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Integrated Management System
Sulphanilic Acid
1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1 Product Identifier
Chemical name:
EC number:
CAS number (EC inventory):
Annex VI index number:
Registration number:
Chemical characterization:
Sulphanilic acid
204-482-5
121-57-3
612-014-00-x
01-2119541820-45-0001
Organic mono constituent substance
1.2 Relevant identified uses of the substance or mixture and uses advised against
Industrial use resulting in manufacture of another substances (use of intermediates), products such as phregulators, flocculants, precipitants, neutralization agents, laboratory chemicals, processing aids in
processes and products (not becoming part of articles), manufacture of fine chemicals and formulation of
preparations and/or re-packaging (excluding alloys).
Relevant identified
Uses (see corresponding Exposure
Scenarios (ES) in annex)
Uses advised against
Manufacturing ES1 (Annex 1)
Manufacturing of fine chemicals ES2 (Annex 2)
Formulation ES3 (Annex 3)
None
1.3 Details of the supplier of the safety data sheet
Company:
CUF – Químicos Industriais, SA
Quinta da Indústria, Beduído
3860-680 Estarreja - Portugal
Telephone:
Fax:
E-mail:
Web Page:
+351 234 810 300
+351 234 810 361
[email protected]
www.cuf-qi.com
Emergency telephone number
CUF – Químicos Industriais, SA
Telephone:
Fax:
Emergency National Number
SOS – Poisons (INEM)
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2. HAZARDS IDENTIFICATION
2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
Classification
Hazard statements:
Eye Irrit. 2A
Skin Irrit. 2
Skin Sens. 1
H315: Causes skin irritation
H317: May cause an allergic skin reaction
H319: Causes serious eye irritation
Classification (67/548/EEC, 1999/45/EC)
Classification
Risk phrases:
Xi - Irritant;
R36/38: Irritating to eyes and skin.
R43: May cause sensitisation in contact with skin.
Additional information
n.a.
2.2 Label Elements
Labelling (REGULATION (EC) No 1272/2008)
Symbol(s):
GHS07: exclamation mark
Signal word:
Hazard statements:
Precautionary
statements:
Warning
H315: Causes skin irritation
H317: May cause an allergic skin reaction
H319: Causes serious eye irritation
P261: Avoid breathing dust/fume/gas/mist/vapours/spray
P264: Wash hands thoroughly after handling
P272: Contaminated work clothing should not be allowed out of the workplace
P280: Wear protective gloves/protective clothing/eye protection/face protection
P362: Take off contaminated clothing and wash before reuse
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Labelling in Annex I of Directive 67/548/EEC
Symbol(s):
Xi - irritant
Risk phrases:
R36/38: Irritating to eyes and skin.
R43: May cause sensitisation in contact with skin.
Safety phrases:
S24: Avoid contact with skin.
S37: Use appropriated gloves.
2.3 Other Hazard
n.a.
3. COMPOSITION/INFORMATION ON INGREDIENTS
3.1 Substances
Hazardous substance
Chemical Name
CAS-No.
EC-No.
REACH No.
Concentration
[%]
Sulphanilic Acid
121-57-3
204-482-5
01-2119541820-45-0001
≥99.7%(w/w)
3.2 Mixtures
n.a.
4. FIRST AID MEASURES
4.1 Description of first aid measures
If inhaled:
Remove patient from exposure. Obtain medical attention.
In case of skin contact:
Immediately flush skin with plenty of water for at least 15 minutes while
removing contaminated shoes and clothing. Obtain medical attention.
In case of eye contact:
In case of contact, immediately flush eyes with eyewash solution or clean
water, holding eyelids apart, for at least 15 minutes. Obtain medical attention
as a precaution.
If swallowed:
Wash out mouth with water. Do not induce vomiting.
4.2 Most important symptoms and effects, both acute and delayed
No data.
4.3 Indication of immediate medical attention and special treatment needed
No data.
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5. FIRE-FIGHTING MEASURES
5.1 Extinguishing media
Suitable extinguishing media:
Water spray, foam, dry powder or CO2
Unsuitable extinguishing media:
n.a.
5.2 Special hazards arising from the substance or mixture
Specific hazards during fire
fighting / Specific hazards
arising from the chemical:
Sulphanilic acid can produce flammable dust clouds in air.
Take precautionary measures against static discharges.
If involved in a fire, it may emit noxious and toxic fumes.
5.3 Advice for firefighters
Special protective
equipment for fire-fighters:
A self contained breathing apparatus and suitable protective clothing
should he worn in fire conditions.
6. ACCIDENTAL RELEASE MEASURES
6.1 Personal precautions, protective equipment and emergency procedures
Ensure suitable personal protection (including respiratory protection) during removal of spillages.
See 8.2.
6.2 Environmental precautions
Do not allow enter drains, sewers or watercourses
6.3 Methods and materials for containment and cleaning up
Protect against dust. Clear up spillages, transfer to a container for disposal. Wash the spillage area in order
to keep it clean.
