Physiology of peroxidation processes in mammalian sperm Patrícia da Fonseca Nunes da Silva Utrecht, 2006 Da Fonseca Nunes da Silva, Patrícia Physiology of peroxidation processes in mammalian sperm 2006 PhD Thesis, Utrecht University, Faculty of Veterinary Medicine-with summary in Dutch and Portuguese ISBN: 90-393-4286-5 ISBN: 978-90-393-4286-2 Cover Design: Patrícia Silva and Johan Jongsma Printed by: Ridderprint, Ridderkerk Physiology of peroxidation processes in mammalian sperm Fysiologie van peroxidatie processen in zoogdiersperma (met een samenvatting in het Nederlands) Fisiologia de processos peroxidativos em esperma de mamíferos (com sumário em Português) Proefschrift ter verkrijging van de graad van doctor aan de Universiteit Utrecht op gezag van de rector magnificus, prof. dr. W.H. Gispen, ingevolge het besluit van het college voor promoties in het openbaar te verdedigen op vrijdag 7 juli 2006 des middags te 4.15 uur door Patrícia da Fonseca Nunes da Silva Geboren op 22 September 1972 te Lissabon, Portugal Promotoren: Prof. Dr. B. Colenbrander Prof. Dr. J.B. Helms Co-promotoren: Dr. B.M. Gadella Dr. B.A.J. Roelen Dr. J.F.H.M. Brouwers The research described in this thesis was financially supported by Portuguese Ministry of Science, Technology and Higher Education - Foundation for Science and Technology (FCT), grant nr. SFRH/2888/2000. Printing of this thesis was financially supported by Department of Biochemistry and Cell Biology, J.E. Jurriaanse Stichting and FCT. “If a man will begin with certainties, he shall end in doubts; but if he will be content to begin with doubts, he shall end in certainties” (Bacon, The advance of learning) “Many of life’s failures are people who did not realize how close they were to success when they gave up.” (T. Edison) “Somewhere, something incredible is waiting to happen.” (C. Sagan) “Science is organized knowledge. Wisdom is organized life.”(I. Kant) “Imperfection is where a person has room for growth.” (author unkown) A vida é um caminho Com uma estrela a guiar Andamos devagarinho Na esperança de a encontrar. (P. Silva, 1998) To God and N. Sra. de Fátima To all alchemists in my live To Johan To my dear parents, António and Carlota