Curriculum Vitae
Name:
Sérgio Jerónimo Rodrigues Dias
Date of Birth
6th January 1971
Nationality
Portuguese
Civil status
Married, 2 daughters
Academic Degrees
Licenciatura in Biology, University of Lisbon (College of Sciences), Lisbon, Portugal,
1/90-7/94.
PhD in Tumor Immunology, Imperial Cancer Research Fund/University College London,
UK, 6/95-12/98.
Professional Training/Appointments
Research Associate, Tropical Medicine, Institute of Tropical Higiene and Medicine of
Lisbon, 1/94-12/94.
Research Associate, Tumor Immunology, Biological Therapies Lab, Imperial Cancer
Research Fund, London, 1/95-7/95.
Phd Student, Tumor Immunology, Biological Therapies Lab, Imperial Cancer Research
Fund, London, 7/95-12/98.
Post-doctoral Fellow, Hematology/Oncology Division, Cornell University Medical
College, 1/99-12/01.
Group leader (Angiogenesis Laboratory), Centro de Investigação em Patobiologia
Molecular(CIPM)/Portuguese Institute of Oncology (IPOFG) and Instituto Gulbenkian
Ciência, Lisbon, 01/02-09/12.
Scientific Coordinator of CIPM/IPOFG. 02/04-09/12.
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Invited Auxiliary Professor of Biochemistry, Faculdade de Ciências Médicas,
Universidade Nova de Lisboa. 05/11-09/12
Associate Professor, Faculdade de Medicina da Universidade de Lisboa. 09/12-present.
Principal Investigator, Instituto de Medicina Molecular (IMM). 09/12-present.
Research Interests
Bone marrow function in homeostasis and in disease; endothelial progenitors and neoangiogenesis; endothelial cell biology and tumor angiogenesis.
Post-graduate Teaching (selected)
S. Dias. Lecture on "Angiogenesis and Cancer" as part of the IPATIMUP Master in
Oncobiology Programme. Porto, 1st March 2002.
S. Dias. Oncology Research Lecture Series on "Angiogenesis and Cancer", IPOFG
(Lisbon), 25-26th July 2002.
S. Dias. "Oncogenesis and Metastasis Course", given to students of the Gulbenkian
(IGC) PhD Programme. 1 week/Year, from 2002-2005.
S. Dias. “Molecular basis for Endothelial Function”. 5th Cell:Materials interaction course,
INEB, Porto. 7-9 July 2004.
S. Dias. “Angiogenesis”. Class for the Masters in Neuroophtalmology, Fac. Medicina
Lisboa. 17th February 2005.
S. Dias. MSc courses: lectures given at IPATIMUP (University of Porto), at University
of Coimbra, at University of Algarve and at the University of Lisbon. (2004-present)
S. Dias. “Biologia do Cancro” (“Cancer Biology”). Classes lectured to 4th Year Medical
Students, Faculdade de Ciências Médicas, Universidade Nova de Lisboa. 2007-2012.
Reviewer activities
Reviewer for Oncogene, Blood, Journal of Biological Chemistry, Leukemia, Diabetes
Care, British Journal of Haematology, Leukemia and Lymphoma, Faseb Journal, Cancer
Research, Experimental Cell Research, Journal of Experimental Medicine, Journal of
Vascular Research, Journal of Tissue Engineering and Regenerative Medicine, Journal of
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Inflammation, Embo Molecular Medicine, Molecular Cancer Research, Molecular
Cancer, Acta Biomaterialia, Clinical Cancer research.
Reviewer of Grants and Fellowships submitted to the Portuguese Science and
Technology Foundation (FCT) (2003-present), Grants Submitted to Ohio University and
to the Israeli Science Foundation.
Reviewer of Abstracts submitted for the Annual Meeting of the European Hematology
Association (2003-2008).
Publications (Dias, Sergio)
2014:
Dos Santos CR, Domingues G, Matias I, Matos J, Fonseca I, de Almeida JM, Dias S.
