from which result of the common use of combinations of different tools, in order to overcome a myriad of sources of uncertainty [Wittenberg, 2009]. 3.1.3 Appointment scheduling in health care units One can separate the problem in Atomedical by its environment and operation, even if both closely related. In its operation, Atomedical uncertainty and complexity is the result of the influence of scheduling exam appointments in the system performance. The problem of appointment scheduling is one of the more important aspects in the operational management of any service. This problem in Health care units has received a huge interest by the scientific community regarding its impacts and optimization. Therefore, a review on the existing literature on this topic was performed, in order to identify the methodologies used, specific contexts and results, through searching Science Direct and Web of Knowledge for specified keywords1 . Each source query abstract was manually searched to pre-screen the relevant articles. Afterwards, the references of each relevant paper was reviewed, in order to identify published material that was not listed in the first place, or was not available in searched databases. In order to better understand the diversity of context and approaches, the most relevant articles were organized in a summary table, Table (A.1), in Appendix A. 1 Spyropoulos [2000] defines scheduling as a part of planing. Therefore, main keywords used to screen articles were: scheduling, medical exam* scheduling, outpatient scheduling, scheduling rules, scheduling procedures and planing patient arrival. Asterisk stands for search all word or word fragment combinations. For instance, exam* finds either exam and its plural, exams. 18 Health care units usually schedule “customer” arrivals in service. The performance of this appointment scheduling is considerably affected by the operating environments. Therefore, the performance of different appointment rules may vary in different systems [Ho, 1999]. Their adaptability to the available information of service and demand variability can simultaneously reduce waiting times and provider idle time [Rohleder, 2000]. The problem of scheduling in health care focus in three points. First it is necessary to take into account the randomness of consultation/examination times, where one can only obtain the mean and standard deviation of this variable while finding a way to optimize an appointment system. This randomness is in the origin of delays for patients and idle times for service providers, both prejudicial to a health care unit performance. In second, appointment intervals are usually the way to overcome the randomness of the system, making use of the distribution values of the consultation/examinations. However, different rules of intervals also contribute to different waiting and idle times of the system. Waiting time is generally considered the time from the patient schedule arrival until his departure. The time spent in contact with the service provider is usually separated, since it does not contribute to the patient perceived time of waiting. The time of patient earliness is usually not taken into account. The idle time of the service provider is the time while the professional is not working, which is critical, since staff represents one of the major cost in health care [Dexter, 1999]. Dexter [1999] also identifies three factors that can also increase long patient waits: lack of patient punctuality, provider tardiness and patients without appointments. The basic trade-off question in any outpatients departments appointment system is patient waitingtime versus physician idle-time. In most cases, these tend to favor the physician at the expense of the patient. However, with the increase of the competitive economic environment of those services, many have started reviewing their appointment systems and seeking ways to optimize both variables [Katz, 1969]. Cayirli et al. [2006] pointed various suggested appointment rules that have been target of studies. For instance, the importance of the study of optimized scheduling systems is expressed in existing patent applications of new systems and methods [Luzon et al., 2009]. The operations of Atomedical have recourse to the ability to integrate scheduling with batching a mix of patients with different and corresponding types of exams, because patients can share the same procedure setup, and the facility can process several exams simultaneously. Potts [2000] offers a review of comprehensive mathematical techniques in this integration, focusing in the design of efficient dynamic programming algorithms for solving these types of problems. Scheduling problems have also been addressed in literature using other methodologies, as multiobjective models (for example, in faculty scheduling assignments [Badri, 1996]) or dynamic programming (for instance, in crew scheduling [Beasley and Caos, 1998]). Hoogeveen [2005] explores the same problem using multicriteria scheduling, looking for a solution that minimizes the given objective function. In the perspective of resources, optimized staff schedules can provide enormous benefits if an organization is to meet customer demands in a cost effective manner while satisfying requirements such as flexible workplace agreements, shift equity, staff preferences, and part-time work [Ernst et al., 2004]. Atabakhsh 19 [1991] reviews the use of artificial intelligence approaches in order to solve the problem of constraint based scheduling. An artificial intelligence system in this field should not replicate the human scheduler but enhance his capabilities by doing more problem solving than was manually possible. The study of queuing systems can be done with mathematical models. However, if one uses more general distributions and assumptions to describe the service, a more complex describing model or even more complex control rules are employed, becoming extremely difficult, if not impossible, to obtain analytical results [Kolesar, 1970]. This is the situation in Atomedical problem, thus being difficult to use such methodologies to find a optimized scheduling of patients. Als [2007] pointed the difficulty of scheduling in a Nuclear Medicine department. For instance, some scintigraphic exams require a constant camera acquisition time in any clinical indication (myocardial perfusion, thyroid uptake and imaging, pulmonary ventilation and perfusion as well as static and dynamic renal scans), while others do not (bone scintigraphy). In the reviewed literature, Table A.1 in Appendix A, the most common methodology uses simulation models. This methodology showed to be the suitable to the complexity of health care units. Given the operations that characterize these places, there are some applications of Monte Carlo Simulations [Bailey, 1954; Denton et al., 2006a; Goitein, 1990; Rising et al., 1973], but DES is widely used in the more recent simulation papers [Cayirli et al., 2006; Coelli et al., 2007; Harper and Gamlin, 2003; Hashimoto and Bell, 1996; Ho and Lau, 1992; Johansson et al., 2010; Katz, 1969; Klassen and Rohleder, 1996; Klassen and Yoogalingam, 2009; Merode et al., 1996; Su, 2003; Wijewickrama and Takakuwa, 2008], given problem complexity. Recent literature shows an increase in the use of optimizations methodologies, such as, linear [Conforti et al., 2010; Kolesar, 1970; Patrick and Puterman, 2008] and integer programming [Chern et al., 2008; Santibáñez et al., 2007], multi-objective optimization [Castro and Petrovic, 2011; Muthuraman and Lawley, 2008] or other types of optimizations methodologies [Billiau et al., 2010; Hannebauer and Müller, 2001; Min and Yih, 2010; Mittal and Stiller, 2011; Podgorelec and Kokol, 1997]. However, in such methodologies, one is only allowed to deal with a well defined uncertainty in a limited number of variables. DES methodology suits better to the complex multi-variable Atomedical problem. Even though, in opposition to more analytical methodologies, DES alone fails to help one optimize configurations of a model. Therefore, it is expected to find combinations with other methodologies, namely as part of optimization techniques, for instance, in the evaluation of the performance of a model in a given configuration, as an alternative to the use of an analytical approach [Gulpnar, 2004]. 3.1.4 Discrete event simulation models DES models are one type of simulation models. Simulation models are proposed tools to model and study complex systems involving uncertainty, for instance, using sensitivity analysis or Monte Carlo analysis [Law and Kelton, 2007; Pidd, 2003]. Simulation techniques have been used to address problems of space or bed allocation. In com- 20 bination with Operation Research techniques, they have been used to look at the problems of staff shift allocation, drug logistics, ambulance or operations theaters scheduling, while the combination with Artificial Intelligence techniques only began more recently [Spyropoulos, 2000]. Other examples in the health care context are provided by Angelis et al. [2003] and Masterson et al. [2004]. Simulation models can be classified along three different dimensions. They can be either static or dynamic. In a static simulation model, one has the representation of the system at a particular time. An example of this is the Monte Carlo model. On the other hand, a dynamic simulation model represents a system as it evolves over time. In static simulations, one has static time increments, and the model analysis is performed with the results obtained within that frames. In dynamic simulation, one has event simulation model, where the model evolves when an event occurs 2 , with variable time increments. Simulations models can also be deterministic or stochastic, where the latter contains any probabilist (i.e. random) components. Stochastic models provide a output that is itself random, an estimation of the true characteristics of the model. Finally, simulations models can be continuous or discrete. The use of each type of model is dependent on the specific objectives of the study. If one wants to study each individual characteristic, a discrete model should be used. If one wants to study individuals in the aggregate, uses equations in a continuous model are more appropriate [Law and Kelton, 2007; Pidd, 2003]. Regarding the specific problem in Atomedical, one is interested in using a dynamic, stochastic and discrete models. As the focus of the study corresponds to events, such as, patients arrival or patient examination, a dynamic model is best suited. The studied system is characterized by the randomness of its variables, such as, waiting time or procurement, therefore, a stochastic models applies to this situation. Because the events do not occur continuously in time, the use of a discrete model is justified. The process of problem analysis using a simulation model is usually an iterative approach, where the current system study is modeled to be simulated. With the simulation results analysis, conclusions can be drawn regarding the correct representation of the model. The model can be then modified to better adapt to the original system, or to study the changes to the original system [Maria, 1997]. In all the steps, decision has to be made, therefore, the role of the problem decision makers in all the process is of major importance [Pidd, 2003]. Even if one could use simulation as a tool within other methodologies, it is pertinent to consider the general steps involved in developing a simulation model, designing a simulation experiment, and performing simulation analysis [Maria, 1997]: (1) Identify the problem, (2) Formulate the problem, (3) Collect and process real system data, (4) Formulate and develop a model, (5) Validate the model, (6) Document model for future use, (7) Select appropriate experimental design, (8) Establish experimental conditions for runs, (9) Perform simulation runs, (10) Interpret and present results and (11) Recommend further course of action. These steps need to be taken into account in any methodology using simulation models 2 An event is considered to be a change in the state of one of the model variables. 21 3.1.4.A Discrete Event Simulation Models in Health Care DES models are widely found in literature regarding health care units since they present the complex system that this methodology intends to overcome. According to Standridge [1999], simulation models are a convenient option in the study of health care units systems, namely because: • Computer simulation conforms both to system structure and available data. This is better than a pure abstracting of the system into a strictly mathematical form due to a high level of complexity. • Simulations supports a low cost, and little risk study of health care systems. • Simulations takes into account variations, that hugely matters in health services, given each patient specific needs. • Unique system requirements for information can be drawn from simulation experiment results. Fone et al. [2003] reviewed the literature of use and benefit of DES models in population health and health care delivery. The identified topics were in increasing order of popularity: infection and communicable disease; costs and economic evaluation; screening and, in a greater number, hospital scheduling and organization. When thinking specifically of health care delivery units, like Atomedical, simulation applications may be classified into four categories: public policy; patient treatment processes; capital expenditure requirements and provider operating policies [Standridge, 1999]. Günal and Pidd [2010] review of literature showed an increase number of papers, with an increased interest in the focus on the patient problems (e.g. waiting time, service quality). The literature focus in the use of DES in health care services studied staff scheduling in emergency departments [Centeno et al., 2003; Evans and Unger, 1996], resources allocation in clinical contexts [Kuban Altinel et al., 1996; Zaki et al., 1997], different screening methods in emergency departments [Ruohonen et al., 2006; Wang, 2009] and clinical practice costing in the same context [Glick et al., 2000]. One also finds a significant number of studies in the topic of scheduling, either of surgeries [Dexter et al., 1999], or of appointments in outpatient services [Cayirli et al., 2006; Harper and Gamlin, 2003; Klassen and Rohleder, 1996; Rohleder and Klassen, 2002; Stahl et al., 2003; Wagner et al., 2004; Wijewickrama and Takakuwa, 2005]. This methodology has been used also in other contexts, for instance, in resource allocation and service planning at outpatient units [Côté, 1999; Williams et al., 2009], in the schedule of staff in wards [Dean et al., 1999] or in the screening procedures for specific diseases in outpatients units [Ramwadhdoebe et al., 2009; Rohleder and Klassen, 2002]. Regarding specific problems in diagnostic health care units, like Atomedical, one found scant literature. For instance, Merode et al. [1996]; van Merode et al. [1995] explores the construction of a decision support system for capacity planning in clinical laboratories, based in a simulation model of the laboratory. In Nickel and Schmidt [2009], the case study focused on the analysis of the patient flow and machinery utilization in a radiology department, under different scenarios. Particularly in the field of Nuclear Medicine, where highly specific operation constraints were already pointed, almost no literature is found, particularly outside general hospitals. Pérez et al. [2010, 2011] point this situation, 22 while developing a DES model of a hospital Nuclear Medicine department in order to study different patients and resources scheduling rules. In other paper, Cameron et al. [2006] addressed the problem of capacity planning in this type of services. In the Portuguese context, one can found previous work about Nuclear Medicine units, as the one in the unit of Hospital Privado de Almada [Fernandes, 2007] and more specifically in Atomedical, as already addressed by Azevedo [2010], that showed how DES is suited to study this type of system operation. The simple use of DES does not address the problem that Atomedical currently faces regarding the indefinition of its environment. To address this type of uncertainty, Chetouane et al. [2012] proposes some tools to study simulation models response to variations using sensitivity analysis. But how can one select the relevant variables to be studied and how can one define their variations? One of the tools makes uses of scenarios construction in order to explorer the field of system inputs uncertainty. Therefore it is concluded that there is a need for a methodology to consider scenarios for Atomedical. Scenarios Planning is an existing tool to perform a more systematic approach of scenarios construction. 3.2 Scenarios Planning in Health Care Atomedical managers face a high complex system due to the multiple factors that might influence operational performance increasing the uncertainty of the problem. Examples of systems analysis methodologies, as already reviewed, showed how difficult becomes the construction of valuable alternative system simulations for decision support in high complexity system models. When one is not able to use more objective tool, some “soft techniques” exist to support a more systematic and accurate procedure to provide valuable system alternatives. Scenarios Planning arises as the obvious methodology to address the environment uncertainty in Atomedical problem. In order to perform the review on the existing literature regarding the use of Scenarios Planning methodologies, the online article databases used before were searched, since not all are covering the same journals, for specified keywords3 . Each source query was manually searched through the abstracts to pre-screen the relevant articles. The keyword “health” was used in order to help finding existing articles related to health care contexts. Afterwards, the references of each relevant paper was reviewed, in order to identify further published material that was not listed in first place, or was not available in searched databases. Additionally, the book Ringland [2006] was used as framework to explore this methodology approach. 3.2.1 Scenarios Planning Uncertainty in the business environment is a constant. A key aspect of strategy is making sense of this uncertainty and respond appropriately in the pursuit of organizational objectives, which means 3 Main keywords used to screen articles were: scenarios planning health care, scenario analysis in health care services. 23 multiple possible futures to an organization, that may be problematic. Scenarios Planning is a sensemaking approach, which aims to identify potential predetermined elements in the business environment, helping to explore and understand uncertainty [Burt, 2010]. Ringland [2006] defines Scenarios Planning as: “That part of the strategic planning that relates to the tools and technologies for managing the uncertainties of the future”. The end of the Second World War set the start of the technique of “future-now” thinking in USA, increasing through the 1960s with the development of long-range planning for business incorporating operations research, economics planning for business incorporating operations research, economics and political strategy alongside hard science and military consulting [Ringland, 2006]. Major companies, like Shell, Corning, IBM and General Motors (GE) get exposed to this type of thinking, leading to a peak of interest in the 1970s. GE used scenarios as part of its planning process, in order to think about the environmental factors affecting its businesses. The method involved using Delphi panels to establish and verify critical variables and indicators, while both trend-impacts analysis and crossimpact analysis would then help to assess the implications of the interactions among critical variables and indicators. GE pioneered an approach whereby the cross-impact effects among likely developments are dealt with qualitatively, with plus or minus signs, which then lead to the development of probable scenarios, as outlined in Georgantzas and Acar [1995] and used until early 1980s where the technique began to be misused. Some confusion existed between scenarios and forecasts. In forecasting the danger is in not knowing when it is right to forecast - expect the results to be accurate - and when forecast cannot be relied on. In domains where forecasting can be reliable, the Delphi method is widely used, but under uncertainty only a correct Scenarios Planning provide an useful tool to management, as summarized in Table (3.2). However, only in the mid-1990s was seen a resurgence of the interest in Scenarios Planning [Ringland, 2006]. Royal Dutch/Shell is a classic example of how Scenarios Planning helped an organization prepare for an uncertain future, referenced and analyzed throughout literature [Cornelius et al., 2005; Rettig, 1998; Ringland, 2006]. This example is of a great importance to Scenarios Planning since multiple organization loosely use Pierre Wack Intuitive Logics, initiated by former Shell group planner Pierre Wack in the 1960s, which became the mainstream scenarios approach [Postma and Liebl, 2005; Ringland, 2006]. Table 3.2: Characterization of Foresight Techniques. Technique Approach Advantage Limitation Appropriate use Projection Extrapolation of historical data Simplicity; reliable historical base Unexpected events Short-term and pre-determined factors Critical technologies Focused discussion by experts Economical; targeted Available expertise, influence factor; criteria for choices Preliminary examination of issues; taps expert views Delphi Large group judgment Influence free process Testing and confirmation; mass involvement Scenarios Construction of alternate possible futures Anti-forecast decision guides; explores uncertainty Construction of questions; resource intensive Plausibility; viewpoints of writers; imagination Source: Mahmud [2011] 24 Coherent possible futures; identify interconnections One of the earlier steps in most Scenarios Planning methods identifies the fundamental determinants actors of future developments. These so-called driving forces or casual factors are classified as either constant, predetermined or uncertain [Postma and Liebl, 2005]. Predictable elements can be more easily addressed by methods and techniques of forecasting. Scenarios Planning is more suitable to deal with a reasonable uncertainty in the not too far distant future. Simplifying the view of future, scenarios provide a clustering of possible future trajectories into distinguishable and meaningful groups [Whitacre et al., 2008] since Scenarios Planning is well equipped to deal with predetermineds and uncertainties. However, it usually leaves the unknowables out of discussion [Postma and Liebl, 2005]. Varum and Melo [2010] study shows evidence of use of the Scenarios Planning in literature in multiples fields, such in economies, government and policies [Mahmud, 2011; Page et al., 2010; Rawluk and Godber, 2011], product and service development [Burt, 2010], environment [Apeldoorn et al., 1998; Karvetski et al., 2011], supply-chain management and logistics [Khor et al., 2008; Papageorgiou et al., 2009], technology [Islei et al., 1999], finance [Xie and Xie, 2008], change management and strategic decision making [Chermack, 2004]. The majority of the literature focus in the process of Scenarios Planning and methodologies. The scant literature in the success of this methodology application report a positive performance of firms [Johnston et al., 2008; Phelps et al., 2001; Visser and Chermack, 2009], although organization strategic inertia was found to be the main cause in process failure[Wright et al., 2008]. An application of Scenarios Planning in Nuclear Medicine unit operations is something new, since this methodology is usually applied in institutions policies, and not in such specific operational context to obtain scenarios and strategies. The generic based Scenarios Planning process architecture is shown in Figure 3.1. While retaining a strong linear structure, the process is multistage, interactive, iterative and data driven, with some steps needing a high level of creativity, where managers should be actively involved [Brien, 2003; Freeman and Pattinson, 2010]. Restrain the many “messy” diversions of thought and dialogue that could stretch and derail the process is critical to have a strong structure. The process has no specific time limits. Concise processes, for example as organized in an urgent reaction to organizational shock or crisis, can be accomplished in a couple of days while processes that explore complex topics, for example the future of a nation, have to be crafted carefully and can take a couple of years to complete. The interactive involvement of individuals and groups at different stages means that contributions management through the process and in structural elements is critical to a successful outcome wherein people move back and forth between interrelated phases and activities [Islei et al., 1999; MacKay and McKiernan, 2010; Postma and Liebl, 2005]. Relevant topics to a planning process will depend on the timescale over which planning is taking place and the level of focus. Over short to moderate timescales (known as tactical and operational planning), the problem is viewed as one of strategic positioning based on relatively small time horizons such that emphasis is placed only on plan agility/flexibility and robustness. This is what one is looking in the Atomedical problem. As timescale is extended out to longer periods, a planning process also needs to account for continuous learning on the implementation strategy and practical challenges [Whitacre et al., 2008]. 