Bibliografia Brasileira Internacional sobre Hepatologia (11)
1)Braz J Infect Dis. 2011 Aug;15(4):377-81.
Thyroid disorders in patients with chronic hepatitis C using interferonalpha and ribavirin therapy.
Andrade LJ, Atta AM, Atta ML, Mangabeira CN, Paraná R.
Universidade Estadual de Santa Cruz, Bahia .
Prospective studied 65 anti-HCV and viral RNA positive patients. Free
thyroxine, thyroid-stimulating hormone, and thyroid peroxidase antibodies
(TPO-Ab) were systematically tested at entry (m0), week 12 (m3) and
week 24 (m6) of treatment.
Mean age of the 65 patients (38 females and 27 males) was 49.61 ± 11.83
years. Seven (10.76%) patients presented baseline thyroid disorders (m0),
three had thyroid dysfunction, and four were TPO-Ab positive.
Veja: http://www.ncbi.nlm.nih.gov/pubmed/21861010
2) Nutr J. 2011 Aug 19;10:86.
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and
high plasma homocysteine in chronic hepatitis C (CHC) infected patients
from the Northeast of Brazil.
Siqueira ER, Oliveira CP, Muniz MT, Silva F, Pereira LM, Carrilho FJ.
Department of Gastroenterology , University of Sao Paulo School of
Medicine,
Hyperhomocysteinemia due to Methylenetetrahydrofolate Reductase
(MTHFR) gene, in particular the C677T (Ala222Val) polymorphism were
recently associated to steatosis and fibrosis.
One hundred seven-four untreated patients with CHC were genotyped for
the C677T MTHFR. Genomic DNA was extracted from peripheral blood
cells and the C677T MTHFR polymorphism was identified by PCR-RFLP.
The homocysteine (Hcy) levels were determined by chemiluminescence
method.
veja: http://www.ncbi.nlm.nih.gov/pubmed/21854603
3) Arq Gastroenterol. 2011 Mar;48(1):62-5.
Research on zinc blood levels and nutritional status in adolescents with
autoimmune hepatitis.
Pereira TC, Saron ML, de Carvalho WA, Vilela MM, Hoehr NF, Hessel G.
Pediatrics Department, FCM, UNICAMP
Zinc deficiency in children and adolescents impairs their growing,
development and immune system.
The study comprised 23 patients with autoimmune hepatitis, aged 10-18
years, adolescents with ages compatible with the patients' ages comprised
the control group. Sample of blood in both groups was collected for the
analyses of plasma zinc and leukocyte zinc by atomic absorption
spectrophotometry, beyond the nutritional status was evaluated in each
adolescent.
Veja : http://www.ncbi.nlm.nih.gov/pubmed/21537545
4) Transplant Proc. 2011 Jan-Feb;43(1):161-4.
Living related donor liver transplantation in children.
Tannuri AC, Gibelli NE, Ricardi LR, Santos MM, Maksoud-Filho JG,
Pinho-Apezzato ML, Silva MM, Velhote MC, Ayoub AA, Andrade WC,
Leal AJ, Miyatani HT, Tannuri U.
Pediatric Surgery and Liver Transplantation Division, Instituto da Criança,
Hospital das Clínicas, Faculdade de Medicina da Universidade de São
Paulo.
The objective of this study was to report our experience with pediatric
orthotopic liver transplantation (OLT) with living related donors.
Indications were biliary atresia (BA; n = 81), primary sclerosing cholangitis
(n = 5), α-1 antitrypsin deficiency (n = 4); cholestasis (n = 9), fulminant
hepatic failure (n = 8), autoimmune hepatitis (n = 2), Alagille syndrome (n
= 4), hepatoblastoma (n = 3), tyrosinemia (n = 2), and congenital hepatic
fibrosis (n = 3). The age of the recipients ranged from 7-174 months
(median, 22) and the weights ranged from 6-58 kg (median, 10). Forty-nine
children (40.5%) weighed ≤10 kg. The grafts included the left lateral
segment (n = 108), the left lobe (n = 12), and the right lobe (n = 1). The
donors included 71 mothers, 45 fathers, 2 uncles, 1 grandmother, 1
grandfather, and 1 sister with a median age of 29 years (range, 16-53 ys)
and a median weight of 68 kg (range, 47-106). Sixteen patients (12.9%)
required retransplantation, most commonly due to hepatic artery
thrombosis (HAT; n = 13; 10.7%).
Veja: http://www.ncbi.nlm.nih.gov/pubmed/21335177
5) Ann Hepatol. 2011 Jan-Mar;10(1):43-9.
Epidemiological assessment of liver disease in northeastern Brazil by
means of a standardized liver biopsy protocol.
Lembrança L, Medina J, Portugal M, Almeida D, Solla J, Gadelha R, de
Freitas LA, Paraná R.
University Hospital, Federal University of Bahia, Salvador.
The main objective of this study was to describe the profile of patients who
were benefitted in a collective effort to perform liver biopsies in Bahia,
A cross-sectional study was conducted with a sample composed of all the
patients who were submitted to liver biopsy during a collective effort
carried out in Bahia between July 2007 and November 2009. At the time of
the procedure, date on the age and gender of patients and the reason for
performing the biopsy were recorded. Data on the degree of fibrosis and the
presence of co-morbidities. Following statistical analysis, the frequency of
the liver diseases that led to the biopsy procedure was described, and the
profile of the patients was stratified into groups according to the most
prevalent etiologies.
Of the 550 patients evaluated, 55.3% were men and 44.7% women. Mean
age was 46.63 ± 11.59 years and there was no statistically significant
difference in age between males and females. Of the 550 patients, 72% had
hepatitis C and the mean age of these patients was 48.49 ± 10.1 years,
significantly higher than the mean age of the patients with hepatitis B
(40.41 ± 12.43 years).
Veja: http://www.ncbi.nlm.nih.gov/pubmed/21301009
6) Autoimmun Rev. 2011 Feb;10(4):189-93.
Autoimmune hepatitis, HLA and extended haplotypes.
Oliveira LC, Porta G, Marin ML, Bittencourt PL, Kalil J, Goldberg AC.
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo,
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease.
Characteristic liver-infiltrating immune cells in portal and periportal areas,
hypergammaglobulinemia and typical autoantibodies indicate an ongoing
autoimmune reaction against liver self antigens, which lead to irreversible
cellular damage and ultimately to severe hepatic failure. A significant part
of adult, but not pediatric AIH patients, exhibit concurrent autoimmune
diseases, further strengthening the immunological etiology of the disease.
Genetic susceptibility to autoimmune hepatitis is strongly associated with
HLA-DRB1 alleles
veja: http://www.ncbi.nlm.nih.gov/pubmed/20933106