DAAD/CAPES Workshop University of São Paulo - Ribeirão Preto - Brazil Differentiation and regeneration potential of glial cells in acute and chronic Central Nervous System pathologies 24 and 25 of October 2013 Prof. Dr. Frank Kirchhoff University of Saarland (German coordinator) Profa. Dra. Elaine Del-Bel FORP-University of Sao Paulo (Brazilian coordinator) Local: Salão Nobre da Faculdade de Ciências Farmacêuticas de Ribeirão Preto i Program OCTOBER 24th 9:00hs Modern techniques to study brain function and pathology 1. Principles of two-photon imaging 45 min Prof. Dr Frank Kirchhoff University of Saarland 2. Animal models to study behavior Prof. Dr. Francisco S Guimaraes FMRP- University of Sao Paulo 45 min 3. Animal models of brain diseases 4. Prof. Dr. Elaine Del-Bel FORP-University of Sao Paulo 30 min COFEE BRAKE 5. RNA interference – the place of gene silencing in the study of glial biology Prof. Dr. Ricardo Titze: University of Brasília 30 min 6. Role of genetic background and transgenic strategy for faithful cell-specific gene recombination Dr. Anja Scheller University of Saarland 45 min LUNCH and DISCUSSIONS 7. Analysis of astrocyte-specific purinergic P2Y1 receptor knockout mice Hannah M. Jahn, PhD student University of Saarland 30 min 8. In vivo and in vitro neuroprotective and anti-inflamatory effects of doxycycline 30 min Rita Raisman-Vozari Directeur de Recherche CRIC –ICM INSERM 975 Hopital de La Salpetriere; Programa de Cátedra Francesa Lévi-Straus -Universidade de São Paulo/Embaixada da França em Ribeirão Preto. Glia in injury and repair 9. Reactive gliosis and synaptic plasticity following axonal lesion: different experimental approaches. 45 min Prof. Dr. Alexandre Oliveira University of Campinas (UNICAMP) 10. Stem cells and growth factors in neuronal repair Dr. Sergiy Kyrylenko (Visiting Professor) UNICAMP 11. Analysis of diverse glial responses upon white matter injuries Prof. Dr. Frank Kirchhoff University of Saarland 30 min 45 min COFEE BRAKE 12. Astrocytic differentiation of oligodendrocyte lineage cells following acute cortical injury 30 min Xianshu Bai, PhD student University of Saarland 13. Physiological biomarkers in the Alzheimer disease Dr. Leonardo Cruz de Souza Federal University of Minas Gerais 30 min DISCUSSIONS ______________________________________________________________ ii OCTOBER 25th 9:00hs Glial signaling in health and mental disease 14. New insights in brain energy metabolism Prof. Dr. Johannes Hirrlinger University of Leipzig 45 min 15. Highlighting glial cells increase in a L-DOPA induced dyskinesia preparation 45 min Prof. Dr. Elaine Del-Bel FORP-University of Sao Paulo 16. Possible role of Calcium-Calmodulin signaling in depressive disorder. 30 min Dr. Frederico Ferreira Researcher Instituto Osvaldo Cruz COFEE BRAKE The cannabinoid system and brain pathology 17. Chronic cannabidiol attenuates the behavioural and glial changes induced by repeated treatment with the NMDA receptor antagonist MK-801 in mice. 15 min Felipe Gomes PhD student FMRP-University of Sao Paulo 18. Neuroinflammatory mechanisms involved with impared extinction of fear conditioning in an model of PTSD: involvement of cannabinoid system. 15 min Dr. Sabrina Lisboa FMRP-University of Sao Paulo 19. Neuroprotection and Reduction of Glial Reaction by Cannabidiol Treatment After Sciatic Nerve Transection in Neonatal Rats. 15 min Matheus Perez PhD student UNICAMP LUNCH and DISCUSSIONS Repair in the peripheral system 20. Neuroprotective Effects of Tempol After Sciatic Nerve Transection in Neonatal Rats. Gabriela Bortolança Chiarotto MSc student UNICAMP 15 min 21. Neuroprotective Effects of Mesenchymal Stem Cells on Spinal Motoneurons Following Ventral Root Axotomy 15 min Aline Barroso Spejo PhD student UNICAMP 22. Neuro-imune interaction in spinal cord and dorsal root ganglion account for the development of chronic pain. 30 min Dr. Ricardo Kusuda FMRP-University of Sao Paulo Intermediate filaments and schaffolds for axonal repair 23. Deletion of the cell adhesion adaptor protein vinculin disturbs the localization of GFAP in Bergmann glial cells Dr. Ulrike Winkler University of Leipzig 30 min 24. Regeneration and Neuroprotection after Ventral Root Avulsion and Repair with fibrin Sealant Combined with Bone Marrow Mononuclear Stem Cells (BMSC) Roberta Barbizan PhD student UNICAMP 15 min 25. Use of Fibrin Sealant as Scaffold for Mesenchymal Stem Cell Grafts in the Peripheral Nerve Regeneration 15 min Luciana Cartarozzi MSc student UNICAMP COFEE BRAKE DISCUSSIONS iii