LDL-cholesterol signaling induces breast cancer proliferation and invasion. Lipids
Health Disease. 13(1):16 (2014)
Rodrigues Dos Santos C, Fonseca I, Dias S, Mendes de Almeida J. Plasma level of LDLcholesterol at diagnosis is a predictor factor of breast tumor progression. BMC Cancer.
14(1):132 (2014)
2013:
Costa A, Afonso J, Osório C, Gomes AL, Caiado F, Valente J, Aguiar SI, Pinto F,
Ramirez M, Dias S. miR-363-5p regulates endothelial cell properties and their
communication with hematopoietic precursor cells. J Hematol Oncol. 2013 Nov
21;6(1):87 (2013)
Caiado F, Carvalho T, Rosa I, Remedio L, Costa A, Matos J, Heissig B, Yagita H, Hattori
K, da Silva JP, Fidalgo P, Dias Pereira A and Dias S. Bone marrow-derived
CD11b+Jagged2+ cells promote epitelial to mesenchymal transition and metastization in
colorectal cancer. Cancer Research, 73(14):4233-46 (2013)
2012:
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Remédio L, Carvalho T, Caiado F, Bastos-Carvalho A, Martins D, Duarte A, Yagita H
and Dias S. Context- and cell-dependent effects of Delta-like 4 targeting in the Bone
Marrow microenvironment. PlosOne, 7(12):e52450. (2012)
Caiado F, Dias S. Endothelial progenitor cells and integrins: adhesive needs.
Fibrogenesis Tissue Repair. 12;5(1):4. (2012)
Cachaco AS, Salvador D and Dias S. Bone marrow malignancies as paradigms of
dysfunctional cell adhesion mechanisms. Journal of Hematological Malignancies. 2(1):
19-36. (2012)
Soares PIP, Dias S, Novo CMM, Ferreira IMM and Borges JP. Doxorubicin vs.
Ladirubicin: Methods for Improving Osteosarcoma Treatment. Mini-Reviews in
Medicinal Chemistry. 12(12):1239-49. (2012)
2011:
Casalou C, Costa A, Carvalho T, Gomes AL, Zhu Z, Wu Y, Dias S. Cholesterol
Regulates VEGFR-1 (FLT-1) Expression and Signaling in Acute Leukemia Cells. Mol
Cancer Res. 9(2):215-24. (2011)
Serpa J, Dias S. Metabolic cues from the microenvironment act as a major selective
factor for cancer progression and metastases formation. Cell Cycle. 10(2). (2011)
Real C, Remedio L, Caiado F, Igreja C, Borges C, Trindade A, Pinto-do-Ó P, Hyagita H,
Duarte A, Dias S. Bone marrow-derived Endothelial Progenitors expressing Delta-like 4
(Dll4) regulate tumor angiogenesis. PlosOne. 6(4):e18323. (2011)
Schmidt T, Kharabi Masouleh B, Loges S, Cauwenberghs S, Fraisl P, Maes C, Jonckx B,
De Keersmaecker K, Kleppe M, Tjwa M, Schenk T, Vinckier S, Fragoso R, De Mol M,
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Beel K, Dias S, et al. Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of
Mice with Imatinib-Resistant Bcr-Abl1(+) Leukemia. Cancer Cell. 14;19(6):740-53.
(2011)
Caiado F, Carvalho T, Silva F, Castro C, Clode N, Dye JF and Dias S. Fibrin E modulates
endothelial progenitors adhesion, differentiation and angiogenic growth factor production and
promotes wound healing. Biomaterials, 32(29):7096-105 (2011).
2010:
Gomes AL, Carvalho T, Torre C, Serpa J and Dias S. Hypercholesterolemia promotes
bone marrow cell mobilization by perturbing the SDF1:CXCR4 axis. Blood
115(19):3886-94 (2010).
