CURRICULUM VITAE
DAVIDE CARVALHO
Date of birth : January 20, 1953
Place of birth : Porto, Portugal
1976 - Medical Degree from Faculty of Medicine of University of Porto with a grade of 16
out of 20
1977 - Research Fellow at the Experimental Cytology Center and Teaching Assistant at
the Facullty of Medicine
1978 - Completion of the General Internship in the Hospital S. João with a grade of 18 out
of 20.
1986 - Completion of Endocrinology Residency with a final grade of 18 out of 20.
1986 - Approval «by unanimity with distinction» as a member of the National College of
Endocrinologists of the Portuguese Medical Association.
1987 - Residency in the Reproductive Endocrinology Unit of the Massachusetts General
Hospital, under the supervision of William Crowley, regarding the technique of hormonal
pulsatility study.
1988 - Approval «by unanimity with distinction» in the Scientific and Pedagogic
Examination of the Academic Carrier at Oporto Faculty of Medicine. The theme presented
was «Somatic Growth and Development».
1993 - Assistant of the Department of Endocrinology, Diabetes and Metabolism at the
Hospital S. João.
1995 – Consultant of Endocrinology
1997 – Head of the Neuroendocrine Unit at the Hospital de S. João and Coordinator of the
Pituitary Tumours Study Group of the Portuguese Society of Endocrinology, Diabetes and
Metabolism
2001 – Received his Ph.D. at the University of Oporto
2001 – Assistant Professor of the Oporto Faculty of Medicine
2005 – Chief of Service of the Department of Endocrinology Hospital S. João, Alameda
Hernani Monteiro, 4200-319 Porto
2009 – Hospital S. João – First “Reference Center” for Surgical Mangement of Obesity”
2009 – Associate Professor of the Oporto Faculty of Medicine
2010 – Head of the Department of Endocrinology, Diabetes and Metabolism at Hospital S.
João
PEER REVIEW ENGLISH PUBLICATIONS
1 - Carvalho D, Pignatelli D, Resende C. Ketoconazole for hirsutism. Lancet 1985; 2:560
2 - Costa J, Ramos D, Massada S, Carvalho D, Pignatelli D. Etomidate and Cushing Syndrome. Anesthesia 1986;
41:211-212
3 - Carvalho D, Portocarrero M, Pignatelli D, Vieira E, Hargreaves M. Radiation cured acromegalics show evidence
of a subnormal GH ( Growth Hormone) response to GHRH (GH-releasing hormone). Advances in Pituitary
Adenomas Research. Landolt AM, Heitz PU, Zaft , Girard J, Del-Pozo E (ed). Pergamon Press, Oxford 1988; 273276
4 - Carvalho D, Figueiredo S, Pignatelli D. Clinical experience with somatrem in growth hormone deficiency. Acta
Pediatrica Scandinava 1988; S 343:240-241
5 - Magalhães MM, Carvalho D, Oliveira MA, Magalhães MC. Nuclear bodies in the normal and hyperfunctional
human adrenal cortex. Hystology and Hystopathology 1989; 4:241-245
6 - Carvalho D, Vinha E, Portocarrero MC, BaldaqueFaria A, Medina JL, Hargreaves MP. Atrial Natriuretic Peptide
and reninaldosterone axis in pituitary dwarfism. Growth Disorders : the state of the art.Cavallo L, Job JC, New M
(eds) Raven Press 1991 ; 303-309
7 - Carvalho D, Nunes R, Santos M, Oliveira V, Tsou R, Teixeira-Santos N, Medina JL, Pais-Clemente M. Auditory
studies in young type 1 (insulin-dependent diabetics. Proc XV World congress of ORL, HEAD and NECK surgery
1994; 197-200.
8 - Pereira J, Vaz R, Carvalho D, Cruz C. Thickening of the pituitary stalk: a finding suggestive of intrasellar
tuberculoma? Case report. Neurosurgery 1995; 36: 1013-15.
