MESALAZINE AND PERIDIVERTICULAR
HISTOLOGY IN PATIENTS WITH NONCOMPLICATED SYMPTOMATIC COLONIC
DIVERTICULAR DISEASE
BAFUTTO, M.; SOUZA, D.H.S.; BAFUTTO, A.A.F.; MARCIANO, R.D.;
COSTA, M.B.G.; OLIVEIRA, E.C.; REZENDE FILHO, J.
Instituto Goiano de Gastroenterologia, Goiânia – Brazil
Disciplina de Gastroenterologia, Faculdade de Medicina,
Universidade Federal de Goiás, Goiânia – Brazil
Departamento de Cirurgia, Faculdade de Medicina,
Universidade Federal de Goiás, Goiânia – Brazil
Introduction
Recent evidence shows that inflammation is the main pathogenic
mechanism for Colonic Diverticular Disease (CDD).(1) Mesalazine
administration has shown clinical improvement in controlled
studies (2,3). There are little data about histological changes after
mesalazine therapy in CDD. In this study, we have evaluated if
there is difference in colonic mucosa histology in patients with
non-complicated symptomatic CDD (NCSCDD) treated with or
without mesalazine.
AIMS
To evaluate the colonic mucosa histology from patients with
NCSCDD treated with and without Mesalazine
1 – Di Mario F. et al., J Clin Gastroenterol. 2006
2 – Gatta L.et al.,J Clin Gastroenterol. 2010
3 – Tursi A and Papagrigoriadis S., Aliment Pharmacol Ther. 2009
Methods
27 patients with NCSDDC were included in this study. In addition to
the clinical examination, the patients underwent an ova and
parasitological examination of stools, stools culture and imaging
exams for the diagnosis of DDC. Exclusion criteria: Patients on
antibiotics and anti-inflammatory, currently or recently; and carriers
of Acute Diverticular Disease or other organic diseases. The patients
were separated in 2 groups: Mesalazine Group (MG) – 11 patients
that had mesalazine administrated p.o. 800 mg, t.i.d. for 60 days;
Control Group (CG) – 16 patients that had only fiber supplements for
60 days.
Mesalazine Group (MG)
Control Group (CG)
11 patients
16 patients
Mesalazine administrated p.o.
800 mg, t.i.d. for 60 days
Only fiber supplements for 60
days
Methods
At the end of 60 days, colonoscopy was performed, with
biopsy at the diverticulum’s edges. On the histopathologic
examination, a Histopathogical Score (HS) was used for
histological evaluation and quantification regarding to
epithelial cells, crypts, lamina propria mononuclear cells and
lamina propria neutrophils (Max score =12 min sore=0). For
statistical analysis, non paired t test and Fisher exact test were
used, with statistical significance for p<0,05.
Histopathological Score
RESULTS
Results
p=0,0147
Conclusion
Colonic mucosal inflammation was absent on most
of the MG patients, fact that didn’t happen on the
CG. The use of mesalazine on NCSDDC is associated
with the normalization of the peridiverticular
histopathology.
The authors declare no financial disclosure.