Cachaco AS, et al and Dias S. TNF-α Regulates the Effects of Irradiation in the mouse
Bone Marrow Microenvironment. PLos ONE Feb 1;5(2):e8980. (2010)
Epiphanio S, Campos MG, Pamplona A, Carapau D, Pena AC, Ataíde R, Monteiro CA,
Félix N, Costa-Silva A, Marinho CR, Dias S, Mota MM. VEGF promotes malariaassociated acute lung injury in mice. PLoS Pathogens. 6(5):e1000916. (2010)
Pasquier E, Dias S. Endothelial Progenitor Cells: Hope Beyond Controversy. Curr
Cancer Drug Targets. 10(8):914-21. (2010)
Serpa J, Caiado F, Carvalho T, Torre C, Goncalves LG, Casalou C, Lamosa P, Rodrigues
M, Zhu Z, Lam EW, Dias S. Butyrate rich colonic microenvironment is a relevant
selection factor for metabolically adapted tumour cells. J Biological Chemistry.
285(50):39211-23. (2010)
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2009:
Costa A, Osório C, Dias S. MicroRNA expression profiling in bone marrow: implications
in hematological malignancies. Biotechnol J. 2009 Jan;4(1):88-97. (2009)
Pinto AE, André S, Silva G, Vieira S, Santos AC, Dias S, Soares J. BCL-6 oncoprotein in
breast cancer: loss of expression in disease progression. Pathobiology. 2009;76(5):23542. Epub 2009 Oct 2. (2009)
2008:
Igreja C et al and Dias S. Detailed Molecular characterization of cord blood derived
Endothelial Progenitors. Experimental Hematology, 36(2):193-203 (2008).
Carvalho T, Elias AP, Nunes T, Peleteiro MC, Dias S. Chemo-angiogenic profile of
bovine urinary bladder tumors distinguishes urothelial carcinomas from
hemangiosarcomas. Vet Immunol Immunopathol. 121(3-4):344-58 (2008).
Fragoso R, et al and Dias S. VEGF signaling on hematopoietic precursors restricts Blymphoid commitment in vitro and in vivo. Experimental Hematology. 36(10):13291336 (2008).
Real C, Caiado F and Dias S. Endothelial Progenitors in Vascular Repair and
Angiogenesis: How Many are Needed and What to do? Cardiovasc Hematol Disord
Drug Targets. (Invited Review). 8(3):185-92 (2008).
Caiado F, Real C, Carvalho T, Dias S. Notch pathway modulation on bone marrowderived vascular precursor cells regulates their angiogenic and wound healing potential.
PLoS ONE. 3(11):e3752. Epub 2008 Nov 18 (2008)
Elias AP, Dias S. Microenvironment Changes (in pH) Affect VEGF Alternative Splicing.
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Cancer Microenvironment. 1(1):131-9. Epub 2008 Jul 29 (2008)
Kerbel RS, Benezra R, Lyden DC, Hattori K, Heissig B, Nolan DJ, Mittal V, Shaked Y,
Dias S, Bertolini F, Rafii S. Endothelial progenitor cells are cellular hubs essential for
neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not
adenomas. Proc Natl Acad Sci U S A. 105(34):E54; author reply E55. (2008)
2007:
Igreja C et al and Dias S. Characterization and clinical relevance of circulating and
biopsy-derived endothelial progenitors in lymphoma patients. Haematologica-The
Haematology Journal. 92(4):469-77 (2007).
Fragoso R, Elias A and Dias S. Autocrine VEGF loops, signaling pathways and leukemia
regulation. Invited review, Leukemia and Lymphoma. 48(3):481-8 (2007).
Casalou C, Fragoso R, Nunes JF and Dias S. VEGF/PLGF induces leukemia cell
migration via P38/ERK1/2 kinase pathway, resulting in Rho GTPases activation and
caveolae formation. Leukemia. 21: 1590-1594 (2007).
Santos SCR et al and Dias S. VEGF and VEGFR-2 (KDR) internalization is required for
endothelial recovery during wound healing. Experimental Cell Research. 313(8):156174 (2007).