9 - Barbosa AP, Carvalho D, Marques L, Monteiro M, Castro-Neves A, Machado-Carvalho A, Cruz J, Medina J.L.
Inefficiency of the anticoagulant therapy in the regression of the radiation-induced neuropathy in Cushing’s disease. J
Endocrinol Invest 1999; 22: 301-5.
10 - Carvalho D. Pereira J, Vilarinho A, Vinha E, M.C. Gonçalves, M Ayres-Basto, L. Castro, L Osório, M. Monteiro,
J.L. Medina and R. Vaz. Transsphenoidal surgery for Cushing’s Disease: an institutional perspective of follow-up and
monitoring of 59 patients. Proceedings of the 12th Eur C Neurosurgery; 2003; 203-6.
11 - Cavaco BM, Guerra L, Bradley KJ, Carvalho D, Harding B, Oliveira A, Santos MA, Sobrinho LG, Thakker RV,
Leite V. Hyperparathyroidism-jaw tumor syndrome in Roma families from Portugal is due to a founder mutation of the
HRPT2 gene. J Clin Endocrinol Metab. 2004 Apr;89:1747-52
12 -Felipe F. Casanueva, Ezio Ghigo, Vera Popovic and the Athens TBI and Hypopituitarism Study Group (Carvalho
D) Hypopituitarism following traumatic brain injury (TBI). A guidelines Decalogue. J Endocrinol Invest 2004; 27:793-5.
13 - Carvalho D. Does genetic subtype of type 2 diabetes (such as MODY) influence your therapeutic decision?
Medicographia 2005; 27: 362-3
14 - Melmed S,. Eur J Endocrinol. 2005 Dec;153:737-40.
15 – Lemos M, Gomes L, Bastos M, Leite V, Limbert E, Carvalho D. Analysis of the PROP1 gene in combined
pituitary hormone deficinecy reveals a novel initiation codon mutation. Clin Endocrinol 2006; 65: 148-56.
16 - T. Lucas, R. Astorga and the Spanish–Portuguese Multicentre Autogel Study Group on Acromegaly( Carvalho
D). Efficacy of lanreotide Autogel administered every 4–8 weeks in patients with acromegaly previously responsive
to lanreotide microparticles 30 mg: a phase III trial. Clinical Endocrinology 2006;65: 320–326
17 - Gomis R, Storms F, Conget I, Sinnassamy P, Davies M; AT.LANTUS Study Group ( … Carvalho, Medina JL…).
Improving metabolic control in sub-optimally controlled subjects with Type 1 diabetes: comparison of two treatment
algorithms using insulin glargine. Diabetes Res Clin Pract. 2007;77 :84-91.
18. Mercado M, Borges F, Bouterfa H, Chang T, Chervin A, Farrall AJ, Patocs A, Petersenn S, Podoba J, Safari M,
Wardlaw J on behalf of the SMS995B2401 Study Group (Carvalho D). A prospective, multicentre study to investigate
the efficacy, safety and tolerability of octreotide LAR (long-acting repeatable octreotide) in the primary therapy of
patients with acromegaly. Clin Endocrinol 2007; 66: 859–868
19 - Davies M, Lavalle-González F, Storms F, Gomis R; AT.LANTUS Study Group (… Carvalho D.) Initiation of
insulin glargine therapy in type 2 diabetes subjects suboptimally controlled on oral antidiabetic agents: results from
the AT.LANTUS trial. Diabetes Obes Metab. 2008 May;10(5):387-99.
20. Davies M, Sinnassamy P, Storms F, Gomis R; AT.LANTUS Study Group (…Carvalho D, Medina JL…) . Insulin
glargine-based therapy improves glycemic control in patients with type 2 diabetes sub-optimally controlled on
premixed insulin therapies. Diabetes Res Clin Pract. 2008; 79:368-75.
