Curriculum vitae
PERSONAL INFORMATION
Constanca Pomba
WORK EXPERIENCE
January 2010–Present
Associate Professor
Maria Constança Matias Ferreira Pomba (Portugal)
Faculty of Veterinary Medicine - Universidade de Lisboa
Internal Medicine and Research activities in Antimicrobial and Biocide Resistance and Vaccine
development and Bacterial Pathogenesis
May 2002–December 2009
Assistant Professor
Maria Constança Matias Ferreira Pomba (Portugal)
Faculty of Veterinary Medicine - Universidade de Lisboa
Internal Medicine and Research activities in Antimicrobial and Biocide Resistance and Bacterial
Pathogenesis
July 1994–April 2002
Assistant Lecturer
Maria Constança Matias Ferreira Pomba (Portugal)
Faculty of Veterinary Medicine - Universidade de Lisboa
Internal Medicine and Research activities in Antimicrobial and Biocide Resistance and Bacterial
Pathogenesis
October 1993–June 1994
Training Assistant Lecturer
Maria Constança Matias Ferreira Pomba (Portugal)
Faculty of Veterinary Medicine - Universidade de Lisboa
Internal Medicine
October 1989–September 1993
Research fellow
Maria Constança Matias Ferreira Pomba (Portugal)
Parasitology (1989-1989)
Animal Virology and Imunology (1991-1993)
EDUCATION AND TRAINING
October 1985–March 1991
Médico-Veterinário
Faculdade Medicina Veterinária, Universidade de Lisboa (Portugal)
Veterinarian
January 1992–July 1994
Master of Science MSc
Faculdade Medicina Veterinária, Universidade de Lisboa (Portugal)
Tropical Veterinary Medicine
October 1998–April 2002
Doctor of Philosophy PhD
Faculdade Medicina Veterinária, Universidade de Lisboa (Portugal)
Veterinary Sciences
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Curriculum vitae
Constanca Pomba
ADDITIONAL INFORMATION
Expertise
• Antimicrobial resistance.
Molecular basis of antimicrobial resistance in Gram–negative and Gram-positive bacteria.
Methodology, breakpoints, MIC, cut-off values, reporting of resistance.
Clonal dispersal of drug-resistant bacterial pathogens.
Surveillance of antimicrobial resistance in Veterinary Medicine and molecular epidemiology of
antimicrobial resistance genes in bacteria of animal origin and Public Health repercussions.
• Antimicrobial chemotherapy
Efficacy of antimicrobials and use of antimicrobials in different target animal species (especially dogs
and cats).
Antimicrobial chemotherapy of multidrug-resistant bacteria.
• Bacterial Pathogenesis and Vaccine development.
Publications
Couto N., Belas A., Kadlec K., Schwarts S., Pomba C. Clonal diversity, virulence, antimicrobial and
biocide susceptibility patterns among human, animal and environmental methicillin-resistant
Staphylococcus aureus in Portugal. Journal of Antimicrobial Chemotherapy, 2015. In press.
Couto N., Belas A., Centeno M., Van Duijkeren E., POMBA C. (2014). First description of fexApositive meticillin-resistant Staphylococcus aureus ST398 from calves in Portugal. Journal of Global
Antimicrobial Resistance, 2014, 2, 342-343.
Biofilm and fluoroquinolone resistance of canine Escherichia coli uropathogenic isolates.
Oliveira M, Dias FR, Pomba C. BMC Res Notes. 2014 Aug 7;7:499. doi: 10.1186/1756-0500-7-499.
Risk factors for faecal colonisation with Escherichia coli producing extended-spectrum and plasmidmediated AmpC ß-lactamases in dogs. Belas A, Salazar AS, Gama LT, Couto N, Pomba C. Vet Rec.
2014 Jun 18. pii: vetrec-2013-101978. doi: 10.1136/vr.101978. [Epub ahead of print]
Pleuromutilins: use in food-producing animals in the European Union, development of resistance and
impact on human and animal health. van Duijkeren E, Greko C, Pringle M, Baptiste KE, Catry B,
Jukes H, Moreno MA, Pomba MC, Pyörälä S, Rantala M, Ružauskas M, Sanders P, Teale C, Threlfall
EJ, Torren-Edo J, Törneke K. J Antimicrob Chemother. 2014 Aug;69(8):2022-31.
Macrolides and lincosamides in cattle and pigs: use and development of antimicrobial resistance.