25 Figure 3.1: Generic architecture of a scenarios planning process. Source: [MacKay and McKiernan, 2010] 3.2.2 Scenarios Planning methodologies Traditional narrative format seeks to create equally plausible and consistent storylines of how the future might unfold from the present [Schoemaker, 1995]. The Scenarios Planning literature prescribes two modes for using scenarios which are described below: Exploratory: Encouraging the exploration of implication scenarios for strategic options using discussion, which are often the end result of the exercise [Schoemaker, 1991]. Any assessments of existing options in this mode tend to follow flexible qualitative descriptions (eg. plus and minus scales to assess the strength of opportunity or threat). Formal Evaluation: Encouraging to explore scenarios implications for strategic options through the formal evaluation of proposed options [Chermack, 2004; Godet and Roubelat, 1996; Klayman, 1993; Morgan et al., 1999; Wollenberg et al., 2000]. The options are fixed and used as inputs usually quantitative analysis [Huss and Honton, 1987]. The coherent discipline is argued by proponents as helping the decision-maker systematically think about choice, promoting a more efficient use of available information (eg. objectives, constraints, external factors) [Goodwin and Wright, 2001; Stewart, 2005], or even actively creating their future in a goal-oriented scenarios planning [Tevis, 2010]. To obtain a set of meaningful scenarios and strategies to evaluate unit operations, one should, therefore, follow a formal mode of this methodology. In Godet [2006] it is proposed a comprehensive method to formal construction of scenarios. Some of the existing tools to perform a formal Scenarios Planning consider a two-by-two matrix whose cells consist of the upper and lower bounds of two key uncertainties [Geus, 1999]. Scenarios narratives may be also be constructed around themes based 26 on the impacts of decisions [Stewart and Scott, 1995] or on varying perspectives of desirable future [Gordon, 2008]. Scenarios may also take the form of variations of parameters of a system model, which can be mathematically defined [Tietje, 2005]. Examples of scenarios planning methods used in multiple organizations are presented in Table (3.3), as reported by Ringland [2006]. Table 3.3: Example of scenarios planning methods used, steps and organizations origin [Ringland, 2006]. Methods Method Steps/Phases Organization U-Process (1) Convening necessary project resources (2) Constructing of relevant, emergent, plausible and clear scenarios and visions. (3) Radiating vision for and with the larger society (1) Data Collection (2) Shaping Factors (3) Pilot Study (4) Expert Workshops Generon Consulting (1) Building the Database (2) Scanning the Range of Possibles and Reducing Uncertainty (3) Developing the Scenarios (1) Identify Focal Issue or Decision (2) Key Forces in the Local Environment (3) Driving Forces (4) Rank by Importance and Uncertainty (5) Selecting the Scenario Logistics (6) Fleshing Out the Scenarios (7) Implications (8) Selection of Leading Indicators and Signposts (1) Project Startup (2) Diagnosis, or Identifying the Focal Issue with Interviews, Analysis, Synthesis, Desk Research and Feedback (3) Issues Workshops with team (4) Development of Scenarios (5) Investigation, Development and Evaluation of Strategic Options (1) Detection of Key Factors (2) Development of Future Projections (3) Combination of Future Projections to Scenarios (4) Analysis of Scenarios and Interpretation of the “Future Space” (1) Decision Focus (2) Research (3) Structured Scenario-Based Decision Making (4) Monitoring and Response French School Shaping Factors-Shaping Actors Godet approach: MICMAC Scenario development by using Peter Schwartz’s methodology Future Mapping Method System, Future-Open and Strategic Thinking Scenario-Based Strategy Development European Commission The Global Business Network SAMI Consulting ScMI Stanford Research Institute Source: [Ringland, 2006] Traditional planning techniques tend to perform less well when faced with high uncertainty and complexity, in contrast with the Scenarios Planning method. Robust scenarios construction provides internally consistency that, in addition, should support the consideration of plausible uncertainties, even if not directly addressed, and challenge managerial thinking [Schoemaker, 1991]. Postma and Liebl [2005] points that this approach do not prevent management surprise regarding the future. 3.2.3 Dealing with Uncertainty in Scenarios Planning Also in Scenarios Planning it is important to understand how uncertainty is managed, namely the relevance of unknowables. Although scenarios approach aims to provide some insight about the unknown evolution of the present in the future, providing relevant information for early-warning purposes, only future predetermined and uncertain variables can be addressed. The predetermined variables exist, since one already knows the alternative future outcomes of events and developments as well as their probabilities. In the case of uncertainties 4 , the outcomes are known but not their probability of occurrence. In the case of unknowable, not even the outcomes are known, and therefore, it is not possible being forecasted, however, they may become very relevant to a decision [Postma and Liebl, 2005]. It is important to distinguish between what is uncertain to one, and what one ignore [Ansoff, 1975]. Schoemaker [1995] distinguish three classes of knowledge: 1) things one knows to 4 Is important to notice that these uncertainties refers to possible futures, and, therefore, are different of quantitative uncertainties addressed in Section 3.1.2 where probabilities can be known. 27 know, 2) things one knows not to know and 3) things one does not know not to know. While the first class is evident, and may be in the field of strategy, scenario building aims help to support the second type of knowledge. Therefore, the main challenge is to reach the third class, as one is searching for something without knowing what it is and where to find it. In spite of this difficulty, making assumptions on the relevant issues or trends/events, and then discuss these, will able one to determine possible implications and explore inconceivable elements of the problem [Schoemaker, 1995]. Many details which are not outlined at the level of a scenario, are needed to fully specify a particular path to the future. Filling in these details involves specifying the structure of a model (i.e. model of the real environment) and specifying the initial conditions. Defining these model details is a sort of problem instantiating, while running the model (i.e. simulating the dynamics of the real environment) allows us to generate an actual path to the future. Due to the randomness of some events, each simulation can take a unique path and result in different future conditions [Whitacre et al., 2008]. The multiple existence of possible futures within a problem instance and multiple problem instances within a scenario are illustrated in Figure 3.2. Scenario! Space! Simulate Dymamics! Instantiate Scenario! Future Space! Problem Instance Space! Figure 3.2: Illustration of multiplicity in possible futures, problem instances within a scenario. Adapted from: [Whitacre et al., 2008] The problem of uncertainty is not completely addressed by Scenarios Planning, mainly when that uncertainty resides in great part inside the system itself. Therefore, proposed Scenarios Planning methods include other methodologies in their steps. 3.2.4 Using Scenarios Planning with other methodologies There is a lack of literature in the use of Scenarios Planning with other problem solving methodologies. Although, in order to support strategy, Scenarios Planning may be integrated with other tools, namely System Modeling [Apeldoorn et al., 1998; Burt, 2010; Papageorgiou et al., 2009; Xie and Xie, 2008], Decision Analysis [Karvetski et al., 2011; Ram et al., 2011; Wright et al., 2009], Programming [Khor et al., 2008] and Bayesian Networks [Cinar and Kayakutlu, 2010]. Lempert et al. [2003] report discusses how, under assumptions of deep uncertainty, a quantitative approach to scenarios can be helpful. The use of quantitative scenarios allows a better use of other methods. For instance, in Whitacre et al. [2008], a basic problem is solved using scenarios as base for the study of solutions performance using meta-heuristics such as Evolutionary Algorithms, and in [Apeldoorn et al., 1998], scenarios provide a set of parameters to a simulation model, in an iterative process. Davis et al. [2007] introduces a way to enhance strategic planning through Massive Scenario 28 Generation, making use of a mathematical model of the problem in analysis as a way to produce large scale number of scenarios. System modeling can be done in the form of behavior-over-time graphs, causal mapping and feedback loops helping in structuring and linking variables and their interaction to provide an understanding of the systemic drivers of these predetermined elements, supporting methodological integration with Scenarios Planning [Burt, 2010]. In Papageorgiou et al. [2009], Scenarios Planning is used to produce scenarios of a transportation system, which are modeled and evaluated using simulation, a similar approach of the one used in Apeldoorn et al. [1998]. Altough none in the specific context of health care services, combination of DES with a simple Scenarios Planning methodology was explored successfully used as reported in existing works [Apeldoorn et al., 1998; Papageorgiou et al., 2009]. 3.2.5 Scenarios Planning in health care The use of Scenarios Planning in health care service context takes few attentions of scientific literature. In the same way of other fields, Scenarios Planning in health care may not prevent the organizations from picking “the wrong future". Yet, it will prepare them to better deal with implications of technology and payment/contracting change, the shift to ambulatory care and the decline in in-patient days. Scenarios Planning is not about predicting the future. It is about preparing an organization for a number of possible futures [Rettig, 1998]. Scenarios allow a pre-prepared game plan available for ready use as the future unfolds. They allow a deliberative response rather than a hastily constructed, urgent reaction in the opinion of Enzmann et al. [2011] which uses Scenarios Planning exploring the future of the field of radiology. Therefore, Scenarios Planning shows to fit the Atomedical problem, addressing the current uncertainty around its future operations environment. In the case of Venable et al. [1993], Scenarios Planning is used in a local public health department, focusing in key health care and organizational issues, resulting in a set of plausible scenarios that aided in strategic planning, encouraged strategic thinking among managers, eliminated or reduced surprise about environmental changes, and improved managerial discussion and communication. Neiner et al. [2004] uses Scenarios Planning, in a health department, to address chronic disease prevention and control, based in behavioral key factors. In Woude et al. [2003] nursing future is explored while Ellis et al. [1990] studies predicted models outcomes of an hospital in different scenarios to understand the interrelations among the fundamentals elements of hospital inpatient care. Ultimately, Lexa and Chan [2010] discusses the scenarios analysis in the sequence of USA deficit reduction policies effects in Health Policies and particularly in Radiology practices. These last two studies present some similarities with the Atomedical problem although do not explore explicitly the operation impacts as being proposed as the result of this literature review. 29 3.3 A combination of Scenarios Planning with Simulation Increasing use of combination of tools from both within and across Operational Research and Management Science to support strategy process has been recently reported [O’Brien, 2011]. Although existing references in Section 3.2 of how Scenarios Planning could combine with other methodologies to solve multiples problems a lack of literature exists in this area, namely in health care units. As seen in Section 3.1, DES is widely used in systems with the type of complexity of diagnostic health care units, like Atomedical. For instance, in problems regarding scheduling and resources management. However, it does not address all the problem uncertainty, namely the one regarding the unit environment context. The impact of those uncertainties in the system performance can be assessed using different alternate environments. This can be done using sensitivity analysis if the number of variables are identified and in small number. However, the case of Atomedical, it lacks in the identification of those variables, and the problem complexity results in a not feasible approach without the use of complementary tools. The use of Scenarios Planning provides multiple simulations conditions to the system model, by providing a methodology that systematically addresses all uncertainty and variables in the construction of meaningful scenarios and strategies, as a result of problem analysis and structured construction methods. In Ellis et al. [1990], the interrelations of the fundamentals elements of a hospital inpatient care are studied through the outcomes of simulating different models in different scenarios, while in Venable et al. [1993], changes to the health units system model are simulated to evaluate performance in different system contexts. Therefore, Scenarios Planning is able to address more operational problems, as Atomedical. However, scenarios are driven from a reduced and predefined variables, and simulation is based in mathematical models due to the problem simplicity compared with Atomedical. The use of DES approaches were already implemented with positive results in other contexts Apeldoorn et al. [1998]; Papageorgiou et al. [2009], however, in simplistic approach and in simpler systems, with predefined variables. Scenarios Planning aims to provide multiple future scenarios to institutions which prepare themselves through strategic planning for each possible situation. In Scenarios Planning literature, scenario terminology is usually used to describe the external system context, while strategies are related to the internal system. But, in Atomedical problem, it is important to make use also of operational scenarios. They are the result of the factors which managers could not interfere, and strategies, which can be direct addressed by the managers. Therefore, a new framework of Scenarios Planning needed to be developed to address this specific application of current techniques. The use of Scenarios Planning in the case of Atomedical needs to perform a complete problem analysis of multi variable systems and be focused in the operations impact, rather in environment scenarios. Recollecting the objective of this work, the purpose of a proposed methodology is to evaluate different possible strategies in different scenarios, in order to guide managers to forestall future scenarios with successful strategies. 30 4 Proposed methodology framework for Scenarios Planning Contents 4.1 4.2 4.3 4.4 Scenarios Planning framework . . . . . . . . Phase 1 - Analysis of the problem . . . . . . . Phase 2 - Scenarios and Strategies . . . . . . Phase 3 - Study of Strategies and Scenarios . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 33 40 42 31 4.1 Scenarios Planning framework In Scenarios Planning methodology no standardized process exist. However the various approaches show a basic structure. As reported in literature review, Shell management way of thinking on dealing with scenarios was the main reference to many other organizations and institutions, resulting in a broader literature in this Shell-scenario approach, and which was improved in Postma and Liebl [2005] as a management tool. Godet [2006] provides complementary tools for specific steps that are similar to Shell-scenario approach. It allows deep Scenarios Planning process, considering realities full of unknowns as objectively as possible. The proposed tools enable users to ask the right questions and identify key variables, analyze actors’ strategies, scan possible futures, reduce uncertainty, obtain a full diagnostic of the company in terms of its environment, identify and evaluate strategic choices and options. Therefore, an articulation of Postma and Liebl [2005] and Godet [2006] frameworks for Scenarios Planning will be the backbone of this work methodology focusing in the unit operations level. The proposed methodology, Figure 4.1, is adapted to the specificity of the Atomedical unit problem, focusing in the examination operations, using, in such way, some complementary tools suggests by both authors. Since Postma and Liebl [2005] and Godet [2006] methodologies lack, in some order, in the use of more quantitative tools, needed to the study of a unit processes, which will rely in the use of a simulation model, some steps/tools will be introduce, as well as other relevant considerations from other reviewed literature. Tool! Phase 1! Analysis of the problem! Step 1! Structural Analysis! Direct Classification of Variables – Dependency Structure Matrix! Problem Identification! Identify the focal issue, question, decision! Identify the problem spectrum! Identify objectives of the result! Step 2! Problem Analysis! System analysis! Retrospective analysis in environment! Actors identification! ! Step 3! Problem Variables! System Analysis! Scenarios and Strategies! Study of Strategies and Scenarios! Phase 2! System Analysis! Phase 3! Structural Analysis! Indirect Classification of Variables - MICMAC! Tool! Step 4! Key Variables! Impact vs Uncertainty Analysis! Step 5! Tool! Scenarios and Strategies Construction! Morphological Analysis! Blocks Method! System Analysis! Tool! Step 6! Step 7! Indicators and Signposts selection! Discrete Event Simulation! System Analysis! Evaluation of Strategies under Scenarios! System Performance under a set of conditions! Strategy Selection Decision! Figure 4.1: Proposed Scenarios Planning Process. 32 Tool! Tool! Multicriteria Methodologies! Godet [2006] reinforce that a scenario is not a future reality, but rather a way of foreseeing the future, concerning for efficiency of coverage, and consistency and feasibility of the possible combinations, for which propose five necessary conditions for a rigorous scenarios construction: relevance, coherence, plausibility, importance and transparency. 4.2 4.2.1 Phase 1 - Analysis of the problem Step One - Identify the focal issue, question or decision The first method steps aims to analyze the problem faces, and to set the system parameters to be addressed. This step is generally performed through a workshop with the multiple visions of the organization. In the case of Atomedical, this was performed through meetings with unit managers. Both Postma and Liebl [2005] and Godet [2006] identify this step as the first one for theirs proposed methods. One must clearly identify the spectrum of the problem that will be addressed, as well as, the result of the question or problem motivating the work. 4.2.2 Step Two - Problem analysis Step two is, at a certain level, identified in Godet [2006] as two steps: diagnosis of firm and capture organization dynamics. However, both are joined in this step. In the case of Atomedical, the focus was in the operations and its dynamics. This is a change regarding the use of Godet [2006] methodology proposal. This step allows the identification of relations and interactions of components set related to the problem, describing it as a system. Besides the recognition of inputs and output of the system, internal relations and interdependencies are also pointed, in order to give assistance to variables identification in the problem context (Postma and Liebl [2005] classifies variables as system forces). Capturing also the organization dynamics can be done by a retrospective look at it in the environment, its development, behavior, strengths and weaknesses face to face with main actors in its strategic environment, from which key questions for the future may arise. It allows to still explore the context of operations usually addressed in Scenarios Planning. The problem of Atomedical is in the boundaries of the context and operations. 4.2.3 Step Three - Identification of problem variables After an initial description of the processes related to problem, a process of teasing out variables and reviewing the mechanisms connecting them is enriched through another workshop, which could make use of diagrams representations for posterior validation by the participants, unit managers in this case. Arcade et al. [1999] suggests, for didactic purposes, to group variables, respectively corresponding to: the internal system, the specific context and the global environment. By focusing in the operations, makes sense to group variables based in the specific contexts of influence of problem 33 objectives. One has to remember also that in a systemic approach, a variable exists only through its relationship with other variables. To identify significant variables it is important to focus in the problem/decision objectives, and identify what can contribute to its success or failure, by taking into account the previously steps on system characterization Godet [2006]. In some way, it is difficult to establish where step two ends and step three begins. 4.2.4 Step Four - Identification of Key Variables In the Scenarios Planning methodology, identification of key variables is very important, as they are the ones on which the system mainly depends. In this step, key variables of the organization and its environment are identified (Postma and Liebl [2005] classifies key variables as driving forces). Key variables identification in Scenarios Planning consists in isolate variables by their impact in the system, uncertainty and independence [Postma and Liebl, 2005]. Key variables are the ones which have significant impact in the system. However, in this sort of methodology, as scenarios are a set of possible futures for key variables, the variables’ impact is also related to the dependence between variables, since a variable has a greater impact if it is independent, and if it influence others (for instance, if a major variable has a huge impact in the system, but it is a result of other variable behavior, we can consider them as one cluster of variables, characterized by the last one behavior) [Postma and Liebl, 2005]. Also, key variables are those with some degree of uncertainty, since others can be predicted or manipulated, and therefore, are either a unchangeable of the problem, or can be addressed in a strategic approach [Godet, 2006]. In this step, a set of tools are suggested in order to help the decision maker to establish the key variables. The use of these tools is complementary to the process, however, they are essential to structure the ideas. The proposed tools cover all key variables criteria, and will help the judgment of workshop members. Despite providing tools to organize the process, it is rather subjective and the result will always depend on the workshop members choices, and may change when considering different persons, or visions. A way to overcome this situation, inside a organization, is to use quantitative tools to take into account different views to the final result, which can be done with the different views of each of the decision managers. Similar approach can be made in the qualitative tools, providing to a decision maker a set of different results, which may help to think about alternative configurations. Therefore, some of the Godet [2006] and Postma and Liebl [2005] proposed tools are introduced and complemented, which can be used in this step in order to identify the key variables of the system as: Scenario: A scenario variable is a key variable, therefore it must have impact or importance to the dynamics of the problem system. It must be also an influential variable to the system. This type of variable is characterized by a lack of knowledge or control, being therefore a system 34 uncertainty. It is also relevant to represent some degree of possibility, thus having the possibility of change in the future, or associated to frequent events. Strategy: A strategy variable is also a key variable, so it must also have impact or importance to the problem system dynamics. It may be also an influential variable to the system. However, this type of variable is characterized by a possibility of control by unit managers. Therefore, it makes no sense to think in possibility of frequency, since it is ultimately a strategic decision. Signpost: A signpost in not usually a key variable, but has contributions to the problem objectives, having then importance or impact in the problem. Therefore, it usually presents a high dependence of other variables, and is prior unknown and uncontrollable by unit managers. 4.2.5 Variables selection tools in Scenarios Planning Structural Analysis Tool for classification of variables dependence and influence - Dependency Structure Matrix and Direct Classification: One of the structural analysis tools allows to perform a direct classification of variables, by the construction of two-dimensional matrix called a structural analysis matrix in Godet [2006]. Similar tools can be found in literature, originally regarding project management and corporate organization, usually called of a Dependency Structure Matrix (DSM) [Yu et al., 2009] (design structure matrix, dependency source matrix, dependency map, interaction matrix, incidence matrix, precedence matrix, and others names are also used in the literature [Browning, 2001]). They can also be found in the study of complex software architectures [Sangal et al., 2005] as it can be applied in system decomposition and integration problems [Browning, 2001]. DSM taxonomy Scenarios Planning methodology uses a static DSM, which is essentially the square matrix: N 2 (with N being the system variables). The construction of a DSM starts from the initial pool of variables, distributed either in the rows and in the columns of a matrix. Each matrix position represents the direct influence between each variable. [Godet, 2006] suggest the use with workshop participants of the qualitative intensities: strong (3), average (2), weak (1) and potential (P). The potential intensity (P) is used to introduce an influence which can vary in different scenarios. This procedure of systematic interrogation allows the decision makers to avoid errors, and also to rank and to classify ideas. In doing so, it creates a common language to the problem and allows one to redefine certain variables and therefore refine the analysis of the system [Godet, 2006]. While building the DSM is important to avoid [Arcade et al., 1999]: • the existence of a direct relation from a variable to another and vice versa. In such a case, one must favor the most direct or operational relation in DSM filling up. • recording a direct variables relation, when relation is established through another listed variable. • considering a relation between variables, if the correlated evolution is only due to the action of a third variable at the same time on both of them. 35 AC/UNU Millennium Project Futures Research Methodology Figure 3 : the structural analysis matrix and its graphs Figure 4.2: DSM and the spontaneous graph representation. Source: Arcade et al. [1999]. The DSM is built in a way that looking into a row, one sees which variables the respective variable influence, and looking into a column, one see which variables the respective variable depends on. A first analysis of the DSM could be made by forming a graph whose vertices correspond to the variables and whose arrows or edges correspond to the pointed relations in the matrix, as indicated (spontaneous graph) in Figure 4.2 [Arcade et al., 1999]. Despite allowing a more clear representation of relations and influences, by capturing pair-wise dependencies of the problem, static DSM can be turned into higher order interactions (linkage groups). One way is toT.