CURRICULUM VITÆ Joaquim José Coutinho Ferreira Lisboa 2013 Identificação Joaquim Ferreira, nascido a 30 de Novembro de 1968, natural de Torres Vedras. Educação Curso Complementar (11º ano) na Escola Secundária n.º 1 de Torres Vedras, com a média final de 19 valores. 12º ano na Escola Secundária n.º 2 de Torres Vedras, com a média final de 20 valores. Admissão no Curso de Medicina da Faculdade de Medicina de Lisboa (FML), com a média de candidatura de 19,8 valores. Licenciatura em Medicina pela FML (1992), com a média final de 17 valores (Bom com Distinção). Especialista em Neurologia pelo Hospital de Santa Maria (HSM) [2001], com a classificação final de 19,7 valores. Especialista em Farmacologia Clínica pela Ordem dos Médicos (2008). Doutoramento em Medicina (Neurologia) pela FML, Universidade de Lisboa, 2009. Actividade Assistencial Membro do Grupo de Doenças do Movimento, Serviço de Neurologia, HSM, 1991 – . Interno do Internato Geral, HSM, Janeiro 1993 – Dezembro 1994. Interno do Internato Complementar de Neurologia, Serviço de Neurologia, HSM, Janeiro 1995 – Fevereiro 2001. Coordenador tratamentos com toxina botulínica, Serviço de Neurologia, HSM, 1998 – Dezembro 2011. Assistente Eventual de Neurologia, Serviço de Neurologia, HSM, Março 2001 – Outubro 2001. Assistente Eventual de Neurologia, Serviço de Neurologia, Hospital de São José, Outubro 2001 – Dezembro 2002. Assistente Hospitalar de Neurologia, Serviço de Neurologia, Hospital Rainha Santa Isabel (Torres Novas), Dezembro 2002 – Julho 2003. Assistente Hospitalar de Neurologia, Serviço de Neurologia, Hospital de Santa Maria (Lisboa), Julho 2003 – . Cargos e Funções Académicas Monitor de Anatomia II, FML, 1988 – 1990. Assistente Livre de Terapêutica Geral, FML, 1995-1998; Assistente convidado, Junho 1998 – 2009. Responsável pela cadeira de Neurofisiologia do Curso Superior de Terapêutica Ocupacional (Escola Superior de Saúde de Alcoitão), ano lectivo de 1996/97. Responsável pela cadeira de Neurologia do Curso Superior de Terapêutica da Fala (Escola Superior de Saúde de Alcoitão), 1997 – 2001. Docente convidado da cadeira de Formação Complementar (6º ano), FML, 2000 – 2001. Assistente de Neurologia da FML com dupla titulação (afecto à Cadeira de Terapêutica Geral) 2001 – 2009. Docente convidado dos Mestrados de Neurociências, Medicina do Sono, Educação Médica e Cuidados Paliativos da FML. Docente convidado da Cadeira de Neurologia da Licenciatura em Nutrição, FML, ano lectivo de 2008/09. Docente convidado do módulo de Doenças Neurodegenerativas do Programa Doutoral para Médicos da Gulbenkian, 2009 – . Responsável pelo módulo Therapeutic Research in Neurosciences do Programa de Mestrado/Doutoramento em Neurociências da FML, 2009 – . Professor Auxiliar Convidado de Terapêutica Geral e Neurologia da FML a 30%, 2009 - 2012. Professor Associado Convidado de Terapêutica Geral e Neurologia da FML a 100%, 2012 – . Actividades no domínio da farmacologia clínica Coordenador do Movement Disorders Cochrane Review Group, Junho 1996 – 2011. Membro do Centro de Medicina Baseada na Evidência, FML, Dezembro 1997 – 2002. Consultor do Centro de Farmacovigilância Sul, FML, Outubro de 2000 – . Secretário do painel de Neurofarmacologia da European Federation of Neurological Societies (EFNS), 2000 – 2003. Actividades de