CURRICULUM VITÆ
1. IDENTIFICATION
Name: Almeida, António José Leitão das Neves.
Place of Birth: Moçâmedes - Angola.
Date of Birth: 16th May 1963.
Address:
Unidade de Ciências e Tecnologia Farmacêuticas
Faculdade de Farmácia
Universidade de Lisboa
Av. Prof. Gama Pinto
1649-003 Lisboa
Tel. +351 21 7946409
Fax. +351 21 7937703
E-mail: [email protected]
EDUCATION
2.1. Higher Education
1987 - Licenciatura in Pharmaceutical Sciences (Industrial Pharmacy), University of Lisbon,
Faculty of Pharmacy, Portugal.
1993 - Ph.D., The University of Aston, Department of Pharmaceutical and Biological Sciences,
Birmingham, UK.
2005 - Habilitation (Agregação) in Pharmaceutical Sciences, University of Lisbon, Faculty of
Pharmacy, Portugal.
2.2. Qualifications
1987 - Qualified pharmacist, by the Portuguese Pharmaceutical Society (Ordem dos
Farmacêuticos), Portugal.
3.
PROFESSIONAL ACTIVITY
3.1.
ACADEMIC CARRIER
1986/88 - Monitor (demonstrator), University of Lisbon, Faculty of Pharmacy, Portugal.
1988/92 - Junior Lecturer Assistant, University of Lisbon, Faculty of Pharmacy, Portugal.
1991/93 - Demonstrator, Department of Pharmaceutical and Biological Sciences, Aston
University, Birmingham, UK.
1992/94 - Senior Lecturer Assistant, University of Lisbon, Faculty of Pharmacy, Portugal.
1994/01- Assistant Professor, University of Lisbon, Faculty of Pharmacy, Portugal.
1994/97 - Visiting Associate Professor, Instituto Superior de Ciências da Saúde - Sul.
2001/ -
Associate Professor, University of Lisbon, Faculty of Pharmacy, Portugal.
2007 –
Visiting Professor, University of Navarra, Faculty of Pharmacy, Spain.
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3.2.
TEACHING ACTIVITY
3.2.1. Under-gradate level
1986/88 - Genetic Engineering and Pharmaceutical Biotechnology, University of Lisbon, Faculty
of Pharmacy, Portugal.
1988/.. - Pharmaceutics and Pharmaceutical Technology, University of Lisbon, Faculty of
Pharmacy, Portugal. Teaching has included: pharmaceutical compounding, parenteral
dosage forms, disperse systems, topical dosage forms, sterilization, lyophilisation, drug
delivery systems, drug targeting, development pharmaceutics, stability of drugs,
regulatory affairs and quality assurance.
3.2.2. Post graduate level
1994/.. - Master course in Advanced Pharmaceutics, University of Lisbon, Faculty of
Pharmacy, Portugal, teaching controlled drug delivery, drug delivery systems and
pharmaceutical development.
1995 -
1st European Course on New Forms and New Routes of Administration of Drugs,
University of Coimbra, Faculty of Pharmacy, Portugal, teaching vaccine delivery
systems.
1997/.. - Master course in Community Pharmacy, University of Lisbon, Faculty of Pharmacy,
Portugal, teaching advanced pharmaceutical compounding.
1998/00 - Post-graduation course on Pharmaceutical Medicine, New University of Lisbon,
Faculty of Medical Sciences, Portugal, teaching pharmaceutical development and
stability of drugs.
1999/-
Master Couse on Advanced Biopharmaceutics and Pharmacokinetics, University of
Lisbon, Faculty of Pharmacy, teaching Controlled drug delivery and drug delivery
systems.
2000 -
6th European Course on New Forms and New Routes of Administration of Drugs,
University of Santiago de Compostela, Faculty of Pharmacy, Spain, teaching drug
delivery to mucosal surfaces.
2000 -
Master course on Medicines Technology, University of Coimbra, Faculty of Pharmacy,
Portugal, teaching targeting of particulate systems to mucosal surfaces.
2001 -
Master course on Pharmaceutical Technology, University of Oporto, Faculty of
Pharmacy, Portugal, targeting of particulate systems to mucosal surfaces.
2001/.. - Post-graduation course in Economical Evaluation of Medicines, Technical University
of Lisbon, School of Economics, Portugal, teaching pharmaceutical development and
stability of drugs.
2001/ -
Master course in Pharmaceutical Regulatory Affairs, University of Lisbon, Faculty of
Pharmacy, Portugal, being responsible for the subject Evaluation of Quality.
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3.3.
SCIENTIFIC ACTIVITY
1986/87 - Research student, University of Lisbon, Faculty of Pharmacy, Portugal. Project:
Modification of Streptomyces erythreus strains to improve streptomicin production.
Supervisor: Prof. Dr. Rui Vidal Correia da Silva.
1987/88 - Research student, Instituto Gulbenkian de Ciência, Oeiras. Project: Caracterization of
Bacillus subtilis mutants. Supervisor: Prof. Dr. Hermínia de Lencastre.
1990/93 - PhD research student, Department of Pharmaceutical and Biological Sciences, Aston
University, Birmingham, UK. Project: Particulate carriers as immunological adjuvants.
Supervisor: Prof. Dr. H. Oya Alpar.
1994/ -
Scientist at the Unidade de Ciências e Tecnologia Farmacêuticas (UCTF), University
of Lisbon, Faculty of Pharmacy, Portugal, responsible for a research line on particulate
carrier systems.
1995/96 - Visiting scientist at the Freie Universität Berlin, Institut für Pharmazie, Berlim,
Germany, (Prof. Dr. Rainer H. Müller), working on the production and characterisation
of solid lipid nanoparticles.
3.3.1. Research Projects
I.
Development of new dosage forms for the controlled delivery of drugs. Funded by the
pharmaceutical industry (Tecnimede - Sociedade Técnico Medicinal, S.A.) and the
European Union (PEDIP II). Duration: 1995-1997.
II.
Development of an antioxidant solution for oral administration. Funded by the
pharmaceutical industry (Helsinn-Produtos Farmacêuticos, S.A). Duration: 1995-1999
III. Production of solid lipid nanoparticles containing protein antigens. In collaboration with
the Freie Universität Berlin, Institut für Pharmazie, Germany (Prof. Dr. Rainer H. Müller).
Funded by DAAD (Germany) and INVOTAN (Portugal). Duration: 1995-2002.
IV. Production
and characterisation microencapsulated vaccines for oral or nasal
administration (P/P/S5, IMUNOPOR). R&D project funded by the European Union
(SINDEPEDIP), in collaboration with several institutions: Laboratório Sorológico,
Laboratório Medinfar, IBET, INETI, IHMT/CMDT e Laboratório de Microbiologia da
FFUL. Coordinator of P/P/S5 (Development of a vaccine agains strangles). Duration: 19972000.
V.
Carrier systems for diagnosis and therapeutic applications associated with the lung
lymphatics. Funded by the Ministry of Science (Praxis XXI, Ciências da Saúde,
2/2.1/SAU/1305/95), in collaboration with IBILI (Coimbra) and Faculdade de Farmácia,
Universidade de Coimbra. Duration 1997-2000.
VI. Biological evaluation of new controlled release dosage forms for beta-adrenergic blocking
drugs. Funded by the Ministry of Science (Praxis XXI, Ciências da Saúde,
2/2.1/SAU/1418/95). Responsible scientist: Prof. J.A.G. Morais. Duration 1998-2003.
