Brief CV note Name: Ana Maria Ferreira Rodrigues Title and or degrees: MD, Rheumatologist Phone: 00351 965555061; E-mail: [email protected]; Address : Unidade de Investigação em Reumatologia - Instituto de Medicina Molecular - Faculdade de Medicina da Universidade de Lisboa, Edifício Egas Moniz - Av. Prof. Egas Moniz, 1649-028 Lisboa, PORTUGAL Academic Degrees and training: - Graduated in Medicine- Faculdade de Medicina da Universidade de Lisboa, 2003. - Rheumatology trainee - Hospital do Santo Espírito de Angra do Heroísmo, Açores and Hospital de santa Maria, Lisboa since 2005. - Rheumatology Specialist since April of 2012. - Phd student in Rheumatology from faculdade de Medicina da Universidade de Lisboa since 2011 - Completed in 2013 the Clinical Scholars Research Training I and II from Harvard Medical School- Portugal Program, a two year training program on clinical research. Current Position: - Rheumatologist head of the Rheumatology Unit from Hospital do Santo Espirito de Angra do Heroísmo since April 2012 - Co-investigator of the Rheumatology Research Unit, Instituto de Medicina Molecular da Faculdade de Medicina da Universidade de Lisboa starting in 2007. - Assistant Lecturer on the discipline of Rheumatology, from Faculdade de Medicina da Universidade de Lisboa, starting in February 2011. Previous professional experience: - General internship 2004-2005, Hospital do Santo Espírito de Angra do Heroísmo, Açores. -Rheumatology trainee - Hospital do Santo Espírito de Angra do Heroísmo, Açores and Hospital de santa Maria, Liboa since 2005. Awards - Faculdade de Medicina de Lisboa/ Astrazeneca prize In 2008 for the project “Avaliação da qualidade do osso de epifises femorais e correlação os factores de risco de fractura em doentes com fractura de fragilidade da anca” - Hospital de Santa Maria prize in 2008 for the project “Avaliação da qualidade do osso de epifises femorais e correlação os factores de risco de fractura em doentes com fractura de fragilidade da anca”. - Osteoporosis prize 2009 from Associação Portuguesa de Osteoporose/ Merck Sharp & Dohme for the Project “Avaliação da qualidade do osso de epifises femorais e correlação com os factores de risco clínicos de fractura em doentes submetidos a artroplastia da anca” Special area of interest and expertise: Osteoporosis and bone quality, inflammatory joint diseases, bone erosion, pediatric rheumatology. Most relevant publications 1- Changes in serum RANKL and OPG with sexual development and their associations with bone turnover and bone mineral density in a cohort of girls. Lucas R, Ramos E, Prata M, Rodrigues AM, Costa L, Severo M, Canhão H, Fonseca JE, Barros H. Clin Biochem. 2014 Apr 22. [Epub ahead of print ] 2- Rheumatoid arthritis bone fragility is associated with upregulation of IL17 and DKK1 gene expression Caetano-Lopes J, Rodrigues AM, Lopes A, Vale AC, Pitts-Kiefer MA, Vidal B, Perpétuo IP, Monteiro J, Konttinen YT, Vaz MF, Nazarian A, Canhão H, Fonseca JE.Clin Rev Allergy Immunol. 2013 Apr 2. 3- At the moment of occurrence of a fragility hip fracture, men have higher mechanical properties values in comparison with women Vale AC, Aleixo IP, Lúcio M, Saraiva A, Caetano-Lopes J, Rodrigues A, Amaral PM, Rosa LG, Monteiro J, Fonseca JE, Vaz MF, Canhão H.BMC Musculoskelet Disord. 2013 Oct 16;14:295 4- BAFF and TACI gene expression are increased in patients with untreated very early rheumatoid arthritis. Moura RA, Canhão H, Polido-Pereira J, Rodrigues AM, Navalho M, Mourão AF, Resende C, Campanilho-Marques R, Madruga Dias J, da Silva JA, Graca L, Fonseca JE. J Rheumatol. 