investigação Membro do Centro de Neurociências de Lisboa, 1992 – 2002. Estagiário no Laboratório de Farmacologia Médica e Clínica e Centro de Investigação Clínica, Toulouse, França, 1999 – 2000. Investigador do Instituto de Medicina Molecular (IMM), 2002 – 2009. Investigador Principal do Instituto de Medicina Molecular (IMM), 2009 – . Cargos em Sociedades Científicas Nacionais Assessor da Comissão de Jovens da Sociedade Portuguesa de Neurologia (SPN), 2000 – 2005. Secretário da Secção de Doenças do Movimento da SPN, Novembro 2001 – 2005. Membro da Comissão de Ensino da SPN, 2005 – 2007. Vice-presidente da Secção de Doenças do Movimento da SPN, Novembro 2006 – 2008. Responsável pelo Grupo de Trabalho da SPN sobre Creditação, 2008 – 2010. Cargos em Sociedades Científicas Internacionais Membro do Steering Committee of Trainees and Junior Neurologists da European Federation of Neurological Societies, Setembro 1998 – Setembro 2001. Vice-presidente da European Association for Young Neurologists and Neurology Trainees (YNT), Setembro 1999 – 2001. Membro do Comité de Educação da Movement Disoders Society (MDS), 2003 – . Membro do Comité de Relações Públicas e Ligação da MDS, 2004 – 2006. Membro do Scientific and Bioethics Advisory Committee da Rede European Huntington Disease Network (Euro-HD), 2006 – 2010. Membro do Grupo de Trabalho da “Website” da MDS, 2007 – 2008. Membro do Comité Executivo da Secção Europeia da MDS, 2007 – 2011. Membro do Comité Executivo da Rede Euro-HD, Setembro 2008 – . Membro do Web Site Editorial Board da MDS, 2008 – 2011. Actividades de coordenação Coordenador do Cochrane Movement Disorders Review Group da Cochrane Collaboration, Junho de 1996 – 2011. Coordenador da Unidade de Ensaios Clínicos da Unidade de Neurofarmacologia do Centro de Neurociências de Lisboa e posteriormente da Unidade Neurológica de Investigação Clínica do IMM, 2000 – . Responsável pelo Comité de Educação da Secção Europeia da MDS, Agosto 2008 – . Coordenador do Grupo de Trabalho sobre Tratamentos Neuroprotectores da EuroHD, 2008 – . Responsável pelo Comité de Relações Públicas e Ligação da MDS, 2009 – 2011. Director Científico da Rede European Huntington Disease Network, 2010 – . Co-responsável pelo Comité de Membros, Relações Públicas e Ligação da MDS, 2011 –. Director do Laboratório de Farmacologia Clínica e Terapêutica da FML, 2011 – . Regente das Disciplinas de Farmacologia Clínica da FML, 2011 – . Presidente da Sociedade Portuguesa de Doenças do Movimento, 2012 – . Orientação de formação e projectos académicos Orientador de formação de 3 internos de neurologia (2 concluídos). Orientador de 9 teses do Mestrado Integrado em Medicina da FML. Orientador de 3 projectos de mestrado em neurociências e 6 projectos de dissertação de doutoramento, em curso. Outras actividades Editor das publicaçoes: Journal of Parkinson’s Disease, Journal of Huntington’s Disease and Frontiers in Movement Disoders. Revisor das publicações: CNS Drugs, European Journal of Neurology, Movement Disorders Journal, Expert Review of Neurotherapeutics, Expert Opinion on Drug Safety, Aging Health, The Journal of Pain, Journal of Neurology, Neuroscience Letters, Sinapse, Journal of Neurology Neurosurgery and Psychiatry, Journal of Medical Ethics, Journal of Neural Transmission, The European Neurological