Pragmatic Approaches to
Technology Transfer and
Commercialization
Vallée S.A.
Belo Horizonte, Y09-1119
Brazilian Animal Protein - Production
PRODUÇÃO BRASIL DE CARNES - MIL TON
2.998
20.000
8.600
9.200
11.032
2004
10.305
2002
9.419
7.577
6.952
8.300
5.000
7.400
10.000
2.872
9.000
2.943
2.620
15.000
3.030
2007
2008
0
2006
AVES
Fonte: ABIEC/CNA/FNP/ABIPECS
BOVINOS
SUÍNOS
Brazilian Animal Protein - Exports
EXPORT BRASIL DE CARNES - MIL TON
604
6.000
530
3.400
2.713
2.424
1.000
965
2.000
476
1.600
3.000
1.697
4.000
3.287
2.403
508
2.532
5.000
2.215
528
2007
2008
0
2002
2004
2006
AVES
Fonte: ABIEC/CNA/FNP/ABIPECS/SECEX
BOVINOS
SUÍNOS
Brazilian Animal Protein
BOVINE
Largest
POULTRY
Largest
SWINE
4th Largest
Worldwide Exporter
Animal Health Markets
World and Brazil
Veterinary Market by Region
(2002 e 2008 %)
2002 E 2008 %
100,0
3,1
2,8
90,0
17,3
15,4
80,0
4,1
4,6
26,4
32,5
REGIÕES
70,0
60,0
50,0
40,0
12,2
11,8
30,0
20,0
36,9
32,9
2002
2008
10,0
0,0
Fonte: IFAH/VETNOSIS 2009
AMÉRICA DO NORTE
AMÉRICA LATINA
EUROPA OCIDENTAL
EUROPA ORIENTAL
ASIA ORIENTAL
OUTROS
Animal Health Market by Species - World
(2002 – 2008 %)
100%
90%
36,8
80%
41,3
ESPÉCIE ANIMAL
70%
60%
12,4
10,8
50%
40%
17,9
16,3
30%
5,2
4,8
27,7
26,8
2002
2008
20%
10%
0%
BOVINOS
Fonte: IFAH/VETNOSIS 2009
OVINOS
SUÍNOS
AVES
ANIMAIS DE CIA/OUTROS
Animal Health Market by Species - Brazil
(2002 – 2008 %)
DISTRIBUIÇÃO DO MERCADO VET BRASIL POR ESPÉCIE - %
2,6
8,6
3,0
10,7
3,0
12,0
23,3
18,4
18,0
7,2
3,0
10,0
3,0
13,0
2,0
55,3
54,9
52,0
2003
2007
2008
BOVINOS
OVI & CAP
SUÍNOS
AVES
PETS
EQUINOS
O comportamento do Mercado Veterinário Brasil por espécie mostra a supremacia de ruminantes, fato que não deve
se alterar nos próximos anos (poderá até aumentar, caso todas as previsões de um Brasil provedor de carnes se confirme).
Fonte: SINAPSE/GAE/GIC
Top 10 Animal Health Companies (2008)
Brazil
World
Market Share
1
15,5 %
1
2
14,4 %
2
3
13,8%
4
6,7 %
5
5,7 %
6
5,7 %
3
44
5
6
7
7
5,4 %
8
4,8 %
IDEXX
3,6 %
BOEHRINGR
8
9
9
CEVA Saúde Animal
10
10
3,3 %
Source: AnImal Pharm / Vetnosis
Craveiro & Vallée
Source: Sinapse 2009
Top 10 Animal Health Companies (2010)
Brazil
World
Market Share
1
29,3 %
1
2
20,1 %
2
3
6,7 %
4
5,7 %
3
4
5
5,4 %
6
4,8 %
IDEXX
7
3,6 %
BOEHRINGR
8
5
6
CEVA Saúde Animal
7
3,3 %
Source: AnImal Pharm / Vetnosis
Craveiro & Vallée
Source: Sinapse 2009
Vallée S.A.
