O ESCORE DE CÁLCIO NA AVALIAÇÃO DA ATEROSCLEROSE EM PACIENTES DIABÉTICOS Waschevicz, M.D.; Silva, C.V.; Rodrigues, P. R. Universidade Católica de Pelotas (UCPEL) e Universidade Federal de Pelotas (UFPEL) INTRODUÇÃO: A doença cardiovascular (DCV) é uma patologia prevalente no mundo e as taxas de morbi-mortalidade entre diabéticos são elevadas. Assim, estabelecer em portadores de Diabetes Mellitus (DM) o Escore de Cálcio Cardiovascular (ECC) é útil para determinar suas necessidades terapêuticas. OBJETIVO: O presente trabalho objetiva uma revisão de literatura sobre a relevância do ECC na investigação de placa aterosclerótica em diabéticos, otimizando as intervenções terapêuticas e reduzindo as taxas de morbi-mortalidade. MATERIAIS E MÉTODOS: Neste estudo, foram pesquisadas publicações que continham o ECC na avaliação da aterosclerose em diabéticos. As bases estudadas foram UpToDate, LILACS e MedLine e os descritores utilizados foram “coronary artery calcification on CT scanning” e “Diabetes Mellitus”. Foram encontradas 152 referências no UpToDate, 148 no MedLine e 31 no LILACS. Dessas, 7 referências no UpToDate, 32 no MedLine e 13 no LILACS mostraram-se pertinentes. RESULTADOS: A partir da análise dos estudos, identificou-se que a quantificação do cálcio coronariano em diabéticos justifica-se nos pacientes com risco cardiovascular moderado aos métodos convencionais. Ainda, o ECC possui valor preditor independente e incremental, quando comparado aos critérios de Framingham, podendo reclassificar um paciente de risco intermediário em alto risco, modificando terapêutica, reduzindo eventos cardiovasculares e acarretando melhores desfechos clínicos. CONCLUSÃO: A utilização do ECC trata-se de um método auxiliar na estratificação de risco e determinação da terapia medicamentosa em diabéticos com risco inicial intermediário. Os indivíduos com riscos extremos devem ser cautelosamente analisados, pois provavelmente o ECC não adicionará benefícios, podendo ainda gerar efeitos colaterais deletérios à radiação ionizante. REFERÊNCIAS: 1) Shemesh J, Motro M, Morag-Koren N, Konen E, Grossman E. Relation of coronary artery calcium to cardiovascular risk in patients with combined diabetes mellitus and systemic hypertension. Am J Cardiol. 2012 Mar 15;109(6):844-50. Epub 2011 Dec 22. 2) Krajnc M, Pečovnik-Balon B, Hojs R, Rupreht M. Comparison of coronary artery calcification and some coronary artery calcification risk factors in patients on haemodialysis and in patients with type 2 diabetes. J Int Med Res.2011;39(3):1006-15. 3) Mineoka Y, Fukui M, Tanaka M, Tomiyasu K, Akabame S, Nakano K, Yamazaki M, Hasegawa G, Oda Y, Nakamura N. Relationship between cardio-ankle vascular index (CAVI) and coronary artery calcification (CAC) in patients with type 2 diabetes mellitus. Heart Vessels. 2012 Mar;27(2):160-5. Epub 2011 Apr 8. 4) Rodrigues TC, Ehrlich J, Hunter CM, Kinney GL, Rewers M, Snell-Bergeon JK. Reduced heart rate variability predicts progression of coronary artery calcification in adults with type 1 diabetes and controls without diabetes. Diabetes Technol Ther. 2010 Dec;12(12):963-9. 5) Rodrigues TC, Biavatti K, Almeida FK, Gross JL. Coronary artery calcification is associated with insulin resistance index in patients with type 1 diabetes. Braz J Med Biol Res. 2010 Nov;43(11):1084-7. Epub 2010 Oct 14. 6) Maffei E, Seitun S, Nieman K, Martini C, Guaricci AI, Tedeschi C, Weustink AC, Mollet NR, Berti E, Grilli R, Messalli G, Cademartiri F. Assessment of coronary artery disease and calcified coronary plaque burden by computed tomography inpatients with and without diabetes mellitus. Eur Radiol. 2011 May;21(5):944-53. Epub 2010 Nov 10. 