55º Congresso Brasileiro de Genética
Resumos do 55º Congresso Brasileiro de Genética • 30 de agosto a 02 de setembro de 2009
Centro de Convenções do Hotel Monte Real Resort • Águas de Lindóia • SP • Brasil
www.sbg.org.br - ISBN 978-85-89109-06-2
74
Prevalence of HPV-16 and HPV-18 in women infected
with human immunodeficiency virus and in controls
from Goiania, GO, Brazil
Saddi, VA1,5; Vaz, LP1; Lima, FC2; Rabelo-Santos, SH2; Alves, RRF1,3; Serafim Filho, J3; Milki, MV1, 4; Araujo,
WCC1; Mühlbeier, DFM1; Carneiro, MAS2; Ayres, FM1
Universidade Católica de Goiás; 2 Universidade Federal de Goiás; 3 Santa Casa de Misericórdia de Goiânia; 4 Centro de Apoio ao Doente
com AIDS; 5 Associação de Combate ao Câncer em Goiás.
[email protected]
1
Keywords: HPV-16, HPV-18, HIV-infected women, HPV-detection, PCR
This study aimed to compare the prevalence of HPV infection and its possible risk factors in HIV-positive and
HIV-negative women, from the city of Goiania-GO. The study group included 60 HIV-positive women assisted by
CADA (Centro de Apoio ao Doente com AIDS), and 60 HIV-negative women assisted by a public health organization.
Detection of HPV genome in cervical cell samples was achieved by using polymerase chain reaction (PCR), with
generic HPV primers GP5+/GP6+, and genotyping employed specific primers for HPV-16 and HPV-18. Both groups
were similar in regard to social demographics and behavioral characteristics, however, significant differences were
observed among their marital status, household income, and education, number of sexual partners, prostitution
history and tobacco smoking. In the group of HIV-positive women, the prevalence of HPV infection was 64.3%,
and in the group of HIV-negative women, it was 32.5%. HPV-16 was the most prevalent genotype in both groups,
corresponding to 67.5% of the HIV-positive women and 32.5% of the HIV-negative women. Among the women who
presented with CIN I, all them were HIV-positive and among those who presented CIN II/CIN III, 85.7% were HIVpositive. The combination of HPV-16 and HPV-18 genotypes was present in 72.2% of the HIV-positive women, and
in 27.8% of the HIV-negative women. Our study demonstrated a greater prevalence of HPV infection in the group of
HIV-positive women. HPV-16 was most common genotype found in both groups; however, co-infection with HPV16 and HPV-18 was significantly more prevalent in those women infected with HIV. Herein we conclude that HIV
infection represents a significant risk factor for HPV infection.
This study was supported by: CNPq, CAPES, FAPEG.