UNIVERSIDADE ESTADUAL DO CENTRO-OESTE
Midwestern State University
Polymeric Nanoparticles in Drug Delivery
Associated professor Najeh Maissar Khalil
Guarapuava - Paraná/Brazil
http://www2.unicentro.br/
Guarapuava City
UNICENTRO, Campus CEDETEG
UNICENTRO, Campus Central
Laboratory of Pharmaceutical Nanotechnology
POLYMERIC NANOPARTICLES IN DRUG
DELIVERY
• Smaller size
• Higher surface area
• Higher drug bioavailability
• Low dose required
• Prolonged drug delivery
• Administered via different routes
• Ability to load hydrophilic or hydrophobic drugs
• Synthetic or natural polymers: biocompatible and biodegradable
Natural Products
Improved neuroprotective effects of resveratrol-loaded
polysorbate 80-coated poly(lactide) nanoparticles in MPTPinduced Parkinsonism. Nanomedicine, v. 10, p. 1127-1138, 2015.
Pharmacokinetics of Curcumin-loaded PLGA and PLGA-PEG
Blend Nanoparticles After Oral Administration In Rats. Colloids
and Surfaces. B, Biointerfaces (Print), v. 101, p. 353-360, 2013.
Influence of the formulation parameters on the particle size and
encapsulation efficiency of resveratrol in PLA and PLA-PEG blend
nanoparticles: a factorial design. Journal of Nanoscience and
Nanotechnology (Print), v. 15, p. 10173-10182, 2015.
Development and validation of an HPLC method using
fluorescence detection for the quantitative determination of
curcumin from PLGA and PLGA-PEG nanoparticles. Current
Pharmaceutical Analysis, v. 8, p. 324-333, 2012.
Resveratrol-Loaded Polymeric Nanoparticles: Validation of an
HPLC-PDA Method to Determine the Drug Entrapment and
Evaluation of Its Antioxidant Activity. The Scientific World
Journal, v. 2013, p. 1-9, 2013.
PHBV/PCL Microparticles for Controlled Release of Resveratrol:
Physicochemical Characterization, Antioxidant Potential and
Effect on Hemolysis of Human Erythrocytes. The Scientific World
Journal, v. ., p. 542937-., 2012.
Nanoencapsulation of gallic acid and evaluation of its cytotoxicity and
antioxidant activity. Materials Science and Engineering: C. v. 60, p.
126–134, 2016.
Bovine Serum Albumin Nanoparticles Containing Quercetin: Characterization and
Antioxidant Activity. Journal of Nanoscience and Nanotechnology. v. 16, 1346-1353, 2016.
Amphotericin B
Amphotericin B-loaded polymeric nanoparticles: formulation
optimization by factorial design. Pharmaceutical Development
and Technology, p. 1-7, 2015.
Poly(L-lactide) Nanoparticles
Reduce
Amphotericin
B
Cytotoxicity and Maintain Its In Vitro Antifungal Activity. Journal
of Nanoscience and Nanotechnology (Print), v. 15, p. 848-854,
2015.
Bovine serum albumin nanoparticles containing Amphotericin B:
characterization, cytotoxicity and in vitro antifungal evaluation.
Journal of Nanoscience and Nanotechnology (Print), v. 15, p.
10183-10188, 2015.
Nanotechnological Strategies for the Treatment of Neglected
Diseases. Current Pharmaceutical Design (Print), v. 19, p.
7316-7329, 2013.
Amphotericin B-Loaded Poly(Lactide)-Poly(Ethylene Glycol)Blend Nanoparticles: Characterization and In Vitro Efficacy and
Toxicity. Current Nanoscience, v. 9, p. 594-598, 2013.
Antitumor drugs
.
Tamoxifen-loaded poly(L-lactide) nanoparticles: Development, characterization and in vitro evaluation of
cytotoxicity. Materials Science and Engineering: C, V. 60, p. 135–142, 2016.
Development and validation of an HPLC method for the determination of fluorouracil in polymeric
nanoparticles. Brazilian Journal of Pharmaceutical Sciences, v. 49, p. 117-126, 2013.
Development and validation of HPLC PDA method for the quantitative determination of Diphenyl diselenide
in (Poly)lactide Nanoparticles. Current Pharmaceutical Analysis, v. 11, 2016.
Patents
"'PROCESSO DE FORMULAÇÃO DE NANOPARTÍCULAS DE
APOCININA (apocynin) REVESTIDAS COM O POLÍMERO NATURAL
BSA E RETICULADAS COM GLUTARALDEÍDO PELO MÉTODO DE
COACERVAÇÃO E FÁRMACO'" , BR10201402962
"PROCESSO
DE
FORMULAÇÃO
DE
NANOPARTÍCULAS
POLIMÉRICAS DE HSA CONTENDO O COMPOSTO APOCININA
(apocynin) POR NANO SPRAY DRYER E COM MODIFICAÇÃO DA
SUPERFÍCIE ATRAVÉS DA INCORPORAÇÃO DO TENSOATIVO
POLISSORBATO 80 (PS80)" , BR1020140296581.
"' PROCESSO DE OBTENÇÃO DE NANOPARTÍCULAS POLIMÉRICAS
CONTENDO O FÁRMACO RESVERATROL ”, BR10201400864.
"PROCESSO DE PRODUÇÃO DE NANOPARTÍCULAS POLIMÉRICAS
CONTENDO O COMPOSTO ÁLCOOL PERÍLICO (perillyl alcohol)
PELO MÉTODO DE EMULSIFICAÇÃO-EVAPORAÇÃO DO SOLVENTE
E AS NANOPARTICULAS", BR1020150244088.
'PROCESSO DE OBTENÇÃO DE NANOPARTÍCULAS POLIMÉRICAS
CONTENDO O FÁRMACO ANFOTERICINA B (amphotericin B)'.
Protocolo: 015110002865." PI1107205.
Main Equipments
Pharmaceutical Nanotechnology Laboratory
• Research Leaders:
Prof. Dr. Najeh Maissar Khalil (DT/CNPq – Nanociências e Novos Materiais)
Profa. Dra. Rubiana M. Mainardes (PQ/CNPq – Biotecnologia)
• • Post-Doctorates: Dra. Soraya Zaioncz
• • Ph.D Students: Luciana Camargo, Daniel Brustolin, Ligia Pedroso, Isabela
de Lima, Rebeca Caparica, Daniele Vieira, Graciela Vieira, Osmar Junior
• • MSc. Student: Emili Antonio, Dyenifer Pereira, Suelen Ladwig, Michel
Tereza
wwww.unicentro.br
http://www2.unicentro.br/estude-pos/
http://www2.unicentro.br/nano/
Najeh Maissar Khalil
[email protected]
[email protected]
Rubiana Mara Mainardes
[email protected]
[email protected]
cooperation
Acknowledgment