BCTRIMS
15th Annual Meeting
XV Congresso Brasileiro de Esclerose Múltipla
e Neuromielite Óptica
August 6 - 9, 2014 Royal Palm Plaza Resort Campinas - São Paulo, Brazil
TABLE OF CONTENTS
Welcome Message ..................................................................................
5
About BCTRIMS ......................................................................................
7
Committees ............................................................................................
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List of Chairpersons and Speakers ...........................................................
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Scientific Programme
Wednesday, August 6 ................................................................13
Thursday, August 7 ....................................................................... 14
Friday, August 8 ...........................................................................
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Saturday, August 9 .......................................................................
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Awards ...................................................................................................
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Instructions for Poster Presenters ............................................................
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Instructions for Speakers .........................................................................
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General Information ................................................................................
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Social Event ............................................................................................. 28
Venue .....................................................................................................
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Secretariat ...............................................................................................
28
Travel Agency .........................................................................................
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Campinas ................................................................................................
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Posters ....................................................................................................
33
Acknowledgements ................................................................................. 43
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BCTRIMS 15th Annual Meeting
WELCOME MESSAGE
Dear Colleagues and Friends,
It is our pleasure to have you present at the BCTRIMS 15th Annual Meeting in
Campinas-SP at the Royal Palm Plaza Resort. The focus of this meeting will be
the mental and cognitive disorders in multiple sclerosis, for which we have the
participation of leading experts in the area.
One of the main objectives of BCTRIMS is to motivate research in Brazil, particularly
in multiple sclerosis, neuromyelitis optica and correlated diseases, bringing the
opportunity for presentation and discussion of research results, as well as for exchange
of scientific experience. Therefore, it is an appropriate event for you to present your
papers and compete for prizes.
Do take this opportunity to discover Campinas, which is the second largest city in São
Paulo State, one of the main business centers in the country and the technological
pole in Latin America, having two big universities – PUCC and UNICAMP. Campinas
also has some attractions well worth visiting, such as the Taquaral Park, Bosque dos
Jequitibás, Metropolitan Cathedral, and Carlos Gomes Square. In addition, there are
many restaurants offering a range of cuisines with local and international flavors,
as well as entertainment options including theater, movies and a rich nightlife with
different types of bars and night clubs.
Prof. Dr. Benito P. Damasceno
Chairman of the BCTRIMS 15th Annual Meeting
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ABOUT BCTRIMS
BRAZILIAN COMMITTEE FOR TREATMENT AND
RESEARCH IN MULTIPLE SCLEROSIS (BCTRIMS)
President
Marco Aurélio Lana-Peixoto
Secretary
Jefferson Becker
Treasurer
Dagoberto Callegaro
Steering Committee
Dagoberto Callegaro
Paulo Diniz da Gama
Marco Aurélio Lana-Peixoto
Angelina Martins Lino
Aílton Souza Melo
Rogério de Rizo Morales
Marcos Moreira
Fernando Coronetti Rocha
Jefferson Becker
Irênio Gomes
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THE ORIGINS OF BCTRIMS
A group of Brazilian neurologists gathered together for a scientific symposium in the city
of Botucatu, São Paulo state, on 28 August 1999. From this event emerged the foundation
of the Brazilian Committee for Treatment and Research in Multiple Sclerosis(BCTRIMS),
a national organization aimed at establishing a network of healthcare professionals
interested in the field of multiple sclerosis and other demyelinating disorders of the
central nervous system. Since its foundation, BCTRIMS has continued to grow, with
current membership exceeding 300 colleagues from around the country, representing
over 30 universities and medical schools in 22 Brazilian states.
BCTRIMS MISSION
The mission of BCTRIMS is to foster collaboration among clinicians and researchers
throughout Brazil in order to implement studies and educational activities on
multiplesclerosis and other demyelinating disorders of the central nervous system, as
well as to develop strategies to influence healthcare providers so that the most effective
actions for benefiting individuals affected by these diseases may be adopted.
BCTRIMS GOALS
• To elucidate the epidemiology, genetics and clinical features of MS and other
demyelinating diseases of the central nervous system in Brazil;
• To build a national MS registry and database;
• To build uniform protocols for research and stimulate cooperative studies in different
regions of the country;
• To publish consensuses and guidelines for diagnosis and treatment of MS and other
demyelinating disorders of the central nervous system;
• To promote continuing medical education activities;
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BCTRIMS 15th Annual Meeting
• To stimulate and support young researchers within the field of MS;
• To organize and promote BCTRIMS Annual Meetigs;
• To represent Brazilian MS researchers in similar international committees;
• To interact with similar organizations throughout the world, in order to exchange
experiences and promote collaborative actions;
• To assist and serve as a consultancy organization to Brazilian government agencies,
in order to formulate strategies for healthcare within the field of MS and other
demyelinating disorders of the central nervous system;
• To provide healthcare professionals and the lay community with information on MS
pathogenesis, diagnosis and treatment.
BCTRIMS ACHIEVEMENTS
The Brazilian Committee for Treatment and Research in Multiple Sclerosis has had
great success since it was established, and has achieved a number of noteworthy goals,
including:
• Meetings with government officials to implement policies for benefiting MS patients,
such as free disease-modifying therapy and multidisciplinary care;
• Assistance to government agencies in matters concerning evaluation of standards of
quality of care delivered by MS centers in Brazil;
• Publication of Guidelines on Treatment of Multiple Sclerosis;
• Promotion of BCTRIMS Annual Meetings since its foundation in 1999;
• Promotion of scientific symposia and other educational activities;
• Publication of “Fascículos de Esclerose Múltipla”;
• Stimulation and support for numerous scientific publications by its members in peerreviewed international medical journals;
• Creation of the BCTRIMS website: www.bctrims.org.br.
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COMMITTEES
BCTRIMS 15TH ANNUAL MEETING
Chairman
Benito Pereira Damasceno
Organizing Committee
Alfredo Damasceno
Alessandro Farias
Benito Pereira Damasceno
Dagoberto Callegaro
Jefferson Becker
Leonardo de Deus Silva
Leonilda M. B. Santos
Marco Aurélio Lana-Peixoto
Thiago de Faria Junqueira
Plataform Presentation Award Committee
Amit Bar-Or
Benito Pereira Damasceno
Marcelo Matiello
Miguel Angel Macias
Rosana H. Scola
Tanuja Chitnis
Tatsuro Misu
Poster Session Award Committee
Alfredo Dasmaceno
Irênio Gomes
Jefferson Becker
Leonilda M. B. Santos
Marcello Matiello
Maria Fernanda Mendes
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LIST OF CHAIPERSONS AND SPEAKERS
Aílton Melo
Salvador
Alessandro dos Santos Farias
Campinas
Alfredo Damasceno
Campinas
Amit Bar-Or
Canada
André L. Muniz Alves dos Santos
Salvador
André Palma da Cunha Matta
Rio de Janeiro
Benito Pereira Damasceno Campinas
Carlos Augusto de A. Damasceno
Juiz de Fora
Carlos Otávio Brandão
Campinas
Carolina de Medeiros Rimkus
São Paulo
Celso Luís Silva de Oliveira
Santos
Cristiane Franklin Rocha Belo Horizonte
Dagoberto Callegaro São Paulo
Dênis Bernardi Bichuetti
São Paulo
Denise Sisterolli DinizGoiânia
Doralina Guimarães Brum Souza
Ribeirão Preto
Douglas Kazutoshi Sato
Japan
Elizabeth Regina Comini Frota
Belo Horizonte
Emerson Leandro Gasparetto
Rio de Janeiro
Brasília
Ernane Maciel
Fabiana Christina Fernando
São Paulo
Felipe Von Glehn Silva
USA
Fernando Cendes
Campinas
Fernando Coronetti G. da Rocha
Botucatu
Fernando Faria Andrade Figueira
Rio de Janeiro
Heloísa Helena Ruocco
Campinas
Irênio Gomes
Porto Alegre
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Jefferson Becker
Porto Alegre
Juliana Machado S. S. Amaral
Belo Horizonte
Larissa Monteiro
Salvador
Leonardo de Deus Silva
Campinas
Leonardo Vedolin
Porto Alegre
Leonilda M. B. Santos
Campinas
Lineu Cesar Werneck
Curitiba
Marcelo Matiello
USA
Márcio Luiz Figueredo Balthazar
Campinas
Marco Aurélio Lana-Peixoto
Belo Horizonte
Marcus Vinícius Magno Gonçalves
Joinville
Maria Fernanda Mendes
São Paulo
Maria Kamimura
São Paulo
Maria Lúcia Brito Ferreira
Recife
Marlise de Castro Ribeiro Porto Alegre
Miguel Angel Macias
Mexico
Mônica Koncke Fiuza Parolin
Curitiba
Natalia Cirino Talim
Belo Horizonte
Uberlândia
Nívea de Macedo Oliveira Morales
Osvaldo J. M. do Nascimento
Rio de Janeiro
Paulo Diniz da Gama
Sorocaba
Ricardo Nitrini
São Paulo
Rodrigo G. Kleinpaul Vieira
Belo Horizonte
Rosana Hermínia Scola
Curitiba
Rogério Rizo de Morales
Uberlândia
Samira Apóstolos São Paulo
Tanuja Chitnis
USA
Tarso Adoni
São Paulo
Tatsuro Misu
Japan
Thiago de Faria Junqueira
Salvador
Wellington Mendes
São Paulo
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SCIENTIFIC PROGRAMME
WEDNESDAY, AUGUST 6
02:00 pm Opening Session
Benito Damasceno, Marco A. Lana-Peixoto, Jefferson Becker,
Dagoberto Callegaro
02:15 pm BCTRIMS Workshop on Clinical Research
Milestones in clinical research: From a good idea to paper publication
Part I: Chairpersons: Benito Damasceno, Lineu Werneck, Aílton Melo
Clinical Research in Brazil
Wellington Mendes
How to design a clinical research project
Fernandes Cendes
• How to transform an idea into a paper?