21. Parving HH, Persson F, Lewis JB, Lewis EJ, Hollenberg NK; AVOID Study Investigators (Carvalho D).Aliskiren
combined with losartan in type 2 diabetes and nephropathy. N Engl J Med. 2008; 358:2433-46.
22. Carvalho A, Amaral-Mendes R, Carvalho D, Carvalho JF. Osteonecrosis of the mandible induced by intravenous
bisphosphonates in oncological patients. Acta Med Port 2008; 21: 505-10.
23. Melmed S, Colao A, Barkan A, Molitch M, Grossman AB, Kleinberg D, Clemmons D, Chanson P, Laws E,
Schlechte J, Vance ML, Ho K, Giustina A; Acromegaly Consensus Group (Carvalho D) . Guidelines for acromegaly
management: an update. J Clin Endocrinol Metab. 2009;94:1509-17.
24. Marques CJ, Pignatelli D, Carvalho B, Barceló J, Almeida AC, Fernandes S, Witchel SF, Sousa M, Oliveira MJ,
Freitas P, Fontoura M, Carvalho D, Barros A, Carvalho F. Mutational Characterization of Steroid 21-Hydroxylase
Gene in Portuguese patients with Congenital Adrenal Hyperplasia. Exp Clin Endocrinol Diabetes 2010 118(8):50512.
25 . Freitas P, Santos AC, Carvalho D, Pereira J, Marques R, Martinez E, Sarmento A, Medina JL. Fat Mass Ratio:
An Objective Tool to Define Lipodystrophyin HIV-Infected Patients Under Antiretroviral Therapy. J Clin Densit 2010;
13: 197- 203.
26. Carvalho B, Marques CJ, Carvalho D, Barros A, Carvalho F. Adrenal Hyperplasia. Novel human pathological
mutations. Hum Genet 2010; 127:482-3
27. Giustina A, Chanson P, Bronstein MD, Klibanski A, Lamberts S, Casanueva FF, Trainer P, Ghigo E, Ho K,
Melmed S; Acromegaly Consensus Group ( Carvalho D) . A consensus on criteria for cure of acromegaly. J Clin
Endocrinol Metab. 2010 ;95:3141-8.
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28. Vitorino R, Alves R, Barros A, Caseiro A, Ferreira R, Calheiros-Lobo M, Bastos A, Duarte J, Carvalho D, Santos
LL, Amado FL. Finding new posttranslational modifications in salivary proline-rich proteins. Proteomics 2010, 10,
3732–3742.
29. Beça A, Egipto P, Carvalho D, Correia F, Oliveira B, Rodrigues A, Amarante J, Medina JL. Nitrogen balance
assessment in burn patients. Acta Med Port 2010; 23: 883-890.
30. Cavaco BM, Santos R, Félix A, Carvalho D, Lopes JM, Domingues R, Sirgado M, Rei N, Fonseca F, Santos JR,
Sobrinho L, Leite V. Identification of de novo germline mutations in the HRPT2 gene in two apparently sporadic
cases with challenging parathyroid tumor diagnoses. Endocr Pathol. 2011 Mar;22(1):44-52.
31 - Freitas P, Carvalho D, Souto S, Santos AC, Xerinda S, Marques R, Martinez E, Sarmento A, Medina JL. Impact
of Lipodystrophy on the Prevalence and Components of Metabolic Syndrome in HIV-infected patients. BMC
Infectious Diseases 2011, 11:246.
32 - Souto SB, Fernandes H, Matos MJ, Braga DC, Pereira J, Carvalho D. Importance of 99mTc-sestaMIBI thyroid
scan in a case of amiodarone induced thyrotoxicosis. Arq Bras Endocrinol Metab. 2011;55:486-89.
33 - Freitas P, Carvalho D, Santos AC, Mesquita J, Correia F, Xerinda S, Marques R, Martinez E, Sarmento A,
Medina JL. Assessment of body fat composition disturbances by bioimpedance analysis in HIV-infected adults. J
Endocrinol Invest. 2011; 34: e321.9.