Journal, Dovepress, Expert Opinion On Drug Metabolism and Toxicology, Parkinsonism and Related Disorders. Principais Áreas de Interesse Doenças do Movimento, Doença de Parkinson, Distonias, Doença de Huntington, Neurofarmacologia Clínica, Ensaios Clínicos. Comunicações em reuniões científicas 238 comunicações em reuniões científicas nacionais e internacionais Trabalhos publicados 121 artigos publicados ou aceites para publicação 12 capítulos de livros Publicações 1. FERREIRA JJ, Katzenschlager R, Bloem BR, Bonuccelli U, Burn D, Deuschl G, Dietrichs E, Fabbrini G, Friedman A, Kanovsky P, Kostic V, Nieuwboer A, Odin P, Poewe W, Rascol O, Sampaio C, Schüpbach M, Tolosa E, Trenkwalder C, Schapira A, Berardelli A, Oertel WH. Summary of the recommendations of the EFNS/MDS-ES review on therapeutic management of Parkinson's disease. Eur J Neurol. 2013 Jan;20(1):5-15. 2. Berardelli A, Wenning GK, Antonini A, Berg D, Bloem BR, Bonifati V, Brooks D, Burn DJ, Colosimo C, Fanciulli A, FERREIRA JJ, Gasser T, Grandas F, Kanovsky P, Kostic V, Kulisevsky J, Oertel W, Poewe W, Reese JP, Relja M, Ruzicka E, Schrag A, Seppi K, Taba P, Vidailhet M. EFNS/MDS-ES recommendations for the diagnosis of Parkinson's disease. Eur J Neurol. 2013 Jan;20(1):16-34. 3. Caldeira D, Fernandes RM, Costa J, David C, Sampaio C, FERREIRA JJ. Branded vs. generic clopidogrel in cardiovascular diseases: a systematic review. J Cardiovasc Pharmacol. 2012 Nov 26. [Epub ahead of print] 4. FERREIRA JJ, Neutel D, Mestre TA, Galitzky M, Thalamas C, Santos AT, Sampaio C, Rascol O. Usefulness of OSLER test in Parkinson's disease. Sleep Med. 2013 Mar;14(3):297-8. 5. Chinnapongse RB, Lew MF, FERREIRA JJ, Gullo KL, Nemeth PR, Zhang FERREIRA JJ.Immunogenicity and long-term efficacy of botulinum toxin type B in the treatment of cervical dystonia: report of 4 prospective, multicenter trials. Clin Neuropharmacol. 2012 Sep;35(5):215-23. 6. Coelho M, FERREIRA JJ. Late-stage Parkinson disease. Nat Rev Neurol. 2012 Aug;8(8):435-42. 7. Mestre TA, FERREIRA JJ. An evidence-based approach in the treatment of Huntington's disease. Parkinsonism Relat Disord. 2012;18(4):316-20. 8. Lee JM, Ramos EM, Lee JH, Gillis T, Mysore JS, Hayden MR, Warby SC, Morrison P, Nance M, Ross CA, Margolis RL, Squitieri F, Orobello S, Di Donato S, GomezTortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, Paulsen JS; PREDICT-HD study of the Huntington Study Group (HSG), Landwehrmeyer GB; REGISTRY study of the European Huntington's Disease Network, Myers RH; HDMAPS Study Group, MacDonald ME, Gusella JF; COHORT study of the HSG. CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion. Neurology. 2012 Mar 6;78(10):690-5. 9. Mestre TA, Lang AE, FERREIRA JJ, Almeida V, de Carvalho M, Miyasaki J, Chen R,Fox S. Associated movement disorders in orthostatic tremor. J Neurol Neurosurg Psychiatry. 2012;83(7):725-9. 10. Rodrigues SM, de Carvalho M, Mestre T, FERREIRA JJ, Coelho M, Peralta R, Vale P. Paralytic shellfish poisoning due to ingestion of Gymnodinium catenatum contaminated cockles - Application of the AOAC HPLC Official Method. Toxicon. 2012;59(5):558-66. 11. Quarrell OW, Handley O, O'Donovan K, Dumoulin C, Ramos-Arroyo M, Biunno I, Bauer P, Kline M, Landwehrmeyer GB, European Huntington’s Disease Network. Discrepancies in reporting the CAG repeat lengths for Huntington's disease. Eur J Hum Genet. 