6.4 Reference to other sections
n.a.
7. HANDLING AND STORAGE
7.1 Precautions for safe handling
Control dust formation. Avoid contact with skin and eyes. Avoid inhalation of high concentrations of dusts.
Take precautionary measures against static discharges.
7.2 Conditions for safe storage, including any incompatibilities
Store in well ventilated areas.
Keep container tightly closed and dry. Do not store with acids.
7.3 Specific end use(s)
See exposure scenarios in annex 1,2 and 3.
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8. EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1 Control parameters
Components
Sulphanilic acid
CAS-No.
Value
3
10 mg/m , 8h
121-57-3
Control
parameters
TWA
3
or dust
4mg/m , 8h
Legal Basis
Form of exposure
Inhalation dust
TWA
Ingested dust
DNEL value(s)
Long-term - systemic effects
dermal
Long-term - systemic effects
inhalation
3.33 mg/kg bw/day
13.33 mg/m³
PENEC value(s)
0.023 mg/L; Assessment factor 1000;
0.0023 mg/L; Assessment factor 1000;
0.23 mg/L; Assessment factor 100;
100 mg/L
PNECaqua (freshwater):
PNECaqua (marine water):
PNECaqua (intermittent releases):
PNECSTP: 100 mg/L
8.2 Exposure controls
8.2.1 Appropriate Engineering Controls
Provide adequate ventilation.
8.2.2 Individual Protection Measures, Such as Personal Protective Equipment
Respiratory protection:
Wear suitable respiratory protective equipment if exposure to high levels of
dust are likely.
Hand protection:
Wear PVC or rubber gloves.
Eye protection:
Wear eye/face protection.
Skin and body protection:
Wear suitable protective clothing.
8.2.3 Environmental exposure controls
No data.
9. PHYSICAL AND CHEMICAL PROPERTIES
9.1 Information on basic physical and chemical properties
Form:
Colour:
Organic powder
White
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Sulphanilic Acid
Odour:
Without characteristic odour
Granulometry:
The substance mass median diameter was determined as
approximately 110 micro.m, while less than 10% of the particles had a
diameter less than 25 micro.m and less than 1% had a diameter less
than 10 micro.m.
Boiling point/boiling range:
The substance decomposes before boiling.
Melting point:
The substance decomposes before melting.
Surface tension:
72.3 mN/m at 20°C and 1000 mg/L; Substance is not surface active.
Flammability (solid, gas):
The substance did not ignite within two minutes and is therefore
considered to be not highly flammable.
Vapour pressure:
Inferior to 10 Pa (at room temperature)
Relative density:
1.4862 at 20°C
Water solubility:
12.51 g/L at 20 °C (very water soluble)
Partition coefficient
noctanol/water:
Log Kow (Pow): - 2.3 at 25 °C. It is very hydrophilic.
Self ignition temperature:
331 °C at 1013 hPa
Explosive properties:
No
Oxidizing properties:
No
9.2 Other information
Dissociation constant:
pKa at 20°C: 3.35
10. STABILITY AND REACTIVITY
10.1 Reactivity
Can react with acids.
10.2 Chemical stability
Stable at normal storage and handling conditions.
10.3 Possibility of hazardous reactions
Can react with acids.
10.4 Conditions to avoid
Avoid contact with acids.
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10.5 Incompatible materials
No data.
10.6 Hazardous decomposition products
No data.
11. TOXICOLOGICAL INFORMATION
11.1 Information on toxicological effects
As the substance is practically non-toxic, it does not need to be classified for acute toxic effects.
As sulphanilic acid is excreted very fast mainly via the urine, it has no potential for bioaccumulation.
Furthermore, sulphanilic acid most likely penetrates the skin only poorly, arising from its very polar nature
and the very low log Pow. Consequently, skin absorption will be low.
The Sulphanilic acid may cause an allergic reaction in contact with skin. Sulphanilic acid is eye irritating.
Hazard class
Dose descriptor
Method/reference
Acute oral toxicity:
LD50: 2000 mg/kg bw (female rat)
test material: sulphanilic acid
OECD Guideline 423 (Acute Oral
toxicity - Acute Toxic Class Method)
LD50: 2000 mg/kg bw (male/female
rat) test material: sulphanilic acid
OECD guideline 402 (Acute Dermal
Toxicity)
Acute dermal toxicity:
Acute inhalation toxicity:
Due to the very low vapour
pressure, inhalative exposure is
highl unlikely. Therefore, an acute
inhalation study is not required.
Skin irritation:
Skin corrosion:
Not irritating
OECD Guideline for the Testing of
Chemicals, Draft Proposal for a New
Guideline, In Vitro Skin Irritation:
Reconstructed Human Epidermis (RhE)
Test Method, Version 7.6, 09.09.09
As the substance is not skin
irritating, it will also not be skin
corrosive.