• The structure of a project
– Background
– What am I trying to show?
– How to show it?
– How to interpret it?
– What does it mean?
04:00 pm Coffee break
04:30 pm BCTRIMS Workshop on Clinical Research
Milestones in clinical research: From a good idea to paper publication
Part II: Chairpersons: Dagoberto Callegaro, André Palma Matta,
Natália Talim
How to deal with the regulatory issues in clinical research
Fabiana Cristina Fernando
• Plataforma Brasil
• The Local Ethical Committee
• ANVISA
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How to write and publish your paper: General rules
Maria Kamimura
• Start choosing an attractive title
• The Abstract is the final part
• Intoduction: Here you say WHY you did your work
• Methods: Say HOW you did it
• Results: Present WHAT you observed when you did it
• Discussion: Comment on how your observations are related with the current knowledge and in which aspects they change it.
• The art of choosing the key references and how to manage them
• Choose the most appropriate periodical to submit your paper: Impact Factor and H-Index
• How to submit your paper; The online techniques
• How to answer to Reviewers’ queries
THURSDAY, AUGUST 7
08:00 am Scientific Session:
Chairpersons: Leonardo de Deus, Carolina Rimkus, Samira Apóstolos
Conventional MRI and the diagnosis of MS: What changed after the 2010 revised criteria
Leonardo Vedolin
Monitoring MS therapy: The concept of sub-optimal response
Fernando Figueira
High-field and advanced MRI techniques in MS: Tips and pitfalls
Emerson Gasparetto
MRI and functional connectivity
Fernando Cendes
Comments
Carolina Rimkus
10:00 am Coffee break
10:20 am Aluízio Marques Lecture
Chairpersons: Alfredo Damasceno, Carlos Otávio Brandão, Thiago Junqueira
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Cognitive dysfunction in MS: Neuroscientific and neuropsychological basis of intervention
Benito Pereira Damasceno
11:00 am ACTRIMS Lecture
Chairpersons: Rosana Scola, Alessandro Farias, Denise Sisterolli
Emerging roles of B cells throughout the MS Spectrum
Amit Bar-Or (Canada)
11:30 am LACTRIMS Lecture
Chairpersons: Mônica Parolin, Marcus Vinícius Gonçalves, Ernane Maciel
Cognition in Latin American MS
Miguel Angel Macías (Mexico)
12:00 am GENZYME SYMPOSIUM
01:00 pm BIOGEN SYMPOSIUM
02:00 pm Scientific Session: Topics in Multiple Sclerosis
Chairpersons: Marcelo Matiello, Paulo Diniz da Gama, Fernando Coronetti
PL-001 – Prevalence of neuromyelitis optica in Belo Horizonte, Brazil
Authors: Anderson Silva, Gisele O. Lima, Diogo C. Carvalho, Tauana S.
Tironi, Izabela C. A. Duarte, Natália Cirino Talim, Lívia Edwiges Cirino
Talim, Juliana M. S. S. Amaral, Rodrigo Kleinpaul, Márcia Prates, Carolina
R. Araújo, Cristiane Franklin Rocha, Marco Aurélio Lana-Peixoto
Institutions: CIEM MS Research Center, Federal University of Minas Gerais
Medical School, Belo Horizonte, Minas Gerais, Brazil
PL-002 - Suboptimal response to therapy in disease-free MS patients:
A paradox?
Authors: Fernando Faria Andrade Figueira, Gustavo Medeiros Andrade
Figueira, Paula Vallegas Soares
Institutions: Hospital São Francisco, Rio de Janeiro, Brazil
PL-003 – The incidence of multiple sclerosis in Joinville, Brazil
Authors: Marcus Vinícius Magno Gonçalves, Norberto Luiz Cabral, Rafaela
Bitencourt Liberato, Juliana Antunes Safanelli, Alexandre Luiz Longo, Carla
Heloisa Cabral Moro
Institutions: Clínica Neurológica e Neurocirúrgica de Joinville, Santa
Catarina, Brazil
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PL-004 – Aquaporin 4 IgG assays in Brazilian patients with neuromyelitis
optica spectrum disorders
Authors: Frederico M. H. Jorge, Douglas Sato, Samira Apóstolos-Pereira,
Renata Simm, Paula Zago, Luana M. Oliveira, Gustavo Linhares, Dagoberto
Callegaro
Institutions: Hospital das Clinicas – FMUSP, São Paulo, Brazil
PL-005 – Brainstem symptoms during the first attack of neuromyelitis
optica spectrum disorders
Authors: Frederico M. H. Jorge, Douglas Sato, Renata Simm, Samira
Apóstolos-Pereira, Luana M. Oliveira, Mário L. R. Monteiro, Gustavo
Linhares, Paula Zago, Dagoberto Callegaro
Institutions: Hospital das Clinicas – FMUSP, São Paulo, Brazil
PL-006 – Cerebrospinal fluid aquaporin-4 antibody levels in neuromyelitis
optica attacks
Authors: Douglas Kazutoshi Sato, Dagoberto Callegaro, Frederico Haidar
Menucci Jorge, Ichiro Nakashima, Shuhei Nishiyama, Toshiyuki Takahashi,
Renata Faria Simm, Samira Luisa Apóstolos-Pereira, Tatsuro Misu,
Lawrence Steinman, Masashi Aoki, Kazuo Fujihara
Institutions: Stanford University, Estados Unidos; Tohoku University, Japan;
University of São Paulo, São Paulo, Brazil
PL-007 – Insulin resistance is correlated with disability in Neuromyelitis
optica
Authors: Wildea Lice Carvalho Jennings Pereira, Ana Paula Kallaur,
Sayonara Rangel Oliveira, Andrea N. C. Simão, Lucas J. Schiavão, Paula R.
V. P. Rodrigues, Edna M. V. Reiche, Damacio R. Kaimen-Maciel
Institutions: Universidade Estadual de Londrina, Paraná, Brazil
PL-008 – Pathologic yawning in neuromyelitis optica spectrum disorders
Authors: Marco Aurélio Lana-Peixoto, Dagoberto Callegaro, Natália Cirino
Talim, Lívia Edwiges Cirino Talim, Samira A. Pereira, Gilberto Belisário
Campos
Institutions: CIEM MS Research Center, Federal University of Minas Gerais
Medical School, Minas Gerais, Brazil; Department of Neurology, University
of São Paulo School of Medicine, São Paulo, Brazil
PL-009 – Properties of the research publications in neuromyelitis optica.