2012;20(1):20-6. 12. Valadas A, Coelho M, Mestre T, Guedes LC, Finisterra M, Noronha A, Rosa MM, Sampaio C, FERREIRA JJ. What motivates Parkinson's disease patients to enter clinical trials? Parkinsonism and Related Disorders. 2011;17(9):667-71. 13. Teodoro T, Pires D, Rosa MM, Coelho M, Sampaio C, FERREIRA JJ. Has "levodopa-induced neuropathy" been reported in Parkinson's disease clinical trials? Mov Disord. 2011;26(10):1966–1967. 14. Orth M, European Huntington's Disease Network, Handley OJ, Schwenke C, Dunnett S, Wild EJ, Tabrizi SJ, Landwehrmeyer GB. Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY. J Neurol Neurosurg Psychiatry. 2011;82(12):1409-12. 15. López-Sendón JL, Royuela A, Trigo P, Orth M, Lange FERREIRA JJ, Reilmann R, Keylock J, Rickards FERREIRA JJ, Piacentini S, Squitieri F, Landwehrmeyer B, Witjes-Ane MN, Jurgens, CK, Roos RA, Abraira V, de Yébenes JG; and the European HD Network. What is the impact of education on Huntington's disease? Mov Disord. 2011;26(8):1489-95. 16. Martins M, Rosa A, Guedes LC, Benedita V, Gotovac K, Violante S, Mestre T, Coelho M, Rosa MM, Martin ER, Vance J, Outeiro T, Wang L, Borovecki F, FERREIRA JJ, Oliveira S, Convergence of miRNA Expression Profiling, α-Synuclein Interacton and GWAS in Parkinson's Disease. PLoS One. 2011;6(10). 17. Reimão S, Morgado C, Neto L, FERREIRA JJ, Coelho M, Rosa MM, Campos J. Diffusion Tensor Imaging in Movement Disorders: Review of Major Patterns and Correlation with Normal Brainstem/cerebellar White Matter. The Neuroradiology Journal 24: 177-186, 2011. 18. Rickards FERREIRA JJ, Souza JD, Crooks J, van Walsem MR, van Duijn E, Landwehrmeyer B, Squitieri F, Simpson SA. Discriminant Analysis of Beck Depression Inventory and Hamilton Rating Scale for Depression in Huntington's Disease. J Neuropsychiatry Clin Neurosci. 2011. 1;23(4):399-402. 19. Saft C, Epplen JT, Wieczorek S, Landwehrmeyer GB, Roos RA, de Yebenes JG, Dose M, Tabrizi SJ, Craufurd D. REGISTRY Investigators of the European Huntington's Disease Network, Arning L. NMDA receptor gene variations as modifiers in Huntington disease: a replication study. PLoS Curr. 2011 Oct 4;3. 20. Orth M, Carsten S. Age-at-onset in Huntington disease. PLoS Curr. Edited: Dec 21, 2011 21. Goetz CG, Stebbins GT, Theeuwes A, Stocchi F, FERREIRA JJ, van de Witte S, Bronzova J.Temporal stability of the Unified Dyskinesia Rating Scale. Mov Disord. 2011;(14):2556-9. 22. Mestre TA, FERREIRA JJ. An evidence-based approach in the treatment of Huntington's disease. Mestre TA, FERREIRA JJ. Parkinsonism Relat Disord. 2011 Dec 15. 23. Rascol O, FERREIRA JJ, Nègre-Pages L, Perez-Lloret S, Lacomblez L, Galitzky M, Lemarié JC, Corvol JC, Brotchie JM, Bossi L. A proof-of-concept, randomized, placebo-controlled, multiple cross-overs (n-of-1) study of naftazone in Parkinson's disease. Fundam Clin Pharmacol. 2011 May 18. [Epub ahead of print] 24. Orth M; European Huntington's Disease Network, Handley OJ, Schwenke C, Dunnett SB, Craufurd D, Ho A, Wild EJ, Tabrizi SJ. Observing Huntington's Disease: the European Huntington's Disease Network's REGISTRY. PLoS Curr. 2010;28(2). 25. Rosa MM, FERREIRA JJ, Coelho M, Freire R, Sampaio C. Prescribing Patterns of Antiparkinsonian Agents in Europe. Mov Disord. 