2006:
Fragoso R, Pereira T, Wu Y, Zhu Z, Cabeçadas J and Dias S. VEGFR-1 (FLT-1)
activation modulates acute lymphoblastic leukemia localization and survival within the
bone marrow, determining the onset of extramedullary disease. Blood, 107(4):1608-16
(2006).
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Sancho M, Vieira JM, Casalou C, Mesquita M, Pereira T, Cavaco BM, Dias S and Leite
V. Expression and function of the chemokine receptor CCR7 in thyroid carcinomas.
Journal or Endocrinology, 191: 229-38 (2006).
2005:
Shmelkov S, et al, Dias S, Jacobson JT, Hempstead BL, Edelberg JM and Rafii S.
Cytokine preconditioning promotes codifferentiation of human fetal liver CD133+ stem
cells into angiomyogenic tissue. Circulation, 111(9):1175-83 (2005).
Vieira JM, Santos SCR, Espadinha C, Correia I, Vag T, Casalou C, Cavaco BM, Catarino
AL, Dias S and Leite V. Expression of vascular endothelial growth factor (VEGF) and
its receptors in thyroid carcinomas of follicular origin: a potential autocrine loop. Eur J
Endocrinol; 153 (5): 701-709 (2005).
2004:
Avecilla ST, Hattori K, Heissig B, Tejada R, Liao F, Shido K, Jin DK, Dias S, et al..
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow
vascular niche is required for thrombopoiesis. Nature Medicine. 10(1):64-71 (2004).
Constantino Rosa Santos S and Dias S. Internal and external autocrine VEGF/KDR loops
regulate survival of subsets of acute leukemia. Blood. 103(10): 3883-9 (2004).
2003:
Moldenhauer A., Nociari MN, Dias S, Lalezari P and Moore MAS. Optimized culture
conditions for the generation of Dendritic cells from peripheral blood monocytes. Vox
sanguinis, 84(3):228-36 (2003).
Zhu Z, Hattori K, Zhang H, Jimenez X, Ludwig DL, Dias S, et al. Inhibition of human
leukemia in an animal model with human antibodies directed against vascular
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endothelial growth factor receptor 2. Correlation between antibody affinity and
biological activity. Leukemia. 17(3):604-11 (2003).
Bais C, Van Geelen A, Eroles P, Mutlu A, Chiozzini C, Dias S, et al. Kaposi's sarcoma
associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells
by activation of the VEGF receptor-2/ KDR. Cancer Cell. 3(2):131-43 (2003).
2002
Dias S*, Choy M*, Alitalo K and Rafii S. VEGF-C signaling through Flt-4 (VEGFR-3)
Mediates Leukemic cell proliferation and survival. Blood, 99: 2179-2184 (2002).
Dias S*, Shmelkov V. S*, Lam G, and Rafii, S. VEGF promotes survival of leukemic
cells by Hsp90-mediated induction of Bcl-2 expression. Blood, 99(7):2532-40 (2002).
Rafii S, Meeus S, Dias S, et al. Contribution of marrow-derived progenitors to vascular
and cardiac regeneration. Seminars in Cell and Developmental Biology, 13(1): 61-7
(2002).
Heissig B, Hattori K, Dias S et al. Recruitment of Stem and Progenitor Cells from the
bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell, 109(5):625-37
(2002).
Hattori K, Heissig B, Wu Y, Dias S, et al. Placental growth factor reconstitutes
hematopoiesis
by
recruiting
VEGFR1(+)
stem
cells
from
bone-marrow
microenvironment. Nature Medicine, 8(8): 841-49 (2002).
2001
Dias S, Choy M and Rafii S. The role of C-X-C chemokines in the regulation of tumor
angiogenesis. Cancer Investigation, 19(7): 732-738 (2001).
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Hattori K, Dias S, et al. VEGF and Angiopoietin-1 stimulate post-natal hematopoiesis by
recruitment of vasculogenic and hematopoietic stem cells. Journal of Experimental
Medicine, 193: 1005-1014 (2001).
