UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL
PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS PNEUMOLÓGICAS
Mestrado e Doutorado
PNP-65 Manifestações Pulmonares das Infecções por Fungos
Oportunistas e Patógenos Primários
Créditos: 2 (30 horas-aula)
Professor: Prof. Luiz Carlos Severo
OBJETIVOS
• Revisar aspectos ecológicos, clínicos, ocupacionais, epidemiológicos, radiológicos,
imunológicos (imunidade celular, soromicologia) e histopatológicos (reação granulomatosa)
das micoses.
• Tematizar o diagnóstico laboratorial: colheita, transporte, processamento do espécime
clínico; identificação microbiológica, divulgando os comemorativos úteis na triagem das
infecções micóticas e estabelecer critérios diagnósticos para as micoses sistêmicas por
fungos
patógenos primários e oportunistas.
CONTEÚDO
I. Micoses por fungos oportunistas de celulas T.
a. Fungos endêmicos com dimorfismo térmico
b. Fungos endêmicos monomórficos
c. Fungos monomórficos de distribuição universal
II. Micoses por fungos oportunistas de fagócitos.
III. Micoses por fungos oportunistas de fagócitos e células T
IV. Infecções bacterianas simulando infecções fúngicas.
a. Actinomicose
b. Nocardiose
c. Rodococose
BIBLIOGRAFIA
• Wheat LJ, Goldman M, Sarosi G. State-of-the-art review of pulmonary fungal
infections. Semin Respir Infect 17: 158-181, 2002.
• Torres HA, Rivero GA, Kontoyiannis DP. Endemic mycoses in a cancer hospital.
Medicine 81: 201- 212, 2002.
• Bag R. Fungal pneumonias in transplant recipients. Curr Opin Pulm Med 9: 193198, 2003.
• Kradin Rl. DIAGNOSTIC PATHOLOGY OF INFECTIOUS DISEASE.
Saunders Elsevier, Philadelphia, PA. 2010.
• Mandell, J. E. Bennett, and R. Dolin (ed.), Principles and practice of infectious
diseases, 7th ed. Churchill Livingstone, Philadelphia, PA. 2010.
• Versalovic J. Manual of clinical microbiology. ASM Press, Washington, DC.
2011.
• Schweigert M, Dubecz A, Beron M, Ofner D, Stein HJ. Pulmonary infections
imitating lung cancer: clinical presentation and therapeutical approach. Ir J Med
Sci. ;182:73-80, 2013.
Actinomicose
•
Mabeza GF, Macfarlane J. Pulmonary actinomycosis. Eur Respir J. 2003
Mar;21(3):545-51.
Aspergilose
• Franquet T, Muller NL, Gimenez A, Guembe P, de La Torre J, Bague S. Spectrum
of pulmonary aspergillosis: histologic, clinical, and radiologic findings.
Radiographics 21: 825-837, 2001.
• Soubani AO, Chandrasekar PH.The clinical spectrum of pulmonary aspergillosis.
Chest 121: 1988- 1999, 2002.
• Pasqualotto AC. Aspergillosis from diagnosis to prevention. Amsterdã, Springer,
2010.
• Guazzelli LS, Severo CB, Hoff LS; Pinto GLF, Camargo JJ; Severo LC. Bola
fúngica por Aspergillus fumigatus em cavidade pleural. J Bras Pneumol 38:
125-132, 2012.
• Pasqualotto AC, Xavier MO, Sánchez LB, de Oliveira Costa CD, Schio SM,
Camargo SM, Camargo JJ, Sukiennik TC, Severo LC. Diagnosis of invasive
aspergillosis in lung transplant recipients by detection of galactomannan in the
bronchoalveolar lavage fluid. Transplantation, 15:90:306-1, 2010.
• Gazzoni FF, Hochhegger B, Severo LC, camargo JJ. Bola fúngica por Aspergillus
fumigatus no pulmão nativo após transplante unilateral de pulmão. J Bras Pneumol,
2013 (epud).
Blastomicose
• Bradsher RW, Chapman SW, Pappas PG. Blastomycosis. Infect Dis Clin North Am
17: 21-40, 2003.
Coccidiodomicose
• Chiller TM, Galgiani JN, Stevens DA.Coccidioidomycosis. Infect Dis Clin North
Am 17: 41-57, 2003.
• Wanke B, Lazera M, Monteiro PC, Lima FC, Leal MJ, Ferreira Filho PL, Kaufman
L, Pinner RW, Ajello L. Investigation of an outbreak of endemic
coccidioidomycosis in Brazil's northeastern state of Piaui with a review of the
occurrence and distribution of Coccidioides immitis in three other Brazilian states.
Mycopathologia 148: 57-67, 1999.
Criptococose
• Andrade NMP, Trabasso P, Mendes RP et al. Consenso em criptococose. Rev Soc
Bras Med Trop, 41524-544, 2008.