VII. Production and release properties of microencapsulated drugs using supercritical fluids.
Funded by the Ministry of Science (POCTI/1999/EQU/34961). In collaboration with
Instituto Superior Técnico, Lisboa. Responsible scientist: Prof. E. Gomes de Azevedo.
Duration 2001-2004.
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VIII. Therapeutic systems for tuberculosis treatment. Funded by the Ministry of Science
(POCTI/Sapiens/36416/99). In collaboration with UNFAB/ INETI, Lisboa Responsible
scientist Dr Eugénia Cruz. Started January 2002.
IX. Development of a microparticulate system for colonic drug delivery. Funded by the Acções
Integradas Luso-Espanholas (Acção nº E-15/03). In collaboration with the Facultad de
Farmácia, Universidad de Sevilla, Spain (Prof. Mercedes Fernández Arévalo).
X.
Development of polymeric microspheres for the delivery of Streptococcus equi antigens.
Project leading to the PhD thesis of Helena Isabel Fialho Florindo (FCT-SFRHBD/14370/03), in collaboration with the Centre for Drug Delivery Research, London School
of Pharmacy, Reino Unido (Prof. H. O. Alpar). Duration: 2003-2007.
XI. A new approach to the production of an anti streptococcal vaccine. Funded by the Ministry
of Science (POCTI/BIO/59147/2004). In collaboration with IBET (Portugal), CDDR,
London and the Karolinska Institute, Sweden. Duração: 2005-2008.
XII. Protein Microencapsulation Using Supercritical Fluids. Financiado pela FCT
(POCTI/EQU/55911/2004). In collaboration with the Instituto Superior Técnico, Lisboa.
Responsible scientist: Prof. E. Gomes de Azevedo. Duration 2005-2008.
3.3. OTHER ACTIVITIES AT THE UNIVERSITY OF LISBON
1998/02 - President of the Faculty’s Assembly of Representatives.
2003/.. - Vice-President of the Faculty’s Scientific Board.
3.5.
1996/ -
3.6.
MEDICINE EVALUATION
Quality expert of the Portuguese Medicines Agency (INFARMED) and the European
Medicines Agency (EMEA), for new medicines evaluation, having participated in the
evaluation of many new medicines by the national, mutual recognition and centralised
procedures for the, including the following: Azilect® (rasagiline mesilate), Carbaglu®
(carglumic acid), Circadin® (melatonine), Fuzeon® (enfuvirtide), Galsulfase®
(ethyl
(recombinant
human
N-acetylgalactosamine-4-sulfatase),
Lyxia®
eicosapentenoate), Nexavar® (sorafenib), Orathecin® (rubitecane), Oxytrol®
(oxibutinine), Sustiva®/Stocrin® (efavirenz), Xaprila® (xaliproden hydrochloride).
OTHER ACTIVITIES
1988/89 - Regulatory affairs at Merck Sharp & Dohme Lda./MSD-AGVET, Lisbon.
1988/89 - National Service (Portuguese Army), at the Military Laboratory, as a Second
Lieutenent.
1997/ -
Referee of Acta Biomaterialia, Drug Delivery Science and Technology, Drug
Development and Industrial Pharmacy, European Journal of Pharmaceutics and
Biopharmaceutics, Journal of Applied Polymer Science, Journal of Controlled
Release, Pharmaceutical Research e Vaccine.
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1997/ -
Vice-President of the CRS Spanish-Portuguese Local Chapter of the Controlled
Release Society (SPLC-CRS) (1998-2002); Treasurer (1997/98); Secretary (20022005).
4.
PUBLICATIONS
4.1.
THESES AND REPORTS
1.
Almeida, A.J. (1987). Melhoramento de estirpes de Streptomyces erythreus, via engenharia
genética para a produção de eritromicina. Final dissertation of the first degree in
Pharmaceutical Sciences. University of Lisbon, Faculty of Pharmacy.
2.
Almeida, A.J. (1988). Contribuição para a caracterização de mutantes de Bacillus subtilis
resistentes à infecção pelo fago Φ105. Final dissertation of the postgraduation course
Modern Techniques in Biology and Biotechnology, Instituto Gulbenkian de Ciência, Oeiras.
3.
Almeida, A.J. (1993). Particulate carriers as immunological adjuvants. Ph.D. thesis,
Department of Pharmaceutical and Biological Sciences, The University of Aston in
Birmingham, Reino Unido.
4.
Almeida, A.J. (2005). Micro- and nanoparticulate translocation across epithelial surfaces:
mechanisms and therapeutic applications. Scientific lecture presented for habilitation,
University of Lisbon, Faculty of Pharmacy.
4.2.
SEMINARS
1.
Almeida, A.J. (1989). Alguns aspectos da aplicação da biotecnologia à industria
farmacêutica. Reuniões Temáticas do Laboratório Militar de Produtos Químicos
Farmacêuticos, Lisbon, 17th March.
2.
Almeida, A.J. (1995). Microsferas biodegradáveis como vectores de antigénios. Conferência
proferida nos II Encontros Farmacêuticos do Laboratório Militar de Produtos Químicos e
Farmacêuticos, Lisboa, 25th January.
3.
Almeida, A.J. (1996). Biodegradable particulate carriers as potential vaccine delivery
systems. Seminar at the Franz-Volhard-Klinik, Medizinische Fakultät der HumboldtUniversität zu Berlin, Germany, 20th March.
4.
Almeida, A.J. (1997). Trends in nasal delivery of vaccines using particulate carriers. Seminar
at the Faculdad de Farmacia, Universidad de Santiago de Compostela, Spain, 17th April.
5.
Almeida, A.J. (1997). Utilización de micropartículas en inmunización mucosal. Seminar at
the Centro de Investigación - Pierre Fabre Ibérica, S.A., Barcelona, Spain, 24th July.
6.
Almeida, A.J. (2000). Fórmulas oficinais e magistrais: requisitos de qualidade. 3º Encontro
de Orientadores de Estágio de Licenciatura da FFUL. Lisbon, 8th Abril.
7.
Almeida, A.J. (2004). Drug delivery and targeting using lipid nanoparticles. Seminar at the
Faculdad de Farmacia, Universidad de Santiago de Compostela, Spain, 22nd March.
8.
Almeida, A.J. (2005). Lipid nanoparticles for controlled drug delivery. Conferência proferida
na Freie Universität Berlin, Institut für Pharmazie, Berlin, Germany, 18th November.
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4.3.
PRESENTATIONS AT SCIENTIFIC MEETINGS
4.3.1. Plenary Lectures and Invited Oral Presentations
1.
Almeida, A.J. (1996). Aplicações farmacêuticas de vectores coloidais. II Jornadas
Farmacêuticas do Instituto Superior de Ciências da Saúde Sul, Monte da Caparica, Portugal,
15-16 May.
2.
Almeida, A.J. (1997). Sistemas avançados de veiculação de fármacos. Reunião Anual do
Colégio de Indústria Farmacêutica da Ordem dos Farmacêuticos, Tomar, Portugal, 4-6
April.
3.
Almeida, A.J. (1998). Mucosal delivery and absorption of particulate systems. Proceed. III
Congresso Hispano-Luso de Libertação Controlada de Medicamentos (Lisboa, Portugal), pp.
9 (PLENARY LECTURE).
4.
Almeida, A.J. (1999). Ensaios de estabilidade e prazo de validade. A Envolvente da
Avaliação de Medicamentos, INFARMED, Lisbon, Portugal, 15th March.
5.
Almeida, A.J. (1999). Mucosal delivery of particles - absorption and translocation accross
epithelial surfaces. I Mediterranean CRS Conference: Drug Delivery in the Third Millennium
(Pisa, Italy). Acta Tecnologiae et Legis Medicamenti, 10: 77 (PLENARY LECTURE).