7) Maurovich-Horvat P, Móri T, Kerecsen G, Fövényi J, Sallai T, Soós P, Préda I, Merkely B, Jermendy G. Assessment of coronary artery calcification using dual-source computed tomography in adult asymptomatic patients with type 1 diabetes mellitus. Med Sci Monit. 2010 Jul;16(7):MT59-64. 8) Moon SS, Choi YK, Seo HA, Jeon JH, Lee JE, Jeong JY, Lee JY, Lee DH, Park WJ, Kim JG, Kim BW, Lee IK. Relationship between cardiovascular autonomic neuropathy and coronary artery calcification in patients with type 2 diabetes. Endocr J. 2010;57(5):445-54. Epub 2010 Feb 26. 9) Zhu HN, Huo Y, Zhou J, Wei HL, Tong L, Chu SY, Han XN. An analysis of clinical factors for coronary artery calcification score. Zhonghua Nei Ke Za Zhi. 2009 Apr;48(4):287-90. 10) Ibebuogu UN, Ahmadi N, Hajsadeghi F, Ramirez J, Flores F, Young E, Gopal A, Wong ND, Budoff MJ. Measures of coronary artery calcification and association with the metabolic syndrome and diabetes. J Cardiometab Syndr. 2009 Winter;4(1):6-11. 11) Elkeles RS, Godsland IF, Feher MD, Rubens MB, Roughton M, Nugara F, Humphries SE, Richmond W, Flather MD; PREDICT Study Group. Coronary calcium measurement improves prediction of cardiovascular events in asymptomatic patients with type 2 diabetes: the PREDICT study. Eur Heart J. 2008 Sep;29(18):2244-51. Epub 2008 Jun 23. 12) Nemoto M, Nishimura R, Sasaki T, Hiki Y, Miyashita Y, Nishioka M, Fujimoto K, Sakuma T, Ohashi T, Fukuda K, Eto Y, Tajima N. Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography. Cardiovasc Diabetol. 2007 Sep 7;6:23. 13) Budoff MJ, Yu D, Nasir K, Mehrotra R, Chen L, Takasu J, Agrawal N, Liu ST, Blumenthal RS. Diabetes and progression of coronary calcium under the influence of statin therapy. Am Heart J. 2005 Apr;149(4):695-700. 14) Yamagami K, Hosoi M, Yamamoto T, Fukumoto M, Yamakita T, Miyamoto M, Yoshioka K, Ishii T, Sato T, Tanaka S, Fujii S. Coronary arterial calcification is associated with albuminuria in type 2 diabetic patient. Diabetes Obes Metab. 2005 Jul;7(4):390-6. 15) Mehrotra R, Budoff M, Christenson P, Ipp E, Takasu J, Gupta A, Norris K, Adler S. Determinants of coronary artery calcification in diabetics with and without nephropathy. Kidney Int. 2004 Nov;66(5):2022-31. 16) Moser KW, O'Keefe JH Jr, Bateman TM, McGhie IA. Coronary calcium screening in asymptomatic patients as a guide to risk factor modification and stress myocardial perfusion imaging. J Nucl Cardiol. 2003 Nov-Dec;10(6):590-8. 17) Dabelea D, Kinney G, Snell-Bergeon JK, Hokanson JE, Eckel RH, Ehrlich J, Garg S, Hamman RF, Rewers M; Coronary Artery Calcification in Type 1 Diabetes Study. Effect of type 1 diabetes on the gender difference in coronary artery calcification: a role for insulin resistance? The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study. Diabetes. 2003 Nov;52(11):2833-9. Erratum in: Diabetes. 2004 Aug;53(8):2177. 18) Snell-Bergeon JK, Hokanson JE, Jensen L, MacKenzie T, Kinney G, Dabelea D, Eckel RH, Ehrlich J, Garg S, Rewers M. Progression of coronary artery calcification in type 1 diabetes: the importance of glycemic control. Diabetes Care. 2003 Oct;26(10):2923-8. 19) Hosoi M, Sato T, Yamagami K, Hasegawa T, Yamakita T, Miyamoto M, Yoshioka K, Yamamoto T, Ishii T, Tanaka S, Itoh A, Haze K, Fujii S. Impact of diabetes on coronary stenosis and coronary artery calcification detected by electron-beam computed tomography in symptomatic patients. Diabetes Care. 2002 Apr;25(4):696-701. 20) Colhoun HM, Francis DP, Rubens MB, Underwood SR, Fuller JH. The association of heart-rate variability with cardiovascular risk factors and coronary artery calcification: a study in type 1 diabetic patients and the general population. Diabetes Care. 2001 Jun;24(6):1108-14. 