2010;25(8):1053-1060. 26. Coelho M, Marti MJ, Tolosa E, FERREIRA JJ, Valldeoriola F, Rosa M, Sampaio C. Late-stage Parkinson's disease: the Barcelona and Lisbon cohort. J Neurol. 2010;257(9):1524-1532. 27. Sampaio C, FERREIRA JJ, Parkinson’s Disease: adjunctive entacapone therapy increases risk of dyskinesia. Nat Rev Neurol. 2010;6(11):590-591. 28. Sampaio C, FERREIRA JJ. A double-blind delayed-start trial of rasagiline in Parkinson's disease. Nat Rev Neurol. 2010;6(3):126-128. 29. Högl B, Arnulf I, Comella C, FERREIRA JJ, Iranzo A, Tilley B, Trenkwalder C, Poewe W, Rascol O, Sampaio C, Stebbins GT, Schrag A and Goetz CG. Scales to Assess Sleep Impairment in Parkinson's Disease: Critique and Recommendations. Mov Disord. 2010;25(16):2704-16. 30. Louis E, FERREIRA JJ. How Comon is the Most Common Adult Movement Disorder? Update on the Worldwide Prevalence of Essential Tremor. Mov Disord. 2010;25(5):534-541. 31. FERREIRA JJ, Neutel D, Mestre T, Coelho M, Rosa MM, Rascol O, Sampaio C. Skin cancer and Parkinson’s disease. Mov Disord. 2010;25(2):139-148. 32. Mestre T, FERREIRA JJ. Pharmacotherapy in Parkinson’s disease: case studies. Ther Adv Neurol Disord. 2010;3(2):117-26. 33. Correia Guedes L, FERREIRA JJ, Rosa MM, Coelho M, Bonifati V, Sampaio C. Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: A systematic review. Parkinsonism Relat Disord. 2010;16(4): 237-242. 34. FERREIRA JJ, Rascol O, Poewe W, Sampaio C, Rocha JF, Nunes T, Almeida L, Soares da Silva P. A Double-Blind, Randomized, Placebo and Active-Controlled Study of Nebicapone for the Treatment of Motor Fluctuations in Parkinson's Disease. CNS Neuroscience & Therapeutics. 2010;16(6):337-347. 35. Olanow CW, Rascol O, Hauser R, Feigin PD, Jankovic J, Lang A, Langston FERREIRA JJ, Melamed E, Poewe FERREIRA JJ, Stocchi F, Tolosa E; ADAGIO Study Investigators. A double-blind, delayed-start trial of rasagiline in Parkinson's disease. N Engl J Med. 2009;361(13):1268-78. 36. Di Fonzo A, Fabrizio E, Thomas A, Fincati E, Marconi R, Tinazzi M, Breedveld GJ, Simons EJ, Chien HF, FERREIRA JJ, Horstink MW, Abbruzzese G, Borroni B, Cossu G, Dalla Libera A, Fabbrini G, Guidi M, De Mari M, Lopiano L, Martignoni E, Marini P, Onofrj M, Padovani A, Stocchi F, Toni V, Sampaio C, Barbosa ER, Meco G; Italian Parkinson Genetics Network, Oostra BA, Bonifati V. GIGYF2 mutations are not a frequent cause of familial Parkinson's disease. Parkinsonism Relat Disord. 2009 (9):703-5. 37. Foreid H, Coelho M, FERREIRA JJ, Ferro J. Reversible iatrogenic subacute cerebellar syndrome, myoclonus and MRI findings following metronidazole administration. BMJ Case Reports 2009 [doi:10.1136/bcr.05.2009.1841] 38. Aziz NA, Jurgens CK, Landwehrmeyer GB, van Roon-Mom WM, van Ommen GJ, Stijnen T, Roos RA, Orth M, Handley OJ, Schwenke C, Ho A, Wild EJ, Tabrizi SJ, Landwehrmeyer GB; EHDN Registry Study Group. Normal and mutant HTT interact to affect clinical severity and progression in Huntington disease. Neurology. 2009;73(16):1280-5. 39. Gouveia LO, Castanho P, FERREIRA JJ. Safety of chiropractic interventions: a systematic review. Spine. 2009;34(11):E405-13 40. Mestre T, FERREIRA JJ, Coelho M, Rosa M, Sampaio C. Therapeutic interventions for disease progression in Huntington's disease. Cochrane Database Syst Rev. 2009;(3):CD006455. 