-L. rearrange the DSM order identify group of close related variables, as one can see Yu, D. E. Goldberg, K. in Sastry, C. F.toLima, and M. Pelikan in Figure 4.3, in a process denominated as clustering [Yu et al., 2009]. In this framework, one can use a simple algorithm to create a graph into a hierarchy under the shape of a tree. This algorithm, whose stages are described in frame 1 hereafter, can moreover be realized Figure 2: DSM clustering examples. without necessarily using information processing tools. clustering of variables (b) and an alternative rearrangement with the same objective (c). Source: Yu et al. [2009]. Figure 4.3: Example of a DSM for a set of variables, in its original (a) shape, after a rearrangement to evidence components within a module maximally interact with each other (Fernandez, 1998). As an example, consider the DSM shown in Figure 2(a). One can see from Figure 2(b) that thecould original DSM rearranged by permuting rows and columns contain most DSM analysis also bewas complemented with a graphical view oftovariables relative level of of the interactions within two separate modules: {A, F, E} and {D, B, C, G}. However, interactions(direct are leftclassification), out of any modules. An alterative arrangement is suggested influence andthree dependence for instance as Figure 4.4 [Godet, 2006]. Structural Analysis in Figure 2(c). This arrangement suggests the forming of two overlapping modules: {A, F, E} and {E, D, B, C, G}. It eliminates two left-out interactions by introducing a bigger but sparser module. Generally speaking, a clustering arrangement is considered to be “good” if only few (or none) interactions are left out and clusters are dense. The DSM representation of a system/product architecture has been shown to be useful because of the visual appeal and simplicity. Numerous researchers have used it to propose architectural improvements by manipulating the order of rows and/or columns in the matrix (McCord and Eppinger, 1993; Pimmler and Eppinger, 1994). In an attempt to automate this manual process of DSM inspection and manipulation, Fernandez (1998) used the simulated annealing search technique to find good DSM clustering arrangements. In his approach, each component starts out by being an individual module and evaluates bids from all the other modules. If any module is able to 36 make a bid that is better than the current base case, then the component is moved inside the module. The objective function is therefore a trade-off between the cost of being inside a module and the overall system benefit. Sharman et al. (2002) attempted using Fernandez’s algorithm on an industrial gas turbine. However, they showed that this 12 The variables are plotted on a two-dimensional matrix whose axes are defined as influence and dependence. Therefore, each variable is defined by these two criteria according to its position on the matrix. Figure 4.4: Variables influence versus dependence chart. Source: Godet [2006] Figure 4 – Different types of variables on the matrix with axes influence and dependence. To draw the influence-dependence chart, assume that tij (i, j = 1, 2, . . . , n) are the elements of a The variables are highly influential and independent. DSMinput of variables T . The(1) following levels for variables can be also defined in it [Lee et al.,These 2010]: variables tend to describe the system under study and condition the system’s dynamic. When at all possible, these variables must be considered a priority when considering 1. Influence (I) of a variable as the row sum of values: strategic plans of action. n X At the intermediate variables (2)Iiare and highly dependent. = both tij (i highly = 1, 2, . .influential . , n) (4.1) j=1 Thus, they are, by their nature, unstable. Any action taken on these variables will cascade throughout the rest of the system, profoundly affecting the system’s 2. Dependence (D) of a variable as the column sum of values: dynamic. n X Dj =influential tij (i = 1,but 2, . . .very , n) dependent. Their behavior (4.2) The resultant variables (3) are not i=1 therefore explains the impacts resulting from other variables, principally input and intermediate variables. Influence versus dependence chart, as shown in Figure 4.4, can be framed into five categories of Excluded variables (4) are neither influential norin dependent. Therefore, theyet have variables. Those are based on the included variable’s role the system’s dynamics [Arcade al., little on2010]: the system under study. Often times these variables simply describe 1999;impact Lee et al., inertial or prevailing trends which change little over time. Other times, these variables are simply autonomous, and therefore have little impact on the system. • (1) Input determinant or “influent” variables - They are very influent and little dependent variExcluding these variables therefore will have few consequences for our analysis. ables, in which the system mainly depends. Finally, there are the clustered variables (5) congregate These • (2) Intermediate or relay variables - They are at which the sametend timeto very influent and together. very dependent, variables are not sufficiently influential or dependent to be included among the and a source of instability, by amplify or forestall an influence to their dependent variables. • (3) Resultant or depending variables - They are at the same time little influent and very dependent, being especially sensitive to the system evolution of influent variables. They are usually exit variables of the system. 37 • (4) Excluded or autonomous variables - They are both little influent and dependent, therefore some how appear quite out of the line with system, and might be excluded in further analysis. • (5) Clustered variables - They are not well defined in the previously categories, since they have either an average influence, an average dependence, or both. They are so, variables that usually behave in a similar way with others, and can be therefore clustered. AC/UNU Millennium Project Futures Research Methodology A final analysis of the influence versus dependence chart can be taken from the variables-points configuration, as illustrated in Figure 4.5. Figure 7 : the shape of the system As illustrated in the chart above, the more the cloud of points spreads along the axis (L Figure 4.5: Shape of variables-points configuration as a way to determine the system stability. The more the shape), the more it can be considered as quite determined (stable). This means that the system's cloud of points spreads in a L shape, the more it can be considered as quite determined (stable), left configuraanswer (in terms of evolution) to a given impulse of determining variables can be anticipated with a tion, since system evolution to a given impulse (given in a input variable) can be anticipated with a certain degree certainty.spreads along the first bisecting line, the more intermediate variables of certainty. However, certain whendegree the ofcloud will be important to the system dynamics, introducing, therefore, a level of uncertainty to the anticipation of its On the other hand, the cloud spreads Source: along first bisecting line,ettheal. system can be evolution based in the input variables, rightwhen configuration. Arcade [1999] considered as quite undetermined (unstable). All the more so when the points are located in the north-east frame. The variable points, characterized by their strong influence and dependence, will play an ambiguous role in the system. They are factors of uncertainty to anticipate its evolution according to that of variables considered determining. Structural Analysis Tool for classification of variables dependence and influence - Indirect The system of the African country-environment as studied by the "African Futures/NLTPS" Classification of Variables: While for a simple DSMs one can easily identify groups of highly reis rather unstable. lated variables, as one shows in Figure 4.3, in a DSM with a higher number of variables is much difficult. This analysisStructural canAnalysis be performed by DSM clustering techniques [Jain22et al., 1999; Yu et al., 2009]. To reduce the computation time, one may make use of heuristics as genetic algorithms [Rogers et al., 2006]. Similar information in system variables indirect relationships can be found, which can be an alternative to a clustering methodology, Godet [2006] proposes a method to get more information from the initial DSM as a part of the tool called as MICMAC 1 [Godet and Durance, 2008]. MICMAC uses a matrix calculation of DSM to determine a new level of influence and dependence of variables (indirect classification), exploring influence paths.The result is a rank of key variables, as the one obtained in the direct classification. However, quite often, is shown that initial hypothesis concerning the variables relationships from the direct classification are misleading, lack evidence, or are ranked with an unexpected dependence or influence [Godet and Durance, 2008]. In MICMAC, by multiplication of the DSM with itself, a new matrix is created which entails the first order indirect influences, which for example is an influence of variable A on C via B. Further multiplication of the new matrix with the original DSM delivers the second order indirect influences (e.g. A on D via 1 MICMAC is the French acronym for Matrix of Crossed Impact Multiplications Applied to a Classification. It is available as a software, which can be downloaded in http://en.laprospective.fr/methods-of-prospective/softwares/59-micmac.html . 38 C and B) and so on [Eelman, 2006]. In MICMAC, it is also possible to evaluate the result when considering potentials (P) influences, which are substituted by the higher influence classification, allowing to compare the influence in calculations. The MICMAC software starts with the DSM, named as Matrix of Direct Influences (MDI), from which is calculated a Matrix of Indirect Influences (MII) that allows one to obtain, together with the MDI: the rank of direct variable influence and dependence, the rank of indirect variable influence and dependence and also the graph representation of variable-to-variable influence/dependence level, based either in the direct or in the indirect matrix. Variables Impact versus Uncertainty Analysis: Postma and Liebl [2005] proposes the use of variable or cluster analysis for its “level of impact” (high/low) and on its “level of (un)certainty” (high/low), as one can see in Figure 4.6. However, regarding uncertainty it is important to explore another field, that is the possibility of occurrence, not addressed neither in Postma and Liebl [2005] or Godet [2006]. This can be seen as a third dimension on the analysis, allowing one to discard those that must 164 T.J.B.M. Postma, F. Liebl / Technological Forecasting & Social Change 72 (2005) 161–173 not see significant changes in the future. Those variables, may be uncertain, but are not expected to have a significant variability, or are associated to rare events with little expression in the system. Postma and Liebl [2005] only chooses the two most important and most unpredictable (uncertain) cluster/variables. However, due to the complexity of the problem, the number of selected cluster/variables, the key variables, will only depend in the defined threshold region. A more restrict selection will result in a higher number of considered variables to scenarios construction, and subsequently a more complex process, but will comprise a wider range of possible futures. This tool allows exclusion of the predictable and/or irrelevant variables, reducing the final number of key variables. It is used in Fig. 1. A possible representation of the process of scenario development [1,15]. parallel with StructuralNote Analysis. Final selection is a result of workshop members subjective judgment that this is essentially the approach proposed by P. Schwartz [13]. By playing out these uncertainties as if they had occurred, each scenario depicts another future state. In doing so, the highlight the importance and consequences of these uncertainties. By making plausible scenario plots or stories [13] and by looking for causal structures, each scenario is filled with based in both tools indication. scenarios together Fig. 2. Scenario construction, adapted from Ref. [17]. Figure 4.6: Scenarios and Strategies resulting in multiple test conditions. For each strategy, multiple s multiple simulations conditions resulting of the [Postma and Liebl, 2005] 39 4.3 4.3.1 Phase 2 - Scenarios and Strategies Step Five - Scenarios and Strategies construction Scenarios and strategies construction is based in the set of key variables identified for the Atomedical problem. On one hand, one must attempt to reduce key scenarios questions uncertainty. For example, this can be made using a survey of experts opinions regarding prevailing trends, faultlines or breaks, in order to identify the most probable variables’ behavior. On the other hand, one must help unit managers considering strategic options for modifying the system in the identified problem. The procedure of scenario construction is rather subjective, but the use of a set of tools can help decision maker to better obtain possible future scenarios in which the described system will perform on. Since this methodology is applied to a more operational context, in opposition to major literature, the focus of scenarios will not be the events itself, but the result of those events in operation scenarios. Different events may be gathered in a similar behavioral scenario regarding operations, for instance, the number of patients that reach the unit. Reducing the importance of completely defining of the story behind scenarios, reduces the need for complex analysis of the unit environment. In strategy construction, one uses the key variables not considered to scenario construction, namely those which behavior could be solely changed or influenced by the decision maker. Only important and predicable variables which behavior decision maker can control are relevant to strategic options, since others will be part of the system model parameters, and will not change in different scenarios/strategies. Variables with low system importance/impact have low interest since they not promote significant changes. In spite of the multiple possibilities, is important to look for coherence in strategic options, looking for compatibility with corporate identity and objectives, as well as, to the considered scenarios. This allows the reduction of the final set of strategic options to be evaluated under each scenario. Morphological Analysis and the Blocks Method: For scenarios and strategies building, Godet and Durance [2008] suggests, among other possibilities, the use of morphological analysis, which use was already documented in multiple case studies (see Godet [2006]). Although it was designed to be used in technological forecasting, it fits well in complex setups construction. Characterization of different components could be made with a certain number of possible states, or hypotheses, as a sort of configurations of the key variables representative possibilities, in the form of blocks. As a tool, blocks methods allows one to build a scenario/strategy that would be a path, by bringing together a possible configuration for each component, can be seen in Figure 4.7. Afterwards relevant, coherent and plausible scenarios/strategies are chosen through morphological analysis. 40 cal analysis for the two classic stages: scenario building and strategic planning. The first analysis provided development scenarios related to what would be at stake in the future of corn growing, especially the technological, economic and regulatory environments of this particular sector. Each scenario asked corngrowers strategic questions which could have different possible answers. Once again morphological analysis enabled the participants to organize their thinking as a group on the most relevant and consistent strategic responses. Relevance, Coherence and Plausibility of Scenario-Building through Morphological Analysis ? stands for all other possibilities At least 320 possible scenarios : 4 x 5 x 4 x 4 Figure 7 – The Blocks Method Using Partial Scenarios (a) Scenarios Partial Scenarios The following scenarios (b) are created by dropping down through each level like a pachinko ball, though non-adjacent hypotheses may be selected. (see figure 7 below) Figure 4.7: Scenarios resulting in relevant, coherent and plausible configurations of uncertain key variables possibilities. The use of the blocks methods is identical in strategies. Source: Godet [2006] In very complex systems, or a system with the need of a very fine level of analysis, two types of scenarios are produced [Godet and Durance, 2008]. The first type is partial and built for a subsystem of variables. As before, a set of hypotheses are determined for each variable and potential combinations defined, as one can see in Figure 4.7(b). The partial scenarios/strategies for each subsystem are then grouped in the global system block method, in which the different 71 partial possibilities will be combined in global setups, as illustrated in Figure 4.7(a). This method allows one to reduce the number of considered scenarios and strategies, either in the subsystem analysis, either in the final setups, by allowing unit managers focusing in meaningful possibilities to the problem in study, yet avoiding blind spots in the process. In this phase is important to systematically stimulate imagination and possibilities field scan. For each key variable, possible states or options must be determined, using problem analysis and data trends, decision maker suggestions or literature/experts forecasts. However, one may be swamped by the various combinations. This reinforce the need for a selection criteria, exclusion or preference constraints factors, which one can have to choices regarding coherence and enhancement of the information level [Godet, 2006]. 41 4.4 4.4.1 Phase 3 - Study of Strategies and Scenarios Step Six - Selection of leading indicators and signposts In order to evaluate the performance of the system in the possible scenarios and strategies configurations, one must identify the leading indicators and signpost of the Atomedical system. These will allow one to determine the behavior of each strategy under each scenario in the pursue of the problem objectives. Leading indicators and signposts must be, therefore, relevant to the Atomedical problem, and allow to directly or indirectly gage the defined objectives parameters set in Step One, in Section 4.2.1. 4.4.2 Step Seven - Evaluation of Strategies under Scenarios The proposed final step methodology is to evaluate the strategic options under the different scenarios, for which performance indicators are determined. In this work, due to the type of system under study, the proposed evaluation is made throughout DES of Atomedical unit model. In order to use DES, the system must be represented by a model, focusing in the unit operation and including the key variables under study. The model includes the influences and dependencies between them and allows to follow and measure the defined leading indicators and signposts. The model must allow the definition of a set of parameters in order to represent the scenarios and strategies defined before. For each strategy and scenario, a simulation is made in the defined set of conditions. After the evaluation, one obtains a set of multiple results for the defined indicators and signposts for each condition. At this level, in a robust Scenarios Planning methodology, one is able to analyze the results in order to predict the evolution of the system under different context/scenarios. Scenarios Planning allows at this level a sort of sensitivity analysis, that provides unit managers additional knowledge about their unit, and options impacts, supporting eventual decision. It also allows a better preparation to act accordingly even if scenarios not exactly equal to the ones consider arise in the future. This is important in Atomedical, since in multi variable problems it is difficult to scenarios and strategies totally represent real situations. However, in such cases, it is important not to perform a choice of constructed strategies based directly on the performance results. For instance, in the realization of one scenario, [Godet, 2006] proposes an optional final approach in strategy decision support using a multicriteria methodology, which helps one to define the importance of each performance component in the final decision. The objective of any used method is to correctly weight each component performance in the pursue of decision maker objectives. However, since the proposed methodology does not aim to propose future solution as the studied strategies, this approach was not developed during this work. 42 5 Scenarios Planning Phase 1: Analysis of Atomedical problem Contents 5.1 Step Two: Problem analysis . . . . . . . . . . . . . . . . . . . . . . . . 5.2 Step Three: Variables in Atomedical problem . . . . . . . . . . . . . . 5.3 Step Four: Systematization and classification of identified variables ables of the problem . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . key vari. . . . . . 44 51 54 43 5.1 Step Two: Problem analysis As the first step in Scenarios Planning, one has already identified the Atomedical problem in Section 2.4, which supported the development of the used methodology. The second set was the analysis of the problem. In order to perform it, one followed a set of meetings with the decision makers and unit visits, where the unit operations were characterized and the problem components identified. In the result analysis one is focused in the identification of the operation components of the problem rather in fully describe the unit operation, already addressed in Azevedo [2010]. 5.1.1 Analysis of the Atomedical unit operations Atomedical operations are a system with some complexity. So, in order to present a clear representation, a flow chart of the main unit processes, Figure B.1 in Appendix B, is presented to identify main processes, existing relations, and possible management interventions on it. Some more specific processes, for instance, for the Myocardial Perfusion exam and RF treatments are not directly included. To better understand the flow chart, each process is briefly presented and analyzed, using references to the corresponding flow chart object. This analysis allowed one to find the problem variables that directly result from the unit examination operation. These were not necessarily the same variables to were addressed in scenarios and strategies. 5.1.1.A Exam scheduling Scheduling of patient exam: Exam scheduling is the first contact that the patient (E.1) has with Atomedical. This contact occur in Atomedical Reception (R.1). Waiting time until attendance (W.1) is currently significant short due the number of existing reception staff. Usually the exam is appointed to the next vacancy, starting in the day after the contact, or available days are suggested in the case of patient mean a later date. The exam is scheduled according with the Schedule Plan of the unit, available in the unit informatics management system. Patients have a significant flexibility to the suggest appointment. When the exam needs some home preparation (for instance come in absolute fast), instructions are given to the patient by the receptionist at this point. Typically waiting time until the exam (W.2) in shorter than 5 working days. Some exams procedures require the presence of the patient in different days, one for administer the RF and other for image acquisition (for instance, images with 67 Ga or Metaiodobenzylguanidine (MIBG)), in which two appointments are performed in the same week according the indicated time gap for that specific examination. Some exams, like the Myocardial Perfusion Study (MPS) need the presence of a cardiologist, so appointments are done in the days/periods they are present in the clinic. 44 Scheduling plan: Through previous activity data and anticipation of future situations, unit operations are set to address expected demand, either regarding total number of exams, either regarding each exam type number. Unit managers are able to distribute the exams in the working day, with a defined exam scheduling plan, used to suggest one existing vacancies. Exams scheduling plan (I.1) is weekly set, empirically, by the Clinical Director, for a period of 2/3 months, allowing early appointments for later dates by the patients. Scheduling plan must be able to adjust needed resources to the level of expected demand, considering each exam needed RFs and level of activity. An important constrain is the unit capacity, defined by the existing equipments and their specific functionalities. Scheduling plan focus the unit response in the exam that generates more income, which usually corresponds to the more demanded (currently the MPS is the more significant). Week scheduling plan must have some flexibility to bear exceptions and unusual occurrences (like emergencies exams). If necessary, the unit managers may asks staff to perform extra working hours in order to address a demand peak or unit unexpected delay. This was a frequent procedure in the past, but now it is a rare situation (occurs only in a case of an equipment failure). Some other occurrences can overcome the scheduling plan, like a delay of the RFs delivery, long equipment failure, in which cases the often solution is delaying the exam for a later time (if limitations are not impeditive of exam execution) or reschedule the exam (if limitations would last long or another equipment could not be used, being so, impeditive of exam accomplishment). Scheduling plan time slots are defined in intervals of half an hour, from 9h00 until 17h30/18h00. For each time slots the Clinical Director defines what types of exams and number of patients are going to be attended. This way, patients start their exams in half an hour intervals, since multiple exams can be performed and most of them need previous preparation (for instance RFs administration) after which the patient may need to wait some time inside (W.4). During this time, other other patients can be prepared or examined. There is a time window to the image acquisition after RFs administration, so waiting inside the unit is managed by the staff along with the equipment vacancy (W.5). In order to sequential administration of the RF of a specific exam, several patient for the same type of exam are scheduled to the same time slot. Because the extra time needed for children, specific slots are made available to them. Longer exams are planned for having priority in early morning, and if possible, in early afternoon. Planning the exam schedule imply adjusting the arrival of new patients with the needed procedures for each exams and with equipments and staff response capacity in order to reduce the internal waiting time to the minimal of procedure necessity and increase the total of number of exams performed, decreasing the costly non working periods of staff and equipments. Radioactive compounds constraint: The key point of examination is the radionuclide availability and activity. As seen, radionuclide are perishable, therefore, their properties (namely their activity) decrease with time. So, all unit operation have to address this limitation, scheduling the exams according with the level activity needed. Since each exam needs a certain level of activity, the quantity of product administrated increase over the time, so the fit between schedule and product delivery mainly 45 influence the quantity of product needed for an equal number of exams. Purchasing the radionuclides (I.3), done by the unit Clinical Director, must be an efficient process in order to diminish the unused product (product which lose activity without being used in a patient). The most important nuclide is the 99m T c produced by a generator made of 99 M o, which reach the unit at Saturdays and Wednesdays, so exams that needed more RF activity are performed closer to the generator arrival. Those that need less activity, like children exams and kidney scintigraphy are performed in the last days of the generator timespan. Specific radionuclides, like MIBG, are delivered once a week, as long as ordered until the previous day, so those exams that need them are performed in the arrival day, which is usually at Tuesday. In emergencies radionuclides are ordered to the supplier, who deliver them as soon as possible, which may not be always possible. Currently only 3 production sites in the world are able to produce this radioactive products. Global shortages of 99m T c emerged in 2009 because two aging nuclear reactors (NRU and HFR) that pro- vided about two-thirds of the world’s supply of 99 M o, were shut down repeatedly for extended maintenance periods. This situation originated supply interruption to Atomedical, being in the origin of exam cancellations. That crisis also resulted in an increase of product price. In present the possibility of occurrence of a similar crisis still exists, as the nuclear reactors continue to get older, and no production alternatives had become available meanwhile. 