6.
Almeida, A.J. (1999). Absorção de vectores medicamentosos coloidais: factores
condicionantes e aplicações terapêuticas. VI Fórum Farmacêutico, subordinado ao tema
Novas Terapias e Tecnologias Farmacêuticas, Oporto, Portugal, 3-4 November.
7.
Rodrigues, M., Peiriço, N., Almeida, A.J., Matos, H., Gomes de Azevedo, E. (2002).
Supercritical fluid technology: applications to microparticle formation for controlled drug
release. V Congreso Hispano-Luso de Liberación Controlada de Medicamentos (Seville,
Spain), Abstract book, pp.39-40.
8.
Almeida, A.J. (2003). Comunidade científica e inovação em Portugal. Ciclo de Conferências:
Indústria Farmacêutica e Medicamentos Inovadores, Ordem dos Farmacêuticos, Lisbon,
20th May.
9.
Almeida, A.J., Toscano, C., Videira, M. (2004). Therapeutic applications of lipid
nanoparticles administered by alternative routes. XII International Workshop on
Bioencapsulation, Vitoria, Spain, 24-26 September (PLENARY LECTURE).
10.
Almeida, A.J. (2004). Pulmonary delivered lipid nanoparticles as potential drug carriers for
cancer therapy. 8th European Congress of Pharmaceutical Sciences (EUFEPS 2004),
Brussels, Belgium. Eur. J. Pharm. Sci., 23 (Suppl. 1): S25-S26.
11.
Almeida, A.J. (2004). Formulação magistral para necessidades hospitalares específicas.
Workshop: Medicamentos para grupos de pacientes com necessidades hospitalares
específicas - V Congresso da APFH, Lisbon, Portugal, 24 November.
12.
Almeida, A.J. (2006). Ensaios de estabilidade aplicados ao produto final. Conferência
proferida no Seminário Especializado: Stability Testing, Institute for International Research,
PTI–Pharmaceutical Training Institute (Lisbon, Portugal), 14th February.
13.
Almeida, A.J. (2006). Estudos de fotoestabilidade. Conferência proferida no Seminário
Especializado: Stability Testing, Institute for International Research, PTI–Pharmaceutical
Training Institute (Lisbon, Portugal), 14th February.
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14.
Almeida, AJ. (2006). Vaccination strategies using nanoparticles. Simpósium New Strategies
for Administration of Drugs Sociedade Portuguesa de Ciências Farmacêuticas (SPCF), 17th
May.
4.3.2. Oral Presentations
1.
Almeida, A.J., Alpar, H.O., Brown, M.R.W. (1992). The efficient encapsulation of
biologically intact high molecular weight proteins into submicron polylactide microspheres.
6th International Conference on Pharmarmaceutical Technology (Paris, France). Abstract
book, pp. 39.
2.
Almeida, A.J., Alpar, H.O., Brown, M.R.W. (1992). Protein adsorbed polylactide
microspheres as mucosal immunoadjuvants. 6th International Conference on Pharmaceutical
Technology (Paris, France). Abstract book, pp. 40.
3.
Almeida, A.J. (1993). Poly(lactic acid) microspheres as immunological adjuvants for tetanus
toxoid. Newpharm’93 (Loughborough, UK).
4.
Poyner, E.A., Alpar, H.O., Almeida, A.J., Brown, M.R.W. (1993). Liposomal and
microencapsulated tobramycin: optimisation, antibacterial activity and in vivo distribution. 9th
International Symposium on Microencapsulation (Ankara, Turkey). Abstract book, pp. 85a.
5.
Almeida, A.J., Runge, S., Müller, R.H. (1996). Production and characteristics of peptideloaded solid lipid nanoparticles (SLN). 42nd Annual Congress of the International
Association for Pharmaceutical Technology (Mainz, Germany). Eur. J. Pharm. Biopharm.,
42 (Suppl.): 44S.
6.
Cerdeira, A.M., Brandão, A., Goucha, P., Cabral Marques, H.M., Almeida, A.J. (1998).
Preparation and characterisation of beads containing a nabumetone: dimethyl-β-cyclodextrin
complex. 17th Pharmaceutical Technology Conference (Dublin, Ireland).
7.
Azevedo, A.F., Almeida, A.J. (1998). Methods for the recovery of an intact protein molecule
from PLGA microspheres: a comparative study. III Congresso Hispano-Luso de Libertação
Controlada de Medicamentos (Lisbon, Portugal). Abstract book, pp. 27-28.
8.
Almeida, A.J, Almeida, S., Gonçalves, C., Videira, M., Azevedo, A.F. (2000) Evaluation of
different methods for surface hydrofobicity determination in particulate colloidal carriers. IV
Congreso Hispano-Luso de Liberación Controlada de Medicamentos (Vitoria, Spain).
Abstract book, pp.41-42.
9.
Ferreira Almeida, P., Almeida A.J. (2001). Sustained release of pindolol from calcium
alginate beads: production and characterisation. II Mediterranean CRS Meeting: New
Perspectives in Controlled Release (Athens, Greece). Abstract book, pp.186.
10.
Videira, M., Florindo, H., Almeida, A.J. (2002). Preparation of solid lipid nanoparticles
(SLN): a potential protein delivery system. V Congreso Hispano-Luso de Liberación
Controlada de Medicamentos (Seville, Spain). Abstract book, pp.69-70.
11.
Leandro, J., Nascimento, C., Tavares de Almeida, I, Almeida A.J., Leandro, P.(2005). Effect
of mannitol and glycerol on storage stability of human phenylalanine hydroxylase. II
Congress of the Portuguese Society of Pharmaceutical Sciences/VI Congress of the
Portuguese-Spanish Chapter of the Controlled Release Society (Coimbra, Portugal). Rev.
Port. Farm., 52 (Supl. 2): 7-8.
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12.
Florindo, H.F., Pandit, S., Somavarapu, S., Almeida, A.J., Alpar, H.O. (2005). Immune
response induced by S. equi enzymatic extract adsorbed to surface modified polycaprolactone
microspheres. Proc. Intern. Symp. Control. Rel. Bioact. Mater., 32: (Miami, EUA), pp. 805806.
13.
Videira, M., Florindo, H.F., Gouveia, L.F. Lobato, M.R., Almeida, A.J. (2005). Triglyceryde
nanoparticles as potential carriers for paclitaxel. 15th International Symposium on
Microencapsulation (Parma, Italy). Abstract book, pp. 225-226.
14.
Alpar H.O., Florindo, H.F., Pandit, S., Gonçalves, L.M.D., Somavarapu, S., Almeida, A.J.
(2006). Production and immune response characterisation of S. equi enzymatic extract
adsorbed polycaprolactone microshperes. 9th International Congress of the World Equine
Veterinary Association (Morocco) 22-26 January 2006.
15.
Souto, E.B., Almeida, A.J., Müller, R.H. (2006). SLN and NLC as viscoelastic enhancers for
topical drug delivery. XIV International Workshop on Bioencapsulation (Lausanne,
Switzerland).
16.
Mendes, L., Rodrigues, C., Almeida, A.J., Castro, M., Soveral, G. (2006). Leite materno e a
presença de mercúrio. XXXIV Jornadas Nacionais de Pediatria, (Aveiro, Portugal). Abstract
book, pp. 47.
17.
Florindo, H.F., Gonçalves, L.M.D., Alpar, H.O., Almeida, A.J. (2006). Adsorption of
Streptococcus equi enzymatic extract on the surface modified PCL nanospheres. VII
Congress Portuguese-Spanish Congress on Controlled Drug Delivery (Pamplona, Spain).