41. Mestre T, FERREIRA JJ, Coelho M, Rosa M, Sampaio C. Therapeutic interventions for symptomatic treatment in Huntington's disease. Cochrane Database Syst Rev. 2009;(3):CD006456. 42. Mestre T, FERREIRA JJ, Jain S. A multimodal approach to physical therapy in Parkinson's disease: Optimizing strategies. Mov Disord. 2009;24(6):946. 43. Mestre T, FERREIRA JJ. Eslicarbazepine acetate: a new option for the treatment of focal epilepsy. Expert Opin Investig Drugs. 2009;18(2):221-9. 44. Ross OA, Spanaki C, Griffith A, Lin CH, Kachergus J, Haugarvoll K, Latsoudis FERREIRA JJ, Plaitakis A, FERREIRA JJ, Sampaio C, Bonifati V, Wu RM, Zabetian CP, Farrer MJ. Haplotype analysis of Lrrk2 R1441H carriers with parkinsonism. Parkinsonism Relat Disord. 2009;15(6):466-7. 45. Stowe RL, Ives NJ, Clarke C, van Hilten J, FERREIRA JJ, Hawker RJ, Shah L, Wheatley K, Gray R. Dopamine agonist therapy in early Parkinson's disease. Cochrane Database Syst Rev. 2008;16;(2). 46. FERREIRA JJ, Finisterra M, Noronha A, Mestre T. Centro de Investigação Clínica como Unidade Funcional da Investigação Biomédica, Sinapse 2008;8(2):27-31. 47. Silveira-Moriyama L, Guedes LC, Kingsbury A, Ayling FERREIRA JJ, Shaw K, Barbosa ER, Bonifati V, Quinn NP, Abou-Sleiman P, Wood NW, Petrie A, Sampaio C, FERREIRA JJ, Holton J, Revesz T, Lees AJ. Hyposmia in G2019S LRRK2-related parkinsonism: Clinical and pathologic data. Neurology 2008;71;1021-1026. 48. Healy DG, Falchi M, O'Sullivan SS, Bonifati V, Durr A, Bressman S, Brice A, Aasly J, Zabetian CP, Goldwurm S, FERREIRA JJ, Tolosa E, Kay DM, Klein C, Williams DR, Marras C, Lang AE, Wszolek ZK, Berciano J, Schapira AH, Lynch T, Bhatia KP, Gasser T, Lees AJ, Wood NW; International LRRK2 Consortium. Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study. Lancet Neurol. 2008;7(7):583-90. 49. FERREIRA JJ, Almeida L, Cunha L, Ticmeanu M, Rosa MM, Januário C, Mitu CE, Coelho M, Correia-Guedes L, Morgadinho A, Nunes T, Wright LC, Falcão A, Sampaio C, Soares-da-Silva P. Effects of nebicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity, and motor fluctuations in patients with Parkinson disease. Clin Neuropharmacol. 2008;31(1):2-18. 50. Fernandes R, FERREIRA JJ, Sampaio C. The placebo response in studies of acute migraine.J Pediatr. 2008;152(4):527-33. 51. Pappert EJ, Germanson T for The Myobloc/Neurobloc European Cervical Dystonia Study Group, Botulinum Toxin Type B vs. Type A in Toxin-Naive Patients with Cervical Dystonia: Randomized, Double-Blind, Noninferiority Trial. Mov Disord. 2008;23(4):510-517. 52. Costa J, Rocha ML, Ferreira JJ, Evangelista T, Coelho M, de Carvalho M. Botulinum toxin type-B improves sialorrhea and quality of life in bulbaronset amyotrophic lateral sclerosis. J Neurol. 2008;255 (4):545-50. 53. Coelho M, FERREIRA JJ, Rosa M, Sampaio C. Treatment options for non-motor symptoms in late-stage Parkinson's disease. Expert Opin Pharmacother. 2008 Mar;9(4):523-35. 54. Gouveia LO, Castanho P, FERREIRA JJ, Guedes MM, Falcão F, e Melo TP. Chiropractic manipulation: reasons for concern? Clin Neurol Neurosurg. 2007 Dec;109(10):922-5. 55. Atadzhanov M, Mwaba P, de Carvalho M, Costa J, FERREIRA JJ. Upper limb tremor induced by peripheral nerve injury. Neurology 2007;69:1381. 56. Fonseca AC, FERREIRA JJ, Albuquerque L, Ferro JM. Sneeze as a precipitating factor of cerebral venous thrombosis. Eur J Neurol 2007;14:7-8. 