Eye irritation/corrosion:
Rabbit ca. 2 (mean) (Time point: 24,
48 and 72 h) (fully reversible); Test
material: sulphanilic acid;
Skin sensitisation:
Not sensitizing;
Germ cell mutagenicity
in vitro:
Negative; S. typhimurium (test mat.:
sulphanilic acid) Doses: 1 - 1000
µg/plate
in vivo:
Negative; mouse and rat; test mat.:
sulphanilic acid
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OECD Guideline 405 (Acute Eye
Irritation/ Corrosion)
OECD Guideline 429 (Skin
Sensitisation: Local Lymph Node Assay)
Equivalent or similar to OECD Guideline
471 (Bacterial Reverse Mutation Assay)
C. Westmoreland and D.G. Gatehouse
(1991)
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Hazard class
Dose descriptor
Method/reference
Carcinogenicity:
No carcinogenic;
Borzelleca rat/mice
Reproductive toxicity oral
Fertility:
NOAEL: 1000 mg/kg bw/day (actual
dose received) (rat male/female)
test mat.:sulphanilic acid
OECD Guideline 421 (Reproduction /
Developmental Toxicity Screening Test)
NOAEL (developmental toxicity):
1000 mg/kg bw/day; (rat) test mat.:
sulphanilic acid
Teratogenicity/
development:
NOAEL (maternal toxicity):
1000 mg/kg bw/day (rat) test mat.:
sulphanilic acid
No data
STOT – single exposure
STOT – repeated
exposure
Aspiration hazard
OECD test guideline 421
OECD test guideline 421
No data
No data
12. ECOLOGICAL INFORMATION
12.1 Toxicity
Information on environmental effects
Hazard class/species
Dose descriptor
LC50 (96 h) Danio rerio: > 100
mg/L test mat. Sulphanilic acid;
Toxicity to fish
EC50 (48 h) Daphnia magna:
23 mg/L (mobility) test mat.
sulphanilic acid;
Toxicity to daphnia and
other aquatic
invertebrates:
Toxicity to algae:
Desmodesmus
subspicatus
EC50 (72 h): 32 mg/L test mat.
sulphanilic acid; based on: cell
number (yield)
NOEC (72 h): 4.6 mg/L test
mat. sulphanilic acid; based
on: cell number (yield)
Toxicity to plants:
Method/reference
OECD Guideline 203 (Fish, Acute Toxicity
Test)
OECD Guideline 202 (Daphnia sp. Acute
Immobilisation Test)
(OECD Guideline 201 (Alga, Growth
Inhibition Test))
No data
12.2 Persistence and degradability
Biodegradability:
Degradation (abiotic):
Biodegradation in water: readily biodegradable
As the substance is readily biodegradable, it will not persist in the environment.
12.3 Bioaccumulative potential
As the substance has a very low log Kow, i. e. < 3, and is biodegradable, it can be assumed to not
bioaccumulate.
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12.4 Mobility in soil
n.a.
12.5 Results of PBT/vPvB assessment
Due to being readily biodegradable and its very low log Kow, the substance will neither persist nor
bioaccumulate in the environment.
12.6 Other adverse effects
n.a.
13. DISPOSAL CONSIDERATIONS
13.1 Waste treatment methods
All the wastes must be treated in an appropriated sewage treatment plant in order to avoid environmental
contamination. Storage should avoid leakage to drains, water courses or soil.
14. TRANSPORT INFORMATION
This substance is not classified as dangerous for transportation.
15. REGULATORY INFORMATION
The elaboration of this safety data sheet was based on the criteria of Dir 67/548/EEC of 27 July (DSD),
transposed into national law by Decree 98/2010 of 11 August, the EC Reg. No 1272 / 2008 of 16 December
(CLP) and the EC Reg. No 1907/2006 of 18 December (REACH).
16. OTHER INFORMATION
This information only concerns the above mentioned product and does not need to be valid if used with
other product(s) or in any process. The information is to our best present knowledge correct and complete
and is given in good faith but without warranty. It remains the user's own responsibility to make sure that the
information is appropriate and complete for his special use of this product.
16.1 Explanations for possible abbreviations mentioned above
PBT: Persistent, bioaccumulative and toxic.
vPvB: Very persistent and very bioaccumulative.
OEL: Occupational exposure limit.
ES: Exposure Scenario
TWA: Time weight average
ELV: Exposure Limit Value
PNEC: Predicted No Effect Concentration
DNEL: Determined No Effect Level
Eye Irrit. 2A: Irritant to eyes category 2A
Skin Irrit. 2: Skin irritant category 2
Skin Sens. 1: Skin sensitising category 1
LEV: Local Exhaust Ventilation
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ANNEXES:
Annex 1: Exposure Scenario 1 - Manufacturing
Annex 2: Exposure Scenario 2 - Manufacturing of fine chemicals
Annex 3: Exposure Scenario 3 - Formulation
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Annex 1: Exposure Scenario 1 - Manufacturing
Annex 2: Exposure Scenario 2 - Manufacturing of fine chemicals
Annex 3: Exposure Scenario 3 - Formulation
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