Abstract book, pp. 32-33.
18.
Albuquerque, M., Silva, A., Salgado, A., Duarte, M.A., Almeida, A.J. (2006). Avaliação da
estabilidade de uma fórmula magistral de pirazinamida em suspensão líquida oral para uso
em pediatria. 11º Simpósio Nacional da APFH, (Estoril, Portugal). Abstract book, pp. 21.
19.
Gonçalves, H., Mancini, G., Ribeiro, H.M., Silva, A, Duarte, M.A., Almeida, A.J. (2006).
Desenvolvimento e caracterização reológica de uma fórmula magistral de L-arginina em gele
semi-sólido para aplicação tópica. 11º Simpósio Nacional da APFH, (Estoril, Portugal).
Abstract book, pp. 22.
20.
Barros, C.T., Almeida, A.J. (2006). Perfil da formulação extemporânea de medicamentos
orais para pediatria nos serviços farmacêuticos hospitalares. 11º Simpósio Nacional da
APFH, (Estoril, Portugal). Abstract book, pp. 23.
4.3.3. Poster Communications
1.
Lencastre, H., Estrela, A.I., Almeida, A.J. (1987). Characterization of a Bacillus subtilis
mutant resistant to infection by phage Φ105. 8º Congresso Nacional de Bioquímica (Póvoa
de Varzim, Portugal). Ciência Biológica, 12 (Supl.): 254.
2.
Alpar, H.O., Rovamo, L., Devi, K., Almeida, A.J., Collier, P.J., Brown, M.R.W. (1991). In
vitro evaluation of antibacterial activities of liposomal tobramycin against Pseudomonas
aeruginosa. 128th British Pharmaceutical Conference (Liverpool, UK). J. Pharm.
Pharmacol., 43 (Suppl.): 122P.
8
3.
Almeida, A.J., Alpar, H.O., Williamson, D., Brown, M.R.W. (1992). Poly(lactic acid)
microspheres as immunological adjuvants for orally delivered cholera toxin B subunit. 643rd
Meeting of the Biochemical Society (Warwick, UK). Biochem. Soc. Trans., 20: 316S.
4.
Alpar, H.O., Malik, A., Almeida, A.J., Brown, M.R.W. (1992). Preparation and
characteristics of gentamicin-containing poly(lactide-co-glycolide) microspheres for lung
targeting. 129th British Pharmaceutical Conference (Birmingham, UK). J. Pharm.
Pharmacol., 44 (Suppl.): 1082.
5.
Almeida, A.J., Alpar, H.O., Brown, M.R.W. (1993). Poly(L-lactic acid) microspheres as a
vaccine adjuvant for tetanus toxoid. Science Link’93 (Macclesfield, UK). Abstract book, pp.
56A.
6.
Almeida, A.J., Alpar, H.O. Brown, M.R.W. (1993). Formulation studies on particulate
carriers as immunological adjuvants. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 20:
390-391 (Washington, USA).
7.
Alpar, H.O., Almeida, A.J., Brown, M.R.W., Williamson, E.D. (1994). Immune responses to
mucosally administered tetanus toxoid in biodegradable PLA microspheres. Proceed. Intern.
Symp. Control. Rel. Bioact. Mater., 21: 867-868 (Nice, France).
8.
Almeida, A.J., Alpar, H.O. (1994). Microsphere adjuvanticity: influence of polymer, dose
and size on the humoral response to microencapsulated tetanus toxoid. 2nd European
Congress of Pharmaceutical Sciences (Berlin, Germany). Eur. J. Pharm. Sci., 2: 189.
9.
Cerdeira, A.M., Goucha, P., Almeida, A.J. (1996). Parameters affecting the formulation of
NSAIDs-containing gastroresistant beads. 3rd European Congress of Pharmaceutical
Sciences (Edimburgh, UK). Eur. J. Pharm. Sci., 4 (Suppl.): S157.
10.
Almeida, A.J., Dingler, A., Runge, S., Müller, R.H. (1996). Nanopartículas de lípidos sólidos
- Sistema coloidal alternativo para veiculação e libertação controlada de fármacos. Congresso
Nacional de Farmacêuticos ‘96/3º Congresso Mundial de Farmacêuticos de Língua
Portuguesa (Lisbon, Portugal). Abstract book, pp. 109.
11.
Almeida, A.J., Runge, S., Müller, R.H. (1996). Estudos de encapsulação de fármacos de
natureza peptídica em nanopartículas de lípidos sólidos. Congresso Nacional de
Farmacêuticos ‘96/3º Congresso Mundial de Farmacêuticos de Língua Portuguesa (Lisbon,
Portugal). Abstract book, pp. 112.
12.
Cerdeira, A.M., Goucha, P., Almeida, A.J. (1996). Mini-grânulos gastro-resistentes contendo
AINEs produzidos por precipitação: I. Parâmetros de produção. Congresso Nacional de
Farmacêuticos ‘96/3º Congresso Mundial de Farmacêuticos de Língua Portuguesa (Lisbon,
Portugal). Abstract book, pp. 110.
13.
Cerdeira, A.M., Goucha, P., Almeida, A.J. (1996). Mini-grânulos gastro-resistentes contendo
AINEs produzidos por precipitação: II. Caracterização. Congresso Nacional de
Farmacêuticos ‘96/3º Congresso Mundial de Farmacêuticos de Língua Portuguesa (Lisbon,
Portugal). Abstract book, pp. 113.
14.
Cerdeira, A.M., Goucha, P., Almeida, A.J. (1997). In vitro release studies on enteric granular
formulations based on HP50. II Congreso Hispano-Luso de Liberación Controlada de
Medicamento (Tenerife, Spain). Abstract book, pp. 119-120.
15.
Cerdeira, A.M., Gouveia, L.F., Goucha, P., Almeida, A.J. (1997). Optimisation of the
formulation of enteric beads prepared by the HP50 precipitation method. II Congreso
9
Hispano-Luso de Liberación Controlada de Medicamentos (Tenerife, Spain). Abstract book,
pp. 117-118.
16.
Gouveia, L.F., Cerdeira, A.M., Almeida, A.J., Morais, J.A.G. (1997). Determination of
dissolution profiles of etodolac in enteric granules by flow injection analysis. II Congreso
Hispano-Luso de Liberación Controlada de Medicamentos (Tenerife, Spain). Abstract book,
pp. 41-42.
17.
Almeida, A.J., Runge, S., Müller, R.H. (1997). Investigations on solid lipid nanoparticles
(SLN) as colloidal carriers for protein antigens. Proceed. Intern. Symp. Control. Rel. Bioact.
Mater., 24: 837-838 (Stockhom, Sweden).
18.
Morais, J.A.G., Almeida, A.J., Cabral Marques, H.M., Cabrita, J.J., Lobato, M.R., Maya,
M.T., Pinto, J.F., Rodrigues, L. (1998). Unidade de ciências e tecnologia farmacêuticas. I
Encontro: Opportunities for Pharmaceutical R&D in Portugal (Oeiras, Portugal). Abstract
book, P-III-17.
19.
Videira, M., Azevedo, A.F., Almeida, A.J. (1998). Entrapment of a high molecular weight
protein into solid lipid nanoparticles. Proceed. 2nd World Meeting on Pharmaceutics,
Biopharmaceutics and Pharmaceutical Technology (Paris, France), pp. 629-630.
20.
Gouveia, L.F., Videira, M., Almeida, A.J. (1998). Determination of diltiazem in solid lipid
nanoparticles by flow injection analysis with liquid-liquid extraction. Proceed. 2nd World
Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (Paris,
France), pp. 631-632.