5.1.1.B Patients’ check-in The check-in is performed also in the Reception (R.2). During it, all necessary data are asked to the patient (for instance if it is the first time in Atomedical a patient chart is open), and the payment is done, and arrival information is given to Nuclear Medicine Technicians (NM Technicians). Patients delays are rare, as the majority reach early to the clinic, and staff can easily overcome them in the examination process (for instance start an imaging capture of another patient first or increasing the time inside the internal waiting rooms). The total waiting time in the unit depends on the type of exam performed, as well as the number of ongoing appointments (which may increase possible delays). Generally patients are called shortly after the internal communication of arrival, and are orientated to the specific internal room. In here they will wait for the exam starting or preparation (W.3). In some occasions priority is given to patients that have a current equipment vacancy (for instance by another patient delay). Sometimes patients arrive without an appointment, often channelized from Hospitals or clinics with emergencies circumstances (E.3). Since this is a predicted situation, scheduling plan already allows to accommodate some of this occurrence in the same or next day. In this case, other patients procedures waiting time are adjusted to open vacancies, and causing minimal disturbance. 46 5.1.1.C Patient preparation Preparation of RF: Most RFs depend on the Technetium generator. Others are prepared with different radionuclide. RFs are prepared from the radioactive products previously to the administration (F.6) by NM Technicians (R.3), used to mark the pharmaceutical compounds (often called “Cold Kits”). This process takes place in the radiopharmacies in the beginning of each working day, and the prepared RFs are taken to the examination room or passed on to the RF administration room. Administration of RFs and other pharmaceuticals: The RFs administration (F.5) is performed by the NM Technicians in the RF administration room, if it is needed some waiting time before the image acquisition, or directly in the Gamma Camera. In RF treatments only a RF administration is performed in the RF administration room. MPS can be performed within a strain situation. Although this could be done inducing physical strain, as the patients are mainly elderly, Atomedical makes use of pharmaceutical compounds in order to induce myocardial strain, achieving a more independent result from the patient physical condition. Needed pharmaceuticals are administrated in the MPS room, in the presence of a cardiologist. Myocardial perfusion image acquisitions are performed in the both conditions. 5.1.1.D Image acquisition: Image Acquisition is the main process flow at the unit, which depends on costly equipments (R.5). Since unit expansion, unite managers report as increase in machine idle time, making hence easier avoiding delays and dealing with emergencies. Operational costs and specialized staff (R.6) represent significant cost, so it is important to make the most use of the machinery possible and avoiding nonworking hours. Patients can be taken to any equipment if it satisfy the needs of this exam type. After image acquisition, the process continues with image pre-processing, which is dependent on the computational performance equipment. NM Technician verifies the image quality, falling back to the NM Doctors if needed. If the image is not found to have a good quality, NM Doctors indications are made to repeat the image acquisition, which increase the exam time, reduces the equipment vacancies, and in some rare cases can involve a new RF administration, if patient is already out of the optimal window of activity. Only after NM Doctors image approval the patients can leave the acquisition room, and the image goes to final processing step. 5.1.1.E Exam reports: After image approval, patients can go home (E.4), and a report (E.5) is made by the NM Doctors (R.8). Usually, exam reports are ready within 3 working days (W.6). In the case of an emergency exam, it receives priority on the report process. Exam reports are delivered (F.11) in an independent desk in the reception (R.9). 47 5.1.1.F Environment context of atomedical unit Competitors: Competition in the field of Nuclear Medicine is done mainly by price, availability and quality. Currently, Atomedical is able to offer a good availability of service. Unit managers identify the main source of competition in other institution that by lowering exam quality offer lower prices, sometimes getting below the minimal cost value of the service. Currently, in the geographic region of Atomedical, it does not exist this type of competition, however some private hospitals are potential competitors by being able to support losses in Nuclear Medicine services, in order to attract clients to other profitable services. Regarding the public health system, the agreement price is fixed by public administration, therefore competition is made mainly in quality. However, other agreements exist with corporation and insurance services, the ability to maintain those agreements is dependent on the prices, hence competitions at this level are very important. Atomedical has been able to maintain prices of these agreements in the past years by reducing cost due to higher service efficiency. Clients: Atomedical clients are mainly patients intending to perform diagnostic exams or to monitor a health condition. First time patients come to Atomedical largely by doctor recommendation, based in exam quality. After the first visit, in those patient needing a continuous monitoring, the choice of Atomedical becomes essentially patients decision, based in service quality in previously visits. Clients composition is a mixture of first time patients and frequent patients. The main variables that influence the number of clients are the exam price, service quality and prestige among clients and doctors and finally availability to clients needs. Current decrease of clients in Atomedical is identified with the price variable. This influence is not due to price competition, but reduction of patients forwarded by public hospitals, as seen before. 5.1.2 Identifying influential variables in problem objectives System analysis must also focus in the problem objectives, to identify variables that influence them, since many of them do not reside in the unit operation but in its context. In Chapter 2, the problem is defined, as well as, the objectives that decision makers aim to achieve. Therefore, those objectives should be the focus of the identification of problem variables, in step three of the first phase of Scenarios Planning methodology. In order to finish problem analysis, one had to understand the contributions to the objectives of reducing operating cost and maintain or improve the defined current service quality, which can be done using cause and effect diagrams. The called “Fishbone” was used to the operational cost, Figure 5.1. Since exam quality and patient waiting time are the core contributors of the service quality, a process-type analysis, based in the core flow processes of Figure B.1 in Appendix B, was used for patient waiting time, Figure 5.2 and exam quality, Figure 5.3. 48 Equipment! People! Unit Staff! Equipment Maintenance! Equipment Acquisition! Equipment Repairs! Number! Staff Training! Equipment Calibration! Working Hours! Facility Maintenance! Extra Working Hours! Administrative Staff! 99mTc Radionuclide Generator! Purchasing and Delivery Costs! Other supplies! Material Manipulation! Unused Decayed Product! Individual Doses of other Radionuclide! Purchasing and Delivery Costs! Unused Decayed Product! Pharmaceutical Compounds – “Cold Kits””! Spoiled Material! Patient Preparation! Radiopharmaceutical patient dose! Image Acquisition! Capture of New Images! Delivery Costs! Materials! Operational Costs! Methods! Figure 5.1: “Fishbone" cause-effect diagram for the operational costs. Figure 5.1 presents the main sources of operational costs at Atomedical. These sources are divided into people, equipment, materials and methods. Since Atomedical provides services, people is one of the major contributor to the operational costs. On one hand is important to take into account costs with training staff and unit administrative support staff. On other hand, the cost with unit staff are dependent of their number, the number of hours they work (since some work also in other places) and finally extra working hours, used in the case of service delays as previous stated. No direct cost was associated to the Atomedical unit environment, but revenues are highly dependent of it, namely due to competitions and the established agreements. Equipments are also a major source of cost, namely: equipment acquisition, outside of this problem; the maintenance and repairs, either by the vendor, either by NM Technicians in the daily calibration performed in the beginning of each working day; and finally the common facility maintenance costs. Regarding materials/products, the 99m T c generator, individual doses of other radionuclides and pharmaceutical compounds purchasing and delivery costs represent a significant cost to the unit. The costs can be addressed managing stock, by balancing high quantity price discount versus unused decayed product. Namely in the pharmaceutical compounds, with usually 6 months of life. Finally, the cost in flaw proceedings, either in material manipulation resulting in spoiled material, either in patient preparation, due to higher quantities needed to achieve the desired doses, either in the need to repeat the image acquisition process, will result in the accumulation over time of significant operation costs. A qualitative analysis of Figure 5.1 points the main cost sources of Atomedical operation. Equipment and Methods are considered by unit managers efficiently optimized. Therefore, a unit cost reduction can be possibly tackled through optimizations of the use of RFs products, reducing the unused product and minimizing the deliveries needed, a better usage of the diagnostic equipment, decreasing the non-working time, and human resources, setting the staff in an efficient match to the 49 demand. The profit objective also depends on the type of exam, so giving priority to exam with higher margins of profit should be also a way to achieve the objective. Radiopharmaceuticals Preparation! Reception Workload! Type of Delivery! Equipment Performance! Room Availability! Schedule Availability! Report Priority! Previous Scheduled Exam Delays or retakes! Patient Availability! Exam Procedures! NM Technician Workload! F.1! F.2! F.5! F.7! F.8! Schedule Exam! Check-In! Patient Preparation! Image Acquisition! Image Processing F.11! F.10! Medical! Report! Medical! Report! Delivery! Waiting! Time! NM Technician Workload! Reception Workload! Patient Earliness or Delay! Emergency Patients! Equipment Availability! Equipment Malfunction! New Images Acquisition! NM Doctor Workload! Exam Type and Quality! Image Complexity! Figure 5.2: Process-type cause-effect diagram for the total patient waiting time since the initial contact until the report delivery. Highlighted variables can be address by unit managers. Processes are based in the main flow of Figure B.1 in Appendix B. Figure 5.2 connects each unit flow process to possible contributions to an increase to waiting time. Patient total considered waiting time begins in the exam schedule and ends in the exam report delivery, and is a result of the time spent in the identified processes, as well the time spent in the waiting queues (W.#) pointed in Figure B.1 in Appendix B, which result mainly from patients not being able to move to the next process, due to lack of availability of the needed resources. It is important to take into account the expected waiting time, due to medical procedure in normal situations and the process delays due to unit operation. The resources limitation may be of staff, due the high level of workload, or of equipments, due lack of availability or malfunctions. The type of exam and complexity also determines the duration of the process, and may origin possible delays either in examination procedure, either during medical reporting (patients with emergency situation are given priority in report production). From the analysis of Figure 5.2 one can identify delaying causes that are independent of the unit, therefore from the unit manager intervention, and causes that can be changed as a result of unit manager interventions (highlighted variables). 50 Radiopharmaceuticals Preparation Quality! Exam Pre-Requisites Patient Information! Data Quality! Mismatch Report Delivery! Software Functionalities! Exam Procedures Fulfillment! F.1! F.2! F.5! F.7! F.8! Schedule Exam! Check-In! Patient Preparation! Image Acquisition! Image& Processing& Exam Pre-Requisites Fulfillment! F.11! F.10! Medical! Report! Medical! Report! Delivery! Exam Quality! Radiopharmaceuticals Suited Radioactive Activity ! Image Retake Possibility! NM Technicians Experience and Performance ! NM Doctor Experience! Image Complexity! Previous Image Approval! Equipment Malfunctions! Figure 5.3: Process-Type Cause-Effect Diagram for the Exam Quality. Processes are based in the main flow of Figure B.1 in Appendix B. Figure 5.3 analysis allows one to conclude that exam quality is mainly a result of the fulfillment of exam procedure (however it is not a common situation), as well as from the equipment and staff performance. The management of the needed RF activity, dependent of the optimal exam period is performed changing the administrated quantity. A succession of events in the overall process can cause image quality reduction. Some of them could only be downplayed, like equipment failures, and procedures have to be able to detect errors and correct them. Unit managers pointed that exam quality is related to the ability to perform good diagnosis reports based in good images. This may require extra time in the procedure, for instance, due to the need of getting statistical significance of the acquisition of photons, which increases the time in lower levels of activity, or in the case image acquisition has to be repeated, in order to obtain a better image. Lack of time to staff perform correctly their tasks was also pointed as a significant cause of failures. Since service quality is an objective, forsake experienced staff or reducing equipment maintenance or products quality were not considered as options for this problem. 5.2 Step Three: Variables in Atomedical problem The system analysis performed in previous sections is important either to support the construction of the DES model of Atomedical in Chapter 7, either to support the identification of system variables to be considered, and study, in the following Scenarios Planning methodology. In this third step of the methodology, a set of operational and environment context variables were drawn from the previous problem analysis and presented to decision makers, related to different domains of the problem. They were discussed and reviewed in order to describe the sources of variability and the level of control, regarding Atomedical problem. The variables in the remaining of this section are identified by an index 51 number in the text to ease the reference to Table B.1, on Appendix B, where they are systematized and described. Problem analysis support the identification of the variables related with the problem objective, and was around them that this methodology variables were drawn, following the categories presented in Figures 5.1, 5.2 and 5.3: People, Equipment, Materials and Products, Methods and Procedures, Unit Environment and Unit performance. 5.2.1 People The role of People in Atomedical operations has a great importance, since staff is its major cost, and is closely attached to the unit operations, while patients are the core of the service. Regarding the staff, one identified some variables related with the allocation and scheduling of staff, and their relation with planned capacity and demand: # 1 Number of Administrative Staff, #2 Schedule - Number of unit staff, # 3 Schedule - Unit staff working hours and # 4 Schedule - Extra working hours of unit staff. Staff workload variables are a representation of how capacity fits to demand, so one has to consider the limitations to operations of a demand higher than capacity, and the costs of staff idle time: #5 Reception Staff Workload, #6 Nuclear Medicine Technicians workload and #7 Nuclear Medicine Doctor workload. Staff workload is also a result of how patient arrival is planned (and how it occurs): #8 Patients scheduling and #9 Patients scheduling. Other variables in this domain contribute to changes in the planning and flow of operations, such as: #10 Staff assiduity, #11 Lack of prerequisites fulfillment by patients and #12 Exams not performed due patient. A final variable that contributes to the unit operation work flow is: #13 Nuclear Medicine Technicians experience. 5.2.2 Equipment Another important domain regards unit equipments, since they are essential in all exams, and represent a significant investment and maintenance cost. #14 Equipment malfunction may contribute to errors in the obtaining of images, and examination delays. The capacity of the unit can be reduced because the need of #15 Equipment repairs, that can be prevented with a regular maintenance, therefore a relevant variable is the #16 Frequency of equipment Maintenance. Managers may address a central variable: #17 Number of equipments. The number of equipments available to exams has a contribution to the #19 Equipment workload. Malfunctions of equipment and image quality are dependent of a convenient #18 Equipment calibration, by the unit staff previous to opening. Examination time is also in the dependency of the #20 Image processing equipment performance. 5.2.3 Materials and products Products and materials used are other important domain in Nuclear Medicine. They are expensive, and most have a few number of providers, that introduces relevant concerns about its availability (#21 Technetium generator availability, #25 Other radionuclides availability and #29 “Cold Kits” availability ) 52 and cost (#22 Technetium generator cost, #26 Other radionuclides cost and #30 “Cold Kits" cost). The delivery frequency (#23 Technetium generator delivery frequency, #27 Other radionuclides delivery frequency and #31 “Cold Kits"s delivery frequency ) need to be articulated with the products expected life, and consider the delivery costs (#24 Technetium generator delivery cost, #28 Other radionuclides delivery cost and #32 “Cold Kits" Delivery Cost). The quantity of product bought in each delivery can possible reduce the price of each unit (#33 Quantity of Technetium Generators bought, #34 Quantity of other radionuclides bought and #35 Quantity of “Cold Kits" bought), but increases possible losses of unused product (#36 Unused technetium, #37 Unused radionuclides and #38 Unused “Cold Kits"). 5.2.4 Methods and procedures The unit operations are the result of the used methods and procedures that articulates the available staff, equipments, products and materials to address patient needs and demand. Even using standard protocols, some aspects may be relevant to the final unit performance. Extra procedures costs may arise from: #39 Used product in each exam/treatment or #40 Product spoiled during preparation. In some cases, an image has to be retaken, with additional spending of time, or even product costs, so one should be aware of the number of #41 Image retake. #42 Priority reports also induce a disruption in normal reporting operations. The #43 Exam reporting duration is a relevant variable, since is may lead to report delivery delays or costly idle time, because each patient has a specificity. It is related to the NM Doctor experience and the #44 Report complexity. One variable with a contribution to the core cost of the exam is #45 Exam duration. In standard protocols, one can use different procedures, that lead to reduction or increase of the duration. Exam procedure is dependent of the patient RF bioactivity, since less activity results in a longer exam. However, even with an excepted activity, RF bioactivity inside the patient can fail to follow the expectation due to #46 Biologic reactions or #47 Staff error. Other costs in procedure are related with the staff allocation in product and equipment preparation: #49 Duration of equipment calibration and #50 Duration of radiopharmaceutical compounds preparation. Managers can reduce costs by reducing unit capacity or adjusting the scheduling plan, changing this way the #48 Schedule availability of exams to patients. Due to the operation scale factors regarding the use of products, the #51 Number of examinations performed in the unit can be, for instance, focused in the more lucrative exams and adjust the schedule more profitable setups. 5.2.5 Unit environment Atomedical unit operations can never be separated from its environment context. It mainly influence the demand, number of patients looking for Atomedical service, and the revenue, dependent of the prices that Atomedical can or need to practice for each examination. Regarding environment, one must take into account competition, namely: #52 Number of competitors, #53 Price of competitors 53 service and #54 Quality of competitors service. Based in the positioning of the unit among competitors, one is able to understand #55 Atomedical unit reputation and the effects in the #58 Number of patients per exam and performed prices. Another important environment analysis is related to how people reach Atomedical. Unit reputation is the main source of affluence, supported by the existing agreements, by which the majority of the people come to the unit. Therefore, the #57 Number of agreements and established #59 Price of exams in agreements influence the potential number of patients and revenue. However, some may come independently, which usually represent a higher profit, so the #62 Number of standalone exams needs to be considered. Revenue is also dependent of the major agreement of Atomedical, the National Health System, since it defines the #61 Price of the exams. Demand is highly affected by the #60 Number of asked exams in National Health Care System. It can be reduced due to economic factors, or alternative examinations, for instance the use of non radioactive methods in children, which look Nuclear Medicine namely for renograms. The number of #56 Emergency patients is also an environment variable that may contributes to disruptive situations to planned Atomedical operations and extra costs. 5.2.6 Unit performance Although the multivariability of Atomedical unit performance, managers can set specific level of performances addressing part of the presented variables. #63 Atomedical Service Quality, #64 Exam Quality and #65 Patient Waiting Time in Unit have a direct relation with the internal variables, and also, an indirect relation with the system inputs. Revenues are related with the examinations performed, and one the level of the #66 Atomedical operations costs allows one to fully characterize the unit profit. 5.3 Step Four: Systematization and classification of identified variables - key variables of the problem A system is described not only by its components, but also by the relationships between them. In this work, one is looking to identify a set of variables of interest of being used in the formulation of scenarios and strategies. This set of variables corresponds to key variables, isolated by their impact in the system, level of uncertainty and independence. To fully characterize them, one must establish the relations between different variables, and determine those criteria for each variable. In order to accomplish this, in step four of Scenarios Planning, it was used the tools available in the MICMAC software to classify variables regarding their influence and dependency, as proposed by Godet [2006], together with a complementary impact vs uncertainty analysis tool, as proposed in Postma and Liebl [2005]. 