2013 Aug;40(8):1293-302. 5- Bilateral evaluation of the hand and wrist in untreated early inflammatory arthritis: a comparative study of ultrasonography and magnetic resonance imaging. Navalho M, Resende C, Rodrigues AM, Pereira da Silva JA, Fonseca JE, Campos J, Canhão H. J Rheumatol. 2013 Aug;40(8):1282-92. 6- Low ratio osteocalcin/ collagen type I bone gene expression is associated with hip fragility fractures” Rodrigues AM, Caetano-Lopes J, Vale AC, Vidal B, Lopes A, Aleixo I, Polido-Pereira J, Sepriano A, Perpétuo IP, Monteiro J, Vaz MF, Fonseca JE, Canhão H. Bone. 2012 Dec;51(6):981-9 7- Smoking is a predictor of worst trabecular mechanical performance in hip fragility fracture patients Rodrigues AM, Caetano-Lopes J, Vale AC, Aleixo I, Pena AS, Faustino A, Sepriano A, Polido-Pereira J, Vieira-Sousa E, Lucas R, Romeu JC, Monteiro J, Vaz MF, Fonseca JE, Canhão H. J Bone Miner Metab. 2012 Nov;30(6):692-9 8- Comparative effectiveness and predictors of response to tumour necrosis factor inhibitor therapies in rheumatoid arthritis Canhão H, Rodrigues AM, Mourão AF, Martins F, Santos MJ, Canas-Silva J, Polido-Pereira J, Pereira Silva JA, Costa JA, Araújo D, Silva C, Santos H, Duarte C, da Silva JA, Pimentel-Santos FM, Branco JC, Karlson EW, Fonseca JE, Solomon DH. Rheumatology (Oxford). 2012 Nov;51(11):2020-6. 9- “Bilateral MR Imaging of the Hand and Wrist in Early and Very Early Inflammatory Arthritis: Tenosynovitis Is Associated with Progression to Rheumatoid Arthritis”. Navalho M, Resende C, Rodrigues AM, Ramos F, Gaspar A, Pereira da Silva JA, Fonseca JE, Campos J, Canhão H. Radiology. 2012 Sep;264(3):823-33 10- Primary biliary cirrhosis in a rheumatoid arthritis patient treated with rituximab, a case-based review. Polido-Pereira J, Rodrigues AM, Canhão H, Saraiva F, da Silva JA, Fonseca JE. Clin Rheumatol. 2012 Feb;31(2):385-9. 11- Portuguese recommendations for the use of biological therapies in patients with axial spondyloarthritis - December 2011 update. Machado P, Bernardo A, Rodrigues A, Malcata A, Nour D, Vieira-Sousa E, Godinho F, Pimentel F, Canhão H, Santos H, Cunha I, Fonseca JE, Costa J, Costa L, Cunha-Miranda L, Maurício L, Cruz M, Santos MJ, Bernardes M, Bogas M, Valente P, Ramiro S, Barcelos A. Acta Reumatol Port. 2012 Jan;37(1):40-7. 12- Portuguese guidelines for the use of biological agents in rheumatoid arthritis - October 2011 update. Fonseca JE, Bernardes M, Canhão H, Santos MJ, Quintal A, Malcata A, Neto A, Cordeiro A, Rodrigues A, Mourão AF, Ribeiro AS, Cravo AR, Barcelos A, Cardoso A, Vilar A, Braña A, Faustino A, Silva C, Duarte C, Araújo D, Nour D, Sousa E, Simões E, Godinho F, Brandão F, Ventura F, Sequeira G, Figueiredo G, Cunha I, Matos JA, Branco J, Ramos J, Costa JA, Gomes JA, Pinto J, Silva JC, Silva JA, Patto JV, Costa L, Miranda LC, Inês L, Santos LM, Cruz M, Salvador MJ, Ferreira MJ, Rial M, Queiroz MV, Bogas M, Araújo P, Reis P, Abreu P, Machado P, Pinto P, André R, Melo R, Garcês S, Cortes S, Alcino S, Ramiro S, Capela S; Portuguese Society of Rheumatology. Acta Reumatol Port. 2011 Oct-Dec;36(4):385-8. 13- Upregulation of inflammatory genes and downregulation of sclerostin gene expression are key elements in the early phase of fragility fracture healing. Caetano-Lopes J, Lopes A, Rodrigues A, Fernandes D, Perpétuo I, Monjardino T, Lucas R, Monteiro J, Konttinen YT, Canhão H, Fonseca JE. PLoS One. 2011 Feb 11;6(2):e16947. 