21.
Videira, M., Almeida, A.J. (1998). Can solid lipid nanoparticles be produced by a simple
emulsion/solidification technique? III Congresso Hispano-Luso de Libertação Controlada de
Medicamentos (Lisbon, Portugal). Abstract book, pp. 125-126.
22.
Almeida, A.J., Almeida, A.P.G., Carrondo, M.J.T., Collares-Pereira, M., Cunha, A., Cruz, P.,
Clemente, A., Gonçalves, L.M.D., Moniz-Pereira, J., Novo, C., Oliveira, J., Santos-Gomes,
G. (1999). Development of diagnostic kits and vaccines for infectious diseases. European
Conference on Perspectives on Infectious Disease Research (Dresden, Germany).
23.
Cerdeira, A.M., Goucha, P., Almeida, A.J. (1999). Crystal size and habit influence on drug
release from enteric beads produced by droplet extrusion/precipitation. Proceed. Intern.
Symp. Control. Rel. Bioact. Mater., 26: 1022-1023 (Boston, USA).
24.
Videira, M., Botelho, F, Pedroso de Lima, J.J. Santos, A.C., Almeida, A.J. (1999). Lymphatic
uptake of radiolabelled solid lipid nanoparticles administered by the pulmonary route.
European Association of Nuclear Medicine Congress (Barcelona, Spain). Eur. J. Nucl. Med.,
26: 1168.
25.
Azevedo, A.F., Almeida, A.J. (1999). Encapsulation efficiency of proteins in PLGA
microspheres by spray-drying: a factorial design approach. I Mediterranean CRS Conference:
Drug Delivery in the Third Millennium (Pisa, Italy). Acta Tecnologiae et Legis Medicamenti,
10: 111.
26.
Almeida, P.J., Almeida A.J. (1999). Alginate beads as an oral delivery system for βadrenergic blocking drugs: a preliminary study. I Mediterranean CRS Conference: Drug
Delivery in the Third Millennium (Pisa, Italy). Acta Tecnologiae et Legis Medicamenti, 10:
112.
10
27.
Videira, M., Almeida, A.J., Botelho, F., Santos, A.C., Gomes, C.M., Pedroso de Lima, J.J.
(1999). SLN as a colloidal carrier system to the lung lymphatics. I Mediterranean CRS
Conference: Drug Delivery in the Third Millennium (Pisa, Italy). Acta Tecnologiae et Legis
Medicamenti, 10: 151.
28.
Videira, M., Almeida, A.J., Müller, R.H. (2000). Incorporation of paclitaxel in SLN®:
assessment of drug-lipid interaction. Proceed. 3rd Word Meeting on Pharmaceutics,
Biopharmaceutics and Pharmaceutical Technology (Berlin, Germany), pp. 453-454.
29.
Gouveia, L.F., Videira, M., Almeida, A.J., Morais, J.A. (2000). Determination of dissolution
profiles of diltiazem tablets and capsules by FIA. 8th International Conference on Flow
Analysis (Warsaw, Poland). Abstract book, pp. 287.
30.
Almeida, A.J., Cerdeira A.M., Goucha, P. (2000) Development of a controlled release
particulate formulation for oral delivery of NSAIDs. IV Congreso Hispano-Luso de
Liberación Controlada de Medicamentos (Vitoria, Spain). Abstract book, pp. 45-46.
31.
Almeida, P.J., Almeida A.J. (2001). Mini-grânulos de alginato de cálcio produzidos por
gelificação ionotrópica para a veículação de pindolol. II Jornadas da Sociedade Portuguesa
de Ciências Farmacêuticas (Lisbon, Portugal). Abstract book, pp. A52.
32.
Videira, M.A., Gano, L., Santos, C., Neves, M.A., Almeida, A.J. (2001). Estudos de
biodistribuição de nanopartículas de lipídicas administradas por via endotraqueal. II Jornadas
da Sociedade Portuguesa de Ciências Farmacêuticas (Lisbon, Portugal). Abstract book, pp.
A68.
33.
Salgado, A.C., Rosa, M.L.D., Almeida, A.J. (2001). Estabilidade do captopril em formulação
magistral líquida para uso pediátrico obtida a partir de comprimidos. IV Congresso Nacional
de Farmacêuticos Hospitalares (Oporto, Portugal). Livro de resumos, pp. 41.
34.
Azevedo, A.F., Galhardas, J., Cunha, A., Cruz, P., Gonçalves, L.M.D., Almeida, A.J. (2002).
Induction of protective immunity against strangles by immunisation with a S. equi enzymatic
extract encapsulated in PLGA microparticles. Proceed. 4th Word Meeting on Pharmaceutics,
Biopharmaceutics and Pharmaceutical Technology (Florence, Italy), pp. 881-882.
35.
Rodrigues, M.A, Peiriço, N.M., Matos, H.A, Almeida, A.J., Gomes de Azevedo, E. (2002).
Microparticles for controlled drug delivery systems using supercritical carbon dioxide.
Proceed. 19th European Seminar on Applied Thermodynamics. (Santorini, Greece).
36.
Ferreira Almeida, P., Almeida, A.J. (2002). Cross-linked calcium alginate particles for
controlled release of drugs. World Congress of Pharmacy and Pharmaceutical Sciences 2002
(Nice, France). Abstract book, pp. 28.
37.
Azevedo, A.F., Cunha, A., Almeida, A.J. (2002). Biodegradable microspheres containing S.
equi antigens for immunisation against strangles. V Congreso Hispano-Luso de Liberación
Controlada de Medicamentos (Seville, Spain). Abstract book, pp. 79-80.
38.
Lavrador, C. Alfaro Cardoso, L., Almeida, A.J. (2002) In vitro evaluation of a veterinary
sustained-release injectable formulation of a β-agonist drug. V Congreso Hispano-Luso de
Liberación Controlada de Medicamentos (Seville, Spain). Abstract book, pp. 123-124.
39.
Videira, M., Pires, M.J., Soares, M., Almeida, A.J. (2003). Determination of particle
concentration in solid lipid particle dispersions. 1º Congresso da Sociedade Portuguesa de
Ciências Farmacêuticas (Lisbon, Portugal). Rev. Port. Farm., 52 (Supl.1): 122.
11
40.
Ferreira Almeida, P.J., Almeida, A.J. (2003). Efeito da redução do tamanho de partícula na
velocidade de libertação do pindolol em formulações de alginato de cálcio/gelatina. 1º
Congresso da Sociedade Portuguesa de Ciências Farmacêuticas (Lisbon, Portugal). Rev.
Port. Farm., 52 (Supl.1): 123.
41.
Videira, M., Santos, A.C., Almeida, A.J. (2003). Stability studies on 99mTc-HMPAO-SLN: a
particulate complex for lung and lymphatic imaging. Proceed. Intern. Symp. Control. Rel.
Bioact. Mater., 30: (Glasgow, UK), pp. 337-338.
42.
Salgado, A.C., Ribeiro, C., Rosa, M.L.D., Duarte, M.A., Almeida, A.J. (2003). Estabilidade
de uma suspensão oral de espironolactona preparada a partir de comprimidos. IX Simposium
Nacional de Farmacêuticos Hospitalares (Oporto, Portugal). Abstract book, pp. 31.
43.
Toscano, C., Videira, M., Farinha, A, Rodrigues, L.M., Almeida, A.J. (2003). Encapsulação
de substâncias com actividade fotoprotectora em nanopartículas lipídicas. Congresso
Nacional dos Farmacêuticos 2003 (Lisbon, Portugal). Abstract book, pp. 205.
