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Inositol hexafosfato metabolismo e funções celulares : Revisão
13/09/10
O inositol hexafosfato ou ácido fítico (IP6) é rico na natureza, facilmente absorvido pelo trato digestivo e deveria estar na dieta habitual
da população mundial não fosse a indústria alimentícia. Ele encontra-se em abundancia nos cereais integrais, nas nozes, nos óleos não
hidrogenados como aqueles de Super mercado, em legumes sem agrotóxicos e na soja e seus derivados os quais não devemos
abusar pelo alto conteúdo em oxalato que diminui a memória e a concentração.
O IP6 além de antiproliferativo e apoptótico aumenta a diferenciação de células neoplásicas provocando a reversão para um fenótipo
normal. Ele aumenta a imunidade e possui efeitos antioxidantes. O IP6 funciona melhor quando administrado junto com o inositol e
desta forma aumenta a eficácia da quimioterapia convencional e controla melhor as metástases. Trabalho piloto mostrou melhoria da
qualidade de vida.
Ácido fítico = mio-inositol-hexafosfato = di-hidrogênio fosfato = C6H14O24P6
José de Felippe Junior
Metabolism and cellular functions of IP6: a review.
Shamsuddin AM. Anticancer Res. 1999 Sep-Oct;19(5A):3733-6.
Department of Pathology, University of Maryland at Baltimore, USA.
Abstract
Inositol hexaphosphate (IP6) has a demonstrably effective anti-cancer action against a variety of experimental tumors. However, the
mechanisms of its actions are yet to be completely discerned. Studies in my laboratory have shown that IP6 is rather rapidly absorbed
by rats in vivo. Ion exchange chromatography demonstrates the presence of inositol and IP1-6 in gastric epithelial cells as early as
within 1 h of intragastric 3H-IP6 administration. The metabolized IP6, in the form of inositol and IP1 is transported via plasma and
reaches distant organs as well as tumors. In rats, the urinary metabolites of IP6 are inositol and IP1. However, in humans 1-3% of total
administered IP6 is excreted in the urine as IP6; the level shows a normal oscillation between 0.5-6 mg/L [F. Grases et al].
Investigations of the uptake and metabolism by a variety of cancer cell lines in vitro also demonstrate an instantaneous absorption of
IP6. The rate and pattern at which IP6 is metabolized by cancer cells varies depending on the cell type. Intracellular inositols
accumulated mostly (80-97%) in the cytosol as inositol and IP1-6. IP6 treatment of all the cell lines tested so far demonstrates that it
is cytostatic and not cytotoxic. Along with inhibition of cell proliferation, there is enhanced differentiation of malignant cells to a more
mature phenotype, often resulting in reversion to normal. Studies of the expression of tumor suppressor gene demonstrate
up-regulation of wild type p53 and down-regulation of the mutant form. Since p53-mediated cell cycle arrest may be the direct result of
induction of WAF-1 gene (p21WAF-1/CIP1), our studies demonstrate that IP6 up-regulates the expression of p21WAF-1/CIP1 in a
dose-dependent manner. These data strongly point towards the involvement of signal transduction pathways, cell cycle regulatory
genes, differentiation genes, oncogenes and perhaps, tumor suppressor genes in bringing about the observed anti-neoplastic action of
IP6.
PMID: 10625949 [
3/10/2011 16:35