• Severo CB, Pinto GI, Sotilli J, Garcia MR, Gazzoni AF, Oliveira FM, Severo
LC. Cryptococcuria as manifestation of disseminated cryptococcosis: Staib agar
as a selective identification medium. Mycoses, 54:e760-e766, 2011.
• Gazzoni AF, Oliveira FM, Salles EM, Mayayo E, Guarro J; Capilla J & Severo
LC. Unusual morphologies of Cryptococcus spp in tissue specimens: report of
10 cases. Rev Inst Med Trop S Paulo, 52: 2010.
Histoplasmose
• Wheat JL. Current diagnosis of histoplasmosis. Trends Microbiol 11: 488-494,
2003.
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Severo LC, Oliveira, FM, Irion K, Porto NS, Londero, AT. Histoplasmosis in Rio
Grande do Sul (Brazil): a 21-years experience. Rev Inst Med Trop São Paulo 43:
183-187, 2001.
Antonello VS, Zaltron VF, Vial M, de Oliveira FM, Severo LC. Orapharyngeal
histoplasmosis: report of eleven cases and review of the literature. Rev Soc Bras
Med Trop, 44:26-9, 2011.
Dall Bello AG, Severo CB, Guazzelli LS, Oliveira FM, Hochhergger B, Severo
LC. Histoplasmose simulando neoplasia de pulmão ou metástases pulmonares. J
Bras Pneumol, 39:1-6, 2013.
Nocardiose
• Beaman, BL & Beaman, I. Nocardia species: host-parasite relationships. Clin
Microbiol Rev, 7: 213- 64, 1994.
• Saubolle MA, Sussland D. Nocardiosis: review of clinical and laboratory
experience. J Clin Microbiol. 2003 Oct;41(10):4497-501.
• Severo LS, Dal Bello AG, Santos IS, Severo CB; Oliveira FM. Actinomicetoses
no Rio Grande do Sul: a propósito de 59 casos, atualizando
actinomicose,
nocardiose e rodococose. Âmbito Hospitalar, Nov/Dez:47-59, 2011.
• Severo CB, Oliveira FM, Cunha L, Cantarelli VV & Severo LC. Disseminated
nocardiosis due to Nocardia farcinica: diagnosis by thyroid abscess culture. Rev
Inst Trop São Paulo, 47: 355-358, 2005.
Paracoccidiodiomicose
• Vergara ML, et al. Consenso em paracoccidioidomicose. Rev Soc Bras Med Trop ,
39: 297-310, 2006.
• Brummer E, Castaneda E, Restrepo A. Paracoccidioidomycosis: an update. Clin
Microbiol Rev 6: 89-117, 1993.
• Dall Bello AG, Severo CB, Oliveira FM, Severo LC. Disseminated
paracoccidioidomycosis (Simulating Metastatic Lung Cancer) and Strongyloides
stercoralis Hyperinfestation in a Steroid-Treated Patient. J Clin Microbiol, 49:
2054-5, 2011.
• Rodrigues GS, Severo CB, Oliveira FM, Moreira JS, Prolla JC & Severo LC.
Association between paracoccidioidomycosis and neoplasia: an account of 24
cases. J Pneumol, 36: 356-62, 2010.
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Pneumocistose
• Totet A, Respaldiza N, Pautard JC, Raccurt C, Nevez G. Pneumocystis jiroveci
genotypes and primary infection. Clin Infect Dis 36:1340-1342, 2003.
• Maskell NA, Waine DJ, Lindley A, Pepperell JC, Wakefield AE, Miller RF, Davies
RJ. Asymptomatic carriage of Pneumocystis jiroveci in subjects undergoing
bronchoscopy: a prospective study. Thorax 58: 594-597, 2003.
Zigomicose
• Severo LC, Oliveira FM, Dreher R, Teixeira PZ, Porto NS, Londero AT.
Zygomycosis: a report of eleven cases and a review of the Brazilian literature. Rev
Iberoam Micol 19: 52-56, 2002.
• Gomes MZ, Lewis RE, Kontoyiannis DP. Mucormycosis caused by unusual
mucormycetes, non-Rhizopus, -Mucor, and -Lichtheimia species. Clin Microbiol
Rev.; 24:411-45, 2011.
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Roden MM, Zaoutis TE, Buchanan WL, Knudsen TA, Sarkisova TA, Schaufele
RL, Sein M, Sein T, Chiou CC, Chu JH, Kontoyiannis DP, Walsh TJ.
Epidemiology and outcome of zygomycosis: a review of 929 reported cases.
Clin Infect Dis.;41:634-53, 2005.
Hibbett DS, Binder M, Bischoff JF, Blackwell M, ET al. A higher-level
phylogenetic classification of the Fungi. Mycol Res.;111:509-47, 2007
Kontoyiannis DP, Lewis RE. How I treat mucormycosis. Blood.;118:1216-24,
2011.
Severo CB, Guazzzelli LS & Severo LC. Zigomicose. J Bras Pneumol, 36: 134141, 2010.
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