44.
Pires, M. J., Videira, M., Almeida, A.J., Gouveia, L.F. (2003) ExcelTM add-in para análise de
granulométrica de pós por tamisação e sedimentação. Congresso Nacional dos
Farmacêuticos 2003, (Lisbon, Portugal). Abstract book, pp. 213.
45.
Rodrigues, M.A, Li, J., Almeida, A.J., Matos, H.A., Gomes de Azevedo, E. (2004)
Efficiencies of water removal from water/ethanol mixtures using supercritical carbon
dioxide. V Encontro Brasileiro de Fluidos Supercríticos, (Florianópolis, Brazil). Abstract
book, PP-063.
46.
Toscano, C., Videira, M., Farinha, A, Rodrigues, L.M., Almeida, A.J. (2004). In vitro
characterisation of solid lipid nanoparticles as a carrier system for photoprotective agents.
European Conference on Drug Delivery and Pharmaceutical Technology (Seville, Spain).
Abstract book, pp. 82.
47.
Mendes, L., Rodrigues, C., Almeida, A.J., Castro, M., Soveral, G. (2004). Determinação
analítica do teor em elementos minerais essenciais e tóxicos nas bebidas alcoólicas mais
consumidas em Portugal. International Conference on Food Protection (Lisbon, Portugal).
Abstract book.
48.
Mendes, L., Rodrigues, C., Almeida, A.J., Castro, M., Soveral, G. (2004). Perfil qualitativo e
quantitativo dos minerais em refrigerantes e néctares. International Conference on Food
Protection (Lisbon, Portugal). Abstract book.
49.
Mendes, L., Rodrigues, C., Almeida, A.J., Castro, M., Soveral, G. (2004). Leite materno determinação de elementos minerais essenciais e tóxicos. 7º Congresso Português de
Pediatria, (Lisbon, Portugal). Acta Pediátrica Portuguesa (publication in CD-ROM).
50.
Ferreira Almeida, P.J., Almeida, A.J. (2004). Pindolol-containing alginate-gelatine
microparticles as an oral controlled release system. 8th European Congress of
Pharmaceutical Sciences (EUFEPS 2004), Brussels, Belgium. Eur. J. Pharm. Sci., 23
(Suppl. 1): S51.
51.
Florindo, H.F., Almeida, A.J. (2004). Protein release from alginate microparticles:
disintegration studies and release mechanisms, 8th European Congress of Pharmaceutical
Sciences (EUFEPS 2004), Brussels, Belgium. Eur. J. Pharm. Sci., 23 (Suppl. 1): S64.
52.
Toscano, C., Farinha, A, Pinto, P.C., Magro, J.M., Rei, F., Almeida, A.J., Rodrigues, (2004).
In vivo evaluation of photoprotective activity of a solid lipid nanoparticle formulation. 8th
12
European Congress of Pharmaceutical Sciences (EUFEPS 2004), Brussels, Belgium. Eur. J.
Pharm. Sci., 23 (Suppl. 1): S47-S48.
53.
Conceição, M., Nascimento, C., Almeida, A.J., Tavares de Almeida, I., Leandro, P. (2004).
Preserving human phenylalanine hydroxylase activity: mechanism of polyol-induced in vitro
stabilisation. 3rd Portuguese-Spanish Biophysics Congress (Lisbon, Portugal). Abstract book,
pp.65.
54.
Salgado, A.C., Rosa, M.L.D., Duarte, M.A., Almeida, A.J. (2004). A importância da
qualidade microbiológica na avaliação da estabilidade de uma suspensão oral de
espironolactona para uso pediátrico. V Congresso da APFH (Lisbon, Portugal). Abstract
book, pp. 11.
55.
Salgado, A.C., Rosa, M.L.D., Duarte, M.A., Almeida, A.J. (2004). Estabilidade de uma
suspensão oral de ranitidina preparada a partir de comprimidos. V Congresso da APFH,
(Lisbon, Portugal). Abstract book, pp. 11.
56.
Mendes, L., Rodrigues, C., Almeida, A.J., Castro, M., Soveral, G. (2005). Leite materno –
Contributo do pescado para a presença de mercúrio. 7º Encontro de Química dos Alimentos
(Viseu, Portugal). Abstract book, pp. 168.
57.
Toscano, C., Farinha, A., Pinto, P.C., Magro, J.M., Rei, F., Almeida, A.J., Rodrigues, (2005).
Biological effects of lipid nanoparticles on skin photobiology. II Congress of the Portuguese
Society of Pharmaceutical Sciences/VI Congress of the Portuguese-Spanish Chapter of the
Controlled Release Society (Coimbra, Portugal). Rev. Port. Far. 52 (Supl. 2): 184-185.
58.
Mendes, L., Rodrigues, C., Almeida, A.J., Castro, M., Soveral, G. (2005). Selénio e leite
materno. II Congresso do Departamento das Ciências e Tecnologias Laboratoriais e
Intervenção Comunitária, Instituto Politécnico de Lisboa (Lisbon, Portugal). Abstract book,
pp. 96.
59.
Rodrigues, L.M.,Toscano, C., Farinha, A., Pinto, P.C., Magro, J.M., Rei, F., Almeida, A.J.,
(2005). Biological effects of lipid nanoparticles on in vivo skin biology. 4th International
Academy of Cosmetic Dermatology World Congress (Paris, France). Les Nouvelles
Dermatologiques, 24 (Sup. 7): 74.
60.
Florindo H.F., Pandit, S., Gonçalves, L.M.D., Somavarapu, S., Almeida, A.J., Alpar, H.O.
(2005). S. equi enzymatic extract adsorbed to polycaprolactone microspheres: production,
characterization and immune response in mice. 15th International Symposium on
Microencapsulation (Parma, Italy). Abstract book, pp. 339-340.
61.
Albuquerque, M., Almeida, A.J. (2005). Preparação e avaliação de uma forma magistral
líquida oral de pirazinamida. Congresso do Hospital de D. Estefânia 2005: Inovar e
Humanizar (Lisboa, Portugal). Abstract book, pp. 49.
62.
Azevedo A.F., Galhardas J., Cunha A., Cruz P., Gonçalves L.M.D., Almeida A.J. (2005).
Immobilisation of Streptococcus equi antigens in biodegradable microspheres induces
protection against experimental infection in mice. MicroBiotec’05 (Póvoa de Varzim,
Portugal). Abstract book, pp. 375.
63.
Florindo H.F., Pandit S., Gonçalves L.M.D., Almeida A.J., Alpar O. (2005). Adsorption
studies of Streptococcus equi antigens onto biodegradable micro/nanoparticles.
MicroBiotec’05 (Póvoa de Varzim, Portugal). Abstract book, pp. 419.
13
64.
Florindo, H.F., Gonçalves, L.M.D., Alpar, H.O., Almeida, A.J. (2006). Adsorption kinetics
of Streptococcus equi enzymatic extract onto surface modified PLA nanospheres. Proc.
Intern. Symp. Control. Rel. Bioact. Mater., 33: (Viena, Austria). P-200 (in CD-ROM).
65.
Ferreira Almeida, P., Moita, J., Almeida, A.J. (2006). Gastroresistent crosslinked alginategelatine particles. Proc. Intern. Symp. Control. Rel. Bioact. Mater., 33: (Viena, Austria). P844 (in CD-ROM).
66.
Souto, E.B., Almeida, A.J., Müller, R.H. (2006). Feasibility studies of lipid-based carriers for
dermal applications. XIV International Workshop on Bioencapsulation (Lausanne,
Suwitzerland).