54 5.3.1 Direct classification of variables - Dependency Structure Matrix using MICMAC In MICMAC, the variables are identified by the same index used in previous section. In order to establish the relationships among variables, Atomedical unit managers were asked to fill in a DSM of all the identified variables. For each variable, by looking row by row, they were asked to give a value corresponding to that variable level of influence in the remaining, listed the in the columns. The level values used were: none influence (0), low influence (1), high influence (2). No intermediate level was considered in order to reduce the subjectivity of the classification. This option represents a decrease of the level of detail of further DSM analysis. However, it reduces the subjectivity by compelling the choice of a high or low level of influence, helpful in the resulting matrix size (66x66). Another possible value to the level of influence was a potential one (P), but unit managers did not identify none among relationship variables, so it was not considered. MICMAC received the variables, and the relationships expressed in the DSM. The result was a visualization of those relations, with the direct level of total influence/dependence of each variables in the systems, as stated in the Equations 4.1 and 4.2. A variable has a greater influence as it directly influence more variables, and that level of influence is higher. The opposite happens with a variable with high dependence, as a result of direct dependence of a greater number of variables, with a high level. Figure 5.4 allows one to visualize the results, in which, variables are represented in an influence versus dependence plan. Figure 5.4: Plan of direct influence versus dependence of Atomedical system variables using MICMAC. Level of influence is represented in the y-axis and the level of dependence in the x-axis. 55 Identification of possible key variables in Figure 5.4 regards variables with a high influence, and low dependence. Those are the system inputs, on which system mainly depends. The behavior of variables with a high dependence should be described by the behavior of others. With low influence and low dependence are autonomous variables. One cannot identify or exclude them as key variables with this tool, but they are candidates to be excluded in further analysis if not shown to be important to the system. Finally, variables with low influence and high dependence are usually the outputs of the system, and good candidates to be considered signposts. Figure 5.5 provided a more clear view of the direct relations between the individual variables using a graph of the direct DSM. Figure 5.5: Graph of direct influence of some Atomedical system variables using MICMAC. Not all variables and influences are shown, since a level of zoom of 25% was applied, in order to provide a neat representation to decision makers, given the high number of variables in question. Red line represent high levels of influence (classified with 2), while dot lines represent low level of influence (classified with 1). Due to the used threshold, only the most significant variables are represented in Figure 5.5. It is possible to, qualitatively, identify some variables that are the focus of others influence: #51 Number of examinations performed in the unit, #58 Number of patients per exam, #64 Exam Quality, #60 Number of asked exams in National Health Care System, #63 Atomedical Service Quality and #66 Atomedical operations costs. It is also possible to identify variables source of influence: #14 Equipment malfunction, #15 Equipment repairs and #49 Duration of equipment calibration. This provides a better understanding of the pointed relations in DSM, so, if necessary, correct the values in order to better characterize the system. In this case, results were validated by decision makers. 56 5.3.2 Indirect classification of variables - Dependency Structure Matrix using MICMAC Direct level of influence/dependence do not allow one to see more than one level of relationships. Therefore, the previous analysis failed in the identification of several variables that intuitively have great influence or dependence in the system. MICMAC allows to explore results of indirect level of influence/dependence. They provide a deeper analysis of the system variable relationships, which can be complemented by a comparison with the direct results. To obtain indirect levels of influence/dependence among variables, MICMAC software uses a matrix calculation of DSM. The number of iterations used depend on the size of the DSM matrix, in order to allow one to explore all the possible levels of influence. The suggested number by MICMAC to the provided DSM was 7 iterations, but after 3 all the path were already explored, as a result of shallow relationships. To understand the differences between direct and indirect variables classifications, Figure 5.6 provides one the influence rank in the direct and indirect classification of variables. One can see how some variables become more influential when considering all their influence path in an indirect classification. Figure 5.6: Compared classification of variables influence in direct (left) and indirect (right) classification using MICMAC. Variables that become less influential have a red line to their new classifications, while a green line indicates new classification of variables that become more influential in the indirect analysis. In indirect classification, similar representations were drawn to those in direct consideration. Figure 5.7 shows variables positions in the influence versus dependence plan in indirect classification. Notice that DSM calculations amplifies the differences of influence/dependence levels between variables. MICMAC results allows one to identify the system inputs, having a high level of influence, and a low dependency, and system outputs, having a low level of influence and a high dependency. The results 57 were analyzed with decision managers, and was observed that many influential/dependent variables were beneath the average lines of classification (similar in the direct classification results). Some variables present higher values, due to deeply description of some system parts, given the existing subjectivity of the in variables identification. Therefore, it was decided to also classify variables as influential or dependent after a reasonable lower threshold. Classification was in the end reviewed by unit managers, that provide the final sets of key variables. The thresholds where empirically defined after finding a level where variables start becoming really less influential/dependent. Those identified as having a high level of influence in the system were marked in red, and those having a high level of dependence were marked in blue, in the Figures 5.7 and 5.8. Some variables show mixed behaviors, while both the levels of influence/dependence show to be significant to the system. The performed identification is systematized in Table B.1 in Appendix B, where variables are either classified as influential, dependent, and neutral, if no relevant behavior. Figure 5.7: Plan of indirect influence versus dependence of Atomedical problem variables using MICMAC. Manually, variables marked in red were identified as system inputs, with a predominant level of influence, while those marked in blue are system outputs, with a predominant level of dependence. For this purpose, a threshold on the level of influence/dependence was considered. In a similar way to the analysis of the direct classification results in MICMAC, a graph of some of the indirect relations between variables was provided to support the analysis, as shown in Figure 5.8. It provides one individual paths, instead of a global classification of the indirect influential/dependence level. This helped the analysis of results in Figure 5.7, showing that indeed, those variables beneath the average line had a predominant influence in the other variables, for instance, in the case of #17 Number of equipments, #60 Number of asked exams in National Health Care System or #53 Price of competitors service. 58 Figure 5.8: Graph of indirect influence of some Atomedical problem variables using MICMAC. Not all variables and influences are shown, since a level of zoom of 25% was applied, in order to provide a neat representation to decision makers, given the high number of variables in question. Variables marked in red were identified as system inputs, with a predominant level of influence, while those marked in blue are system outputs, with a predominant level of dependence. Numbers on the side of lines represent non normalized level of influence between those variables, taking into account the full path of influence to other variables. With the use of MICMAC tool, decision managers were able to evaluate the level of independence of the identified variables, and understand clearly how the systems variables influence each others. Many times, due to system complexity, and to the high number of variables, it is not notorious without the help of tools like MICMAC software. The results of indirect analysis were used to identify key variables at the expenses of the direct ones. At this level, one still lacks in the variables characterization of impact in the system and level of uncertainty in order to fully identify the key problem variables. 5.3.3 Impact versus Uncertainty Analysis To perform an impact and uncertainty analysis, as proposed by Postma and Liebl [2005], one needs to evaluate the level of system impact/importance of each variable and also the level of knowledge/control by the unit managers. In order to accomplish this, unit managers were asked to classify each variable according to the level of importance/impact in the system, and to the level of knowledge/control they had. 59 Prof. Dr. Fernando Godinho work is more focused on the management level of the unit, and Dr.ª Guilhermina Cantinho work is more focused on the unit operational level. Therefore, both were asked to separately classify the set of variables, allowing one to compare their different perceptions of the unit operations. The results of each classification are shown in Figures 5.9 and 5.10. In Figure 5.10, the different variables classifications, regarding the ones presented in Figure 5.9, were highlighted in green, and arranged in the lower half of each classification box. Results were represented in a discrete plan of impact/importance versus certainty/control, with several variables having similar classifications. Level of Impact/Importance (1- Low, 5- High)! 5! 2! 17! 18! 37! 39! 54! 55! 63! 33! 45! 49! 20! 60! 66! 29! 47! 14! 23! 51! 53! 6! 22! 61! 65! 38! 40! 21! 42! 43! 58! 11! 25! 52! 64! 3! 4! 8! 62! 1! 30! 36! 50! 57! 10! 12! 15! 56! 59! 13! 34! 35! 19! 31! 41! 7! 16! 32! 48! 5! 9! 26! 27! 24! 4! #! 1 – Not Excepted/ Rare! #! 5 – Highly Possible/Frequent! #! NA – Not Applicable! 44! 3! 28! Level of Possibility/ Frequency! 46! 2! 1! 1! 2! Level of Certainty/Control 3! 4! 5! (1-Known or Controllable 5-Unknown or Uncontrollable)! Figure 5.9: Plan of level of impact/importance versus level of certainty/control of Atomedical problem variables in a management vision of the unit. Also the level of possibility/frequency of uncontrollable variables are illustrated using a gray scale. Some changes in a variable may have great importance, but represent rare events, thus, influencing little large periods of unit operations. So, for those variables that are not controllable by the managers, unit managers were asked to classify them regarding the level of possibility/frequency of significant variable changes, either if it is uncertain or known. For instance, a patient not being able to perform an exam due to the lack of pre-requesites fulfillment is an uncertainty and can have a great impact in operations, however, being a rare event with low chance of change in the future, the 60 variable#11 Lack of prerequisites fulfillment by patients does not represent an interesting problem key variable, since it is not significantly relevant to Atomedical unit operations. The used classification was from Not Excepted/Rare (1) to Highly Possible/Frequent (5), in a similar scale to other evaluated criteria. An indication of Not Applicable (NA) was used in the controllable variables. Each classification result was also included in the Figures 5.9 and 5.10 using an increasing gray scale of background in each variable representation. Level of Impact/Importance (1- Low, 5- High)! 5! 47! 66! 2! 17! 18! 39! 63! 64! 20! 62! 61! 50! 23! 33! 34! 35! 14! 38! 21! 42! 60! 45! 55! 10! 36! 51! 3! 59! 37! 43! 44! 65! 22! 29! 30! 53! Level of Possibility/ Frequency! 6! 4! 11! 16! 19! 41! 8! 12! 58! 7! 54! 57! 1! 48! 56! 4! 15! 5! 9! 27! 40! 26! 31! 52! #! 1 – Not Excepted/ Rare! #! 5 – Highly Possible/Frequent! #! NA – Not Applicable! 3! 49! 24! 28! 25! 32! 46! 2! 13! 1! 1! 2! 3! 4! 5! Level of Certainty/Control (1-Known or Controllable 5-Unknown or Uncontrollable)! Figure 5.10: Plan of level of impact/importance versus level of certainty/control of Atomedical problem variables in a operational vision of the unit. Also the level of possibility/frequency of uncontrollable variables are illustrated using a gray scale. Most differences are mainly insignificant, representing mostly a shift in the perception of scale. Although, some of the variables’ classification do not agree at all, such as, #11 Lack of prerequisites fulfillment by patients or #61 Price of the exams. One can use this mismatch to validate the classification, since, some times it represents miss identifications of importance or frequency by one of the persons. 61 5.3.4 Key Variables Variables identification was complemented with system analysis, as systematized with the tools used. Those results were assembled in Table B.1 in Appendix B. Unit managers were asked to provide a final classification and identification of the key variables. They can be either associated to scenarios, if representing a system uncertainty, or be either associated to strategies, if representing a controllable system variable. Unit managers were also asked to classify variables of interest of being considered signpost. While influence and dependence classification was based solely in one contribution, impact/importance, control/certainty and possibility/frequency classifications had two distinct visions contributions, which provided higher information to the problem. System and problem analysis, besides assist unit managers’ classification of variables, provide a deeper insight of the problem, preparing them to the next phases. Methodology tools and their results aimed only to assist this classification. Unit managers had the final word when choosing what were the key variables and those that should stop being considered at this point. Therefore, some final classifications may not fully follow previous descriptions, since it was defined that complementary results information do not suit the real importance of the variable to further problem analysis. During the classification process, some of the chosen strategic variables presented also a high dependence. That was despite the possibility of control by unit managers, they may act in response to other variables changes, like staff scheduling may respond to changes in the number of incoming patients. This is a difficult distinction to make directly in the MICMAC tools results, since identified strategic variables in such cases show also to highly dependent, such as #2 Schedule - Number of unit staff or #8 Patients scheduling. In signpost identifications, some are characterized as being controllable, but are the result of the control of other variables. This misidentification was considered to be correct in classifying some signposts, such in the case of staff workload: # 4 Schedule - Extra working hours of unit staff, #5 Reception Staff Workload and #6 Nuclear Medicine Technicians workload. The result of this classification is expressed in Table B.1 in Appendix B. 62 6 Scenarios Planning Phase 2: Atomedical Scenarios and Strategies Contents 6.1 6.2 6.3 6.4 Step Five: Scenarios constructions for the Atomedical problem Step Five: Strategies in the Atomedical problem . . . . . . . . . Step Six: Signposts for the Atomedical problem . . . . . . . . . Scenarios and strategies in the Atomedical problem . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64 68 71 72 63 6.1 Step Five: Scenarios constructions for the Atomedical problem Construction of Scenarios for the Atomedical problem is based in the scenarios key variables identified in Chapter 5. Methodology framework suggests the use of morphological analysis such as block method to the multiple options. This methodology aims to reduce to a group of meaningful, coherent and broad enough final scenarios. These tools were used to help unit managers to analyze variables and establish the scenarios to be studied. Blocks method suggest gathering variables within subsystems. Those subsystems can be drawn from the system components of Atomedical operations, represented in the process flow chart of Figure B.1 in Appendix B. It identifies main system components that may be used to group the variables, based in component that they influence or are associated. Scenarios are connected to those components where management cannot intervene, and some level of uncertainties may arise, namely inputs and processes or tasks. Therefore, given previous key variables, one can separate them into systems components as suggested in Table 6.1. Table 6.1: Scenarios key variables separation into Atomedical unit subsystems. Subsystems are driven of systems flow chart of Figure B.1 in Appendix B, representing system inputs or tasks where key variables uncertainties is expressed. E.1 - Patient Looking for Exam # 52 Number of Competitors # 55 Atomedical Unit Reputation # 57 Number of Agreements # 58 Number of Patients per Exam # 60 Number of asked exams in National Health Care System E.3 - Emergency Patient # 56 Emergency Patients F.5 - Patient Preparation # 21 Technetium Generator Availability # 25 Other Radionuclides Availability # 29 “Cold Kits" Availability F.7 - Image Acquisition # 15 Equipment Repairs F.9 - Need new image? # 14 Equipment Malfunction F.10 - Medical Reporting # 42 Priority Reports # 43 Exam Reporting Duration # 44 Report Complexity Others variables remain since they are not directly associated with the unit processes. They influence at a financial level, being connected to the costs and revenues of the performed exams. Because the scenario construction is aimed to be used in a simulation model, regarding unit operations, the influence of these variables may be inferred outside model simulation, in a post analysis of the resulting data of exams performed, and resources used. Those variables can be separated by Operational Costs (# 22 Technetium Generator Cost, # 26 Other Radionuclides Cost and # 30 “Cold Kits" Cost) and Unit Revenues (# 53 Price of Competitors Service, # 61 Price of exams of National Health Care System and # 62 Number of standalone exams). Scenarios Planning is not a forecasting tools, therefore, scenarios do not represent all possible unit future conditions, neither all possible evolutions. The objective is to identify scenarios that could represent future challenges to unit managers. Thus, helping their preparation by identifying impacts 64 in the system, and suggesting overcoming strategies. Evaluating those strategies in the different scenarios brings more knowledge to prepare unit manager to the future. In this work, scenarios are focused in operations. So, rather than explore the possible events, this exploration of scenarios focus in the events impacts on the considered scenario variables and the attached result in unit operations. Therefore, instead of drawing a storyline for scenario variables as a final result, the variables uncertainties are analyzed so that scenarios considerations focus in the effects in operations, even if they are a common result to distinct events. Following the morphological analysis with unit managers, one analyzed each group of variables, to suggest possible futures of interest. The resulting variations in the inputs of the unit subsystem are then drawn as partial scenarios. Further analysis allows to exclude scenarios that do not represent relevant changes for the study problem. 6.1.1 Subsystems Scenarios analysis E.1 - Patient Looking for Exam: It is important to analyze how the system inputs are influenced by different scenarios regarding the number of patients coming to Atomedical. In competition, one has #52 Number of Competitors and #55 Atomedical Unit Reputation. While an increase in the number of competitors might decrease the incoming patients, the unit reputation (service quality and price) is important in the reduction of it. Although it is not excepted new competitors, big players, as big private health care companies, may in the future increase their capacity and offer. Regarding #57 Number of Agreements, the total and size of agreements with health systems influence the number of potential clients. National Health System is the source of the majority of the patients. However, due to recent constraints in the situation of national economy, unit managers noticed a decrease of the number of exams required by doctors, as they are asked to undertake more saving concerns in their practice. This results in a reduction of the #60 Number of asked exams in National Health Care System. #58 Number of Patients per Exam represents a variation in the number of patients per exam. On one hand, this reduction is constant for all exams, due to the general environment of Atomedical. On the other hand, patient per exam distribution may also change, through a variation in specific exams. Since Nuclear Medicine exams expose patients to radiation, children exams are being substituted by other technologies, as they face more risk in exposure to radioactivity. In sum, it exists the possibility of a change of the number and distribution of patients per exam, to be considered in the construction of partial scenarios by unit managers. The operation of 2009, already in current machinery setup, is a representation of full capacity operation. This represents a optimal scenario of a future comeback from current patient decrease. In the opposite, the environment can represent a stabilization of the number of patients, or a continuous decrease to drastic values if the environment context further deteriorates. As a major system input, a study of step evolution allows to perform a sensitive analysis on this variable [Chetouane et al., 2012]. The distribution of number of exams is not significant in operations, despite the reduction in children renograms. However, bone studies had seen a greater reduction than the other exams with no 65 visible explanation, starting from August 2011. e is an interest to understand the impact of further reductions. E.3 - Emergency Patient: # 56 Emergency patients in Atomedical are patients for whom a exam was asked in short notice. Atomedical schedule those exams even if the normal scheduling is full. The number of emergency patients is unpredictable, but, by the unit experience, it is correlated with the total number of patients. However, despite the impact in operations, they are flexible and have a low frequency of occurrence resulting in low perturbations. Therefore, no scenario was considered here. F.5 - Patient Preparation: # 21 Technetium Generator Availability, # 25 Other Radionuclides Availability and # 29 “Cold Kits" Availability may affect patient preparation. Nuclear Medicine units are dependant on a short number of suppliers, and in the past the availability of technetium generator suffered already from shortage. For possible disruption of product supply, if it does not comprise the operation, the only consequence may be an increase of the product costs. In an extreme scenario, the unit will not be able to perform exams. However, the consequences are easily predicted and there is no interest to study in this approach a drastic scenario of unit stoppage. The impact of an increase of product cost may be considered in a system financial analysis. F.7 - Image Acquisition: The Gamma Camera have a central role in unit operations. For in- stance, lowering the level of maintenance may result in an increase need of # 15 Equipment repairs, reducing unit capacity. Due to the existence of three full Gamma Cameras, a repair is easily managed. However, in the reduction of the equipments, the impact of stoppages becomes needs to be evaluated. One may also study the impact of an increase in the number of repairs needed, currently negligible. F.9 - Need new image?: Image quality is guaranteed, since acquisition is made until significance in the result. However, lack of equipment maintenance can result in # 14 Equipment malfunction, and in poor image which results in new images being taken. This is usually made while the patient is still inside the examination room, so one can consider an increase of the duration of each procedure. F.10 - Medical Reporting: # 43 Exam reporting duration influence the time for patients to receive the medical report. This variable depends on the experience of the NM Doctors and on the # 44 Report complexity, since each exam has its own specificities. The # 42 Priority reports, that are produced first than previous exams, may also delay other reports. However, the impact of an increase in the report production average time can be directly obtained. Evaluation results can be used to determine if NM Doctors are enough in different procurements, and to study the impact in reporting 66 time variations. Therefore, it does not represent an interesting scenario, since can be inferred from other data. 6.1.2 Scenarios Previous analysis of subsystem scenarios allowed unit managers to engage in the construction of scenarios for the Atomedical unit. Proposed methodology aims to provide a sort of sensitivity analysis under uncertainty context, when the system is too far complex, due to the number and range of variables. Therefore, the previous analysis provided a structured thinking to meaningful scenario construction, so, there is no need to study all possible scenarios. Therefore, the resulting interesting system variables for study under the scenarios variables were: E.1 - Patient Looking for Exam Number and per exam distribution of incoming patients F.7 - Image Acquisition Probability of equipment stoppage for repair F.9 - Need new image? Probability of need for image retakes resulting in an increased exam time The proposed methodology does not aim to study the effects of extreme scenarios for Atomedical, since their results in operations do not result in major uncertainty. For instance, if all equipments stopped working, the unit would be unable to perform exams, or if the incoming patients came below a drastic number, it was clear unit inviability. Therefore, and instead of the extreme variable conditions consideration used in most Scenarios Planning literature, this work focused in the intermediate scenario conditions as they have higher interest in studying unit operations. Since one is focused in an operational problem, from the implementation of Scenarios Planning methodology, it arises the common influence of most contexts in few system variables. So, as an identified major system input, one suggested considering the number of