The use of the web of science database
Authors: Lívia Edwiges Cirino Talim, Natália Cirino Talim, Mariza C. T.
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Talim, Jane R. Guirado, Gisele O. Talim, Diogo C. Carvalho, Tauana S.
Tironi, Izabela C. A. Duarte, Anderson Silva, Rodrigo Kleinpaul, Márcia
Prates, Juliana M. S. S. Amaral, Carolina R. Araújo, Cristiane Franklin
Rocha, Marco Aurélio Lana-Peixoto
Institutions: CIEM MS Research Center, Federal University of Minas Gerais
Medical School, Belo Horizonte, Minas Gerais, Brazil
PL-010 – The growth rate of scientific publications in neuromyelitis optica
spectrum disorders
Authors: Gisele de Oliveira Lima, Natália Cirino Talim, Lívia E. C. Talim,
Rodrigo Kleinpaul, Márcia Prates, Diogo Couto de Carvalho, Tauana de
Sousa Tironi, Izabela C. A. Duarte, Anderson F. Silva, Mariza C. T. Talim,
Jane R. Guirado, Carolina Reis Araújo, Cristiane Franklin Rocha, Marco
Aurélio Lana-Peixoto
Institutions: CIEM MS Research Center, Federal University of Minas Gerais
Medical School, Belo Horizonte, Minas Gerais, Brazil
04:00 pm Coffee break
04:30 pm Scientific Session: Topics in Multiple Sclerosis
Chairpersons: Osvaldo Nascimento, Cristiane Franklin Rocha, Rogério de Rizo Morales
PL-011 – Clinical efficacy and safety of natalizumab in Brazilian patients
with multiple sclerosis
Authors: Renata Simm, Douglas Sato, Frederico M. H. Jorge, Samira
Apóstolos-Pereira, Mirella Fazzito, Gustavo Linhares, Luana M. Oliveira,
Dagoberto Callegaro
Institutions: Hospital das Clínicas (FMUSP), São Paulo, Brazil
PL-012 – How can we detect balance problems in multiple sclerosis
patients with low disability?
Authors: Bruna Antinori-Vignola, Cristiana Borges Pereira, Dagoberto
Callegaro
Institutions: University of São Paulo, São Paulo, Brazil
PL-013 – Activation of plasmacytoid dendritic cells in neuromyelitis optica
patients
Authors: Marília Domingues Andrade, Felipe Von Glehn, Alliny Carolina
Dionete, Adriel Santos Moraes, Carlos Otávio Brandão, Rafael P. C. D.
Carneiro, Alfredo Damasceno, Fernando Pradella, Guilherme A. D. Morais,
Paula Giovana Russini, Alessandro S. Farias, Benito P. Damasceno, Charles
P. Tilbery, Leonilda Maria Barbosa Santos
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Institutions: Universidade Estadual de Campinas (Unicamp), São Paulo,
Brazil
PL-014 – Administration of embryonic stem cells attenuates the
development of experimental autoimmune encephalomyelitis
Authors: Paula Giovana Russini, Talita Glaser, Rosemeire Florença de Paula,
Mariana Peres Almeida Santos, Fernando Pradella, Gleigy Ana Araújo Silva,
Elaine Conceição de Oliveira, Alessandro Santos Farias, Alexander Henning
Ulrich, Leonilda Maria Barbosa Santos
Institutions: Universidade Estadual de Campinas (Unicamp), São Paulo,
Brazil; Universidade Estadual de São Paulo (USP), São Paulo, Brazil
PL-015 – Correlation between serum markers and scores of disease
severity and fatigue in neurologically stable multiple sclerosis patients
under therapy with interferon beta-1a
Authors: Giordani Rodrigues Passos, Irênio Gomes, Adriana Gutterres
Pereira, André Palma da Cunha Matta, Bruna Schilling Panizzutti, Clarissa
Severino Gama, Flávio Pereira Kapczinski, Helena Fussiger, Juliana
Castilhos Beauvalet, Luciana Schermann Azambuja, Osvaldo Nascimento,
Jefferson Becker
Institutions: Antônio Pedro University Hospital – Federal Fluminense
University, Rio de Janeiro, Brazil; São Lucas Hospital – Pontifical Catholic
University of Rio Grande do Sul, Rio Grande do Sul, Brazil
PL-016 – Differential oxidative stress and cytokine profile between
progressive and relapsing-remitting multiple sclerosis patients
Authors: Ana Paula Kallaur, Sayonara Rangel Oliveira, Andrea Name
Colado, Helena Kaminami Morimoto, Daniele Frizon Alfieri, Paula Raquel
do Vale Pascoal Rodrigues, Lucas José Vaz Schiavão, Karimy Sayuri Nagata
Maekawa, Danilo Macedo Grotti, Douglas Francisco Rodrigues, Francieli
Delongui, Damácio Ramon Kaimen-Maciel, Edna Maria Vissoci Reiche
Institutions: State University of Londrina, Paraná, Brazil
PL-017 – Effect of type I interferon in the tolerogenic function
of plasmacytoid dendritic cells in experimental autoimmune
encephalomyelitis
Authors: Mariana Peres Almeida Santos, Ana Leda F. Longuini, Rosemeire
O. Paula, Paula G. Russini, Fernando Pradella, Adriel S. Moraes, Guilherme
A. D. Morais, Alessandro S. Farias, Leonilda M. B. Santos
Institutions: Universidade Estadual de Campinas (Unicamp), São Paulo,
Brazil
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PL-018 – Natalizumab increases hla-g expression in pdcs of multiple
sclerosis patients
Authors: Alliny Carolina Dionete, Adriel Santos Moraes, Marília Domingues
Andrade, Alfredo Damasceno, Felipe Von Glehn, Leonilda Maria Barbosa
Santos
Institutions: Unicamp, São Paulo, Brazil
PL-019 – Respiratory impairment is associated with fatigue in patients
with relapsing-remitting multiple sclerosis
Authors: Fernanda Machado Taveira, Renan Barros Domingues, Antônio
Lúcio Teixeira Júnior
Institutions: Federal University of Minas Gerais (UFMG), Minas Gerais,
Brazil
PL-020 – Tumor necrosis factor beta (TNFB) NcoI polymorphism is
associated with serum cytokine and adiponectin levels in relapsingremitting multiple sclerosis patients
Authors: Ana Paula Kallaur, Sayonara Rangel Oliveira, Andrea Name
Colado Simão, Helena Kaminami Morimoto, Daniele Frizon Alfieri, Wildea
Lice de Carvalho Jennings Pereira, Paula Raquel do Vale Pascoal Rodrigues,
Lucas José Vaz Schiavão, Karimy Sayuri Nagata Maekawa, Danilo Macedo
Grotti, Douglas Francisco Rodrigues, Damácio Ramon Kaimen-Maciel, Edna
Maria Vissoci Reiche
Institutions: State University of Londrina, Paraná, Brazil
08:00 pmGala Dinner
friday, AUGUST 8
08:00 am Poster Session: Presentation and discussion
Epidemiology and MRI
Panel 1: Alfredo Damasceno, Carolina Rimkus, Fernando Figueira,
Leandro Lucatto, Aílton Melo
Immunology and basic science of MS
Panel 2: Amit Bar-Or, Leonilda M.B. Santos, Alessandro Farias,
Elizabeth Comini Frota
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NMO, ADEM, CIS
Panel 3: Tanuja Chitnis, Tatsuro Misu, Marcelo Matiello, Lineu César
Werneck
MS treatment and multidisciplinary care
Panel 4: Maria Fernanda Mendes, Larissa Monteiro, Heloísa H. Ruocco, Tarso Adoni
10:00 am Coffee break
10:20 am Top 10 of the Year: How the best papers impact our practice
Jefferson Becker, Dênis Bichuetti
Panel: Tatsuro Misu, Amit Bar-Or, Tanuja Chitnis, Alfredo Damasceno
12:00 am NOVARTIS SYMPOSIUM
01:00 pm NOVARTIS SYMPOSIUM
02:00 pm Scientific Session: Devic’s neuromyelitis optica
Chairpersons: Dagoberto Callegaro, Marcelo Matiello, Rodrigo Kleinpaul
Pathology of NMO spectrum disorders
Tatsuro Misu (Japan)
What does MOG-IgG in NMO patients mean?