21) Schurgin S, Rich S, Mazzone T. Increased prevalence of significant coronary artery calcification in patients with diabetes. Diabetes Care. 2001. Feb;24(2):335-8. 22) Jasinowodolinski, Dany; Szarf, Gilberto. Escore de cálcio na avaliação cardiovascular do paciente com diabetes. Arquivos brasileiros de endocrinologia e metabologia; 51(2):294-298, mar. 2007. 23) Milei, José; Grana, Daniel R. Importancia y fisiopatología de las calcificiones vasculares. Prensa médica argentina; 92(1):1-7, mar. 2005. 24) Mendoza Rodríguez, Vladimir; Llerena Rojas, Luis Roberto; Hilario Villanueva, Luis; Llerena Rojas, Lorenzo; Rodríguez Nande, Lidia. Puntuación de calcio en arterias coronarias y presencia de estenosis angiográficamente significativas. Rev. cuba. med;46(3), jul.-sep. 2007. 25) Santos Filho, Raul Dias dos. Comparação da prevalência e gravidade de calcificação da artéria coronaria avaliada pela tomografia ultra-rápida (EBT) entre populações brancas entre populações brancas brasileiras, portuguesas e norte-americanas. São Paulo; s.n; 90] p, 2004. [ 26) Meneghelo, Romeu S; Santos, Raul D; Almeida, Breno; Hidal, Jairo; Martinez, Tania; Moron, Renato; Ramires, José Antonio F; Nasri, Fabio. Distribuição dos escores de cálcio coronariano determinados pela tomografia ultra-rápida em 2.253 homens brancos assintomáticos . Arquivos Brasileiros de Cardiologia; 81(supl.7): 27-36, dez. 2003. 27) Feldman, Carlos Jader; Vitola, Domingos; Schiavo, Nádia. Dectecçäo de doença arterial coronariana baseada no índice de calcificaçäo obtido pela tomografia computadorizada heliocoidal. Arquivos Brasileiros de Cardiologia; 75(6): 471-80, Dez. 2000. 28) Méndez Uriburu, L; Luján, M; Méndez Uriburu, M; Méndez Uriburu, F; Pace, G; Carabajal, R.Detección de depósitos cálcicos en arterias coronarias por TC. Revista argentina de radiologia; 61(1): 25-7, ene.-mar. 1997. 29) Lardani, Hector; Comini, Pedro; Gessaghi, Hugo; Bustos, Luis; Palacios, Alejandro; Chambre, Dionisio. Valor de la calcificación coronaria en la detección de aterosclerosis coronaria: su importancia en la mujer. Bol. Acad. Nac. Med. B.Aires;63:125-34, jan.-jun. 1985. 30) Almeida, F.K; Esteves, J.F; Gross, J.L; Biavatti, K.; Rodrigues, T.C. Escore de cálcio coronariano prediz estenose e eventos na insuficiência renal crônica pré-transplante. Arq. bras. cardiol;97(4):346-349, out. 2011. 31) Detrano R; Guerci AD; Carr JJ; Bild DE; Burke G; Folsom AR; Liu K; Shea S; Szklo M; Bluemke DA; O'Leary DH; Tracy R; Watson K; Wong ND; Kronmal RA. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med; 358(13): 1336-45, 2008 Mar 27. 32) Chow CK; Sheth T. What is the role of invasive versus non-invasive coronary angiography in the investigation of patients suspected to have coronary heart disease? Intern Med J; 41(1a): 5-13, 2011 Jan. 33) Rozanski A, Gransar H, Shaw LJ, Kim J, Miranda-Peats L, Wong ND, Rana JS, Orakzai R, Hayes SW, Friedman JD, Thomson LE, Polk D, Min J, Budoff MJ, Berman DS. Impact of coronary artery calcium scanning on coronary risk factors and downstream testing the EISNER (Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research) prospective randomized trial. J Am Coll Cardiol. 2011 Apr 12;57(15):1622-32 34) Budoff MJ; Nasir K; Kinney GL; Hokanson JE; Barr RG; Steiner R; Nath H; Lopez-Garcia C; Black-Shinn J; Casaburi R. Coronary artery and thoracic calcium on noncontrast thoracic CT scans: comparison of ungated and gated examinations in patients from the COPD Gene cohort. J Cardiovasc Comput Tomogr; 5(2): 113-8, 2011 Mar-Apr. 35) Lee HJ, Kim YJ, Hur J, Nam JE, Kim TH, Choe KO, Choi BW. Coronary artery anomalies: detection on coronary artery calcium scoring scan. AJR Am J Roentgenol. 