67.
Barros, C.T., Almeida, A.J., Contente, M. (2006). Extemporaneous formulation of oral
paediatric medicines in Portuguese hospitals. 35th European Symposium on Clinical
Pharmacy. (Viena, Austria).
68.
Souto, E.B., Almeida, A.J., Müller, R.H. (2006). Controlled release of cyclosporine A from
triacylglycerol-based lipid nanoparticles VII Congress Portuguese-Spanish Congress on
Controlled Drug Delivery (Pamplona, Spain). Abstract book, pp. 141-142.
69.
Souto, E.B., Almeida, A.J., Müller, R.H. (2006). Solid lipid microparticles (SLM) versus
nanoparticles (SLN): effects on reduction of volatility of essential oils. 2006 AAPS Annual
Meeting and Exposition (San Antonio, USA). AAPS Journal, 8 (S2): Abstract M1146.
70.
Silva, A., Albuquerque, M., Salgado, A, Almeida, A.J., Duarte, M.A. (2006). Estudo da
actividade bactericida da pirazinamida em estirpes hospitalares multiresistentes numa
formulação magistral. 11º Simpósio Nacional da APFH, (Estoril, Portugal). Abstract book,
pp. 37.
71.
Mendes, L., Rodrigues, C., Almeida, A.J., Castro, M., Soveral, G. (2006). Mercury and
human milk. XX Encontro Nacional da SPQ (Campus da Caparica, Portugal). Abstract book,
pp. 258.
72.
Nascimento, C., Ramos, L., Almeida, A.J., Tavares de Almeida, I., Leandro, P. (2006). Effect
of addictives on the biological function of recombinant human phenylalanine hydroxylase:
solution and lyophilisation assays. XV Nacional Congress of Biochemistry (Aveiro, Portugal).
Abstract book, vol. 2, pp. 91.
4.4.
PAPERS PUBLISHED IN CONFERENCE PROCEEDINGS
1.
Almeida, A.J., Alpar, H.O., Brown, M.R.W. (1992). The efficient encapsulation of
biologically intact high molecular weight proteins into submicron polylactide microspheres.
Proceed. 6th International Conference on Pharmarmaceutical Technology, Vol. I, pp. 35-43.
2.
Almeida, A.J., Alpar, H.O., Brown, M.R.W. (1992). Protein adsorbed polylactide
microspheres as mucosal immunoadjuvants. Proceed. 6th International Conference on
Pharmaceutical Technology, Vol. I, pp. 44-51.
3.
Cerdeira, A.M., Brandão, A., Goucha, P., Cabral Marques, H.M., Almeida, A.J. (1998).
Preparation and characterisation of beads containing a nabumetone: dimethyl-β-cyclodextrin
complex. Proceed. 17th Pharmaceutical Technology Conference, Vol. I, pp. 42-51.
14
4.
Rodrigues, M.A., Peiriço, N.M., Matos, H.A., Almeida, A.J., Gomes de Azevedo, E. (2002).
Microparticles for controlled drug delivery systems using supercritical carbon dioxide.
Proceed. 19th European Seminar on Applied Thermodynamics, pp.144-147.
5.
Rodrigues, M.A., Li, J., Almeida, A.J., Matos, H.A., Gomes de Azevedo, E. (2004)
Efficiencies of water removal from water/ethanol mixtures using supercritical carbon
dioxide. V Encontro Brasileiro de Fluidos Supercríticos, (in CD-ROM).
6.
Almeida, A.J., Toscano, C., Videira, M. (2004). Therapeutic applications of lipid
nanoparticles administered by alternative routes. In: Pedraz, J.L., Orive, G., Poncelet, D.
(eds), XII International Workshop on Bioencapsulation, pp. 69-72.
7.
Souto, E.B., Almeida, A.J., Müller, R.H. (2006). SLN and NLC as viscoelastic enhancers for
topical drug delivery. Proc. XIV International Workshop on Bioencapsulation & COST 865
meeting (Lausanne, Switzerland) O6-5.
8.
Souto, E.B., Almeida, A.J., Müller, R.H. (2006). Feasibility studies of lipid-based carriers for
dermal applications. Proc. XIV International Workshop on Bioencapsulation & COST 865
meeting (Lausanne, Switzerland). P-27
4.5.
PAPERS IN JOURNALS WITH REFEREES
1.
Almeida, A.J., Alpar, H.O., Brown, M.R.W. (1993). Immune response to nasal delivery of
antigenically intact tetanus toxoid associated with poly(L-lactic acid) microspheres in rats,
rabbits and guinea-pigs. Journal of Pharmacy and Pharmacology, 45: 198-203.
2.
Alpar, H.O., Almeida, A.J., Brown, M.R.W. (1994). Microsphere absorption by the nasal
mucosa of the rat. Journal of Drug Targeting, 2: 147-149.
3.
Alpar, H.O., Almeida, A.J. (1994). Identification of some physico-chemical characteristics of
microspheres, which influence the induction of the immune response following mucosal
delivery. European Journal of Pharmaceutics and Biopharmaceutics, 40: 198-202.
4.
Almeida, A.J. (1994). Vaccine delivery systems. Revista Portuguesa de Farmácia, 44: 3-13.
5.
Poyner, E.A., Alpar, H.O., Almeida, A.J., Gamble, M.D., Brown, M.R.W. (1995). A
comparative study on the pulmonary delivery of tobramycin encapsulated into liposomes and
PLA microspheres following intravenous and endotracheal delivery. Journal of Controlled
Release, 31: 41-48.
6.
Almeida, A.J., Alpar, H.O. (1996). Nasal delivery of vaccines. Journal of Drug Targeting, 3:
455-467.
7.
Almeida, A.J., Runge, S., Müller, R.H. (1997). Peptide-loaded solid lipid nanoparticles
(SLN): influence of production parameters. International Journal of Pharmaceutics, 149:
255-265.
8.
Cerdeira, A.M., Goucha, P., Almeida, A.J. (1998). Hydroxypropyl methylcellulose phthalate
beads containing a model non-steroid anti-inflammatory drug. International Journal of
Pharmaceutics, 164: 147-154.
9.
Paulo, M.G., Cabral Marques, H.M., Morais, J.A.G., Almeida, A.J. (1999). An isocratic LC
method for the simultaneous determination of vitamins A, C, E and β-carotene. Journal of
Pharmaceutical and Biomedical Analysis, 21: 399-406.
15
10.
Cerdeira, A.M., Gouveia, L.F., Goucha, P., Almeida, A.J. (2000). Drug particle size
influence on enteric beads produced by a droplet extrusion/precipitation method. Journal of
Microencapsulation, 17: 733-741.
11.
Lavrador, C., Almeida, A.J., Cardoso, L.A. (2002). Avaliação in vitro de um injectável
subcutâneo para libertação prolongada de um fármaco β-agonista. Revista Portuguesa de
Ciências Veterinárias, 97: 29-34.
12.
Videira, M., Botelho, M.F., Santos, A.C., Gomes, C.M., Pedroso de Lima, J.J., Almeida, A.J.
(2002). Pulmonary delivery of SLN as a colloidal drug carrier system to the lung lymphatics.
Journal of Drug Targeting, 10: 607-613.
13.
Rodrigues, M., Peiriço, N., Matos, H., Gomes de Azevedo, E., Lobato, M.R., Almeida, A.J.
(2004). Microcomposites theophylline/hydrogenated palm oil from a PGSS process for
controlled drug delivery systems. Journal of Supercritical Fluids, 29: 175-184.
14.
