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DNA lesão. Crianças com câncer apresentam maior número de lesões
cromossômicas nos linfócitos do sangue – técnica do micronúcleo
07/02/11
Lucia Regina Ribeiro
DNA damage in lymphocytes and buccal mucosa cells of children with malignant tumours undergoing chemotherapy.
Minicucci EM, Ribeiro DA, de Camargo B, Costa MC, Ribeiro LR, Favero Salvadori DM.
Clin Exp Med. 2008 Jun;8(2):79-85. Epub 2008 Jul 11.
Department of Pathology, Faculty of Medicine, Botucatu Medical School, UNESP, 18618-000, Botucatu, SP, Brazil.
Comment in:
Clin Exp Med. 2009 Mar;9(1):77-8; author reply 79-80.
Abstract
The aim of the present study was to evaluate DNA damage (micronucleus) in cytokinesis-blocked lymphocytes and exfoliated buccal
mucosa cells from children with malignant tumours and under chemotherapy. Micronucleated cells (MNCs) were assessed from children
before and during chemotherapy. A total of 21 healthy children (controls), matched for gender and age, were used as control. The
results pointed out higher frequencies of micronucleated lymphocytes in children with malignant tumour before any therapy when
compared to healthy probands. Furthermore an increase of micronucleated lymphocytes during chemotherapy was detected when
compared to the data obtained before chemotherapy. No statistically significant increases of MNCs were noticed in buccal mucosa cells
at any of the timepoints evaluated. Taken together, these data indicate that the presence of malignant tumours may increase the
frequency of DNA damage in circulating lymphocytes, these cells being more sensitive for detecting chromosome aberrations caused by
anti-cancer drugs.
PMID: 18618217
10/10/2011 16:59