34 - Caseiro A, Vitorino R, Barros AS, Ferreira R, Calheiros-Lobo MJ, Carvalho D, Duarte JA, Amado F. Salivary
peptidome in type 1 diabetes mellitus. Biomed Chromatogr. Biomed Chromatogr. 2012 May;26(5):571-82.
35. Colao A, Petersenn S, Newell-Price J, Findling JW, Gu F, Maldonado M, Schoenherr U, Mills D, Salgado LR,
Biller BM; Pasireotide B2305 Study Group (Carvalho D). A 12-month phase 3 study of pasireotide in Cushing's
disease.N Engl J Med. 2012 Mar 8;366(10):914-24.
36. Freitas P, Carvalho D, Santos AC, Madureira AJ, Xerinda S, Martinez E, Pereira J, Sarmento A, Medina JL.
Central/Peripheral Fat Mass Ratio Is Associated With Increased Risk of Hypertension in HIV-Infected Patients. J Clin
Hypertens (Greenwich). 2012 Sep;14(9):593-600.
37.Ribeiro da Silva M, Santos-Carvalho M, Cacho-Rodrigues P, Neves N, Moura-Gonçalves, Pinto R, Carvalho D.
Rare Vertebral Metastasis in a case of Hereditary Paraganglioma. Hereditary Cancer in Clinical Practice 2012, 10:12
38. Freitas P, Carvalho D, Santos AC, Mesquita J, Matos MJ, Madureira AJ, Martinez E, Sarmento A, Medina JL.
Lipodystrophy defined by Fat Mass Ratio in HIV-infected patients is associated with a high prevalence of glucose
disturbances and insulin resistance. BMC Infect Dis. 2012 Aug 6;12(1):18
39. Rodrigues P, Castedo JL, Damasceno M, Carvalho D. Ectopic Cushing's syndrome caused by a pulmonary
ACTH-secreting tumor in a patient treated with octreotide. Arq Bras Endocrinol Metabol. 2012 Oct;56(7):461-4.
40. Carvalho B, Pereira M, Marques CJ, Carvalho D, Leão M, Oliveira JP, Barros A, Carvalho F. Comprehensive
Genetic Analysis and Structural Characterization of CYP21A2 Mutations in CAH Patients. Exp Clin Endocrinol
Diabetes. 2012 Oct;120(9):535-9
41. Parving HH, Brenner BM, McMurray JJ, de Zeeuw D, Haffner SM, Solomon SD, Chaturvedi N, Persson F, Desai
AS, Nicolaides M, Richard A, Xiang Z, Brunel P, Pfeffer MA; ALTITUDE Investigators (Carvalho D). Cardiorenal end
points in a trial of aliskiren for type 2 diabetes. N Engl J Med. 2012 Dec 6;367(23):2204-13.
42. Freitas P, Carvalho D, Santos AC, Matos MJ, Madureira AJ, Marques R, Martinez E, Sarmento A, Medina JL.
Prevalence of obesity and its relationship to clinical lipodystrophy in HIV-infected adults on anti-retroviral therapy. J
Endocrinol Invest. 2012 Dec;35(11):964-70.
43. Savona-Ventura C, Vassallo J, Marre M, Karamanos BG; MGSD:GDM Study Group (Carvalho D) .
Hyperglycaemia in pregnancy in Mediterranean women. Acta Diabetol. 2012 Dec;49(6):473-80.
44. Souto SB, Baptista PV, Barreto F, Sousa PF, Braga DC, Carvalho D Ovarian intratumoral 21-hydroxylase
deficiency in a postmenopausal hirsute woman. Arq Bras Endocrinol Metabol. 2012 Dec;56(9):672-6.
45. Savona-Ventura C , Vassallo J, Marre M, Karamanos BG for the MGSD-GDM study group ( Carvalho D). A
composite risk assessment model to screen for gestational diabetes mellitus among Mediterranean women. Int J
Gynecol Obstet 2013;120:240–244.