Pyörälä S, Baptiste KE, Catry B, van Duijkeren E, Greko C, Moreno MA, Pomba MC, Rantala M,
Ružauskas M, Sanders P, Threlfall EJ, Torren-Edo J, Törneke K. Vet J. 2014 May;200(2):230-9.
Oliveira M, Dias FR, Pomba C. Biofilm and fluoroquinolone resistance of canine Escherichia coli
uropathogenic isolates. BMC Res Notes. 2014 Aug 7;7:499.
Belas A, Salazar AS, Gama LT, Couto N, Pomba C. Risk factors for faecal colonisation with
Escherichia coli producing extended-spectrum and plasmid-mediated AmpC β-lactamases in dogs.
Vet Rec. 2014 Aug 30;175(8):202.
Pomba C, Endimiani A, Rossano A, Saial D, Couto N, Perreten V. First report of OXA-23-mediated
carbapenem resistance in sequence type 2 multidrug-resistant Acinetobacter baumannii associated
with urinary tract infection in a cat. Antimicrob Agents Chemother. 2014;58(2):1267-8.
Within-lineage variability of ST131 Escherichia coli isolates from humans and companion animals in
the south of Europe. Pomba C, López-Cerero L, Bellido M, Serrano L, Belas A, Couto N, CavacoSilva P, Rodríguez-Baño J, Pascual A. J Antimicrob Chemother. 2014 Jan;69(1):271-3.
Virulence genotypes of Escherichia coli canine isolates from pyometra, cystitis and fecal origin.
Mateus L, Henriques S, Merino C, Pomba C, Lopes da Costa L, Silva E. Vet Microbiol. 2013 Oct
25;166(3-4):590-4.
Biocide and antimicrobial susceptibility of methicillin-resistant staphylococcal isolates from horses.
Couto N, Belas A, Tilley P, Couto I, Gama LT, Kadlec K, Schwarz S, Pomba C. Vet Microbiol. 2013
Sep 27;166(1-2):299-303. doi: 10.1016/j.vetmic.2013.05.011. Epub 2013 Jun 10.
Genetic Relatedness, Antimicrobial and Biocide Susceptibility Comparative Analysis of MethicillinResistant and -Susceptible Staphylococcus pseudintermedius from Portugal. Couto N, Belas A, Couto
I, Perreten V, Pomba C. Microb Drug Resist. 2013 Jul 2. [Epub ahead of print]
First report of swine-associated methicillin-resistant Staphylococcus aureus ST398 in Lithuania.
Ruzauskas M, Couto N, Belas A, Klimiene I, Siugzdiniene R, Pomba C. Pol J Vet Sci. 2013;16(1):1257.
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Constanca Pomba
M. D. Pinho, S. C. Matos, C. Pomba, A. Lübke-Becker, L. H. Wieler, S. Preziuso, J. Melo-Cristino, M.
Ramirez. (2013). "Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin
of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp.
equisimilis" Journal of Clinical Microbiology ;51(4):1099-109.
T.M. Braga, C. Pomba, M. F. Silva Lopes (2013). “High-level vancomycin resistant Enterococcus
faecium related to humans and pigs found in dust from pig breeding facilities”. Vet Microbiol., 161 (34):344-9.
N. Couto, P. Tilley, J. Simões, J.P. Sales Luis, C. Pomba. (2012). “First Report of Methicillin-Resistant
Staphylococcus aureus ST5 and ST398 from Purebred Lusitano Horses” Journal of Equine Veterinary
Science, Vol. 32, Nº5, pp. 300–304.
L. Fernandes, M. Centeno, A. Belas, T. Nunes, P. Lopes Alves, N. Couto, C. Pomba. (2012).
“Immediate after birth transmission of epidemic Salmonella enterica Typhimurium monophasic strains
in pigs is a likely event” Journal of Antimicrobial Chemotherapy, Vol. 67, Nº12, pp. 3012-3014.
K. Kadlec, A.T. Feßler, N. Couto, C.F. Pomba, S. Schwarz. (2012). “Unusual small plasmids carrying
the novel resistance genes dfrK or apmA isolated from methicillin-resistant or -susceptible
staphylococci” Journal of Antimicrobial Chemotherapy, Oxford Journals, Vol. 67, Nº10, pp. 2342-2345.
