Name: Dario Simões Zamboni
Address: Department of Cell Biology and Microbial Pathogenesis, School of Medicine Ribeirão Preto - University of São
Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, Brazil - 14049-900. Phone: 00 55 16 36023265; e-mail:
[email protected]
Year
1994-1998
1998-2003
Title or activity
BSc Biology
Ph.D.
Institution
University of Brasilia, DF, Brazil
Department of Microbiology, Immunology and Parasitology,
Federal University of Sao Paulo, SP, Brazil.
2003-2006
Pos-Doc
Section of Microbial Pathogenesis, Yale University, School of
Medicine. USA.
2006-2011
Assistant
Professor
Department of Cell Biology and Microbial Pathogenesis, School of
Medicine Ribeirão Preto - University of São Paulo at Ribeirão Preto
2011-present Associate
Professor
Department of Cell Biology and Microbial Pathogenesis, School of
Medicine Ribeirão Preto - University of São Paulo at Ribeirão Preto
www.inmunocolombia2015.com
2. Professional history
1994-1997
Scientific Initiation fellowship from CNPq (for bachelor student of Biology at University of
Brasilia).
1998-2003
Ph.D. fellow from FAPESP (for Ph.D. Student at Federal University of São Paulo).
2003-2006
2003 Fellow of the PEW Latin American Fellows Program in the Biomedical Sciences (for
postdoctoral training at Yale University School of Medicine).
2006-2011
Assistant Professor, Dept. of Biologia Celular, Molecular e Bioagentes Patogênicos, University
of São Paulo, Medical School of Ribeirao Preto, SP.
2011-present Associate Professor (Livre Docente), Dept. of Biologia Celular, Molecular e Bioagentes
Patogênicos, University of São Paulo, Medical School of Ribeirao Preto, SP.
3. List of 20 most relevant publications
* = Corresponding author
1. Ataide MA, Andrade WA, Zamboni DS, Wang D, Souza Mdo C, Franklin BS, Elian S, Martins FS, Pereira D, Reed
G, Fitzgerald KA, Golenbock DT, Gazzinelli RT. Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation
Mediates Inflammation and Hypersensitivity to Bacterial Superinfection. PLoS Pathog. 2014;10(1):e1003885.
2. Silva GK, Costa RS, Silveira TN, Caetano BC, Horta CV, Gutierrez FR, Guedes PM, Andrade WA, De Niz M,
Gazzinelli RT, Zamboni DS, Silva JS. Apoptosis-Associated Speck-like Protein Containing a Caspase Recruitment
Domain Inflammasomes Mediate IL-1β Response and Host Resistance to Trypanosoma cruzi Infection. J
Immunol. 2013;191(6):3373-83.
www.inmunocolombia2015.com
3*. Hori JI, Pereira MS, Roy CR, Nagai H, Zamboni DS. Identification and functional characterization of K+ transporters
encoded by Legionella pneumophila kup genes. Cell Microbiol. 2013;15(12):2006-19.
4*. Lima-Junior DS, Costa DL, Carregaro V, Cunha LD, Silva AL, Mineo TW, Gutierrez FR, Bellio M, Bortoluci KR,
Flavell RA, Bozza MT, Silva JS, Zamboni DS. Inflammasome-derived IL-1β production induces nitric oxidemediated resistance to Leishmania. Nat Med. 2013;19(7):909-15.
5*. Silva GK, Cunha LD, Horta CV, Silva AL, Gutierrez FR, Silva JS, Zamboni DS. A parent-of-origin effect determines
the susceptibility of a non-informative F1 population to Trypanosoma cruzi infection in vivo. PLoS One.
2013;8(2):e56347.
6*. Case CL, Kohler LJ, Lima JB, Strowig T, de Zoete MR, Flavell RA, Zamboni DS, Roy CR. Caspase-11 stimulates
rapid flagellin-independent pyroptosis in response to Legionella pneumophila. Proc Natl Acad Sci U S A.
2013;110(5):1851-6.
7. Hori JI, Zamboni DS. The mouse as a model for pulmonary Legionella infection. Methods Mol Biol.
2013;954:493-503.
8*. Pereira MS, Morgantetti GF, Massis LM, Horta CV, Hori JI, Zamboni DS. Activation of NLRC4 by flagellated
bacteria triggers caspase-1-dependent and -independent responses to restrict Legionella pneumophila replication in
macrophages and in vivo. J Immunol. 2011;187(12):6447-55.
9*. Massis LM, Zamboni DS. Innate Immunity to Legionella pneumophila. Frontiers in Microbiology. 2011;2:109.
doi: 10.3389/fmicb.2011.00109
10*. Frutuoso MS, Hori JI, Pereira MS, Junior DS, Sônego F, Kobayashi KS, Flavell RA, Cunha FQ, Zamboni DS. The
pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with
Legionella pneumophila. Microbes Infect. 2010;12(11):819-27.
11*. Silveira TN, Zamboni DS. Pore formation triggered by Legionella spp. is an Nlrc4 inflammasome-dependent host
cell response that precedes pyroptosis. Infect Immun. 2010;78(3):1403-13.
12*. Silva GK, Gutierrez FR, Guedes PM, Horta CV, Cunha LD, Mineo TW, Santiago-Silva J, Kobayashi KS, Flavell
RA, Silva JS, Zamboni DS. Cutting edge: nucleotide-binding oligomerization domain 1-dependent responses
account for murine resistance against Trypanosoma cruzi infection. J Immunol. 2010;184(3):1148-52.