14- Dynamic contrast-enhanced 3-T magnetic resonance imaging: a method for quantifying disease activity in early polyarthritis. Navalho M, Resende C, Rodrigues AM, Gaspar A, Fonseca JE, Canhão H, Campos J. Skeletal Radiol. 2012 Jan;41(1):51-9 15- Chronic arthritis leads to disturbances in the bone collagen network. (Editor’s Choice) Caetano-Lopes J, Nery AM, Canhão H, Duarte J, Cascão R, Rodrigues A, Perpétuo I, Abdulghani S, Amaral PM, Sakaguchi S, Konttinen YT, Graça L, Vaz MF, Fonseca JE. Arthritis Res Ther. 2009.12: R9. 16- Cytokine pattern in very early rheumatoid arthritis favours B-cell activation and survival. Moura RA, Cascão R, Perpétuo I, Canhão H, VieiraSousa E, Mourão AF, Rodrigues AM, Polido-Pereira J, Queiroz MV, Rosário HS, Souto-Carneiro MM, Graca L, Fonseca JE. Rheumatology (Oxford). 2011 Feb; 50(2):278-82 17- Alterations on peripheral blood B cell subpopulations in very early arthritis patients. Rheumatology (Oxford).49(6):1082-92. Moura RA, Weinmann P, Pereira PA, Caetano-Lopes J, Canhão H, Sousa E, Mourão AF, Rodrigues AM, Queiroz MV, Souto-Carneiro MM, Graça L, Fonseca JE. (2010) 18- Identification of cytokine network sustaining neutrophils and Th17 activation in early Rheumatoid Arthritis Cascão R*, Moura RA*, Perpétuo I, Canhão H, Sousa E, Mourão AF, Polido-Pereira J, Rodrigues AM, Queiroz MV, Souto-Carneiro MM, Rosário HS, Graça L, Fonseca JE (2010). Arthritis Res Ther, 12:R196 19- BioRePortAP, an electronic clinical record coupled with a database: an example of its use in a single centre Campanilho-Marques R, Polido-Pereira J, Rodrigues A, Ramos F, Saavedra MJ, Costa M, Martins F, Pereira da Silva JA, Canhão H, Fonseca JE. (2010). Acta Reumatol Port. Apr-Jun;35(2):176-83. 20- Evaluation of bone mechanical strenght and fracture risk assessment(FRAX®) in patients with hip joint replacement surgery". A. Rodrigues, J. Caetano-Lopes, et al." Acta Reumatológica Portuguesa. 2009; 34:504-510 21- Rituximab use in pediatric autoimmune diseases: 4 case reports. Contemporary Challenges in Autoimmunity Polido-Pereira, J, Ferreira, D, Rodrigues AM, Nascimento, C, Costa, P, Almeida, M, Esteves da Silva, JE, Simão C, Stone, R, Ramos, F, Neto, A, Teixeira da Costa, JC, Melo-Gomes, J, Gomes-Pedro, J, Viana-Queiroz, M, Canhao H, Fonseca JE.: Ann. N. Y. Acad. Sci. 2009. 1173:712-720. 22- Predictors of damage progression in portuguese patients with Systemic Lupus Santos MJ, Vinagre F, Nero P, Barcelos F, Barcelos A, Rodrigues A, e tal. Erythematosus. Ann. N. Y. Acad. Sci.2009. 1173: 822-828 23- Ankylosing spondylitis susceptibility and severity – contribution of TNF gene promoter polymorphisms at positions -238 and -308. Sousa E*, Caetano-Lopes J*, Pinto P*, Pimentel F, Teles J, Canhão H, Rodrigues A, Resende C, Mourão AF, Ribeiro C, Pinto TL, Miranda Rosa C, Pereira da Silva JA, Branco J, Ventura F, Viana Queiroz M, Fonseca JE.. Ann. N. Y. Acad. Sci. 2009. 1173; 581-8. 24- RESPONDIA. Ibero-American Spondyloarthropaties Registry: Portuguese Group. Elsa Sousa, Miguel Sousa, Fernando Pimentel, Ana Filipa Mourão, Ana Rodrigues, Helena Santos, Viana Queiroz, Ana Teixeira, Jaime Branco, Anabela Barcelos Reumatol Clin 2008; 4:68-72. Book chapter Rodrigues AM and Caetano-Lopes J. (2011) O laboratório na avaliação da qualidade do osso. In Guia clínico da SPM – qualidade óssea, Quodem S.L ed. Barcelona. (ISBN: 978-84-694-2784-2)