Dias S, et al. Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling
pathways is essential to induce long-term remission of xenotransplanted human
leukemias. Proc Natl Acad Sci (PNAS), 98(19):10857-62 (2001).
Gill MT, Dias S, et al. Vascular Trauma Induces Rapid but Transient Mobilization of
VEGFR2+AC133+ Endothelial Precursor Cells. Circulation Research, 88: 167–174
(2001).
Franco S, MacKenzie KL, Dias S, Alvarez S, Rafii S, Moore MAS. Clonal variation in
phenotype and lifespan of human embryonic fibroblasts (MRC-5) transduced with the
catalytic component of telomerase (hTERT). Experimental Cell Research, 268(1):14-25
(2001).
Rafii S, Dias S, et al. Infection of Endothelium with E1-E4+, but not E1-E4-, Adenovirus
gene transfer vectors enhances leukocyte adhesion and migration by Modulation of
ICM-1, VCAM-1, CD34 and chemokine expression. Circulation Research, 88: 903 –
910 (2001).
Lane WJ, Hattori K, Dias S, et al Anagrelide metabolite induces thrombocytopenia in
mice by inhibiting megakaryocyte maturation without inducing platelet aggregation.
Experimental Hematology, 29(12):1417-24 (2001).
Moore MA, Hattori K, Heissig B, Shieh JH, Dias S, Crystal RG, Rafii S. Mobilization of
endothelial and hematopoietic stem and progenitor cells by adenovector-mediated
elevation of serum levels of SDF-1, VEGF, and angiopoietin-1. Annals of the N. Y.
Academy of Sciences, 938:36-45 (2001).
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Lyden D, Hattori K, Dias S, et al. Impaired recruitment of bone-marrow-derived
endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth.
Nature Medicine, 7(11):1194-201 (2001).
2000
Roboz G, Dias S, et al. ArsenicTrioxide induces a dose and time-dependent apoptosis of
endothelium and may exert an anti-leukemic effect via inhibition of angiogenesis. Blood,
96(4):1525-30 (2000).
Dias S, et al. Autocrine stimulation of VEGFR-2 activates human leukemic cell growth
and migration. Journal of Clinical Investigation, 106: 511-521 (2000).
Scott K, Holdsworth H, Balkwill F and Dias S. Exploiting changes in the tumour
microenvironment with sequential cytokine and matrix metalloprotease inhibitor
treatment in a murine breast cancer model. British Journal of Cancer, 83(11), 153843 (2000).
Lane W*, Dias S*, et al. SDF-1 induced megakaryocyte migration and platelet
production is dependent on matrix metalloproteinases. Blood, 96: 4152-4159 (2000).
1998
Dias S, Thomas H and Balkwill F. Multiple cellular and molecular changes associated
with tumour stasis and regression during IL-12 therapy of a murine breast cancer model.
International Journal of Cancer: 75, 151-157 (1998).
Dias S, Boyd R and Balkwill F. IL-12 regulates VEGF and MMPs in a murine breast
cancer model. International Journal of Cancer: 78:361-365 (1998).
* shared first authorship
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Personal References
Professor Frances Balkwill
Centre Lead, Centre for Cancer and Inflammation, Cancer research UK Center of
Excellence, St Bartholomew’s and The Royal London School of Medicine and Dentistry,
3rd Floor Science Building, Charterhouse Square
London EC1M 6BQ, UK.
[email protected]
Dr. Shahin Rafii
Howard Hughes Investigator, Arthur Belfer Professor of Genetic Medicine, Director of
the Ansary Stem Cell Institute and Tri-SCI Stem Cell Center at Joan and Sanford I. Weill
Weill Cornell Medical College.
1300 York Avenue, New York, NY 10021 USA.
[email protected]
Dr. David Lyden
Associate Professor of Cell and Developmental Biology,
Weill Cornell Medical College. 1300 York Avenue, New York, NY 10021 USA.
[email protected]
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