L.B. Price, M. Stegger, H. Hasman, M. Aziz, J. Larsen, P.S. Andersen, T. Pearson, A.E. Waters, J.T.
Foster, J. Schupp, J. Gillece, E. Driebe, C.M. Liu, B. Springer, I. Zdovc, A. Battisti, A. Franco, J.
Zmudzki, S. Schwarz, P. Butaye, E. Jouy, C. Pomba, M.C. Porrero, R. Ruimy, T.C. Smith, D.A.
Robinson, J.S. Weese, C.S. Arriola, F. Yu, F. Laurent, P. Keim, R. Skov, F.M. Aarestrup. (2012).
“Staphylococcus aureus CC398: host adaptation and emergence of methicillin resistance in livestock.”
MBio, American Society of Microbiology, Vol. 3, Nº 1, e00305-11.
E. Van Duijkeren, B. Catry, C. Greko, M. A. Moreno, M. C. Pomba, S. Pyörälä, M. Ruzaukas, P.
Sanders, E. J. Threlfall, J. Torren-Edo e K. Törneke [SCIENTIFIC ADVISORY GROUP ON
ANTIMICROBIALS (SAGAM)]- (2011) Review on methicillin-resistant Staphylococcus
pseudintermedius. Journal of Antimicrobial Chemotherapy, 66 (12):2705-14.
Marques C., Ferreira M., Gomes J., Leitão N., Costa M., Serra P., Duarte Correia J. H., Pomba C.
(2011). “Blood type A, B and AB frequencies in 515 domestic shorthair cats from Lisbon area”.
Veterinary Clinical Pathology. 40, 185–187.
Cavaco L. M., Hasman H., Aarestrup F. M., MRSA collaborating group (MRSA-CG) (Members of
MRSA-CG: Jaap A Wagenaar, Haitske Graveland, Kees Veldman, Dik Mevius, Alexandra Fetsch,
Bernd-Alois Tenhagen, M. Concepcion Porrero, Lucas Dominguez, Sophie A Granier, Eric Jouy,
Patrick Butaye, Eva Kaszanyitzky, Adam Dán, Jacek Zmudzki, Antonio Battisti, Alessia Franco, Stefan
Schwarz, Montserrat Gutierrez, J Scott Weese, Shengui Cui, Constança Pomba) (2011). “Zinc
resistance of Staphylococcus aureus of animal origin is strongly associated with methicillin
resistance”. Veterinary Microbiology. Accepted for publication 14 February.
Couto N., Pomba C., Moodley A., Guardabassi, L. (2011). “Prevalence of methicillin-resistant
staphylococci among dogs and cats attending a veterinary teaching hospital in Portugal”. Veterinary
Record. Accepted for publication.
T. M. Braga, P. E. Marujo, C. Pomba e M. F. Silva Lopes (2011) Involvement, and dissemination, of the
enterococcal small multidrug resistance transporter QacZ in resistance to quaternary ammonium
compounds. Journal of Antimicrobial Chemotherapy, 66: 283–286.
Kadlec K., Pomba C. F., Couto N., Schwarz S. (2010). “Small plasmids carrying vga(A) or vga(C)
genes mediate resistance to lincosamides, pleuromutilins and streptogramin A antibiotics in methicillinresistant Staphylococcus aureus ST398 from swine”. Journal of Antimicrobial Chemotherapy. 65:
2692–2698.
Pomba C., Baptista F. M., Couto N., Loução F., Hasman H. (2010). “Methicillin-resistant
Staphylococcus aureus CC398 isolates with indistinguishable ApaI restriction patterns in colonized
and infected pigs and humans”. Journal of Antimicrobial Chemotherapy, 65, 2479-2481.
Baptista F. M., Alban L., Nielsen L. R., Domingos I., Pomba C., Almeida V. (2010). “Use of Herd
Information for Predicting Salmonella Status in Pig Herds”. Zoonoses and Public Health, 57 (Suppl. 1),
57 (Suppl. 1), 49–59
Pomba C. Couto N., and Moodley A. (2010). “Treatment of a lower urinary tract infection in a cat
caused by a multidrug-methicillin-resistant Staphylococcus pseudintermedius and Enterococcus
faecalis”. J Feline Medicine and Surgery. 12, 802-806.