13. Shin S, Case CL, Archer KA, Nogueira CV, Kobayashi KS, Flavell RA, Roy CR, Zamboni DS. Type IV secretiondependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella
pneumophila. PLoS Pathogen. 2008; 4(11):e1000220.
14. Zamboni DS, Kobayashi KS, Kohlsdorf T, Ogura Y, Long EM, Vance RE, Kuida K, Mariathasan S, Dixit VM,
Flavell RA, Dietrich WF, Roy CR. The Birc1e cytosolic pattern-recognition receptor contributes to the detection and
control of Legionella pneumophila infection. Nature Immunology. 2006;7(3):318-325.
15. Ren T, Zamboni DS, Roy CR, Dietrich WF, Vance RE. 2006. Flagellin-deficient Legionella mutants evade
caspase-1- and Naip5-mediated macrophage immunity. PLoS Pathogen. 2006; 2(3): e18.
16. Zamboni DS, Campos MA, Torrecilhas AC, Kiss K, Samuel JE, Golenbock DT, Lauw FN, Roy CR, Almeida IC,
and Gazzinelli RT. Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of
pro-inflammatory cytokines and resistance to infection. The Journal of Biological Chemistry. 2004; 279(52):
54405-54415.
17. Zamboni DS. Genetic control of natural resistance of mouse macrophages to Coxiella burnetii infection in vitro:
macrophages from restrictive strains control parasitophorous vacuole maturation. Infection and Immunity. 2004;
72(4): 2395-2399.
18. Zamboni DS, and Rabinovitch M. Phagocytosis of apoptotic cells increases the susceptibility of macrophages to
infection with Coxiella burnetii phase II through down-modulation of nitric oxide production. Infection and
Immunity. 2004; 72(4): 2075-2080.
19. Zamboni DS, McGrath S, Rabinovitch M, and Roy CR. Coxiella burnetii express type IV secretion system
proteins that function similarly to components of the Legionella pneumophila Dot/Icm system. Molecular
Microbiology. 2003; 49(4): 965-976.
www.inmunocolombia2015.com
20. Zamboni DS, and Rabinovitch M. Nitric oxide partially controls Coxiella burnetii phase II infection in mouse
primary macrophages. Infection and Immunity. 2003; 71(3): 1225-1233.
4. Ongoing Research Grants
• Coordenador of “Auxílio Regular à Pesquisa” FAPESP #2012/09363-6 (09/2012 a 08/2014). Funding Agency:
FAPESP.
• Participant of the National Institute for Science and Vaccines Development. Role: Participant. Coordinator: Ricardo
T. Gazzinelli. (2009-2012). Funding Agency: CNPq/ Ministry of Science and Technology.
• Participant of the “Núcleo de Apoio à Pesquisa em Doenças Inflamatórias” (NAP/DIM) Role: Participant.
Coordinator: Fernando Queiróz Cunha. Duration: 2011-2013. Funding Agency: University of São Paulo, Programa
da ProReitoria de Pesquisa USP (PRP/USP).
• Principal investigator of the “CEPID - Centros de Pesquisa, Inovação e Difusão / Edital 2011” FAPESP #
2013/08216-2. Role: Principal Investigator. Coordinator: Fernando Queiróz Cunha (06/2013 a 05/2018). Funding
Agency: FAPESP.
5. List of ongoing supervisions
a) Post-doctorate
• Rafael de Liz. Fellowship: CNPq/Atração Jovem Talento/CSF.
• Juliana Issa Hori. Fellowship: FAPESP Proc. 11/51023-5.
• Liliana Moura Massis. Fellowship: CAPESP/PNPD.
• Djalma de Souza Lima Júnior. Fellowship: FAPESP Proc. 13/08216-2.
b) PhD students
• Alexandre Luiz Neves Silva. Fellowship: FAPESP Proc. 12/15932-3.
• Catarina Veltrini Horta. Fellowship: FAPESP Proc. 12/02786-9.
• Mariana Aprigio Assis. Fellowship: CNPq Proc. 140090/2011-8.
• Talita Duarte Fernandes. Fellowship: CAPES.
• Danielle Pini Alves Mascarenhas. Fellowship: CNPq.
c) Masters students
• Lincoln Leandro Fonseca. Fellowship: CAPES.
• Anna Karoline Aguiar Fleuri. Fellowship: CNPq Proc. 134094/2012-3.
• Juliana Magro Ribeiro. Fellowship: FAPESP Proc. 2014/00447-8.
• Renata Stifanic. Fellowship: CAPES.
6. Academic quantitative indicators
Type
Quantity
www.inmunocolombia2015.com
Publications in journal with selective editorial police
44
Book Chapter
3
Supervision of master’s dissertation
9
Supervision of PhD thesis
6
Supervision of Pos-Doc
3
Citation (ISI, Web of Science (17/01/2014)
=1006, H-index: 17
Link para ResearcherID: http://www.researcherid.com/rid/D-3024-2012
Citation (Google Scholar (21/01/2014)
=1503, H-index: 18
Link para MyCitations: http://scholar.google.com.br/citations?user=HKmMojgAAAAJ
7. Other relevant information
Member of the Third World Academy of Science (TWAS).
Affiliate Member of the Brazilian Academy of Sciences.
Member of the Brazilian Committee of the PEW program in biomedical Sciences.
Research fellow of the Brazilian National Research Council (CNPq-PQ1C).
Fellow of the PEW Latin American Fellows Program in the Biomedical Sciences (for postdoctoral training at Yale
University School of Medicine).
Director of the Brazilian Society for Immunology (SBI, 2010-2011).
Coordinator of the host/parasite section of the Brazilian Society for Microbiology (SBM, 2009-2013).
www.inmunocolombia2015.com