Craveiro & Vallée
PORTFOLIO
Vaccines
Montes Claros – MG
Brazil
Anti--parasitics
Anti
Supplements
Therapeutics
Sales in 2008: U$ 85 million
Craveiro & Vallée
Vallée S.A.
Vallée Brazil
Vallée Latin America
Mexico
Venezuela
Bolivia
Paraguay
Vallée S.A. R&D
• Technology Management
– Scientists and Research Assistants
– Biologicals and Pharmaceuticals Labs (Development)
– Partnerships (Universities and Research Institutes)
– Experimental Farm and Countrywide Partners (Farmers)
• Veterinary Pharmaceutical Product Development
– Basic science (genomics)
– Applied science (physiology and pathology)
– Innovative manufacturing processes
– Innovative delivery systems
Vallée S.A. R&D
• Brazilian Livestock Peculiarities
– Worldwide consumers (E.U.
E.U.,, Russia,
Russia, Middle East
East,, Asia)
Asia)
• Veterinary Drug Restrictions
– Cattle (~200 million heads in 2008)
• Beef (160 million
million))
– 80% Boos Indicus (128 million of Nelores)
– 20% Boos Taurus (32 million of heads of European
Breeds)
– Extensive system (pasture), managed 2-3 times yearly
Vallée S.A. R&D
• Brazilian Livestock Peculiarities
• Dairy (40 million
million))
– Boos Taurus (Holsteins and Jerseys)
– Boos Indicus (Gir and Guzerá)
– Semi-intensive systems (majority)
Partnership between Vallée and Brazilian Universities Sponsors: Vallée and MCT – Ministry of Science and
Technology of Brazil
Controlled Release of Pharmaceuticals
Development of Micro and Nanostructured
systems
Long term drug release (180 d following injection)
Anti – Tick Vaccine (Rhipicephalus microplus
microplus))
Functional genomics of target tissues/organs of
R.microplus
Immune – reactive peptides using Phage Display
Libraries
Partnership between Vallée and Brazilian Universities Sponsors: Vallée and MCT – Ministry of Science and
Technology of Brazil
Swine Enzootic Pneumonia (Mycoplasma
hyopneumoniae))
hyopneumoniae
19 potential antigens for a subsub-unit vaccine
Caseous Lymphadenitis (Corynebacterium
pseudotuberculosis)
pseudotuberculosis)
Gene overexpression
DNA vaccine
Future Perspectives and
Potential for R&D Cooperation
R&D Cooperation
• 88% of Brazilian Market is food producing animals
• Improvement of Animal Performace
• Animal Health Industries Role
– Disease Prevention
• Vaccines
• Nutritional Management
– Performace Enhancers
– Animal Welfare
– Products Adapted to Management
– Food Safety
R&D Cooperation
DISEASE PREVENTION
•New Vaccines
• Tick, mastitis, tuberculosis,
papillomatosis, porcine
circovirus, equine infectious
anemia, babesiosis and
anaplasmosis.
•New Antiparasitic Drugs
• Overcome nematode resistance
to ivermectin
•Nutritional Management
• Better understanding of both
bovine species needs under
tropical conditions
ANIMAL WELFARE
PERFORMANCE ENHANCERS
• Alternatives to antibiotic Growth
Promoters, and to hormones (Bovine
somatotropin)
• Better exploration of probiotics
FOOD SAFETY
• Bacteriophage control of
salmonellosis and E. coli infections
and shedding in chickens, calves,
piglets, and lambs.
•Better exploration of probiotics
PRODUCTS ADAPTED TO
MANAGEMENT
•Immunocastration
•Controlled Release Formulations
•Natural Antibiotics
•Stable Liquid Vaccines
R&D Cooperation
• Tech
Tech--Tools
–
–
–
–
Genomics
Nutrigenomics
Transgenesis and Genetic Modified Organisms
Nanotechnology (Bioeletronics)
• Manufacturing Processes
• Resources Exploration
– Brazilian Biodiversity
• Microbial
• Plant
THANK YOU!
Dr. Otto D. Mozzer
Director of Technology
Vallée S.A.
[email protected]
Source: The Economist