Catry B., Van Duijkeren E., Pomba M.C., Greko C., Moreno M. A., Pyorala S., Ruzauskas M.,
Sanders P., Threlfall E. J., Ungemach F., Torneke K., Munoz-Madero C. and Torren-Edo J. - Scientific
Advisory Group on Antimicrobials (SAGAM) (EMA) (2010). “Reflection paper on MRSA in foodproducing and companion animals: epidemiology and control options for human and animal health”.
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Constanca Pomba
Epidemiol. Infect., 138, 626-44.
Pyürälä S., Greko C., and Matias Ferreira Pomba M. C. (2009). “Use of glycopeptides in veterinary
medicine”.The Veterinary Record, 543.
Greko C., Badiola J. I., Catry B., van Duijkeren E., Moreno M. A., Matias Ferreira Pomba M. C.,
Pyürälä S., Ruzauskas M., Sanders P., Threlfall E. J., Ungemach F., Törneke K. and Torren-Edo, J. Scientific Advisory Group on Antimicrobials of the Committee for Medicinal Products for Veterinary
Use, European Medicines Agency (EMEA)(2009). “Reflection paper on the use of third and fourth
generation cephalosporins in food producing animals in the European Union: development of
resistance and impact on human and animal health”. Journal of Veterinary Pharmacology and
Therapeutics. 32, 515–533.
Silva E., Leitão S., Tenreiro T., Pomba C., Nunes T., Lopes da Costa L., Mateus L. (2009). “Genomic
and phenotypic characterization of Escherichia coli isolates recovered from the uterus of puerperal
dairy cows”. Journal of Dairy Science 92, 6000-10.
Pomba C., Hasman H., Cavaco L. M., Diniz da Fonseca J., and Aarestrup F. M. (2009). “First
description of MRSA CC30 and CC398 from swine in Portugal”. International Journal of Antimicrobial
Agents, 34, 193–194.
Pomba C., Fonseca J. D., Baptista B.C., Correia J.D., and Martínez-Martínez,L.(2009). "Detection of
the Pandemic O25–ST131 Human Virulent Escherichia coli CTX-M-15-producer Clone Harbouring
the qnrB2 and aac(6’)-Ib-cr Genes in a Dog". Antimicrobial Agents and Chemotherapy, 53, 327–328.
Delgado M., Neto, I., Duarte-Correia, J. H. and Pomba, C. (2007). “Antimicrobial resistance and
evaluation of susceptibility testing among pathogenic enterococci isolated from dogs and cats”.
International Journal of Antimicrobial Agents, 30, 98-100.
Pomba-Féria, C. and Caniça, M. (2003). “A novel sequence framework (blaTEM-1G) encoding the
parental TEM-1 beta-lactamase”. FEMS Microbiology Letters, 220 (2), 117-180.
Féria, C., Ferreira, E., Duarte Correia, J., Gonçalves, J. and Caniça, M. (2002). “Patterns and
mechanisms of resistance to beta-lactams and to beta-lactamase inhibitors in uropathogenic
Escherichia coli isolated from dogs in Portugal”. Journal of Antimicrobial Chemotherapy, 49 (1), 77-85.
Féria, C., Machado, J., Duarte Correia, J., Gonçalves and Gaastra, W. (2001). “Distribution of papG
alleles among uropathogenic Escherichia coli isolated from different species”. FEMS Microbiology
Letters 202 (2), 205-208.
Féria, C., Machado, J., Duarte Correia, J., Gonçalves and Gaastra, W. (2001). “Virulence genes and P
fimbriae PapA subunit diversity in canine and feline uropathogenic Escherichia coli”. Veterinary
Microbiology 82 (1), 81-89.
Projects
Participation as a coordinator:
2013-2015:PTDC/CVT-EPI/4345/2012, "Immunogenicity of vaccine candidate antigens from
Staphylococcus pseudintermedius in Canis canis", Centro de Investigação Interdisciplinar em
Sanidade Animal, Fundação para a Ciência e a Tecnologia.
2011-2013: PTDC/SAU-SAP/113651/2009, "Use of cephalosporins in pigs - assessing the link
between usage, resistance and food safety", Centro de Investigação Interdisciplinar em Sanidade
Animal, Fundação para a Ciência e a Tecnologia.
2008-2009: Community base-line study, “Survey on the prevalence of Methicillin-resistant
Staphylococcus aureus in herds of breeding pigs to be carried out in the Member States”, 2008/55/EC
- Responsible for the Analysis of the MRSA Survey in Portugal as the Coordinator of the Laboratory of
Antimicrobial Resistance of the Faculdade de Medicina Veterinária – Universidade Técnica de Lisboa.