incoming patients as an anchor variable scenario building and study. Therefore, for each partial scenario in F.7 - Image Acquisition and F.9 - Need new image?, full scenarios will result from the combination with drawn scenarios for E.1 - Patient Looking for Exam. One may consider the following partial scenarios for patients procurement: • 2011 Number of Exams and Distribution (Current Scenario) • 2009 Number of Exams and Distribution (Optimist Scenario) • 75% of the Number of Bone Studies Exams from the 2011 Number of Exams • 75% of the 2011 Number of Exams and 2011 Distribution • 50% of the 2011 Number of Exams and 2011 Distribution (Pessimist Scenario) Regarding more operational variables, in F.7 - Image Acquisition, one considered the partial scenario where Gamma Cameras have a malfunction probability resulting in an increase of the stoppage time by year, from a neglected value to 2%. For the F.9 - Need new image?, in a pessimist scenario, one might consider an increase on 10% in the average time of images acquisition comparing the current examination times. These scenarios are only relevant when the unit is close to its capacity, where those stoppages and delays could affect significantly the operations. Therefore, the scenario drawn 67 from these variables were only combined with the current and 2009 patient procurement scenarios. As a final result of scenario construction, one ends with 9 final scenarios combinations: 2009 2009 Exams Data (Optimist Scenario) 2011 2011 Exams Data (Current Scenario) 2011-75 75% of the 2011 Exams Data 2011-75B 75% of 2011 Bone Studies 2011-50 50% of the 2011 Exams Data (Pessimist Scenario) 2011-Chamber 2011 Exams Data and Gamma Camera malfunction probability of 2% 2009-Chamber 2009 Exams Data and Gamma Camera malfunction probability of 2% 2011-Time 2011 Exams Data and 10% increase on the average time of images acquisition 2009-Time 2009 Exams Data and 10% increase on the average time of images acquisition 6.2 Step Five: Strategies in the Atomedical problem Scenarios Planning at an operational level are useful for decision makers to construct and evaluate possible interventions strategies in the system under the considered scenarios. This step does not intends to provide a definitive strategy setup, but to give Atomedical unit managers a view of how their actions can influence the system, and its impact in different scenarios, as an approach of sensitivity analysis. For this purpose, one must take into account the strategic key variables. Again, the use of morphological analysis, and a blocks method framework, allows one to reduce the number of final strategies in a structured and meaningful way. As before, process flow chart, of Figure B.1 in Appendix B, was used to put key variables in operational context groups. Strategies are connected to those components which unit managers can directly influence, or where their decisions can indirectly change the range of uncertainty of the system. Some strategies may be target similar system components as scenarios, so, they should be taken into account, avoiding redundant considerations for system setups. One can gather previous key variables as suggested in Table 6.2. Table 6.2: Strategies key variables separation into Atomedical unit subsystems. Subsystems are driven from the systems flow chart of Figure B.1 in Appendix B, from system inputs or tasks connected to key variables uncertainties. I.1 - Scheduling Plan # 8 Patients scheduling # 45 Exam duration I.2 - Staff Management # 2 Schedule - number of unit staff # 3 Schedule - unit staff working hours I.3 - Radioactive Material Purchasing # 23 Technetium generator delivery frequency # 27 Other radionuclides delivery frequency I.4 - Equipment/Facilities Investment # 16 Frequency of equipment maintenance # 17 Number of equipments # 18 Equipment calibration # 20 Image processing equipment performance # 39 Used product in each exam/treatment E.1 - Patients Looking for Exam # 54 Quality of competitors service # 63 Atomedical service quality # 64 Atomedical exam quality As considered in scenarios construction, financial strategies may be evaluated outside model 68 simulation, namely, with variables that influence unit revenues, but can be drawn based in the total number of exams, for instance, the # 59 Price of exams in agreement. 6.2.1 Subsystems Strategies analysis I.1 - Scheduling Plan, I.2 - Staff Management and I.3 - Radioactive Material Purchasing: The schedule, staff managements and product purchasing were gathered since they are always managed together. They are optimized through combinations performed by the unit managers given all system constraints and mainly based in their experience. Since the construction of alternative optimization methods for this purpose are not part of this work, one is limited to consider those that were used before in the unit, or were newly defined by the unit managers.# 8 Patients scheduling plan of exam appointments is the main unit managers strategic intervention, allocating equipment and staff in articulation with the excepted # 45 Exam duration. Exam duration depends in staff experience, equipment, and exam procedures. # 2 Schedule - number of unit staff contribute to the design capacity of the unit, however it is established a minimum number of workers to perform each tasks. # 3 Schedule - unit staff working hours relates with the unit working period, to settle shifts, in order to cover the full working period of the unit. The # 23 Technetium generator and # 27 Other radionuclides delivery frequency influence and result of the schedule. The Technetium generator is delivered only two times a week, and exam schedule is optimized to best fit to the activity decrease of the products. Other radionuclides are only delivered when exams are asked. Atomedical unit examination schedule changed to better adapt to the changes in the incoming patients. Therefore, it is difficult to consider the previous unit schedules outside their context, since their performance is connected to the match that exists with the distribution of patients per exam. As a strategy to overcome a reduction in the number of clients, unit managers considered as new schedule strategy decreasing the unit working period from the actual 8h00/21h00 to 8h30/18h00. This allows the decrease in 2 NM Technicians and 1 Reception Worker in a new shift organization, reducing staff idle time. This was based in initial schedule used in calibration (2011), so, more Scenarios should be considered for this strategy regarding a reduction a reduction to 75% and 50% of the 2011 Number of Exams and Distribution should be considered for this strategy. I.4 - Equipment/Facilities Investment: In a Nuclear Medicine unit, equipments are a key part of the procedures and unit performance. # 16 Frequency of equipment maintenance may influence the possibility of the need of repairs, which may reduce temporarily the number of available equipments. However, this influence is already expressed in scenarios, so lowering costs to reduce the level of maintenance becomes redundant in this analysis. Acquisition equipment are the main unit capacity driver. Equipments are relatively new, but represent significant costs in annual maintenance (comparable to the cost of three staff persons). Equipment stoppage is already a reality in competitors units to save in maintenance costs. However, it is 69 considered an extreme option, due the severe degradation of the equipments out of maintenance. Although, given being a drastic strategy, it is important to evaluate the effects current unit performance and optimist scenarios where unit capacity becomes again a major issue. Another possibility to unit managers is to make equipment improvements, for instance, upgrading existent equipment, in order to reduce the time of image acquisition and processing, that can be significant if combined with a higher administrated activity. In cardiac studies, the majority of exams performed, these improvements could represent a reduction of 20% in the total time of the acquisition time. However, one has to consider the costs in the upgrade, and that the use of higher activities are more prejudicial exam to patients. E.1 - Patients Looking for Exam: Unit managers can choose to compete with the # 54 Quality of competitors service by providing a better service, or following the strategy of lowering price, possible if costs are reduced. However, this is only possible by reducing # 64 Atomedical exam quality and # 63 Atomedical service quality. Less quality may reduce the number of patients, but lower prices might compensate, or even increase the final number is some contexts. Service and exam quality was set as an objective to retain or improve, since current unit quality assure a very good reputation among competitors. Therefore, only price variations can be considered to attract more patients. The procurement variation is already addressed in scenarios, and the impact of exam price variations might be explored in a financial evaluation of simulations results. 6.2.2 Strategies Each considered subsystem strategies have to be now combined in global unit strategies. Strategies complement scenarios in future analysis of system situation. Therefore, it is important to spread possibilities, avoiding redundant consideration, since one already draw the scenarios to be studied. Strategies are aimed to overcome such scenarios, through unit managers’ intervention, that have to be coherent, feasible and respect the established values and objectives. Again, this methodology aims to explore the effects of meaningful strategies on the system, not all strategies possibilities and combinations. From the strategies analysis, and the drawn scenarios, result interesting system variables to be study under the strategic variables: I.1 - Scheduling Plan, I.2 - Staff Management and I.3 - Radioactive Material Purchasing: Articulated weekly exam schedule with number of staff in each period (Reception and NM Technicians) and available radioactive products (technetium and other radionuclides) I.4 - Equipment/Facilities Investment: Number of equipments and time duration of exam acquisitions Under the guidance of block method framework in variables analysis, it was chosen a set of strategies that will be evaluated together with the drawn scenarios. Morphological analysis aims to provide 70 in the Scenarios Planning Framework an increase of final information together with a reduction of the complexity. A set of combination of scenarios and strategies have to make sense in providing unit managers more understanding about Atomedical, preparing them to the future. In order to simplify the strategies focused in the examination part of the system, they are only evaluated against an optimist, current and pessimist scenario of procurement. The set of strategies and scenario to be considered together are presented below: Strategy 0 Current Strategy (as defined in model calibration for 2011) Scenarios for evaluation: 2009 2009 Exams Data (Optimist Scenario) 2011 2011 Exams Data (Current Scenario) 2011-75 75% of the 2011 Exams Data 2011-75B 75% of 2011 Bone Studies 2011-50 50% of the 2011 Exams Data (Pessimist Scenario) 2011-Chamber 2011 Exams Data and Gamma Camera malfunction probability of 2% 2009-Chamber 2009 Exams Data and Gamma Camera malfunction probability of 2% 2011-Time 2011 Exams Data and 10% increase on the average time of images acquisition 2009-Time 2009 Exams Data and 10% increase on the average time of images acquisition Strategy 1 Reduction on the working period of the unit from 8h30 until 18h00 Scenarios for evaluation: 2011 2011 Exams Data (Current Scenario) 2011-75 75% of the 2011 Exams Data 2011-50 50% of the 2011 Exams Data (Pessimist Scenario) Strategy 2 Decrease the number of Gamma Camera to 3 Scenarios for evaluation: 2009 2009 Exams Data (Optimist Scenario) 2011 2011 Exams Data (Current Scenario) 2011-50 50% of the 2011 Exams Data (Pessimist Scenario) Strategy 3 20 % reduction on the image acquisition duration in Cardiac Studies Scenarios for evaluation: 2009 2009 Exams Data (Optimist Scenario) 2011 2011 Exams Data (Current Scenario) 2011-50 50% of the 2011 Exams Data (Pessimist Scenario) 6.3 Step Six: Signposts for the Atomedical problem Signposts are a preparation to the next phase of Scenarios Planning. They are important to evaluate system performance in the constructed scenarios and strategies. Since they result of the problem analysis, they were included in the phase 2 of this work. Signposts need to be coherent with the problem objectives, allowing to evaluate the influence in operations of the different studied setups, in 71 order to prepare unit managers to better react to future and present problems. In the analysis of the problem and the system, some variables were identified as signpost. They were mostly variables with identified impact/importance to unit managers, usually with a significant dependence and not directly controllable. Others make sense due to the lack of prior behavior knowledge. Being scenarios planning an iterative method, other signpost might have arisen directly from the strategies and scenarios constructed. Although, no more signpost were considered. Signpost are of extreme importance in the simulation model design and its implementation, since simulation results must provide information about them. One can divide the previously identified signpost variables in the following categories: Resources Workload # 4 Schedule - Extra working hours of unit staff, # 5 Reception staff workload, # 6 NM Technicians workload, # 7 NM Doctors workload and # 19 Equipment workload Used Products # 33 Quantity of Technetium generator bought, # 35 Quantity of “Cold Kits” bought, # 36 Unused Technetium, # 38 Unused “Cold Kits” Patients # 48 Schedule availability, # 65 Patient waiting time in unit Operational Performance # 41 Image retake, # 51 Number of examinations # 66 Atomedical operations costs Some of those signposts result directly from the systems inputs, while others are embedded in scenarios and strategies assumptions, as # 41 Image retake. It is important to notice that Atomedical operations costs are the result of the design capacity, from which arises the resources’ workload, and the used products. Revenues, are related to the number of examinations and their distribution, which may be used afterwards to study the financial performance of the unit regarding different prices of exams. Although, the study of the financial performance of the unit is not part of the scope of this work. 6.4 Scenarios and strategies in the Atomedical problem Scenarios Planning methodology was used to analyze the Atomedical problem and construct scenarios and strategies to address it. They result from the identified key variables of the problem, therefore, aimed to provide more information to the unit managers regarding their problem. The methodology used allowed to perform this task in a systematic way, aiming a final coherence and deeper tools to explore the uncertainty of the problem. The resulting scenarios explore the results of changes in the Atomedical context, as well as, explore significant internal changes that can escape the unit managers control. Therefore, focusing in the unit operations, it was possible to fully integrate with the DES model. In reviewed literature, similar studies used a lighter methodology approach to simply draw simulation scenarios and strategies. However, as novelty, one was able to fully use Scenarios Planning to wide the unit managers views of their operations and challenges, while focusing in an operational type of problem. 72 7 Scenarios Planning Phase 3: Evaluation of Strategies and Scenarios - Discrete Event Simulation Model Contents 7.1 7.2 7.3 7.4 Atomedical Simulation Model . . . . . . . . . . . . . . . . . . Atomedical DES Model Calibration and Validation . . . . . . Implementation of Scenarios and Strategies into the Model Simulation results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74 78 80 81 73 The use of a DES model provides one a tool to address the uncertainty related with the unit processes by considering in the model a statistical variation of its events. This complements environment uncertainty, in the Atomedical problem in study, addressed in the construction of scenarios and strategies. Scenarios and strategies were combined with DES using the model inputs and parameters, which allowed the definition of different simulation setups instances. 7.1 Atomedical Simulation Model For the purpose of evaluating scenarios and strategies drawn in the previous part of scenarios planning methodology, one used a DES model of Atomedical. Previous work of Azevedo [2010] in Atomedical resulted in the development of a DES model of the processes. The processes described in 2010 remain the same nowadays, despite the changes of environment. The used DES model of Atomedical was reviewed and enhanced in order to satisfy the needs of the actual problem. The simulation model was implemented in Simul8 Simulation Software 1 . The Atomedical model focus in the processes of unit examination (administrative operations were not modeled). They can be divided into three sub-systems: Scheduling; Examination and Reporting. Those subsystems connect between them through a sequence feeding of work and through resource sharing, as one can see in Figure 7.1. Model calibration, validation and result analysis need to take into account the existence and importance of all those parts and their connections. Those subsystems may respond differently to the contexts, but the final system evolution results of the interaction of sub-systems responses through the existing connections or through resource usage. Examination! Scheduling! Reception Staff! Exam ! Schedule! Reporting! NM Technicians! NM Technicians! Exams! ! Info! RF Preparation! RF! Radiopharmacy! Patients! Exam! Reporting! Patients! Patient Check-in! Patients! Exams! RF Administration Cabinet! Patients! Reception Desk! NM Technicians; ! NM Doctor;! Processing Equip.! RF Administration! Reception Staff! Patients! NM Technicians; ! Pre-Processing Equip.;! Reception Desk! Gama Chambers; Stress Test Room! Patients! Report Cabinet! Reports! Figure 7.1: Systems and sub-systems of simulation model. Modeled tasks are represented inside sub-systems. The Scheduling sub-system models the way that, after a patient arrival, Reception Staff schedule the patient exam to the next available slot in the exams schedule plan. At the level of Examination, 1 Simul8 Simulation Software is a commercial software focused in process improvement from the Simul8 Corporation. A student license was used for the purpose of this work. More information available in http://www.simul8.com/ 74 it was modeled the way that resources (equipment and staff) accomplish the event tasks of the patients’ exam procedures. In the model, the number of exam procedures was restricted by directly simulating the most important exams in terms of revenues and gathering the remain into two typical type of procedures (more information on Table 2.1, Section 2.1). The model explicitly simulates the following exams: Bone Scintigraphy, Myocardial Perfusion Study, Thyroid Scintigraphy, Renograms. The Renogram procedure in the model represents the different types of renograms performed. Exams that were not explicitly modeled were simulated into two groups: exams that are dynamics, which means that the image acquisition is made immediately after the injection of the RF; and exams that require a waiting time between RF administration and image acquisition. In the residual exams with waiting period in the clinic after the RF administration were also included the exams where RF administration is done one or more days prior to the exam, since, as simplification, only the exam part is considered in the model. More information about the unit exams included in the model can be found in Azevedo [2010]. In the grouped exams, different times of waiting and acquisition exist. Therefore, for model calibration, it is considered statistical distributions of times in those events, based in the sample of exams included. The purpose of including these exams is not their modeling, but the consideration of inference in unit operations, but to consider the interference in unit operations. Thus, they will not be considered in the exams types analysis of result. The model uses the statistical variation in modeled events times to address not explicit time components, such as patient and/or staff travel inside the clinic, or patients preparation. Also, if patients remain inside the clinic after the closing hour, staff remains extra hours to complete the day exams. After the Examination, the patients exit the clinic, and the exams produced pass to the final sub-system, Reporting. Here, the NM Doctor performs the reports for the finished exams. A complementary procedure related with the radiopharmacy was also included, where the RF are prepared, in order to model the occupancy of a NM Technician in this procedure. The workload of the radiopharmacy vary with the number of exams in each day. The individual preparation of RF before administration is included, in the model, as part of the time of the injection procedure. As a simplification of the real system, the simulation model was built based in some simplifications and assumptions, in order to reduce the complexity of the model to a set of variables that mainly define and influence the problem in study. Some of those are related to the scheduling of exams, procedures, and staff that was considered in the model. More information about the construction of the model of Atomedical operations and exams can be found in Azevedo [2010]. 7.1.1 Simul8 DES Model Implementation The implementation of the Atomedical DES model was performed in Simul 8 Simulation Software. Simul 8 software is based in Work Centers (WC), Resources (RES) and Queues (SB), that were used to represent the different model tasks, staff and the waiting rooms/waiting periods, respectively. 75 The Work Items represents the Patients and flow through the model following a Job Matrix. This matrix defines different paths for each type of exam through the existing Work Center. Since the tasks performed in each Work Center depend on the type of exam, the Job Matrix provides also information relative to time spent in tasks. The implemented model in Simul8 is represented in Figure 7.2. Figure 7.2: Atomedical Simul8 Simulation model. Simulation model is based on three types of items: Work Centers (name started with WC), Resources (name started with RES) and Queues (name started with SB). Work Centers can need a Resource to perform a task, and they are connected to each other through Queues, where the Patients wait for Work Centers and/or Resources, availability. Work Items, defined as Patients, flow through the model, following the arrows that connect the represented items. They start at an initial point, WEP Patients, an exit the model at WEPex Patients, following the path described for their type of exam in the Job Matrix. In the background of the model, simulation runs different events (for instance the entry or exit of a Work Item through Queues and Work Centers, or Resource allocation). Time between events, such as, the duration of a task, is set by statistical distributions, from which is randomly drawn to each event. Also in the background, Simul8 allows the implementation of complementary Visual Logic routines. They are attached to events or runs in a timely base, and can read, define or change the model variables. Therefore, Visual Basic was used to perform complex tasks in events, like scheduling, to personalize parameters for tasks, or to update the number of available of resources. One can see an example of the used Visual Logic routines in Code Snippet 7.1. Visual Basic was also used to connect the Simul8 to Excel, in order to import and to extract the data of the simulation (variable values or tables of data), due to the limitations of the Simul8 version. One defined the simulation to run the model during 52 weeks, in order to simulate the unit operations during a year. However, in the first weeks results were not collected. This is called the warm-up period, during which the simulation is evolving to correctly reproduce the reality of unit that is already 76 in operation, allowing that model parts, as queues, to acquire normal operating conditions. Code Snippet 7.1: Illustration of Visual Logic Code used. This code runs in a timely base. At specific times the calculations of parameters are performed for other routines or output produce. 1 VL SECTION : Time Check L o g i c ’ Repeated a t a s e t t i m e i n t e r v a l I F HOUR[ S i m u l a t i o n Time ] < 21.5 SET RES NM T e c h n i c i a n s . Max A v a i l a b l e = ss s h i f t s [DAY[ S i m u l a t i o n Time ] , h ] SET nmt = ss s h i f t s [DAY[ S i m u l a t i o n Time ] , h ] 6 SET h = h+1 I F HOUR[ S i m u l a t i o n Time ] = 21 I F MINUTE [ S i m u l a t i o n Time ] = 0 SET v a r _ e n t r y = bd e n t r y BreakDown WEP P a t i e n t s , 0 11 I F HOUR[ S i m u l a t i o n Time ] = 7 I F MINUTE [ S i m u l a t i o n Time ] = 30 SET nday = [ [ 5 * [WEEK[ S i m u l a t i o n Time ] − 1 ] ] +DAY[ S i m u l a t i o n Time ] ] SET nexamesday = RF[ 1 , nday ] SET r f v a r = 0 16 WHILE r f v a r <= RF[ 1 , nday ] Add Work To Queue P a t i e n t s , SB Day RF SET r f v a r = r f v a r +1 SET h = 1 BreakRestart WEP P a t i e n t s 21 I F HOUR[ S i m u l a t i o n Time ] >= 21 I F NOT ( n p a t i e n t s o u t = nexamesday ) SET RES NM T e c h n i c i a n s . Max A v a i l a b l e = ss t u r n o s [DAY[ S i m u l a t i o n Time ] , 2 7 ] SET d a y e x t r a w o r k i n g h o u r s = d a y e x t r a w o r k i n g h o u r s +0.5 I F HOUR[ S i m u l a t i o n Time ] = 23 26 I F MINUTE [ S i m u l a t i o n Time ] = 30 SET ss daysummary [ 1 , d a y l i n e ] = DAY[ S i m u l a t i o n Time ] SET ss daysummary [ 3 , d a y l i n e ] = d a y e x t r a w o r k i n g h o u r s SET ss daysummary [ 4 , d a y l i n e ] = n p a t i e n t s o u t SET ss daysummary [ 1 8 , d a y l i n e ] = dw_c4 31 SET ss daysummary [ 2 2 , d a y l i n e ] = t _ d a y s t r e s s i n g SET ss daysummary [ 2 7 , d a y l i n e ] = h o u r p a t i e n t e x i t ... SET d a y l i n e = d a y l i n e +1 SET n p a t i e n t s o u t = 0 36 SET d a y e x t r a w o r k i n g h o u r s = 0 SET dw_c4 = 0 SET t _ d a y s t r e s s i n g = 0 SET h o u r p a t i e n t e x i t = 0 The implementation of the used Atomedical DES model was enhanced by solving detected errors, optimizing routines and providing a deeper level of operational indicators for the purpose of the problem in study. The enhancements were made at the level of: Simulation: The warm-up period is usually set in Simul8. However, to allow a more flexible result analysis, all results were set to be collected. The result analysis in Excel uses a week of simulation filter that allows to set the warm-up period. Model: The model was set to start RF preparation after the patient arrival. However, this procedure is done based on the total exam scheduled for the day. Therefore, it was set that RF preparation was made during 2 hours in the beginning of the morning and of the afternoon, from an initial pool based in all the exams scheduled to the day. Model: Only the Renograms and the Thyroid Scintigraphy exams are performed in Camera 4. Using a common Queue for all the Camera Work Centers, the model failed to follow the Job Matrix, so, all types of exams might use Camera 4. To correct this, one used two Queues, for which exams are directed by the Job Matrix, according to their type. Only the Queue that receives the Renograms and the Thyroid Scintigraphy allows the access to Camera 4. 