57. FERREIRA JJ, Silva JM, Freire R, Pignatelli J, Guedes LC, Feijo A et al. Skin cancers and precancerous lesions in Parkinson's disease patients. Mov Disord 2007;22:1471-5. 58. Di Fonzo A, Chien HF, Socal M, Giraudo S, Tassorelli C, Iliceto G et al. ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease. Neurology 2007;68:1557-62. 59. FERREIRA JJ, Guedes LC, Rosa MM, Coelho M, van Doeselaar M, Schweiger D et al. High prevalence of LRRK2 mutations in familial and sporadic Parkinson's disease in Portugal. Mov Disord 2007;22:1194-201. 60. Mestre TA, FERREIRA JJ, Pimentel J. Putaminal petechial haemorrhage as the cause of non-ketotic hyperglycaemic chorea: a neuropathological case correlated with MRI findings. J Neurol Neurosurg Psychiatry 2007;78:549-50. 61. FERREIRA JJ, Costa J, Coelho M, Sampaio C. The management of cervical dystonia. Expert Opin Pharmacother 2007;8:129-40. 62. Goetz CG, Damier P, Hicking C, Laska E, Muller T, Olanow CW et al. Sarizotan as a treatment for dyskinesias in Parkinson's disease: a double-blind placebo-controlled trial. Mov Disord 2007;22:179-86. 63. Poewe W, FERREIRA JJ, Wolters E, Emre M, Onofrj M, Hsu C, Tekin S, Lane R, on behalf of the EXPRESS Investigators. Long-Term Benefits of Rivastigmine in Dementia Associated With Parkinson’s Disease: An Active Treatment Extension Study. Mov Disord 2006;21 (4):456–461. 64. Kappos L, Antel J, Comi G, Montalban X, O’Connor P, Polman CH et al for the FTY720 D2201 Study Group. Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis. N Engl J Med 2006;355:1124-40. 65. Castro-Caldas A, Delwaide P, Jost FERREIRA JJ, Merello M, Williams A, Lamberti P et al. The Parkinson-Control study: a 1-year randomized, double-blind trial comparing piribedil (150 mg/day) with bromocriptine (25 mg/day) in early combination with levodopa in Parkinson's disease. Mov Disord 2006;21:500-9. 66. Olanow CW, Schapira AH, LeWitt PA, Kieburtz K, Sauer D, Olivieri G et al. TCH346 as a neuroprotective drug in Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol 2006;5:1013-20. 67. Correa Neto FERREIRA JJ, Cardoso F, Teixeira AL Jr, Maia DP, Beato R, Ferreira J. The chorea of Zeze. Acta Med Port 2006;19:127-32. 68. Costa J, Henriques R, Barroso C, Ferreira J, Atalaia A, de Carvalho M. Upper limb tremor induced by peripheral nerve injury. Neurology 2006;67:1884-6. 69. FERREIRA JJ, Couto M, Costa J, Coelho M, Rosa MM, Sampaio C. Botulinum toxin for the treatment of pain syndromes. Acta Reumatol Port 2006;31:49-62. 70. Montastruc JL, Sommet A, Olivier P, Bagheri FERREIRA JJ, Gony M, LapeyreMestre M et al. Drugs, Parkinson's disease and parkinsonian syndroms: recent advances in pharmacovigilance. Therapie 2006;61:29-38. 71. FERREIRA JJ, Desboeuf K, Galitzky M, Thalamas C, Brefel-Courbon C, Fabre N et al. Sleep disruption, daytime somnolence and 'sleep attacks' in Parkinson's disease: a clinical survey in PD patients and age-matched healthy volunteers. Eur J Neurol 2006;13:209-14. 72. Di Fonzo A, Tassorelli C, De Mari M, Chien HF, Ferreira J, Rohe CF et al. Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease. Eur J Hum Genet 2006;14:322-31. 73. Rascol O, Brooks DJ, Melamed E, Oertel WH, Poewe W, FERREIRA JJ, Stocchi F et al. 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