Douglas Sato (Japan)
The International Diagnostic Criteria for NMO spectrum disorders
Marco A. Lana-Peixoto
Diagnosis and management of pediatric NMO
Tanuja Chitnis (USA)
Comments and discussion
Marcelo Matiello (USA)
04:00 pm Coffee break
04:30 pm Awards Presenting Session
Chairpersons: Benito Pereira Dasmaceno, Marco A. Peixoto-Lana, Jefferson Becker, Leonilda M. B. Santos
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BCTRIMS – Aluízio Marques Award
BCTRIMS – Roberto Melaragno Filho Award
BCTRIMS – Gilberto Belisário Campos Young Investigator Award
BCTRIMS – Genzyme Award for Excellence in Scientific Production
04:40 pm Scientific Session: Cognitive dysfunction in Multiple Sclerosis
Chairpersons: André Muniz, Maria Lúcia Brito, Marlise de Castro Ribeiro
Cognitive dysfunction in MS: methodological issues and measurement with current and future batteries.
Benito Pereira Damasceno
MRI predictors of cognitive dysfunction
Alfredo Damasceno
Cognitive reserve as a protective factor
Ricardo Nitrini
Comments and discussion
Márcio Luiz Figueredo Balthazar
saturday, AUGUST 9
08:00 am Scientific Session: What is new in immunology of demyelinating diseases of the CNS
Chairpersons: Carlos Augusto Damasceno, Celso Luis Silva de Oliveira, Juliana Santiago Amaral
Plasmocytoid dendritric cellls in multiple sclerosis
Leonilda M. B. Santos
Immunomodulatory Effect of vitamin D3
Alessandro dos Santos Farias
CSF Oligoclonal Bands Disappearance: How could it impact MS brain cortical layer atrophy?
Felipe von Glehn
10:00 am 6th BCTRIMS Colloquium on MS and NMO Research
Irênio Gomes, Jefferson Becker, Dagoberto Callegaro,
Marco A. Lana-Peixoto, Doralina Brun
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• Works in Progress
1. Vitamin D in multiple sclerosis: A Brazilian Study
2. Studies in regulatory proceedings
• Call for New Studies
1. Cognition in Mutiple Sclerosis. A Multicenter Brazilian Study
Alfredo Damasceno
2. Brazilian Protocol for MRI Study in Demyelinating Diseases of the Central Nervous System
Carolina Rimkus, Fernando Figueira, Emerson Gasparetto, Leonardo Vedolin
11:00 am BCTRIMS Multicentric Research Groups Meeting
• MS Epidemiology Study Group – Marco A. Lana-Peixoto
• NMO in Children – André Palma Matta
• Vitamin D Study Group – Dagoberto Callegaro
• Pediatric MS Study Group – Nívea de Macedo O. Morales
• Neuroradiology Study Group – Carolina Rimkus
• Cognition Study Group – Benito Pereira Damasceno
12:00 am Closing Session and Invitation for the BCTRIMS 16th Annual Meeting 2015
Benito Pereira Damasceno, Marco A. Lana-Peixoto, Dagoberto Callegaro, Jefferson Becker, Irênio Gomes
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AWARDS
BCTRIMS – Aluízio Marques Award
The Aluízio Marques Award is given to the best poster presented at the BCTRIMS
Annual Meeting.
Multiple sclerosis was first described in Latin America by Aluízio Marques, in 1923. At
the time Marques a young medical student at University of Brazil, in Rio de Janeiro.
During his vacations and a visit to a hospital ward in Recife, where his uncle Juan
Marques delivered medical care and taught Internal Medicine, he observed a patient
with spastic paralysis, nystagmus, and intention tremor, the characteristics clinical triad
of the disease, as he had learned from Charcot’s writings.
His observations were then published in Jornal de Medicina, in Pernambuco. With a
special interest in disease of the central nervous system Aluízio Marques made a lot of
important contributions to Brazilian neurology. In 1943 he described the first cases of
Devic’s neuromyelitis optica in Latin America.
Bctrims – Roberto Melaragno Filho Award
The Roberto Melaragno Filho Award is given to the best poster for Multidisciplinary
Care presented at the BCTRIMS Annual Meeting.
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Roberto Melaragno Filho graduated from the School of Medicine of the University
of São Paulo in 1942, before joining the Neurology Department at the university the
following year as a Volunteer Assistant.
He later went on to Paris, where he trained extensively in neurology under Professor
Raymond Garcin. In 1963, upon his return to Brazil, he founded the Neurology
Department at the São Paulo State Hospital, where he remained as Chairman until his
retirement in 1989.
During this time, he received countless accolades for his work there from all over the
country, and he spent much of his time giving lectures and disseminating knowledge
to fellow physicians regarding the art of diagnosing and treating MS and other
demyelinating disorders of the central nervous system. He was a founding member of
the Brazilian Academy of Neurology and helped establish the Brazilian Association of
Multiple Sclerosis (ABEM), as well as being a member of many editorial boards. He was
the author of numerous scientific papers and, in addition, published several neurology
textbooks and a book aimed at MS patients. Professor Melaragno gained many awards
over the course of his lifetime and it is with great honor and respect that the BCTRIMS
dedicate this most celebrated award in his memory.
Bctrims – Gilberto Belisário Campos Young
Investigator Award
The Gilberto Belisário Campos Young Investigator Award is a research incentive prize
given to the best platform presentation made at the BCTRIMS Annual Meeting.
This award is offered by BCTRIMS, in collaboration with Novartis, and comprises of a
diploma and sponsorship to annual the ACTRIMS/ECTRIMS Meeting.
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BCTRIMS 15th Annual Meeting
Gilberto Belisário Campos graduated from the School of Medicine at the Federal
University of Minas Gerais (Universidade Federal de Minas Gerais - UFMG) in 1958, and
subsequently pursued his training there in neurology and neurosurgery at the Hospital
das Clínicas, UFMG. In 1959, he continued his studies at the University of Wisconsin,
USA, where he graduated in basic neurological sciences, under the supervision of C.
Woolsey, F. Forster and M. Javid. Together with C. Woolsey and W. I. Welker, he
went on to conduct several prominent researches, nowadays considered classics, related
to comparative studies of the organization of sensory and motor areas (mapping) by
anatomical and electrophysiological methods, involving various animal species.
He returned to Brazil in late 1963, where he began academic activities in the Neurology
Department of the School of Medicine, UFMG. Gilberto Belisário Campos was
responsible for the beginning of comparative experimental neurophysiological research
within Brazil. He retired in 1991, and in 1997 he was elected Professor Emeritus at
the School of Medicine of the Federal University of Minas Gerais. BCTRIMS is deeply
honored to dedicate this award to his memory.
Bctrims – Genzyme Award for Excellence in Scientific
Production
Unrestricted educational grant given to the MS Center that presents the highest number
of works at the Meeting.
BCTRIMS 15th Annual Meeting
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INSTRUCTIONS FOR POSTER PRESENTERS
The following information is intended to guide poster presenters for the Poster Discussion
Session which will be held on August 8 at 8:00 am. Each Poster will be discussed by
a Panel of Experts following its presentation by one of its authors. Questions by the
audience may follow.
As a poster presenter, please pay attention to the following requirements:
• You must disclose any financial interest that you (or your spouse/partner) may have
with a commercial company or the manufacturer of any commercial product/service
that may influence your presentation;
• Present your message objectively, spending no longer than 3 minutes;
• Emphasize the objectives;
• Do not detail the methodology;
• Summarize the results;
• Emphasize the conclusions;
• Answer the questions from the Panel and the audience cordially.
