The role of HGF and c-MET in
Gastric Cancer
Andre Marcio Murad MD, PhD
Chief, Oncology Department. Hospital das Clinicas
Federal University of Minas Gerais
Belo Horizonte, MG – Brazil
Disclosure:
Andre Marcio Murad MD, PhD
- AMGEN Rilomet-1 Phase III Trial Steering
Commitee Member and Clinical Investigator
Normally, only stem cells and progenitor cells express MET, which allows
these cells to grow invasively in order to generate new tissues in an embryo
or regenerate damaged tissues in an adult. However, cancer stem cells are
thought to hijack the ability of normal stem cells to express MET, and thus
become the cause of cancer persistence and spread to other sites in the body.
Hepatocyte growth factor (HGF)/MET signaling pathway transduces invasive growth
signals from mesenchymal to epithelial cells.
©2011 by American Society of Clinical Oncology
Appleman L J JCO 2011;29:4837-4838
C-Met/HGF and tumors
Rilotumumab: an Investigational, Fully Human Monoclonal Antibody
HGF/SF
Rilotumumab (AMG 102)
MET
PIP3
PIP2
X
Ras
PI3K
AKT
Gab1
Rac1
cdc42
ERK
X
X
Survival
Birchmeier C, et al. Nat Rev Mol Cell Biol. 2003;4:915–925.
Ma PC, et al. Cancer Metastasis Rev. 2003;22:309–325.
Garbay C, et al. Biochem Pharmacol. 2000;60:1165–1169.
Aznar S, Lacal JC. Cancer Lett. 2001;165:1–10.
MEK
Raf
Gab1 Shp2
Migration
Invasion
Proliferation
Thank you!