Toxinology and Vaccines
April 14-15 2014
Butantan Institute
Structural biology,
Therapeutic targets
+ venoms/toxins,
Imaging, Vaccine
Organizing Committee
Butantan Institute
Dr. Jorge Kalil
Dr. Yara Cury
Dr. Ivo Loyola
Dr. Paulo Lee Ho
Dr. Ana Marisa Chudzinski-Tavassi
Dr. Alexander Precioso
Dr. Solange Serrano
Dr. Carlos W. Magalhães
Rapporteur: Ana Leary
Technical Support:
Eiko Kawabata; Ludmila Sambiase;
Fernanda Paiva Guimarães;
Antonio Carlos O.R. da Costa;
Maria Lucia Righetti; Liana M.
Moretti; Luiz do Amaral Jr; Marcos
Henrique L. Lopes; Ricardo Braga
Financial support
University of São Paulo
Prof. Dr. Guido Cerri
Director of the Medical School
Dr. Raul Machado Neto
President of Academic Agency
for National and International
Cooperation at Universidade de
São Paulo
Dr. Eduardo M. Krieger
Executive Director for
International Relations from the
Medical School of the University
of São Paulo
Technical Support:
Talita de Almeida
Jackeline Bonfim
Dr. Gilles Bloch
Director of the Life Sciences
Dr. Renaud Blaise
International Affairs
Dr. Denis Servent
Head of the Toxin, Receptor
and Ion Channel Group,
Toxinology and Vaccines
April 14-15 2014
Butantan Institute
Structural biology,
Therapeutic targets
+ venoms/toxins,
Imaging, Vaccine
CEA Participants:
Gilles BLOCH (Director of the Life Sciences),
Eric QUEMENEUR (Director of programs and valorization),
Renaud BLAISE (International Affairs),
Jean-Marc GROGNET (Head of IBITECS Institute),
Denis SERVENT (researcher /IBITECS-SIMOPRO),
Raphael GUEROIS (researcher /IBITECS-SB2SM),
Michel LEONETTI (researcher /IBITECS-SPI),
Bernard MAILLERE (researcher /IBITECS-SIMOPRO),
Roger Le Grand (researcher /IMETI-SIV),
Thierry VERNET (researcher /IBS-LIM),
Cyril POUPON (researcher /I2BM-NeuroSpin),
Raphaël BOISGARD (researcher /I2BM-SHFJ),
Bertrand KUHNAST (researcher /I2BM-SHFJ).
Financial support
Toxinology and Vaccines
Schematic scientific program
preliminary program
Day 1 April, 14
9:00 – 9:15h
Opening ceremony
13:00 – 14:30h
9:15 – 9:35h
Presentation about Butantan Institute
(Prof. Dr. Jorge Kalil, Director)
14:30 – 18:10h
Imaging Session
Chairs: Yara Cury (IBu) and Cyril Poupon (CEA)
9:35 – 9:55h
Presentation about Faculty of Medicine/USP
(Prof. Dr. Giovanni Guido Cerri, Director)
14:30 – 15:05h
9:55 – 10:15h
Presentation about Life Sciences CEA
(Dr. Gilles Bloch, Director)
Anatomo-functional mapping of the
human brain at the mesoscale and at
cellular scales using ultra-high field MRI
(Dr. Cyril Poupon, CEA/DSV-I2BM)
10:15 – 10:35h
Coffee break
15:05 – 15:40h
10:35 – 13:00
Structural Biology Session
Chairs: Solange Serrano (IBu) and Eric
Quémeneur (CEA)
IMAGE platforms used in research of Butantan Institute
(Dr. Luis Roberto Camargo Gonçalves,
Laboratory of Pathophysiology/IBu)
15:40 – 16:15h
Fluorine-18: from basic radiotracers to
the labelling of macromolecules (Dr.
Bertrand Kuhnast, CEA/DSV-I2BM)
16:15 – 16:30h
Coffee break
16:30 – 17:05h
Perspectives of Molecular Imaging in Oncology and Neuropsychiatry in Brazil (Dr.
Carlos Alberto Buchpiegel, Instituto de Radiologia, Hospital das Clinicas, FM/USP)
10:35 – 11:10h
Advanced methods in structural biology
and super-resolution light microscopy for
pathogen studies (Dr. Thierry Vernet, CEA/
11:10 – 11:45h
Using structural information to understand
biological function at the molecular level (Dr.
Solange Serrano, LETA/IBu)
11:45 – 12:20h
Modeling and design of protein-protein
interactions (Dr. Raphael Guerois, CEA/
17:05 – 17:40h
In vivo Molecular imaging of toxin targets and
toxic effects using Positron Emission Tomography (Dr. Raphaël Boisgard, CEA/DSV-I2BM)
12:20 – 12:55h
Elucidating structure and function of protein
kinase C (Deborah Schechtman, IQ/USP)
17:40 – 18:10h
General Discussion-Day 1 Highlights
Toxinology and Vaccines
Schematic scientific program
preliminary program
Day 2 April, 15
9:00 – 12:00h
Toxins and therapeutic targets session
Chairs: Ana Marisa Chudzinski-Tavassi (IBu) and
Jean-Marc Grognet (CEA)
14:00 – 14:30h
Butantan Vaccines Production: State of the art
and challenges for the future (Dr. Paulo Ho,
Director of DDTP)
9:00 – 9:30h
Toxins and GPCRs, a Promising Interaction (Dr.
Denis Servent, CEA/DSV-IBITECS)
14:30 – 15:00h
Clinical Trials of New Vaccines in Butantan Institute (Dr. Alexander Precioso, Clinical Trials/IBu)
9:30 – 10:00h
Local lesions induced by animal venoms/toxins
(Dr. Denise Tambourgi, Laboratory of Immunochemistry/IBu)
15:00 – 15:30h
New approaches dedicated to the preparation
of highly immunogenic vaccines (Dr. Michel
10:00 – 10:30h
Cancer gene therapy targeting the p53
pathway and beyond
Dr. Bryan E. Strauss, Centro de Investigação
Translacional em Oncologia, Instituto do Câncer
do Estado de São Paulo
15:30 – 15:50h
Coffee break
15:50 – 16:20h
Towards the development of a CD4 epitope-based HIV vaccine: new developments (Prof.
Dr. Edécio Cunha Neto, Departamento de
Clinica Médica, FM/USP)
16:20 – 16:50h
New vaccine approaches to prevent from viral
diseases: From preclinical to clinical developments (Dr. Roger Le Grand, CEA/DSV-IMETI)
16:50 – 17:20h
Lessons from HIV prevention studies
(Prof. Dr. Esper Georges Kallas, Departamento
de Clinica Médica, FM/USP)
17:20 – 18:00h
General Discussion-Day 2 Highlights
10:30 – 10:50h
Coffee break
10:50 - 11:20h
Toxinology and Neuroscience
(to be announced)
11:20 – 11:50h
Toxins and therapeutic targets
(Dr. Irina Kerkis, Laboratory of Genetics, IBu)
12:00 – 13:30h
13:30 – 18:00h
Vaccines session Chairs: Alexander Precioso
(IBu) and Roger Le Grand (CEA)
13:30 – 14:00h
Prediction of immunogenicity in humans of
vaccines and therapeutic proteins (Dr. Bernard

Toxinology and Vaccines - Consulat Général de France à São Paulo