2010 May;194(5):W382-7. 36) Mao SS, Pal RS, McKay CR, Gao YG, Gopal A, Ahmadi N, Child J, Carson S, Takasu J, Sarlak B, Bechmann D, Budoff MJ. Comparison of coronary artery calcium scores between electron beam computed tomography and 64-multidetector computed tomographic scanner. J Comput Assist Tomogr. 2009 Mar-Apr;33(2):175-8. 37) Timothy S. Church a,., Benjamin D. Levine b,c, Darren K. McGuirec, Michael J. LaMontea, Shannon J. FitzGerald a, Yiling J. Chenga, Thomas E. Kimball d, Steven N. Blair a, Larry W. Gibbons d, Milton Z. Nichamana. Coronary artery calcium score, risk factors, and incident coronary heart disease events. Atherosclerosis 190 (2007) 224–231. 38) Nasir K, Raggi P, Rumberger JA, Braunstein JB, Post WS, Budoff MJ, Blumenthal RS. Coronary artery calcium volume scores on electron beam tomography in 12,936 asymptomatic adults. Am J Cardiol. 2004 May 1;93(9):1146-9. 39) Horton KM, Post WS, Blumenthal RS, Fishman EK. Prevalence of significant noncardiac findings on electron-beam computed tomography coronary artery calcium screening examinations. Circulation ; 2002 Jul 30;106(5):532-4. 40) Raggi P, Cooil B, Ratti C, Callister TQ, Budoff M. Progression of coronary artery calcium and occurrence of myocardial infarction in patients with and without diabetes mellitus. Hypertension ; 2005 Jul;46(1):238-43. Epub 2005 Apr 25. 41) Iori E, Bendinelli S, Faggiano P. Coronary artery calcium identified by multislice TC as marker of early coronary artery disease. Monaldi Arch Chest Dis. 2003 Mar;60(1):63-72. 42) Budoff MJ, Lane KL, Bakhsheshi H, Mao S, Grassmann BO, Friedman BC, Brundage BH. Rates of progression of coronary calcium by electron beam tomography. Am J Cardiol. 2000 Jul 1;86(1):8-11. 43) Rumberger JA, Brundage BH, Rader DJ, Kondos G. Electron beam computed tomographic coronary calcium scanning: a review and guidelines for use in asymptomatic persons. Mayo Clin Proc. 1999 Mar;74(3):243-52. 44) Callaway MP, Richards P, Goddard P, Rees M. The incidence of coronary artery calcification on standard thoracic CT scans. Br J Radiol. 1997 Jun;70(834):572-4. 45) Gopal A, Nasir K, Liu ST, Flores FR, Chen L, Budoff MJ. Coronary calcium progression rates with a zero initial score by electron beam tomography. Int J Cardiol. 2007 Apr 25;117(2):227-31. Epub 2006 Jul 26. 46) JOHN A. RUMBERGER, PH.D., M.D.; BRUCE H. BRUNDAGE, M.D.; DANIEL J. RADER, M.D.; GEORGE KONDOS, M.D. Electron beam computed tomography and coronary artery disease: scanning for coronary artery calcification. MAYO CLIN PROC. 1999;74:243-252. 47) Ambarish Gopal MD, Matthew J. Budoff MD. Coronary calcium scanning. American Heart Hospital Journal Vol 4, Issue 1, pages 43–50, Winter 2006. 48) Detrano RC, Anderson M, Nelson J, Wong ND, Carr JJ, McNitt-Gray M, Bild DE. Coronary calcium measurements: effect of CT scanner type and calcium measure on rescan reproducibility-MESA study. Radiology. 2005 Aug;236(2):477-84. Epub 2005 Jun 21. 49) Gerber, T.C; Manning, W.J; Gersh, B.J; Yeon, S.B. Diagnostic and prognostic implications of coronary artery calcification detected by computed tomography. UpToDate, August 2012. 50) Wilson, Peter W.F; Cannon, C.P; Downey, B.C. Overview of the possible risk factors for cardiovascular disease. UpToDate, August 2012. 51) Gerber, T.C; Manning, W.J; Gersh, B.J; Bax,J.J; Yeon, S.B. Noninvasive coronary angiography with cardiac computed tomography and cardiovascular magnetic resonance. UpToDate, August 2012. 52) Deedwania, P.C; Kaski, J.C; Downey, B.C. Silent myocardial ischemia: Diagnosis and screening. UpToDate, July 2012.