Association between methylation in mismatch repair genes, V600E BRAF
mutation and microsatellite instability in colorectal cancer patients
Molecular Biology Reports
Carla G. Rasuck1,2, Sinara M. O. Leite3, Flavia Komatsuzaki4, Alessandro C. S. Ferreira1, Vanessa C.
Oliveira1, Karina B. Gomes2,5
1.
2.
3.
4.
5.
Genetic Molecular Department, Instituto Hermes Pardini, Belo Horizonte, MG, Brazil.
Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Department of Coloproctology, Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil.
Engineering College of Minas Gerais - FEAMIG, Belo Horizonte, MG, Brazil.
Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Email correspondence to
Karina Braga Gomes – [email protected]
Individual associations of clinical and molecular variables with age and gender
Variable
Age
Gender
P Value
P Value
RER status
0.3102
0.8001
Amsterdam II criteria
0.6282
1.000²
Bethesda criteria
1.000²
0.6361
Family history
0.6232
1.000²
BRAF V600E mutation
0.4622
1.000²
Methylation status
0.684
2
0.2692
Right-sided tumor
0.0371
0.6721
Left-sided tumor
0.0161
0.9781
Rectum tumor
0.6131
0.3001
Metachronous tumor
0.6562
0.5132
Synchronous tumor
0.3772
1.000²
1-Pearson Chi-square Asymptotic Test; 2- Pearson Chi-square Exact Test
* Statically significant: p<0.05.