INSTRUCTIONS FOR SPEAKERS
The following information is intended to guide speakers towards developing their
presentations. As a member of our faculty, you must meet some requirements.
Please pay attention to the following:
• You must disclose any financial interest that you (or your spouse/partner) may have
with a commercial company or the manufacturer of any commercial product/service
that may influence your presentation;
• Make sure that your objectives and message are appropriate for the audience;
• Emphasize the points that you wish the audience to take away with them;
• Ensure that your visual aids will not overwhelm the audience or take their attention
away from your core message;
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BCTRIMS 15th Annual Meeting
• Try not to read from your slides; speak conversationally;
• Align your message according to the available time. You should estimate that it will
take you approximately a minute to discuss each slide;
• A 5-minute time at the end of each presentation is reserved for discussion;
• Invite the audience to ask you questions. Answer them cordially.
GENERAL INFORMATION
Abstracts – Abstracts of all posters accepted for presentation are published in English
in the Arquivos de Neuro-Psiquiatria, the Official Journal of the Brazilian Academy of
Neurology.
Language – English and Portuguese are the official languages of the congress. All
posters and PowerPoint slides will be presented in English. Oral presentations may
be presented either in Portuguese or in English. Simultaneous translation is not
available.
Meals – The registration fee includes coffee breaks, lunch box (first come, first served)
and admission to the Gala Dinner.
Mobile phones – The Organizing Committee kindly requests that participants should
turn cellular devices and pagers to vibration mode upon entering official program
sessions, satellite symposia, exhibits and social functions.
No Smoking – Smoking is prohibited in the scientific sessions, exhibitions and Gala
Dinner.
Speaker’s Service Center (SSC) – A Speaker’s Service Center (SSC) is available
for convenience. All speakers are kindly requested to hand in their PowerPoint
presentations at the SSC at least 2 hours before their lecture.
Tourist Information – The tourist information desk, which is located next to the Congress
Secretariat, will be available to help you to book tour tickets or make restaurant
reservations, or to assist you in any other way.
BCTRIMS 15th Annual Meeting
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SOCIAL EVENT
Gala Dinner
Thursday, August 7 – Time: 8:00 pm
Royal Palm Plaza – Hibisco Room
VENUE
Royal Palm Plaza
Av. Royal Palm Plaza, 277 – Jardim Nova Califórnia, Campinas, SP
Phone: + 55 19 2117-8002 | www.royalpalm.com.br
SECRETARIAT
Fernanda Prestes Gerenciamento de Eventos Ltda.
Phone: +55 11 5081-8028
www.fernandapresteseventos.com.br
[email protected]
TRAVEL AGENCY
Flytour American Express – Unidade Chácara Santo Antônio
Tel.: + 55 11 5189-4104 – Fax.: + 55 11 5189-4109
www.flytour.com.br
[email protected]
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BCTRIMS 15th Annual Meeting
campinas
Located in the northeastern region of São Paulo State, Campinas was founded in
1774 initially as a simple outpost on the way to Minas Gerais and Goiás serving the
“Bandeirantes” who were in search of precious minerals.
In the first half of the 19th century, Campinas became a growing population center
with many coffee, cotton and sugarcane farms.
The construction of a railway linking the city to São Paulo and Santos seaport in 1867
was very important for its growth. In the second half of the 19th century following the
abolition of slavery, farming and industrialization attracted many foreign immigrants,
mainly from Italy, to replace the lost manpower.
Coffee became an important export and the city became wealthy. As a consequence,
a large service sector was established to attend the needs of the growing population,
and in the first decades of the 20th century, Campinas could already boast an opera
house, theaters, banks, movie theaters, radio stations, a philharmonic orchestra,
newspapers, a good public education system, hospitals, and important research
centers.
The state of São Paulo gained much of its wealth during the days of the coffee boom
when it was one of the largest exporters of coffee beans, making coffee plantations an
integral part of São Paulo’s history.
METROPOLITAN CATHEDRAL OF CAMPINAS
– Dedicated to Our Lady of the Conception,
the church originates from 1883. It has a
construction style of rammed-earth walls and an
interior full of wood sculptures and carvings
BOSQUE JEQUITIBÁS – The park is an area of
preserved natural woodland in the midst of the
city. On offer to visitors are a mini-zoo, Museum
of Natural History, aquarium and an interesting
animal house
BCTRIMS 15th Annual Meeting
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The construction of the first Brazilian highway in 1938, between Campinas and São
Paulo, the Anhanguera Highway, was a turning point in the integration of Campinas
into the rest of the state.
Nowadays, Campinas is a city that impresses visitors with its indicators of quality of
life and growth potential. Despite being modern, Campinas still maintains traits of a
rich history built mainly by the importance of the coffee economy in the 19th and 20th
centuries.
It is rich in historical, cultural and scientific attractions. The technological and scientific
production is well-known worldwide. This makes the city one of the 40 main centers
of high technology in the world.
One of the centers of excellence that was created as a response to the growing
demand for qualified personnel in this region is UNICAMP – Universidade Estadual
de Campinas – that was officially founded in 1966 and developed a strong tradition
in education, research and services to society. UNICAMP has three campuses – in
Campinas, Piracicaba and Limeira – which are home to 22 teaching and research
centers. It also has a vast hospital complex (two large hospitals in Campinas, and one
in each of the neighboring towns of Sumaré and Hortolândia); 23 interdisciplinary
centers; two technical high schools; and a series of support units for around 50
thousand people within an environment in which thousands of research projects are
carried out.
PREPARATORY SCHOOL OF ARMY CADETS – Transferred to Campinas in 1959, the school houses in its
Great Events Hall an invaluable city collection of chandeliers from the old municipal theatre
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BCTRIMS 15th Annual Meeting
Campinas was the birthplace of opera
composer Carlos Gomes (1836-1896)
and of the President of the Republic
Campos Salles (1841-1913).
The city provides a rich cultural
setting with numerous attractions of
interest, including:
COFFEE MUSEUM – Located in an old farm of the Brazilian
Coffee Institute (Instituto Brasileiro do Café - IBC), within
the Parque do Café in Campinas. It has a rich collection
related to the coffee growing history of the region
• Parque do Taquaral – home to a
lake, amphitheater and planetarium
• Largo do Café – home to the
Museu do Café (Coffee Museum)
• Monsenhor Emílio José Salim
Ecological Park – home to a
museum, trails and sports facilities
• Bosque dos Jequitibás – forest
reserve with a zoo, museum and
ranch house
• Castro Mendes Theater (Teatro
Castro Mendes)
• Museum of the Old Railway Station
CAMPINAS ECOLOGICAL PARK – This 110 hectare
area of an old farm called Mato Dentro is home to the
Emílio José Salim Ecological Park, opened in 1987 to
restore and preserve the local architectural and ecological
environment
• Arena Theatre
• Hopi Hari Amusement Park
• Capricorn Observatory
(Observatório de Capricórnio)
• Metropolitan Cathedral
• Central Market (Mercadão)
• Numerous shopping malls, including
Campinas Shopping, Shopping
Iguatemi and Shopping Parque
Dom Pedro
CARLOS GOMES MUSEUM – Integrated with the Center
of Sciences, Arts and Letters, the museum includes in its
collection personal objects, the piano, instruments and
various possessions of the composer Carlos Gomes
Photos: C&VB. Author: Rubens Chiri.
BCTRIMS 15th Annual Meeting
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BCTRIMS 15th Annual Meeting
POSTERS
Epidemiology and MRI
PO-001 – APPLYING SINGLE PHOTON EMISSION TOMOGRAPHY (SPECT) ON THE
STUDY OF COGNITIVE DISORDERS IN MS PATIENTS
Authors: Henrique Cal, Osvaldo J. M. Nascimento, André P. C. Matta, João G. D.
Farinhas, Caroline Bittar, Manuela Bezerra, Carlos Bruno Nogueira, Felipe S. L.
Vianna, Lígia Andrade
Institutions: Universidade Federal Fluminense, Rio de Janeiro, Brazil.