2006-2010: Project CIISA 82/06 “Molecular characterization of the resistance mechanisms to
fluoroquinolones of clinical Escherichia coli strains of animal origin”, Centro de Investigação
Interdisciplinar em Sanidade Animal, Fundação para a Ciência e a Tecnologia.
1999-2001: Project CIISA 36/99 “Bacterial urinary tract infection in dogs: a molecular approach to
pathogenesis and antimicrobial resistance”, Centro de Investigação Interdisciplinar em Sanidade
Animal, Fundação para a Ciência e a Tecnologia.
Participation as member of the FMV team in the following research projects:
2009-2011: Project CIISA 83/09 “Salmonella on pig herds in Portugal – within-herd prevalence,
serotype distribution and antimicrobial resistance of isolates”, Centro de Investigação Interdisciplinar
em Sanidade Animal, Fundação para a Ciência e a Tecnologia.
2003-2008: Project POCTI/43033/CVT/2001, “Resistance to fluoroquinolones and beta-lactams in
enteric Escherichia coli strains isolated from farm animals”, Fundação para a Ciência e a Tecnologia.
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Constanca Pomba
2000-2005: Project POCTI/3482/CVT/99, “Staphylococci of animal origin: molecular identification,
mechanisms of antimicrobial resistance and virulence”, Fundação para a Ciência e a Tecnologia.
2000-2005: Project POCTI/36253/CVT/99, “Mechanisms of resistance to beta-lactams and
quinolones of uropathogenic Escherichia coli strains isolated from animals”, Fundação para a Ciência
e a Tecnologia.
1991-1993: Project PMCT/C/AGR/947/90, “Study of the immune cellular mechanisms mediated by
cytotoxic T lymphocytes (LCT) in African Swine Fever Infection”, Fundação para a Ciência e a
Tecnologia.
Memberships
Desde/Since 2010 European Society of Nephrology and Urology (ESVNU).
Desde 2007 Sociedade Portuguesa de Doenças Infeccciosas e Microbiologia Clínica.
Desde 2006 European Society of Veterinary Internal Medicine (ESVIM).
Desde 2006 American Society for Microbiology (ASM).
Desde 2005 European Society of Clinical Microbiology and Infectious Diseases (ESCMID).
Desde 1996 Associação Portuguesa dos Médicos Veterinários Especialistas de Animais de
Companhia (APMVEAC). 1ª Secretária da Assembleia Geral desde Dezembro de 2002.
Desde 1996 Associação Europeia dos Médicos Veterinários Especialistas de Animais de Companhia
(FECAVA).
Desde 1996 World Small Animal Veterinary Association (WSAVA).
Desde 1993 Sociedade Portuguesa de Imunologia.
Desde 1992 Ordem Nacional dos Médicos Veterinários.
Desde 1990 Sociedade Portuguesa de Patologia Animal.
Desde1989 Sociedade Portuguesa de Ciências Veterinárias.
Other Relevant Information
Expert of the European Agency for Evaluation of Medicinal Products (2003).
Member of the Antimicrobial Working Party (AWP)/Scientific Advisory Group on Antimicrobials
(SAGAM) of the European Agency for Evaluation of Medicinal Products (2007). Vice-President AWP
(2013).
Responsible for the Clinical Bacteriology section of the Laboratório de Análises Clínicas of the of the
Faculdade de Medicina Veterinária(FMV)-UTL(2000).
Chief of the Animal Blood Bank of the Veterinary Teaching Hospital of the FMV-UTL (2008).
Member of the Governmental Group for Veterinary Medicine Evaluation of Direcção Geral de
Veterinária, Ministério de Agricultura e Pescas (2009).
Head of the Laboratory of Antimicrobial and Biocide Resistance of the FMV – UTL (2010).
Referee for the “Journal of Microbiological Methods”, "Revista da Sociedade Portuguesa de Ciências
Veterinária", “Diagnostic Microbiology and Infectious Diseases”, "Journal of Antimicrobial
Chemotherapy", "Veterinary Microbiology", “Plos One”, “Antimicrobial Agents Chemotherapy”,
“Microbial Drug Resistance”, “International Agents and Antimicrobial Chemotherapy”.
Editor of the Journal of Antimicrobial Chemotherapy from the BSAC (2014)
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