46. Freitas, P; Carvalho, D. Lipodystrophy: beyond generalization? Panminerva Medica 2013. 55: 253-68.
47.Marques-Pinto, A; Carvalho, D. Human Infertility: are endocrine disruptors to blame? Endocr Connect 2013; 2(3):
R15-29.
48.Nogueira, C; Souto, SB; Vinha, E; Braga, DB; Carvalho, D. Oral glucose lowering drugs in type 2 diabetic patients
with chronic kidney disease. Hormones 2013, 12(4): 483-494.
49. Ribeiro-Santos, L; Durães, C; Prazeres, H; Mendes, A; Alvelos, I; Suzete-Moreira, C; Canedo, P; Neves, C;
Carvalho, D; Sobrinho-Simões, M; Soares, P. A polymorphism in the promoter region of Selenoprotein S gene
(SEPS1) contributes to Hashimoto's thyroiditis susceptibility. J Clin Endocrinol Metab 2014, 99:E719-23.
50. Souto, SB; Baptista, PB; Braga, DC; Carvalho, D. Ovarian Leydig cell tumor in a post-menopausal patient with
severe hyperandrogenism. Arquivos Brasileiros de Endocrinologia e Metabologia 2014;58(1):68-75.
51. Freitas P, Carvalho D, Santos A C, Madureira AJ, Martinez E, Pereira J, Sarmento A, and Medina JL Adipokines,
hormones related to body composition, and insulin resistance in HIV fat redistribution syndrome. BMC Infectious
Diseases 2014; 14:347
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52. Viriato, D; Calado, F; Gruenberger, JB; Carvalho, D; Silva-Nunes, J; Johal, S; Viana, R. Cost-effectiveness of
metformin plus vildagliptin compared with metformin plus sulphonylurea for the treatment of patients with type 2
diabetes mellitus: a Portuguese healthcare system perspective. J Medical Economics 2014;17:499-507.
53. Freitas P, Carvalho D, Santos A C, Madureira AJ, Martinez E, Pereira J, Sarmento A, and Medina JL. Carotid
intima media thickness is associated with body fat abnormalities in HIV-infected patients. BMC Infectious Diseases
2014; 14:348.
54. Pivonello R, Petersenn S, Newell-Price J, Findling JW, Gu F, Maldonado M, Trovato A, Hughes G, Salgado LR,
Lacroix A, Schopohl J, Biller BM; Pasireotide B2305 Study Group (Abs R, Allolio B, Auchus R, Bertherat J, Biller
BM, Boguszewski C, Boscaro M, Brue T, Bruno O, Caron P, Cavagnini F, Carvalho D, Chabre O,Chervin A, Chik
C, Colao A, Çömlekçi A, Cortet C, Czepielewski M, Degli Uberti E, Estour A, Feldt-Rasmussen U, Fleseriu M, Freda
P, Gadelha M,Gershinsky M, Ghigo E, Glaser B, Gu F, Guitelman M, Guler S, Hamrahian A, Imran SA, Jin
Z, Jorgensen JO, Kadioğlu P, Katznelson L, Lacroix A,Leal Cerro A, Loli P, Lu L, Ludlam W, Mantero F, Martino
E, Mercado M, Moreira A, Nogueira K, Ning G, Østergaard Kristensen L, Petersenn S,Piaditis G, Portocarrero
L, Rohmer V, Rubens R, Salgado L, Samson S, Schopohl J, Shimon I, Strasburger C, Tabarin A, Terzolo
M, Tsagarakis S,Unger N, Valkusz Z, Van Gaal L, Välimäki M, Vidal E, Webb S, Weiss R, Zgliczyński W).
Pasireotide treatment significantly improves clinical signs and symptoms in patients with Cushing's disease: results
from a Phase III study. Clin Endocrinol (Oxf). 2014; 81(3):408-417.