PO-002 – NATALIZUMAB TREATED PATIENT PROFILE IN HOSPITAL GERAL DE
FORTALEZA - HGF: A REFERENCE CENTER FOR MULTIPLE SCLEROSIS TREATMENT
Authors: José Artur Costa d’Almeida, Patrícia Chagas Rocha d’Almeida, Nair Antônia
Assunta Corso, Maria Luiza Pereira de Melo, Gabriela Joca Martins, Ivna Lacerda
Pereira Nóbrega, Heitor Dourado, David Guerreiro Ferreira
Institutions: Hospital Geral de Fortaleza, Ceará, Brazil.
PO-003 – Primary progressive multiple sclerosis: Epidemiological
findings in brazilian patients
Authors: Luana Michelli Oliveira, Samira Apóstolos-Pereira, Dagoberto Callegaro,
Frederico M. H. Jorge, Gustavo Emílio Linhares Souza, Renata Faria Simm, Lucas
Silvestre Mendes
Institutions: Faculdade de Medicina da Universidade de São Paulo (FMUSP),
São Paulo, Brazil.
PO-004 – REVISITING MRI CRITERIA FOR DEMYELINATING DISEASES DISCUSSING
THE IMPLICATIONS FOR LATIN AMERICAN POPULATIONS
Authors: Carolina de Medeiros Rimkus, Dagoberto Callegaro, Cláudia da Costa Leite
BCTRIMS 15th Annual Meeting
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Institutions: Department of Neurology, Hospital das Clínicas, Faculdade de Medicina
da Universidade de São Paulo (FMUSP), São Paulo, Brasil; Department of Radiology,
Laboratory of Medical Investigation (LIM-44), Faculdade de Medicina da Universidade
de São Paulo (FMUSP), São Paulo, Brazil.
PO-005 – THE PRESENT ROLE OF ADVANCED MAGNETIC RESONANCE IMAGING
IN THE DIAGNOSIS OF DEMYELINATING DISEASES
Authors: Carolina de Medeiros Rimkus, Dagoberto Callegaro, Cláudia da Costa Leite
Institutions: Department of Neurology, Clinical Hospital, Faculdade de Medicina da
Universidade de São Paulo (FMUSP), São Paulo, Brasil; Department of Radiology,
Laboratory of Medical Investigation (LIM-44), Faculdade de Medicina da Universidade
de São Paulo (FMUSP), São Paulo, Brazil.
PO-006 – The prevalence of antibodies against JC virus in Brazilian
patients with multiple sclerosis
Authors: Renata Simm, Douglas Sato, Frederico M. H. Jorge, Lucas Silvestre, Gustavo
Linhares, Samira Apóstolos-Pereira, Dagoberto Callegaro
Institutions: Hospital da Clínicas (FMUSP), São Paulo, Brazil.
PO-007 – The prevalence of multiple sclerosis in Joinville, Brazil
Authors: Rafaela Bitencourt Liberato
Institutions: Clínica Neurológica e Neurocirúrgica de Joinville, Santa Catarina, Brazil.
Immunology, basic science and clinical findings
PO-008 – Correlation between serum S100β and BDNF and scores of
cognition, depression and anxiety in neurologically stable multiple
sclerosis patients under therapy with interferon β-1a
Authors: Giordani Rodrigues Passos, Jefferson Becker, Osvaldo Nascimento,
Luciana Schermann Azambuja, Juliana Castilhos Beauvalet, Helena Fussiger, Flávio
Kapczinski, Clarissa Severino Gama, Bruna Schilling Panizzutti, André Palma da
Cunha Matta, Adriana Gutterres Pereira, Irênio Gomes
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BCTRIMS 15th Annual Meeting
Institutions: São Lucas Hospital – Pontifical Catholic University of Rio Grande do Sul,
Rio Grande do Sul, Brazil.
PO-009 – Correlation between vitamin D and the Expanded Disability
Status Scale in patients with multiple sclerosis: role of the
oxidative stress
Authors: Sayonara Rangel Oliveira, Ana Paula Kallaur, Andrea Name Colado Simão,
DamÁcio Ramon Kaimen-Maciel, Douglas Francisco de Carvalho Rodrigues, Wildea
Lice de Carvalho Jennings Pereira, Paula Raquel do Vale Pascoal Rodrigues, Lucas
José Vaz Schiavão, Edna Maria Vissoci Reiche
Institutions: Universidade Estadual de Londrina, Paraná, Brazil.
PO-010 – Effect of the immunomodulators on B lymphocytes and
plasmacytoid dendritic cells from patients with multiple sclerosis
Authors: Adriel Santos Moraes, Alliny Carolina DIonetti, Marília Domingos Andrade,
Ana Leda Figueiredo Longhini, Felipe Von Glehn, Alfredo Damasceno, Benito Pereira
Damasceno, Alessandro Santos Farias, Juliana Amm, Rafael P. Carneiro, Charles P.
Tilbery, Leonilda Maria Barbosa Santos
Institutions: Unicamp, São Paulo, Brazil.
PO-011 – Increased levels of IFN-g and decreased levels of IL-4 are
associated with disturbance in pyramidal functional system in
multiple sclerosis patients
Authors: Ana Paula Kallaur, Sayonara Rangel Oliveira, Andréa Name Colado Simão,
Michael Maes, Helena Kaminami Morimoto, Daniele Frizon Alfieri, Josiane Lopes,
Wildea Lice de Carvalho Jennings Pereira, Paula Raquel do Vale Pascoal Rodrigues,
Lucas José Vaz Schiavão, Edna Maria Vissoci Reiche, Douglas Francisco Rodrigues,
Felipe Inácio Ferreira da Silva, Karimy Sayuri Nagata Maekawa, Danilo Macedo Grotti
Institutions: Universidade Estadual de Londrina, Paraná, Brazil.
PO-012 – Neuropathic Pain in Multiple Sclerosis: A Contact Heat
Evoked Potential Stimulator (CHEPS) Evaluation
Authors: Victor Kosac, Osvaldo J. M. Nascimento, Andre P. C. Matta, Camila Pupe,
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Eduardo Davidovich, João G. D. Farinhas, Caroline Bittar, Felipe Vianna, Frederico
Prado, Bruno Coutinho, Carlos Bruno Nogueira, Ligia Andrade, Karina Lebeis
Institutions: Universidade Federal Fluminense, Rio de Janeiro, Brazil.
PO-013 – Pain Profile in Multiple Sclerosis patients
Authors: André P. C. Matta, Osvaldo José Nascimento, José Vinícius Martins da Silva,
João Gabriel Dib Farinhas, Mariana Ferreira Xavier, Raquel Custódio da Silveira,
Lucas Senra Corrêa Carvalho, Bruno da Silva Moraes, Manuela Bezarra de Carvalho
Institutions: Hospital Universitário Antônio Pedro, Rio de Janeiro, Brazil.
PO-014 – Relationship between temporomandibular disorders (TMD)
and multiple sclerosis (MS)
Authors: Lucas Senra Corrêa Carvalho, André Palma Cunha Matta, Osvaldo José
Moreira Nascimento, Jose Vinícius M. Silva, João Gabriel Dib Farinhas, Manuela
Bezerra Carvalho, Bruno Silva Moraes, Henrique Sá Rodrigues Cal
Institutions: Universidade Federal Fluminense, Rio de Janeiro, Brazil.
PO-015 – Serum markers and symptoms of depression and anxiety in
neurologically stable multiple sclerosis patients under therapy
with interferon beta-1a
Authors: Giordani Rodrigues Passos, Irênio Gomes, Adriana Gutterres Pereira, André
Palma da Cunha Matta, Bruna Schilling Panizzutti, Clarissa Severino Gama, Flávio
Pereira Kapczinski, Helena Fussiger, Juliana Castilhos Beauvalet, Luciana Schermann
Azambuja, Osvaldo Nascimento, Jefferson Becker
Institutions: Antônio Pedro Hospital, Federal Fluminense University, Rio de Janeiro,
Brazil; São Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul, Brazil.