77 Visual Logic: The way as Visual Logic code saves the information of a Patient item was very slow because needs to search its information in a table. This time increased during simulation with the size of table. Instead of a search routine, an index direct to the location was used. Visual Logic: Previously, only waiting time in queues were collected. To provide more performance information, all Waiting Time (WT) and time of tasks in the simulation are collected. Visual Logic: To support used product analysis from the simulation, the used resources in each day are collected in day summaries. An Excel spreadsheet is used to import data to the model and extract simulation results. In the Excel spreadsheet, the user introduces a set of model inputs, like the Schedule Plan, the Job Matrix or the NM Technicians shifts. Together with the Simul8 software parameters, one is able to control all the variables connected to scenarios and strategies, as stated in Sub Section 6.1.2 and Sub Section 6.2.2. The Visual Basic routine allows to extract every detail of the simulation, as the time between events for every Patient, or the use of resources. This data is at the end of the simulation exported to an Excel document that performs the statistical analysis of outputs (per type of exam and weekday analysis), which completes the extraction of all the signpost identified in Section 6.3. A comprehensive resume of the outputs implemented is presented in Table 7.1. Table 7.1: Simulation Model Outputs and Signpost. Type Output Signposts Staff Workload # 7 NM Doctors workload, # 6 NM Technicians workload and # 5 Reception staff workload # 6 NM Technicians workload Productivity Staff Workload Distribution Work Centers Workload Last Patient Out Number of Reports Number of Exams Quality Financial Time in Clinic Waiting Time for Exam day Waiting Time in Queues Waiting Time for Report Exam Duration Exam Profit "Cold Kits" Expenditure Technetium Expenditure 7.2 # 19 Equip. Workload and # 66 Atomedical operations costs # 4 Schedule - Extra working hours of unit staff # 51 Number of Examinations # 65 Patient waiting time in unit # 65 Patient waiting time in unit # 65 Patient waiting time in unit and # 41 Image Retake # 35 Quantity of "Cold Kits" bought, # 38 Unused "Cold Kits" and # 66 Atomedical operations costs # 33 Quantity of Technetium generator bought, # 36 Unused Technetium and # 66 Atomedical operations costs Atomedical DES Model Calibration and Validation In order to correctly simulate the Atomedical operations in the Simul8 DES Model, one has to calibrate it using the model parameters and inputs, so it represents the actual procedures. For this purpose, the existing real data or information provided by the staff was used. In model calibration one used the parameters described in Azevedo [2010] for the times of the tasks inside the unit. Parameters for procedures and tasks times were considered together with unit managers to remain the same since 2009. They are intrinsic to the unit operations, despite changes 78 in that values may be used for new setups in scenarios/strategies evaluation. Parameters associated with a significant variability were considered stochastic, in order to take advantage of the possibility to model stochastic events provided by the DES. It was needed to define the context of the number patients that look at Atomedical services, and the distribution of the type of exams. For this purpose, one used the data regarding the year 2011, in which 21265 exams were performed. Regarding the exam schedule plan and staff shifts, the ones used in September 2011 were considered. The calibrated model was simulated for one year runtime and half-year warm-up period. The resulting output values were discussed with the unit staff, in order to validate the model for the real system in study (Table 7.2). Results allow the comparison of the simulation model with the data of real performance of Atomedical. However, the year 2011 saw a change in the unit environment context. The calibration parameters were adapted during the year, namely agenda and shifts. However, the model assumes the same setting to the entire period of simulation, what limits the validation. Table 7.2: Calibration Model Simulation Results. Results are based in current context of Atomedical in 2011. The total exams performed are related to the entire year operation while the renaming indicators are only relative to half-year exams results, after a warm-up period. The standard deviation (SD) do not follow a normal distribution. Exams Indicators Patients per Day Total Exams Average SD 79.4 20571 16.5 Bone Scintigraphy Days Until Exam (days) Time in Clinic (min) WT in Clinic (min) WT for Exam (min) 1.7 163.93 16.92 5.58 0.79 14.12 13.65 7.21 Myocardial Perfusion Days Until Exam (days) Time in Clinic (min) WT in Clinic (min) WT for Stress Test (min) WT for Exam (min) 13.05 93.12 21.14 7.41 1.62 1.99 15.12 14.86 6.60 3.18 Thyroid Scintigraphy Days Until Exam (days) Time in Clinic (min) WT in Clinic (min) WT for Exam (min) 1 52.35 15.35 0.12 0.00 13.76 13.58 0.54 Renograms Days Until Exam (days) Time in Clinic (min) WT in Clinic (min) WT for Exam (min) 1 48.63 9.23 1.99 0.00 10.54 7.86 3.11 7.40 0.14 99.83 8.67 0.74 133.14 WT in RF Administration (min) WT in Preprocess (min) WT for Report (min) Results allow to observe if the set of parameters are correctly expressed in the simulation (i.e. number of patients and exams, examination time) and if the model outputs present similar behavior to those described by the unit managers. The number of patients and exams followed what was set as parameter for the simulation. Despite of that, the total of performed exams is a decreased. That fact result of the a warm-up period in simulation and the increased waiting time in scheduling Myocardial perfusion exams, compared with what happened in Atomedical. The time of the examination (resulting from subtracting the waiting time from the total time in the unit) is according the type of exams procedures, and the excepted duration from the used calibration parameters. From the analysis of the model outputs, as already stated, the time for scheduling a Myocardial Perfusion exam is above the 79 real time. This fact is due to the agenda used (from September 2011) do not fit the exams distribution of 2011, since the number of exam decreased after the summer of that year. Therefore, the agenda designs a unit capacity that targets an environment context of inferior procurement than simulated. However, since one is mainly looking to evaluate model variations in different scenarios/strategies, this shift from the real unit operation values was not relevant. Regarding the remaining waiting times results, they are in line with what happens in Atomedical. The model was considered to be a valid approximation of the real system in 2011, being therefore, able to sustain further work in scenarios/strategies evaluation in Scenarios Planning. 7.3 Implementation of Scenarios and Strategies into the Model At this point one has a base model for this work. However, that base model has to be adapted to represent the drawn scenarios and strategies. In each of them, specific system parts are addressed, and its initial situation changed accordingly to the scenarios/strategy in study. There is a need to define how those changes will be expressed in the model in order to be simulated. It is important to notice that previous model design had already taken into account the needed adaptation to scenarios/strategies in the inclusion of parameters or inputs for simulation model setup. Regarding scenarios, different exams’ procurement (number of patients and distributions) were defined as a change on the time between patient arrival and the distribution of the exam types for those patients. The scenario of an increase stoppage time of Gamma Cameras was defined by reducing the Gamma Cameras Work Centers efficiency (efficiency defines the amount of time in which equipment will work). As set in the strategy definition, the efficiency level of one Gamma Camera was set to 98%, corresponding to doubling the maximum stoppage time currently. For simulating an increase in the average time of image acquisition, one defined an increase of 10% in all Gamma Cameras exam time from the initial values defined during calibration. Regarding strategies, Strategy 1 one has a change in the unit working hours. For this purpose, the reception working time was reduced to the time between 8h30 and 18h00. The time between patient arrival was adjusted in each scenario for this new working period (in order to preserve the same patients arrivals per day that value has to decrease). A new Schedule Plan input to the model was set by unit managers to fit the new working time, in order to the last patient entry occur about 3 hours before closing hour. The NM Technicians shifts were also adjusted to this new schedule. For implementing Strategy 2, the reduction in the number of equipment, the work of one Gamma Camera is suspended (since the Gamma Camera 4 is used only in some exams, one of the other Cameras is chosen). For the purpose of simulating Strategy 3, the decrease in the exam duration in Cardiac Studies, the time of the image acquisition inside the Gamma Camera is reduced by 20 %. The DES model was this way set to simulate and evaluate the design scenarios and strategies. 80 7.4 Simulation results In this work, one introduced the use of full Scenarios Planning methodology focusing in an operational problem. As a result, unit managers were able to better understand the problem and their unit. The challenge from the unit context uncertainty was addressed successfully. However, the behavior of the unit was difficult to predict. This level of uncertainty still needs to be tackled. For that purpose, one used the Simul 8 DES model to evaluate the constructed scenarios and strategies. Therefore, different simulation models were built to represent them. The results of the simulations allowed unit manager to gain further insight about the different impacts in their unit. The quantity of data that can be extracted from a simulation can be enormous and difficult to analyze. However, this methodology does not imply a fully study of the unit operations. Focusing in the trends in the selected signpost, one was able to provide more information about the problem reducing the complexity of analysis. Therefore, the presented results are focused in the data of interest to the problem. Simulating only some scenarios for the obtained strategies provides a simpler, but robuster, sensitivity analysis of the problem. For this purpose, the results are compared to a control simulation. This simulation changes, based on the main change that the scenario/strategy combination provides. Strategy 0 in the 2011 scenario was considered a base simulation. For the remain, the results in Strategy 0 were compared with the 2011 one, since it was only changed the number of patients. For the remain Strategies, other variables are changed. Therefore, in order to remain focused, those simulations are compared with Strategy 0 in the equivalent scenarios of procurement. Changes are highlighted using arrows near the comparison values. They represent 10% to 20% different, highlighted as yellow, and more than 20%, highlighted as green (increase) and red (reduction). The analysis of results focused in the data statistical analysis of each patient performed exam, scheduled to a day after the warm-up period. More data was also extracted from the day summaries in the result collection period. Further detail focus in different type of exams. Simulation variability was included by the study of multiple exams results, rather than just on one final result. The used signposts indicators for results can be divided into three groups: service quality, unit performance and unit workload. Therefore, the results were analyzed considering those groups, by comparing the evolution of indicators along the different simulations. That way, the aim was the identification of the impacts in the indicators on each simulation conditions. 7.4.1 Unit performance indicators Unit performance indicators are focused in the unit response to the number of incoming patients. Tables 7.3, 7.4, 7.5 and 7.6 show the total amount of patients, and the number of patients per day, in the result collection period (half a year). Those values mostly resulted from the defined parameters. However, if the available vacancies in the schedule plan are almost complete, the number of exams could be less than the expected number of incoming patients, due to the unit not being able to fulfill all 81 requests in a timely manner. For instance, in 2009, the percentage of Schedule, Table 7.3, indicates almost none vacancies in the schedule. The resulting total number of exams is below the setting, as a result of a significant waiting list. Schedule fulfillment decreases with the procurement. Table 7.3: Unit performance results for Strategy 0 under the procurement scenarios, regarding the average (AVG) of exams within the collection period. Each day exit hour of the last patient does not change accordingly to the decrease of the number of patients, due to the model not being flexible and adjusted to day vacancies. However, the existing decreases are due to the change on the waiting time in unit tasks. A significant increase of the waiting times resulted in later exit hours, Table 7.4. The waiting times follow the number of exams performed, due to a fixed unit capacity. Reports follow the same reduction of the number of patients, as expected. Table 7.4: Unit performance results for Strategy 0 under the operational scenarios, regarding the average (AVG) of exams within the collection period. Table 7.4 focus in the operational scenarios, for the same number of patients and schedule. The scenario of lower availability of Gamma Camera had significant impact on patients waiting time, but only under the context of almost full schedule. The increase in 10% of the time of image acquisitions had less impact, and only regarding the patient waiting time. Table 7.5: Unit performance results for Strategies 1 and 2 under the procurement scenarios, regarding the average (AVG) of exams within the collection period. 82 Table 7.5 addresses the results of Strategies 1 and 2 results. The reduction of the working period (Strategy 1) fits well to maintain the level of performance while the procurement decreases to half of the levels of 2011. However, the use of such schedule in the scenario of 2011 had a significant impact in the unit performance, and the unit was not able to perform all the exams before the expected closing hour, 18h00. Using a schedule with lower total vacancies, the total number of exams performed decreased, while comparing to the control simulations. For Strategy 2, the reduction of the number of cameras resulted in doubling the waiting times of the patients, for all scenarios. However, in the 2009 scenario, only the exit time of the last patient increased, since less patients are schedule to the end of the day. Table 7.6: Unit performance results for Strategy 3 under the procurement scenarios, regarding the average (AVG) of exams within the collection period. Table 7.6 focus in Strategy 3, the reduction of the time of the Myocardial Perfusion exam. It allowed a slight reduction in the patient waiting time. But further analysis of the impact of this strategy is needed regarding only this type of exams. 7.4.2 Service quality indicators Service quality indicators are focused in the patients waiting time. They detail the unit performance indicators regarding each type of modeled exams. They explore the time to the examination day and the time inside the clinic, namely the waiting times for main tasks such as: Exam and RF administration. The last one is similar to all type of exams. The waiting time for RF administration decreased with the procurement. The Myocardial Perfusion represents about half of the examinations. Therefore, it was the only one to see a significant decrease in time to the examination, with lower procurements. In 2011-75, 2011-75B and 2011-50, it decreased to values of two working days. These results show that the used schedule sets an insufficient capacity for the procurement of 2009 and 2011 for some exams. In 2009 simulation, a new agenda was used, so, the results show a better fit to the exams distribution. Consequently, the waiting time did not increased significantly, as it would be expected, and in some cases, decreased, namely in the two most performed exams: Myocardial Perfusion and Bone Scintigraphy. In the scenario 2011-75B, only Bone Scintigraphy exams decreased, but without significant values. 83 Table 7.7: Service quality results for Strategy 0 under the procurement scenarios, regarding the average (AVG) of exams within the collection period. Time in Clinic changes with the variation of the waiting time inside the unit, Table 7.7. The impact of procurement in the waiting time was more significant in the Myocardial Perfusion exam. This was mainly due to the level of waiting time for the Stress Test, performed individually in just one room. The waiting times in clinic were not the same for all exams, due to the schedule fit of different exams entry hours to the unit capacity. Even in lower procurements than the 2011 scenario, the total waiting in clinic, and wait for exam, presented low reductions. Table 7.8: Service quality results for Strategy 0 under the operational scenarios, regarding the average (AVG) of exams within the collection period. 84 Table 7.8 focus in the operational scenarios. Both exam duration increased and a low Gamma Chamber availability resulted in an increasing waiting time for the exam in those more frequent. The increase in the waiting time for performing the image acquisition was more significant than the one in the total wait in clinic. The increase of the global waiting time is mainly due delays of image acquisition. The reduction of availability of Gamma Cameras allowed to free NM Technicians for the task of RF administration, reducing it waiting time, namely, in a scenario of high procurement (2009). The increase of the examinations times had the opposite effect, reducing the availability of the NM Technicians and increasing the waiting time for RF administration. Table 7.9: Service quality results for Strategies 1 and 2 under the procurement scenarios, regarding the average (AVG) of exams within the collection period. At this level, the indicators impacts of Strategies 1 and 2 are shown in Table 7.9. Strategy 1 increased the time to the exam day in all scenarios. This change was more significant in higher procurement scenarios, given the reduced capacity in the new schedule. This strategy also increased the waiting times. In Bone Scintigraphy, a reduction of the waiting time for performing the image acquisition was due to the new schedule fit to unit capacity for this exam. Therefore, if it allows a higher entry of patients comparing with the unit capacity, it will result in the deterioration of the waiting times. In Strategy 2, as in the Strategy 0 operational scenarios, the increase of NM Technicians availability contributed to the reduction of the waiting time in other tasks: RF administration and Stress test. However, the total waiting time increased, as a result of the waiting time for image acquisition. 85 Table 7.10: Service quality results for Strategy 3 under the procurement scenarios, regarding the average (AVG) of exams within the collection period. Table 7.10 states Strategy 3 results. Its impacts were the excepted reduction of the waiting time for the exam in Myocardial Perfusion. As a consequence, one can observe a small decrease also in the same waiting time for the other exams. However, the change in the total waiting time was not significant, given the lack of optimization of the schedule to this reduction in the examination time. 7.4.3 Unit workload indicators Unit workload indicators provide information about the use of the unit capacity. Unit capacity is set by its equipment and staff availability. An analysis of the different simulation results supports the understanding of the need or surfeit of resources in the study contexts. Tables 7.11, 7.12, 7.13 and 7.14 provide the overall results. Table 7.11: Unit resources workload results for Strategy 0 under the procurement scenarios, regarding the average (AVG) of exams within the collection period. 86 Table 7.12: Unit resources workload results for Strategy 0 under the operational scenarios, regarding the average (AVG) of exams within the collection period. Table 7.13: Unit resources workload results for Strategies 1 and 2 under the procurement scenarios, regarding the average (AVG) of exams within the collection period. Table 7.14: Unit resources workload results for Strategy 3 under the procurement scenarios, regarding the average (AVG) of exams within the collection period. For Strategy 0, Table 7.11, the workload was directly proportional to the procurement. The resources were not in use most of the time, even on low procurements, giving room to resources reduction. However, a low level of workload does not correspond necessarily to lower waiting times. In Table 7.12, the reduction of the availability of Gamma Cameras resulted in an increase of the remaining working times. From Table 7.13, Strategy 1 implements a reduced schedule, which means that less patients enter the unit, resulting in the decrease of the resources workload. Unit seems to better use of their resources with more patients. The flexibility of the operations allows to manage better the continuous use of equipments, under that conditions. Strategy 2, as the Strategy 0 operational scenarios, presented a higher use of the remaining Gamma Cameras. In Strategy 3, Table 7.14, as the duration of exams was reduced, the use of the Gamma Cameras was reduced. 87 7.4.4 Results Summary Some insights arise from the results analysis. The impact on operations, by variations on the examination times, is minimized by flexibility of the operations, influencing only the resulting waiting time of the patient (see Figure 7.4). The number of Gamma Cameras are the key to the flexibility of the exam management (see Figure 7.6). The option of their reduction, in the context of low procurement, allows to decrease costs, but sacrifices the service quality regarding patients waiting time. Table 7.8 shows that it mainly results from the wait for image acquisition. Waiting time for RF administration mainly results from the level of availability of NM Technicians. Even if the schedule fulfillment is not near completion, it may result in the reduction of the number of exams (see Figure 7.5). The fit to unit capacity of the schedule of patient entry in the unit, influence the waiting times inside it (see Figure 7.9). A constraint in the number of free equipment or free staff, at a given moment, results in the block of operations. This can occur in different periods. Therefore, a better organization of the resources and schedule would allow an optimization of resources workload (see Figure 7.11). Myocardial Perfusion must be the focus of unit management due to the higher impacts in the service quality indicators. To increase the capacity of the unit to this exam, is important to address the number of simultaneous stress tests performed (currently just one). Strategy 0 was the base for scenarios evaluation. The reduction on the level of procurement reduced the number of performed exams (2009, 2011-75 and 2011-50). Fitting the schedule might result in lack of response to all the patients, increasing the unit waiting list. Changes in number of exams of Bone Scintigraphy (2011-75B) resulted in a reduced impact to service quality indicators (see Table 7.7). Increase in the examination time (2011-Time and 2009-Time) or Gamma Camera availability (2011-Chamber and 2009-Chamber) resulted in the increase of the waiting times. Strategy 1 allows to reduce the working period, and therefore costs. However, the studied schedule plan was not optimized, which resulted on increased waiting times and inefficient resources use. This strategy is not recommended to procurements above 75% the scenario of 2011, due to significant loss in the number of exams and service quality. Strategy 2 allows to increase the usage of the Gamma Cameras, however, it increases the waiting times on all procurement scenarios tested. Given the irreversibility of this option, the cost reduction might not justify the loss of service quality. Strategy 3 allowed the improvement of service quality, namely regarding the Myocardial Perfusion exam, however, with the studied schedule, the improvements in the general unit performance indicators were not significant. The results of this simulation evaluation provided clear insights about Atomedical operations. Most of the results supported what unit managers already knew from their experience. Nevertheless, DES helped to them preview some of the strategies they were considering. Despite corroborating some effects of the options in study, the level of impact of some of them sustain further review and study regarding the efficiency and effectiveness in current and future scenarios. 