Ferreira Almeida, P.J., Almeida A.J. (2004). Cross-linked alginate-gelatine beads: a new
matrix for controlled release of pindolol. Journal of Controlled Release, 97: 431-439.
15.
Salgado, A.C., Rosa, M.L., Duarte, M.A., Almeida, A.J. (2005). Stability of spironolactone in
an extemporaneously prepared aqueous suspension: importance of microbiological quality of
compounded paediatric formulations. European Journal of Hospital Pharmacy 11: 68-73.
16.
Rodrigues, M., Li, J., Almeida, A.J., Matos, H.A., Gomes de Azevedo, E. (2006).
Efficiencies of water removal from water/ethanol mixtures using supercritical carbon
dioxide. Brazilian Journal of Chemical Engineering, 23: 205-212.
17.
Azevedo, A.F., Galhardas, J., Cunha, A., Cruz, P., Gonçalves, L.M.D., Almeida, A.J. (2006).
Microencapsulation of Streptococcus equi antigens in biodegradable microspheres and
preliminary immunisation studies. European Journal of Pharmaceutics and
Biopharmaceutics, 64: 131-137.
18.
Videira, M.A., Gano, L., Santos, C., Neves, M., Almeida, A.J. (2006). Lymphatic uptake of
lipid nanoparticles following endotracheal administration to rats. Journal of
Microencapsulation, 23: 855-862.
19.
Rodrigues, M., Jun, L., Matos, H., Almeida, A.J., Gomes de Azevedo, E. (2007). Control of
the morphology of microparticles produced by supercritical CO2 from water/ethanol
solutions. (submitted).
20.
Almeida, A.J., Souto, E. (2007). Solid lipid nanoparticles as drug delivery systems for
peptides and proteins. Advanced Drug Delivery Reviews (submitted)
21.
Souto, E., Almeida, A.J., Müller, R.H. (2007). Lipid nanoparticles (SLN®, NLC®) for
cutaneous drug delivery: structure, protection and skin effects. Advanced Drug Delivery
Reviews (submitted).
4.6.
1.
BOOK CHAPTERS
Almeida, A.J., Alpar, H.O. (1997). Mucosal immunisation with antigen-containing
microparticles. In: Gander, B., Merkle, H.P. and Corradin, G. (eds.), Antigen Delivery
Systems: Immunological and Technological Issues. Harwood Academic Publishers,
Amsterdam. pp. 207-226.
16
2.
Cruz, M.E.M., Almeida, A.J., Corvo, M.L. (2003). Sistemas de libertação controlada de
fármacos. In: Lima, N. and Mota, M. (eds.), Biotecnologia: Fundamentos e Aplicações. Lidel
- Edições Técnicas, Lisboa. pp. 359-376.
4.7.
PATENTS
1.
Goucha, P., Cerdeira, A.M., Almeida, A.J. (2000). Process for formulating granular matrices
by precipitation of polymers in an acidic medium. European Patent EP 1018335.
2.
Goucha, P., Cerdeira, A.M., Almeida, A.J. (2000). Apparatus for the preparation of spherical
polymer particles. European Patent EP 1018364.
3.
Ferreira Almeida, P., Almeida A.J. (2004). Partículas de um polissacárido e uma poliamina
interligados por um agente de cross-linking, contendo uma substância activa para libertação
lenta. Portuguese Patent nº 102728.
4.8.
OTHER PUBLICATIONS
1.
Almeida, A.J. (1995). Microemulsões como sistemas terapêuticos para a administração oral
de péptidos. Notícias de Farmácia Hospitalar. 11: 5-6.
2.
Almeida, A.J., Morais, J.A.G. (1999). Guia dos principais medicamentos. In: Tratamentos
Médicos e Alternativos. Selecções do Reader’s Digest, Lisboa, pp. 444-466 (translation).
3.
Salgado, A.C., Rosa, M.L.D., Almeida, A.J. (2002). Estabilidade do captopril em formulação
magistral líquida para uso pediátrico obtida a partir de comprimidos. Boletim da APFH, 52:
2-4.
4.
Salgado, A.C., Rosa, M.L.D., Almeida, A.J. (2003). Estabilidade do cloridrato de ranitidina
em formulação magistral líquida para uso pediátrico obtida a partir de comprimidos. Boletim
da APFH, 74, 7-10.
5.
Almeida, A.J. (2005). Formulação magistral para necessidades hospitalares específicas:
pediatria. Mundo Farmacêutico, 15: 52-54.
6.
Almeida, A.J. (2006). Estratégias de utilização de microesferas e nanopartículas em vacinas.
Mundo Farmacêutico, 25: 26-28.
5.
GRANTS
1982/86 - Fundação Calouste Gulbenkian – grant for pregraduation studies.
1986/87 - Atral-Cipan, S.A. – pharmaceutical industry grant for research.
1987/88 - Instituto Nacional de Investigação Agrária / Instituto Gulbenkian de Ciência (Fundo
Social Europeu) – grant for research.
1990/91 - INVOTAN – NATO grant for PhD studies in the UK.
1991/93 - JNICT (Programa Ciência) - grant for PhD studies in the UK.
1995 -
Deutscher Akademischer Austauschdienst (DAAD) – Postdoctoral grant for research
in Germany.
1996 -
INVOTAN – NATO grant for research in Germany.
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6.
AWARDS
1989 -
Military award for services at the military laboratory during national service.
2001 -
The APFH-Farmoz Award for the best poster presentation at the IV Congresso
Nacional de Farmacêuticos Hospitalares (Oporto, Portugal):“Salgado, A.C., Rosa,
M.L.D. e Almeida, A.J., Estabilidade do captopril em formulação magistral líquida
para uso pediátrico obtida a partir de comprimidos”.
2002 -
Scientific Merit Award, to the work “Salgado, A.C., Rosa, M.L.D. e Almeida, A.J.,
Estabilidade do captopril em formulação magistral líquida para uso pediátrico obtida
a partir de comprimidos”, on the 125th aniversary to the Paediatric Hospital (Hospital
de D. Estefânia).
2005 -
Best Presentation Award to the presentation “Albuquerque, M., Almeida, A.J.,
Preparação e avaliação de uma forma magistral líquida oral de pirazinamida”,
Congresso do Hospital de D. Estefânia 2005.
2006 -
Best Oral Presentation Award a the VII Congress Portuguese-Spanish Congress on
Controlled Drug Delivery (Pamplona, Spain, 22-24 October) to the presentation
Florindo, H.F., Gonçalves, L.M.D., Alpar, H.O., Almeida, A.J. Adsorption of
Streptococcus equi enzymatic extract on the surface modified PCL nanospheres.
Best Poster Award at 11º Simpósio Nacional da Associação Portuguesa de
Farmacêuticos Hospitalares (Estoril, 8-11 November) to the presentaion “Silva, A.,
Albuquerque, M., Salgado, A, Almeida, A.J., Duarte, M.A. Estudo da actividade
bactericida da pirazinamida em estirpes hospitalares multiresistentes numa
formulação magistral.
7.
SCIENTIFIC SOCIETIES
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Portuguese Pharmaceutical Society (Ordem dos Farmacêuticos; since 1987).
Portuguese Biochemical Society (Sociedade Portuguesa de Bioquímica; since 1987).
Portuguese Biotechnological Society (Sociedade Portuguesa de Biotecnologia; since
1987).
Controlled Release Society (CRS; since 1993). Founder of the Spanish-Portuguese
Local Chapter (1995).
International Association for Pharmaceutical Technology (APV; since 1995).
Portuguese Society for Pharmaceutical Sciences (Sociedade Portuguesa de Ciências
Farmacêuticas; founder in 1998).
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