55. Carvalho D, Nogeuira C, Freitas P.GH, acromegaly and glucose metabolism. J Diabetes Metab Disord Control
2014, 1(4): 00023.
56. Barbosa, M; Veríssimo, R; Bennett, M; Carvalho, D. Cross-cultural psychometric assessment of the Leeds
Assessment of Neuropathic Symptoms and Signs (LANSS) pain scale in the Portuguese population. Pain Practice
2014; 14(7): 620–624.
57.Nogueira C, Souto SB, Rios E, Pereira J, Vinha E, Freitas P, Carvalho D. Vertebral osteoporotic fractures with
height loss secondary to Cushing's disease. Acta Reumatol Port. 2014 Feb 18. [Epub ahead of print]
58. Lau E, Carvalho D, Oliveira J, Fernandes S, Freitas P.Familial partial lipodistrophy type 3 resulting from a new
mutation on PPARG gene. Hormones 2015 ( Epub ahead of print)
59. Lau E, Freitas P, Costa J, Batista R, Máximo V, Coelho R, Matos-Lima L, Eloy C, Carvalho D. Loss of
mitochondrial SDHB expression: what is its role in diffuse thyroid lipomatosis? Hormone and Metabolic Research
2015 ( Epub ahead of print)
60. Belo B, Magalhães A, Freitas P, Carvalho D. Familial Partial Lipodystrophy, Dunnigan variety - challenges for
patient care during pregnancy. BMC Research Notes 2015
61. Lau; E; Carvalho, D; Freitas, P. Gut microbiota: association with NAFLD and metabolic disturbances. Biomed
Res International 2015 ( Epub ahead of print)
62. Castro-Vale, I, , van Rossum EF, Machado JC, Mota-Cardoso R, Carvalho D. Genetics of glucocorticoid
regulation and posttraumatic stress disorder - what do we know? Neuroscience & Biobehavioral Reviews 2015;
63. Belo S, IL-4 and IL-6 levels and adipose tissue distribution in HIV-1 patients under antiretroviral therapy", J
Endocrinological Invest 2015
Prizes
European NeuroEndocrine Association – Best Poster Clinical Science Award 1999
Hippocrates Prize 2003 of the Mediterranean Group for the Study of Diabetes
Endocrine Society Presidential Poster Award 2014
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Member of the Program and Organizing Committee of the International Congress of
Endocrinology 2004
Member of the Executive Board of the Mediterranean Group for the Study of
Diabetes (2007-2009; 2009-2011)
Chairmen of the Organizing Committee od the European Society of Endocrinology
Clinical Update Course – Porto 2010
Member of the Scientific Committee of the Meeting of the European Neuroendocrine
Association Liege 2010
Member of the Scientific Committee of the European Congress of Obesity 2014
Chairmen of the Organizing Committee od the European Congress of Obesity – Porto
2017
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Member of several associations: EASD, ADA, American Association of Clinical
Endocrinology, American Endocrine Society, European Group of Insulin Resistance,
Diabetes Education Study Group, Mediterranean Group for the Study of Diabetes,
European Neuroendocrine Association, Pituitary Society
Portuguese Journals Published Papers
More than one hundred papers in Portuguese peer-review journals
Books and Monographs
Obesity – Prevention and therapeutics. 2007 – Editorial Presença
Clinical trials
NOR IR PLO 94/01 – Principal Investigator
HOE 490/4017 – Investigator
F32-PT-IOEH – Investigator
A-92-52030-046 – Investigator
BiASP – 1241 – Principal Investigat
HOE 901/3504 – Investigator
HOE 901/3505 - Investigator
CSM995B2401 – Principal Investigator
OASIS – Principal Investigat
Avoid Study CSPP100C2201 – phase II – Principal Investigator.
SOM230 B2305 – Phase II – Principal investigator. National coordinator
Altitude study – Principal Investigator
LTS11717 – Principal investigator
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