A model of the cell, population growth and drug effect on the cell cycle.
Nakano F.; Dias M. H.; Armelin H.A.
Escola de Artes, Ciências e Humanidades - USP
We present a simple computer model of the cell and its use to test hypotheses
and fit cell population growth, cell synchronization and drug effect.In this model
a single cell is a probabilistic automaton with states G1, S, G2, M. Transitions
between states are probabilistic given a parameter. At M (mitosis) cell divides in
two daughter cells. H3 histone presence indicates that the cell is in mitosis and
its signal is proportional to the quantity of mitotic cells. We show that
dependence between the cells is necessary to properly fit desynchronization
data and indicator degradation is necessary to fit cell cycle blockage data.
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