PO-016 – Temporomandibular disorders (TMD) symptoms in multiple
sclerosis (MS) patients
Authors: Lucas Senra Corrêa Carvalho, André Palma Cunha Matta, Osvaldo José
Moreira Nascimento, Jose Vinícius M. Silva, João Gabriel Dib Farinhas, Manuela
Bezerra Carvalho, Bruno Silva Moraes, Henrique Sá Rodrigues Cal
Institutions: Universidade Federal Fluminense, Rio de Janeiro, Brazil.
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BCTRIMS 15th Annual Meeting
MS treatment and multidisciplinary care
PO-017 – CENTRAL PAIN IN LONGITUDINALLY EXTENSIVE TRANSVERSE MYELITIS
WITH NO BRAIN LESIONS: CLINICAL CHARACTERIZATION OF PAIN SYNDROMES
Authors: Fernanda Valerio da Silva, Samira Luiza Apóstolos-Pereira, Diego Toledo
Rodrigues, Ricardo Galhardoni, Ediane Arimateia Silva, Vinícius A. Anjos, Antônia L.
Rodrigues, Manoel Jacobsen Teixeira, Daniel Ciampi Andrade
Institutions: Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
PO-018 – GASTRIC ADENOCARCINOMA DURING LONG-TERM EXPOSURE TO
GLATIRAMER ACETATE THERAPY FOR MULTIPLE SCLEROSIS. A CASE REPORT
Authors: Rodrigo Kleinpaul, Juliana M. S. S. Amaral, Natália C. Talim, Lívia E. Talim,
Márcia Prates, Carolina R. Araujo, Cristiane F. Rocha, Marco Aurélio Lana-Peixoto
Institutions: CIEM MS Research Center, Federal University of Minas Gerais Medical
School, Minas Gerais, Brazil.
PO-019 – Interferon and glatiramer acetate are associated with
decreased tumor necrosis factor alpha and increased interleukin 4
in multiple sclerosis patients
Authors: Ana Paula Kallaur, Sayonara Rangel Oliveira, Andrea Name Colado Simão,
Michael Maes, Helena Kaminami Morimoto, Daniele Frizon Alfieri, Wildea Lice de
Carvalho Jennings Pereira, Paula Raquel do Vale Pascoal Rodrigues, Lucas José Vaz
Schiavão, Douglas Francisco Schiavão, Karimy Sayuri Nagata Maekawa, Felipe Inácio
Ferreira da Silva, Damácio Ramon Kaimen-Maciel, Edna Maria Vissoci Reiche
Institutions: Universidade Estadual de Londrina, Paraná, Brazil.
PO-020 – Nursing Care in Multiple Sclerosis Clinic in Joinville / SC:
reducing the time of initiation of treatment after diagnosis
Authors: Rafaela Bitencourt Liberato, Juliana Antunes Safanelli, Francielly Kleine
Maria Amorim
Institutions: Clínica Neurológica e Neurocirúrgica de Joinville, Santa Catarina, Brazil.
BCTRIMS 15th Annual Meeting
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PO-021 – PAPILLARY THYROID CARCINOMA IN THE COURSE OF INTERFERON
BETA THERAPY FOR MULTIPLE SCLEROSIS
Authors: Rodrigo Kleinpaul, Juliana Machado Santiago Amaral, Livia Talim, Carolina
Araújo, Márcia Prates, Natália Talim, Marco Aurélio Lana-Peixoto
Institutions: CIEM MS Research Center, Federal University of Minas Gerais Medical
School, Belo Horizonte, Minas Gerais, Brazil.
PO-022 – Posturography for early detection of low-level disabilities
underestimated by the Expanded Disability Status Scale (EDSS)
Authors: Bruna Antinori-Vignola, Cristiana Borges Pereira, Dagoberto Callegaro
Institutions: Universidade de São Paulo, São Paulo, Brazil.
PO-023 – PREDICTION OF FALLS IN PATIENTS WITH RELAPSING REMITTING
MULTIPLE SCLEROSIS
Authors: Buno da Silva Moraes, André Palma Matta, Osvaldo J. M. Nascimento, João
Gabiel Dib Farinhas, Manuela Bezerra Carvalho, Henrique Sá Rodrigues Cal, José
Vinícius Martins, Lucas Senra Corrêa Carvalho, Raquel Custódio Silveira
Institutions: Universidade Federal Fluminense, Rio de Janeiro, Brazil.
PO-024 – STUDY OF THE HIPPOCAMPUS OF EARLY MULTIPLE SCLEROSIS
PATIENTS USING PROTON MAGNETIC RESONANCE SPECTROSCOPY
Authors: Thiago de F. Junqueira, Carolina M. Rimkus, Maria C. G. Otaduy, Cláudia
C. Leite, Melissa A. R. Machado, Eliane C. Miotto, Míriam H. Tsunemi, Dagoberto
Callegaro
Institutions: Department of Biostatistics, Botucatu Institute of Biosciences (UNESP), São
Paulo, Brazil; Department of Neurology, University of São Paulo Medical School, São
Paulo, Brazil; Department of Radiology, University of São Paulo Medical School, São Paulo,
Brazil; Division of Psychology, University of São Paulo Medical School, São Paulo, Brazil.
PO-025 – The treatment of multiple sclerosis after natalizumab
Authors: Renata Simm, Douglas Sato, Frederico M. H. Jorge, Samira ApóstolosPereira, Paula Zago, Dagoberto Callegaro
Institutions: Hospital das Clínicas (FMUSP), São Paulo, Brazil.
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BCTRIMS 15th Annual Meeting
NMO, ADEM and CIS
PO-026 - ANTI-AQP4 SEROPOSITIVE NEUROMYELITIS OPTICA ASSOCIATED
WITH MULTIPLE AUTOIMMUNE DISORDERS: 40 RELAPSES IN A 29-YEAR
FOLLOW-UP
Authors: Tauana de Sousa Tironi, Diogo Couto de Carvalho, Izabela C. A. Duarte,
Natália Cirino Talim, Lívia Edwiges Cirino Talim, Anderson Silva, Gisele de Oliveira
Lima, Juliana M. S. S. Amaral, Márcia Prates, Rodrigo Kleinpaul, Carolina dos Reis
Araújo, Cristiane Franklin Rocha, Marco Aurélio Lana-Peixoto
Institutions: Centro de Investigação em Esclerose Múltipla De Minas Gerais – CIEM,
Belo Horizonte, Minas Gerais, Brazil.
PO-027 – Aquaporin-4 antibody-positive myelitis initially biopsied due
to suspected spinal cord tumors: diagnostic considerations
Authors: Douglas Kazutoshi Sato, Tatsuro Misu, Cristiane Franklin Rocha, Dagoberto
Callegaro, Ichiro Nakashima, Masashi Aoki, Kazuo Fujihara, Marco Aurélio Lana-Peixoto
Institutions: Federal University of Minas Gerais, Minas Gerais, Brazil; Tohoku University
School of Medicine, Japan; University of São Paulo, São Paulo, Brazil.
PO-028 – Clinical phenotypes and age in neuromyelitis optica
spectrum disorders
Authors: Paula Zago Melo, Samira Apóstolos-Pereira, Frederico Haidar Jorge, Renata
Faria Simm, Dagoberto Callegaro, Douglas Kazutoshi Sato
Institutions: Hospital das Clínicas, University of São Paulo, Sao Paulo, Brazil.
PO-029 – Conversion of Clinical Isolated Syndrome (CIS) for multiple
sclerosis: report of four years of monitoring
Authors: Rafaela Bitencourt Liberato, Juliana Antunes Safanelli, Norberto Luiz Cabral,
Marcus Vinícius Magno Gonçalves, Alexandre Luiz Longo, Carla Heloísa Cabral Moro
Institutions: Clínica Neurológica e Neurocirúrgica de Joinville, Santa Catarina, Brazil.