88 8 Final remarks 89 During this work, the Decision Problem of Atomedical unit managers was explored using a new Scenarios Planning methodology. This framework provided a tool to address the uncertainty of the problem, both in the Atomedical context and in unit operations. This was possible by integrating in the study of Atomedical operations a full procedure of Scenarios Planning with the methodology of DES. The Scenarios Planning methodology provides a framework to study the complexity of the problem that unit managers face in Atomedical. The process of understanding Atomedical as a system, and identifying the variables of the problem provided to the unit managers further insight of it. The identification of all variables is impossible, but a deep analysis of the unit operation dynamics allowed to explore main variables that influence the patients examination. It is depended of the internal variables, where the operational uncertainty resides, but also on the input variables, that are influenced by an uncertainty of the unit context. Problem objectives were highly based in the operations. Therefore, one could identify the problem variables as those that might influence operations. They are directly related to unit examination tasks, resources, and inputs. Structuring the problem and the operations as a systems allows to simplify its analysis. Variables in a system are dynamic, as they establish relations between them. The influence and dependence between variables is of extreme importance to understand the system behavior. It allows the focus in a core of interesting variables that guide the system response to internal and external changes. The use tools to explore the relations between variables revealed of high interest on underlying relations that were not intuitive to unit managers, but significant to understand the problem. The results were obtained from the subjective classification of variables by unit managers. Although, they resulted to be very objective, by correctly describing the known and the background relations that drive the problem in Atomedical. The use of tools that allow to quantify the description of the problem is very important to address the subjectivity inherent to a Scenarios Planning methodology. The identification of the key variables of the problem is the core part of the methodology. They allow to simplify further the system analysis, without losing from it important information about the problem. The parameters of choice of the key variables were already presented in an informal way in the process of identification of the system variables. Therefore, the number of variables excluded in that step was reduced. From the key variables, one was able to construct scenarios and strategies. This part is highly subjective. The aim is to identify scenarios and strategies that allows one to study the system, getting the possible information towards the futures of the unit. For this purpose, few tools exist, and they only provide support to structure the process. By successfully analyzing the problem and the characterization of the system in the initial steps of Scenarios Planning, unit managers were provided with enough information to support a more objective choice of each variable options. However, the construction of scenarios and strategies in such operational problem, as the one of Atomedical, needs to focus in fewer, but coherent and complementary, scenarios. Scenarios and strategies need to cover the field of possible changes in the context and quantify them at the level of the system inputs and parameters. Exploring systematically all the possibilities in such multi-variable problem was a limitation of the pro90 posed methodology. It missed, sometimes, to remain objective, since it was depended almost only on the unit managers perspectives and knowledge. This limitation is common to all Scenarios Planning methodologies and only minimized by the deeper knowledge of the system from the previous analysis. Nevertheless, the scenarios and strategies constructed from the Atomedical problem were able to provide a wide exploration of the system uncertainty, minimizing the number of total scenarios and strategies to be simulated. Using this methodology one has to balance the number of scenarios to be evaluated and the additional information provided. Applying Scenarios Planning in strategic problems, and focused in operations, one has to take into account the short time to explore the several scenarios. This was the case of this work in Atomedical. With the Atomedical proposed scenarios and strategies, one was able to explore the internal uncertainty regarding the unit response to context changes. DES model allowed to represent the system complexity, its variables and interactions. The problem objectives could have been addressed using mathematical models, in order to support the use of optimization tools, for instance, on the scheduling plan. However, they could not represent the complexity of the Atomedical system in a feasible manner. However, using DES within the Scenarios Planning methodology, it supported a sort of sensitivity analysis of the system, that enrich the knowledge obtained. Despite of that, further work could be used to study the financial performance of Atomedical and to optimize unit operation parameters, now that the existing uncertainties were identified and characterized. The results of the evaluation of simulations provided further information regarding the impacts of the scenarios and strategies in the objectives of the decision problem. The schedule plan is the more important tool of the management. Patients of the Myocardial Perfusion exam are the more affected by operational changes. The analysis of results should support the development of new and better strategies in Atomedical. The proposed framework of Scenarios Planning allows to overcome much of the subjectivity of the exploration of uncertainty. Further work could take advantages of the integration of data and information from the different stakeholders to tackle it. An integration of optimization techniques, focused in the variables identified in Scenarios Planning would be an important development in the support of unit managers, if combined with the DES that addresses the complexity of the system. Regarding the application of the methodology in Atomedical, the results of DES could have been used to explore the financial aspect of the unit operations. Using the resulting data of number of exams and resources used, one might in a future work provide unit managers more information about the cost of individual exams, to guide their prices strategies. The results of this methodology do not aim to provide unit managers a solution for their problem, but rather a deeper understanding of it. The Scenarios Planning methodology was successful in exploring the uncertainty of Atomedical problem, and providing a framework to deal with it in their choices. Learning how different contexts influence the unit, and the impact of different strategies, provides unit managers the tools to tackle future realization of path explored in scenarios. 91 92 Bibliography Als, C. (2007). Optimizing patient throughput in nuclear medicine: a semi-quantitative tool for scheduling bone scintigraphy. 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Socio-Economic Planning Sciences, 31(3):173– 189. 103 104 A Literature review in the scheduling problem in health care units A-1 A-2 Table A.1: Table of Literature in the Scheduling Problem in Health Care Units Table of Literature in the Scheduling Problem Reference Context Problem Methodology Results Bailey [1954] Generic Medical Care Facilities Queueing in inpatient, outpatient care and Appointment System for a Clinic Session Statistical Theory of Queues using Monte-Carlo type investigation Simple variations in the number of beds may largely reduce the waiting-lists in inpatient care. Waiting time in outpatient care can be mathematical predicted under intervals according with the average demand and available supply. The number of patients set in an appointment block is directly correlated with the average waiting-time and indirectly correlated with the consultant average idle period in a clinical session. Katz [1969] Generic outpatients departments of hospitals Appointment systems performance DES A simulator that enables a user to evaluate the effectiveness of an alternative appointment systems in a given clinical environment. Kolesar [1970] Generic Medical Care Facilities Hospital Services Admission Scheduling Linear ming Program- Linear Programming Markovian decision model is presented as an alternative to both analytic queuing and computer simulation, allowing a greater flexibility than the first, with more efficiency than the second. Rising et al. [1973] A university health service outpatient clinic Daily arrival patterns of patients and scheduling policy. Monte Carlo simulation model Alternative decision rules for scheduling appointment periods during the day lead to an increase patient throughput and physician utilization. Subsequent real-world results demonstrated the validity of the models predictions. Lev [1976] Diagnostic Radiology Department at Temple University Management systems scheduling techniques Data Analysis The scheduling techniques, and improved utilization of available equipment contribute to a better service to patients rather than providing more technicians and orderlies are available, in the studied case. Johannes and Wyskida [1978] Clinical arMedicine Nucle- Scheduling patients and clinical instruments for each physician requested Nuclear Medicine study Computerized heuristic model Heuristic showed to be able to provide a good basic schedule for use in Clinical Nuclear Medicine. Charnetski [1984] Hospital suites operating Scheduling operating room surgical procedures with early and late completion penalty costs Mathematical model and a two-stage Monte Carlo programming model Solutions provided capacity/utilization ranges for effective scheduling to either minimize or equalize the two types of costs. and continued on next page continued from previous page Table of Literature in the Scheduling Problem Methodology Results Reference Context Problem Goitein [1990] Massachusetts General Hospital Boston Patients consultations pointment Ho and Lau [1992] Scheduling appointments for medical clinic outpatients Klassen and Rohleder [1996] Monte Carlo simulation Patients’ average waiting time and physician’s idle time per patient Performance in waiting and idle times in different scheduling rules DES A simple procedure for identifying the best scheduling rule for given environmentalparameter values Family practice outpatient clinic Medical outpatient appointment DES It was possible to improve considerably on some of the "best" rules found in the existing literature, by using multiple performance measures. The "best" decisions depend on the goals of the particular clinic as well as the environment it encounters. However, good or best results were obtained in all cases that clients with large service time standard deviations are scheduled toward the end of the appointment session. Merode et al. [1996] Facilities for clinical laboratories Determining the performance of planning rules given the equipment and staffing of the clinical laboratory and the demand for laboratory services DES Rules which are considered effective in industry perform not so well as several of the alternative rules investigated in the experiments. Hashimoto and Bell [1996] Internal Medicine Clinic Evaluate patients spent time in clinical steps. DES Changes in the number of staff and their performance have an effect in the time spent by patients. Podgorelec Kokol [1997] and Small specialized therapy studios Scheduling patients with different physical therapy needs to a limited number of therapeutic devices and a limited number of therapists Optimization using Machine Learning and Genetic Algorithm New method for patient scheduling under highly constrained conditions using effective and low computing resources consumptions, adequate for very complex problems. Hannebauer Müller [2001] and Medical Diagnostic Unit Medical appointment scheduling Distributed constraint optimization problem System produces an optimized diagnostic unit calendar. Harper and Gamlin [2003] Ear, Nose and Throat Outpatient Department Effects in the clinic of various appointment schedules DES Identification of a number of critical factors that influence patient waiting times and of alternative appointment schedules that improve service without the need for extra resources. Su [2003] Outpatient Clinics Analyze several scheduling solutions DES Setting the appropriate arrival time interval for preregistered patients had significantly impact in the queuing problems in outpatient services. Cayirli et al. [2006] Outpatient Clinics Scheduling care visits DES Patient sequencing has a greater effect on ambulatory care performance than the choice of an appointment rule, and that panel characteristics such as walk-ins, no-shows, punctuality and overall session volume, influence the effectiveness of appointment systems. of ap- ambulatory A-3 continued on next page A-4 continued from previous page Reference Context Problem Table of Literature in the Scheduling Problem Methodology Results Denton [2006a] et al. Mayo Clinic Rochester, MN in Outpatient surgery scheduling Monte-Carlo simulation model Model can be used to evaluate multiple competing criteria for different staffing scenarios, and a simple scheduling heuristic based on the scheduling of the bottleneck (surgery) activity can lead to simultaneous improvements in expected patient waiting time and overtime. Denton [2006b] et al. Mayo Clinic Rochester, MN in Outpatient surgery scheduling Two-stage stochastic programming model A simple sequencing rule based on surgery duration variance can be used to generate substantial reductions in total surgeon and outpatient surgery team waiting, idling and overtime costs. Coelli et al. [2007] Brazilian Cancer Institute, Rio de Janeiro, Brazil Mammography Clinic performance DES The exam repeat rates and equipment maintenance scheduling simulations indicated that a large impact over patient waiting time would appear in the smaller capacity configurations. DES showed to be a useful tool for defining optimal operating conditions for the studied clinics, indicating the most adequate capacity configurations and equipment maintenance schedules. Santibáñez et al. [2007] Hospitals in a British Columbia Health Authority Schedule surgical blocks for each specialty Mixed integer programming model Result showed that, without increasing post-surgical resources hospitals, is possible to handle more cases by scheduling specialties differently. Chern et al. [2008] Two Large Hospitals in Taiwan Hospital health examination scheduling problem Binary integer programming model using a heuristic algorithm Proposed algorithm showed to be very efficient in solving the presented problem in its specific complexity and constrains. Wijewickrama and Takakuwa [2008] Large outpatient ward in Nagoya university hospital Evaluation of developed appointment systems form combinations of existing literature rules DES Combined appointment systems rules lead to design most effectively than they work alone in the performance of service waiting/idle time. Patrick and Puterman [2008] Generic Surgery Outpatient Optimize the scheduling of patients with multiple priorities Markov decision processes, linear programming and simulation Shows how queuing theory provides managers with insights into the causes for excessive wait times and the relation- ship between wait times and capacity. Muthuraman and Lawley [2008] Wishard Primary Care Clinic of Indianapolis, Indiana Stochastic Overbooking Model for Outpatient Clinical Scheduling with No-Shows Multi-objective optimization Results provided a natural stopping criterion for the over booking scheduling policy studied. continued on next page continued from previous page Table of Literature in the Scheduling Problem Methodology Results Reference Context Problem Klassen and Yoogalingam [2009] Outpatient Clinics Improving Performance in Outpatient Appointment Services Optimization DES Billiau et al. [2010] Generic radiotherapy department Radiotherapy Scheduling Dynamic Distributed Constraint Optimisation Problem A scalable solution to provide a scheduling system which significantly improved hospital efficiency. Conforti [2010] al. Generic radiotherapy department Radiotherapy Scheduling Linear Programming Optimization The developed model can be used to increase the efficiency of patient treatment delivery, since it is possible to reduce the waiting time from the therapeutic decision until the first radiation treatment. al. Outpatient department of general hospitals Outpatients appointment scheduling with multi-doctor sharing resources DES Results show that, under multiple-doctor and resource-sharing environment, collection of the seemingly optimal appointment rules for individual doctors does not lead to optimal performance for the system. Min and Yih [2010] Generic Surgery Optimal surgery schedule of elective surgery patients with uncertain surgery operations and deterministic demand Stochastic mization opti- Obtained an optimal surgery schedule with respect to minimizing the total cost of patient costs and overtime costs. Castro and Petrovic [2011] Nottingham City Hospital Radiotherapy scheduling pre-treatment Optimization Multiobjective Model Multi-objective problem can be solved as separated in single-objective optimisation problems with hierarchical objectives. Gocgun [2011] Harborview Center Medical Multi-category patient scheduling decisions in computed tomography Finite-horizon Markov decision process (MDP) Comparative study of an optimal policy with several intuitive, heuristic decision rules under different scenarios. Sensitivity analyses were performed to evaluate the impact of specific parameters on model outcomes. Outpatient department of general hospitals Appointment scheduling problem Robust optimization framework Average cost of the robust schedule is within 25% of the average cost of considered stochastic optimal schedule. Johansson [2010] Mittal and [2011] et et et al. Stiller Outpatient treatment with Integration of analytical and simulation method. A-5 A-6 B Atomedical problem analysis B-1 B-2 I.1! E.3! Scheduling! Plan! E.1! W.1! Patient! Looking for ! Exam! Attendance! waiting! F.1! Schedule Exam! R.9! Emergency! Patient! W.2! Waiting! for! Exam! day! E.2! Schedule! Patient! Arrive! Reception! Staff! W.3! F.2! Waiting for! Exam! Start! Check-In! W.5! F.4! Need Preparation?! ! No! Yes! F.8! F.7! Vacancy! Waiting! Image Acquisition! Image Processing! ! Need new images?! ! Yes! F.5! R.1! Reception! Staff! R.2! Patient Preparation! Reception! Staff! Pre-Exam ! Procedure! R.5! Nuclear Medicine Technicians! Image Acquisition Equipment! F.6! R.3! I.2! Nuclear Medicine Technicians! Daily Radiopharm aceutical! Preparation! Patient! Departure! F.11! Exam! Report! Waiting! Medical! Report! Delivery! E.5! Medical! Reporting! R.7! Image Processing Equipment! R.4! No! W.6! F.10! R.6! W.4! E.4! F.9! Exam ! Report! R.8! Nuclear Medicine ! Doctor! Radiopharmac eutical! Diagram'Legend:' Management(Interven,on( F.#!Process(Flow( Management( Staff ! Management! I.3! I.3! Radioactive Material! Purchasing! Equipment/ Facilities Investment! Process(or(Task( I.#! Interven,on( R.#!Resources( Buffer(or(Queue(( Decision(or(Evalua,on( Resources( Input=Output( External( E.#!Interven,on(((( W.#!Pa,ent(Wai,ng( Pa,ent(Flow( Resources(Flow( Influence(or(Effect( Figure B.1: Atomedical general examination process flow chart. Management interventions (I.#) are those appointed by the unit manager as their possible interventions on the system. Table B.1: Atomedical Problem Variables and Analysis Results. Each variable is classified according the results of the used tools regarding the following dimensions: Importance/Impact, Influence, Dependence and Knowledge/Control. This support final classification made by unit managers, identifying the key variables, and classsifying them as: strategy, scenario or signpost. The exclusion of variables due to corresponding to rare events is also expressed in the final classification. Atomedical Problem Variables and Analysis Results # Name 1 2 3 4 5 6 7 8 9 10 11 Number of Administrative Staff Schedule - Number of Unit Staff Schedule - Unit Staff Working Hours Schedule - Extra Working Hours of Unit Staff Reception Staff Workload NM Technicians Workload NM Doctor Workload Patients Scheduling Patients Arriving Delay Staff Assiduity Lack of Prerequisites fulfillment by patients 12 Exams not performed due patient 13 NM Technicians Experience 14 15 16 17 18 19 20 Equipment Malfunction Equipment Repairs Frequency of Equipment Maintenance Number of Equipments Equipment Calibration Equipment Workload Image Processing Equipment Performance Description Atomedical Operations - People Administrative Staff needed to support Atomedical Operations Number of staff allocated to each unit task in each moment Working hours assign to each unit staff Extra working hours to perform all the day exams Reception staff time allocated to tasks and idle time NM Technicians time allocated to tasks and idle time NM Doctors time allocated to tasks and idle time Schedule for acceptance of patients to examinations Time of patient arrive after appointment Unexpected lack of staff member in unit Number of patients not following prerequisites to exam in situation unknown by staff Number of patients not performing exam due not following the prerequisites or not showing up (considering only common exams) Level of NM Technicians Experience Atomedical Operations - Equipment Existence of not detected equipment errors or malfunctions Time of equipment stoppage due to repair by outside service Frequency of equipment maintenance by outside service Number of existing equipments Frequency of equipment calibration by NM Technician In use and idle time of equipments Time of image processing equipment to produce quality images Atomedical Operations - Materials/Products rol act ontion C /Imp e / e c e t c n en dg ca ce orta uen end wle ssifi Imp Infl Dep Kno Cla 0 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 0 1 0 1 0 1 1 1 1 1 1 1 1 0 0 0 1 1 1 0 0 0 0 1 0 0 1 None Strategy Strategy Signpost Signpost Signpost Signpost Strategy None (Rare) None (Rare) None (Rare) 1 0 1 0 None (Rare) 0 1 0 1 None 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 1 0 0 0 1 1 1 0 1 Scenario Scenario Strategy Strategy Strategy Signpost Strategy continued on next page B-3 B-4 continued from previous page Atomedical Problem Variables and Analysis Results # Name Description 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 Technetium Generator Availability Technetium Generator Cost Technetium Generator Delivery Frequency Technetium Generator Delivery Cost Other Radionuclides Availability Other Radionuclides Cost Other Radionuclides Delivery Frequency Other Radionuclides Delivery Cost "Cold Kits" Availability "Cold Kits" Cost "Cold Kits"s Delivery Frequency "Cold Kits" Delivery Cost Quantity of Technetium Generators bought Quantity of other radionuclides bought Quantity of "Cold Kits" bought Unused Technetium Unused radionuclides Unused "Cold Kits" 39 40 41 42 43 44 45 46 Used product in each exam/treatment Product spoiled during preparation Image Retake Priority Reports Exam Reporting Duration Report Complexity Exam duration Patient Real Activity - Biologic Reaction Availability of the Technetium Generator in supplier Cost of the Technetium Generator Delivery frequency of the Technetium Generator at Atomedical Delivery Costs of the Technetium Generator at Atomedical Availability of other radionuclides in supplier Cost of other radionuclides Delivery frequency of other radionuclides at Atomedical Delivery Costs of other radionuclides at Atomedical Availability of "Cold Kits" in supplier Cost of "Cold Kits" Delivery frequency of other "Cold Kits" at Atomedical Delivery Costs of "Cold Kits" at Atomedical Quantity of Technetium Generators bought in each delivery Quantity of other radionuclides bought in each delivery Quantity of "Cold Kits" bought in each delivery Unused technetium due to decay Unused radioactive products due to decay Unused "Cold Kits" due to end of life time Atomedical Operations - Methods and Procedures Administrated product to achieve needed activity level Spoiled product during radiopharmaceutical compounds preparations Number of performed new image acquisition Number of produced urgent reports Duration of exam reporting performed by NM Doctor Number of reports with the need second opinion or deeper study and analysis Time of staff and equipment occupancy of an exam Number of significant variations in the activity during the exam due to biologic unexpected interaction of administrated compounds Number of significant variations in activity due staff error in preparation or administration 47 Patient Real Activity - Staff error rol act ontion mp I C / e / e c e nc ce en dg cat orta uen end wle ssifi Imp Infl Dep Kno Cla 1 1 1 0 1 1 1 0 1 1 1 0 1 1 1 1 1 1 1 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 1 1 1 0 0 0 Scenario Scenario Strategy None Scenario Scenario Strategy None Scenario Scenario None None Signpost None Signpost Signpost None Signpost 1 1 1 1 1 1 1 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0 Strategy None (Rare) Signpost Scenario Scenario Scenario Strategy None 1 0 0 0 None (Rare) continued on next page continued from previous page Atomedical Problem Variables and Analysis Results # Name 48 Schedule Availability 49 Duration of Equipment Calibration 50 Duration of Radiopharmaceutical Compounds Preparation 51 Number of Examinations 52 53 54 55 Number of Competitors Price of Competitors Service Quality of Competitors Service Atomedical Unit Reputation 56 Emergency Patients 57 Number of Agreements 58 Number of Patients per Exam 59 Price of Exams in Agreement 60 Number of asked exams in National Health Care System 61 Price of exams of National Health Care System 62 Number of standalone exams 63 64 65 66 Atomedical Service Quality Atomedical Exam Quality Patient Waiting Time in Unit Atomedical Operations Costs Description Waiting time to appointment after intend dates of examination Duration of equipment calibration performed by NM Technician Duration of Radiopharmaceutical compounds preparation performed by NM Technician Number of Examinations Performed in a period Atomedical Unit Environment Number of competitors in the region Number of Competitors with lower service price Number of Competitors with higher service quality Level of Atomedical reputation among doctors for recommending to new patients Number of Patients without previous appointment or in urgent need of examination Number of people included in price agreements (outside national health care system) Number of incoming patients at Atomedical in each exam Established price for exams in new agreements General number of patients asked to perform a nuclear medicine exam (including subsystems) Price of the exams payed by National Health Care System Number of exams from patients fully paying the exam at Atomedical Atomedical Performance Level of quality of service to patients Level of quality of exam reports Delay regarding expected patient time in unit General costs of Atomedical unit operations rol act ontion mp I C / e / e c e t nc ce en dg ca orta uen end wle ssifi Imp Infl Dep Kno Cla 1 0 1 1 1 0 1 0 0 0 0 1 Signpost None None 1 1 1 0 Signpost 1 1 1 1 1 1 0 1 0 0 0 0 0 0 1 0 Scenario Scenario Strategy Scenario 1 0 0 0 Scenario 1 1 1 0 Scenario 1 1 1 1 0 1 0 1 0 0 1 0 Scenario Strategy Scenario 1 1 0 0 0 1 0 0 Scenario Scenario 1 1 1 1 1 0 0 0 1 1 1 1 1 1 0 0 Strategy Strategy Signpost Signpost B-5 B-6