BCTRIMS 15th Annual Meeting
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PO-030 – DENGUE FEVER-ASSOCIATED NEUROMYELITIS OPTICA SPECTRUM
DISORDER
Authors: Juliana M. S. S. Amaral, Natália Cirino Talim, Lívia Edwiges Cirino Talim,
Márcia Prates, Rodrigo Kleinpaul, Carolina R. Araújo, Cristiane Franklin Rocha, Kazuo
Fujihara, Douglas Sato, Marco Aurélio Lana-Peixoto
Institutions: CIEM MS Research Center, Federal University of Minas Gerais Medical
School, Belo Horizonte, Minas Gerais, Brazil; Tohoku University, Sendai, Japan.
PO-031 – FREQUENCY OF AUTOIMMUNE DISEASES AND AUTOANTIBODIES IN
PATIENTS WITH NEUROMYELITIS OPTICA
Authors: Wildea Lice Carvalho Jennings Pereira, Ana Paula Kallaur, Sayonara Rangel
Oliveira, Andrea N. C. Simão, Lucas J. V. Schiavão, Paula R. V. P. Rodrigues, Francieli
Delongui, Daniele F. Alfieri, Karimy S. N. Maekawa, Danilo M. Grotti, Edna M. V.
Reiche, Damácio R. Kaimen-Maciel
Institutions: Universidade Estadual de Londrina, Paraná, Brazil.
PO-032 – ISOLATED BRAINSTEM SYNDROME AS THE SOLE MANIFESTATION OF
NEUROMYELITIS OPTICA SPECTRUM DISORDER
Authors: Natália Cirino Talim, Lívia Edwiges Cirino Talim, Rodrigo Kleinpaul, Juliana
M. S. S. Amaral, Márcia Prates, Carolina R. Araújo, Cristiane Franklin Rocha, Kazuo
Fujihara, Douglas Sato, Marco Aurélio Lana-Peixoto
Institutions: CIEM MS Research Center, Federal University of Minas Gerais Medical
School, Belo Horizonte, Minas Gerais, Brasil; Tohoku University, Sendai, Japan.
PO-033 – LONGITUDINALLY EXTENSIVE TRANSVERSE MYELITIS IN
SCHISTOSOMIASIS
Authors: Juliana M. S. S. Amaral, Igor Ornelas, Natália Cirino Talim, Lívia Edwiges
Cirino Talim, Rodrigo Kleinpaul, Márcia Prates, Diogo Couto de Carvalho, Tauana
de Sousa Tironi, Izabela C. A. Duarte, Anderson F. Silva, Gisele de Oliveira Lima,
Carolina dos Reis Araújo, Cristiane F. Rocha, Marco Aurélio Lana-Peixoto
Institutions: CIEM MS Research Center, Federal University of Minas Gerais Medical
School, Belo Horizonte, Minas Gerais, Brazil.
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BCTRIMS 15th Annual Meeting
PO-034 – NEUROMYELITIS OPTICA SPECTRUM DISORDER AND SJÖGREN
SYNDROME CO-EXIST IN A COMMON AUTOIMMUNE MILIEU
Authors: Diogo Couto de Carvalho, Tauana de Sousa Tironi, Denise S. Freitas, Izabela
C. A. Duarte, Gisele de Oliveira Lima, Anderson F. Silva, Natália Cirino Talim, Lívia
Edwiges Cirino Talim, Juliana M. S. S. Amaral, Márcia Prates, Carolina Reis Araújo,
Cristiane Franklin Rocha, Marco Aurélio Lana-Peixoto
Institutions: CIEM MS Research Center, Federal University of Minas Gerais Medical
School, Belo Horizonte, Minas Gerais, Brazil.
PO-035 – OPTIC NEUROPATHY IN INFLAMMATORY BOWEL DISEASE
Authors: Diogo Couto de Carvalho, Tauana de Sousa Tironi, Izabela C. A. Duarte,
Gisele de Oliveira Lima, Anderson Silva, Natália Cirino Talim, Lívia Edwiges Cirino
Talim, Juliana M. S. S. Amaral, Márcia Prates, Rodrigo Kleinpaul, Carolina dos Reis
Araújo, Cristiane Franklin Rocha, Marco Aurélio Lana-Peixoto
Institutions: CIEM MS Research Center, Federal University of Minas Gerais Medical
School, Belo Horizonte, Minas Gerais, Brazil.
PO-036 – Plasmaférese em pacientes com neuromielite óptica e
espectro de doença - resposta clínica
Authors: Gustavo E. S. Linhares, Samira Pereira Apóstolos, Luana M. Oliveira, Renata
Simm, Frederico J. M. Haiddar, Dagoberto Callegaro
Institutions: Universidade de São Paulo, São Paulo, Brazil.
PO-037 – RELAPSING LONGITUDINALLY EXTENSIVE TRANSVERSE MYELITIS IN
HUMAN T-LYMPHOTROPIC VIRUS TYPE 1-2 INFECTION
Authors: Juliana M. S. S. Amaral, Natália Cirino Talim, Lívia Edwiges Cirino Talim,
Márcia Prates, Rodrigo Kleinpaul, Carolina R. Araújo, Cristiane Franklin Rocha, Kazuo
Fujihara, Douglas Sato, Marco Aurélio Lana-Peixoto
Institutions: CIEM MS Research Center, Federal University of Minas Gerais Medical
School, Belo Horizonte, Minas Gerais, Brazil; Tohoku University, Sendai, Japan.
BCTRIMS 15th Annual Meeting
41
PO-038 – SHORT DORSOLATERAL TRANSVERSE MYELITIS IN NEUROMYELITIS
OPTICA SPECTRUM DISORDER
Authors: Rodrigo Kleinpaul, Natália Cirino Talim, Lívia Edwiges Cirino Talim, Juliana
M. S. S. Amaral, Márcia Prates, Carolina Reis Araújo, Cristiane Franklin Rocha, Marco
Aurélio Lana-Peixoto
Institutions: CIEM MS Research Center, Federal University of Minas Gerais Medical
School, Belo Horizonte, Minas Gerais, Brazil.
PO-039 – TRANSIENT STENOSIS OF CEREBRAL ARTERIES IN NEUROMYELITIS
OPTICA SPECTRUM DISORDER
Authors: Rodrigo Kleinpaul, Thiago Cardoso Vale, Natália Cirino Talim, Lívia Edwiges
Cirino Talim, Juliana M. S. S. Amaral, Márcia Prates, Carolina R. Araújo, Cristiane F.
Rocha, Kazuo Fujihara, Douglas Sato, Marco Aurélio Lana-Peixoto
Institutions: CIEM MS Research Center, Federal University of Minas Gerais Medical
School, Belo Horizonte, Minas Gerais, Brazil; Tohoku University, Sendai, Japan.
PO-040 – TRIGEMINAL NEURALGIA MAY HERALD NEUROMYELITIS OPTICA
SPECTRUM DISORDERS
Authors: Natália Cirino Talim, Lívia Edwiges Cirino Talim, Juliana M. S. S. Amaral,
Rodrigo Kleinpaul, Márcia Prates, Carolina R. Araújo, Cristiane Franklin Rocha, Marco
Aurélio Lana-Peixoto
Institutions: CIEM MS Research Center, Federal University of Minas Gerais Medical
School, Belo Horizonte, Minas Gerais, Brazil.
PO-041 – DIFFERENTIAL DIAGNOSIS OF RECURRENT LONGITUDINALLY
EXTENSIVE TRANSVERSE MYELITIS
Authors: Paula Zago Melo, Samira Apostólos-Pereira, Renata Faria Simm, Frederico
Haidar Jorge, Gustavo Linhares, Luana Michelli, Douglas Kazutoshi Sato, Dagoberto
Callegaro
Institutions: Hospital das Clínicas, University of São Paulo, São Paulo, Brazil.
42
BCTRIMS 15th Annual Meeting
ACKNOWLEDGEMENT
The Organizing Committee wishes to express their thanks and appreciation to the sponsors,
who have so generously contributed to the success of the BCTRIMS 15th Annual Meeting.
BCTRIMS 15th Annual Meeting
43
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Projeto e Edição
Grupo
de
Design Gráfico Ltda.
Revisão do inglês pelo TrocaLingua (www.trocalingua.com).