JBCS
Journal of the Brazilian Chemical Society
ISSN 0103-5053
Vol. 26, No. 7, July, 2015
Cover Picture
Using an orthologue-based approach, we synthesized and assayed a series of thiazolyl-1H-benzo[d]imidazole derivatives as
inhibitors of Mycobacterium tuberculosis inosine 5’-monophosphate dehydrogenase (MtIMPDH). From these experiments, a
benzo[d]imidazole compounds was described to inhibit the enzyme in the low micromolar range, which places this compound
among the most potent in vitro MtIMPDH inhibitors developed to date. Details are presented in the Article Synthesis
and Evaluation of Thiazolyl-1H-benzo[d]imidazole Inhibitors of Mycobacterium tuberculosis Inosine Monophosphate
Dehydrogenase by Kenia Pissinate, Diana Carolina Rostirolla, Laura de Miranda Pinheiro, Priyanka Suryadevara, Perumal
Yogeeswari, Dharmarajan Sriram, Luiz Augusto Basso, Pablo Machado, and Diógenes Santiago Santos on page 1357.
Contents
Editorial
1313
Thoughts about the Chemistry of Natural Products
Paulo Cezar Vieira
iv
J. Braz. Chem. Soc.
Communication
1315
Kinetic Parameters of Soot Oxidation Catalyzed by Nanosized
ZnO-CeO2 Solids
Leandro F. Nascimento, Paulo C. de Sousa Filho,
Juliana F. Lima and Osvaldo A. Serra
Graphical Abstract
CeO2 based catalysts are used for the determination of the activation
parameters on the soot combustion reaction
Articles
1321
SI online
Ethanolysis Optimisation of Jupati (Raphia taedigera Mart.)
Oil to Biodiesel Using Response Surface Methodology
Leyvison R. V. da Conceição, Carlos E. F. da Costa, Geraldo N.
da Rocha Filho, Edenir R. Pereira-Filho and José R. Zamian
Graphical Abstract
The synthesis process of biodiesel using acid oil (jupati oil), ethanol, and
acid catalyst has been optimised employing experimental design and
response surface methodology
1331
SI online
Biological Activity Studies on Metal Complexes of
Macrocyclic Schiff Base Ligand: Synthesis and Spectroscopic
Characterization
Parveez Gull and Athar Adil Hashmi
Graphical Abstract
The present work shows the coordination chemistry of CoII, CuII and NiII
complexes and the synthesized macrocyclic ligand. The mononuclear
complexes were characterized by various spectroscopic techniques. In
the search of new antimicrobial agents, these complexes were
screened in vitro for their antimicrobial activities and the effect
of the central metal attached in these complexes and
the macrocyclic ligand were compared
1338
Comparative Study of First-Derivative Spectrophotometry
and High Performance Liquid Chromatography Methods for
Quantification of Paclitaxel in Liposomal Formulation
Marcos V. Barbosa, Liziane O. F. Monteiro, Andréa R.
Malagutti, Mônica C. Oliveira, Alvaro D. Carvalho-Junior and
Elaine A. Leite
Graphical Abstract
A new derivative spectrophotometric method was developed,
validated, and compared to HPLC for the determination
of PTX in a liposomal formulation
1344
SI online
Fast Microwave-Assisted Resolution of (±)-Cyanohydrins
Promoted by Lipase from Candida antarctica
Sandra S. Ribeiro, Irlon M. Ferreira, João P. F. Lima,
Bruno A. de Sousa, Rafaela C. Carmona,
Alcindo A. Dos Santos and André L. M. Porto
Graphical Abstract
Enzymatic kinetic resolution (EKR) of (±)-cyanohydrins was performed
by using immobilized lipase from Candida antarctica (CALB) under
conventional ordinary conditions (orbital shaking) and under microwave
radiation (MW). Under the latter experimental conditions, good
performance and shorter reactions times were achieved
Vol. 26, No. 7, 2015
1351
Determination of Adulterants in Diesel by Integration of LED
Fluorescence Spectra
Marilena Meira, Cristina M. Quintella, Erika M. O. Ribeiro,
Humbervânia R. G. Silva, Alexandre K. Guimarães,
Saionara Luna, Weidson L. Silva and Irlane J. de Brito
Graphical Abstract
A simple and rapid methodology for determining the content of
adulterants in diesel and biodiesel-diesel blends by integration of
fluorescence spectra
1357
SI online
Synthesis and Evaluation of Thiazolyl-1H-benzo[d]
imidazole Inhibitors of Mycobacterium tuberculosis Inosine
Monophosphate Dehydrogenase
Kenia Pissinate, Diana Carolina Rostirolla, Laura Miranda
Pinheiro, Priyanka Suryadevara, Perumal Yogeeswari,
Dharmarajan Sriram, Luiz Augusto Basso, Pablo Machado and
Diógenes Santiago Santos
Graphical Abstract
Using the knowledge obtained from the orthologous enzyme, a series of
thiazolyl-1H-benzo[d]imidazole derivatives was synthesized and assayed
as inhibitors of Mycobacterium tuberculosis inosine 5’-monophosphate
dehydrogenase (MtIMPDH)
1367
MCM-41 for Meloxicam Dissolution Improvement: in vitro
Release and in vivo Bioavailability Studies
Asaad F. Hassan, Sally A. Helmy and Ahmed Donia
SI online
Graphical Abstract
MCM-41 was used for poorly water soluble meloxicam (MLX) as model
drug. The in vitro release of MLX was performed at pH 1.2 and 6.8
1379
SI online
Chemometric Study of the Antiproliferative Activity of Some
New Hydantoin Derivatives: Assessment of Activity and
Chromatographic Lipophilicity Data
Tatjana Lj. Djaković Sekulić, Adam Smoliński, Nemanja P.
Trišović, Gordana S. Ušćumlić and Biljana Dj. Božić
Graphical Abstract
Chemometric approach to the study of antiproliferative activity of newly
synthesized hydantoins
1387
Comparison between Ultraviolet and Infrared Spectroscopies
for the Simultaneous Multivariate Determination of Pyrantel
and Praziquantel
Mário S. Piantavini, Flávia L. D. Pontes, Leandro X. Weiss,
Marcelo M. Sena and Roberto Pontarolo
Graphical Abstract
Ultraviolet-partial least squares (UV-PLS) and diffuse reflectance
infrared Fourier transform spectroscopy-PLS (DRIFT-PLS)
methods for the simultaneous quantification of two veterinary
pharmaceutical drugs pyrantel pamoate (PP) and
praziquantel (PZ) in commercial tablets and capsules
v
vi
J. Braz. Chem. Soc.
1396
SI online
Efficient Synthesis of Rhodanine-Based Amides via Passerini
Reaction using Tetramethylguanidine-Functionalized Silica
Nanoparticles as Reusable Catalyst
Robabeh Baharfar, Razieh Azimi, Sheida Barzegar and
Mojtaba Mohseni
Graphical Abstract
The efficient synthesis of novel rhodanine-based amide derivatives
via Passerini reaction using tetramethylguanidine-functionalized silica
nanoparticles as a reusable heterogeneous base catalyst, and the
antibacterial activity of the synthesized compounds are described
1405
Polymerization of Ethylene with Zirconocene Heterogenized
on Spherical ZSM-5
Cristiano Favero, Marcelo L. Mignoni, Roberto F. de Souza
and Katia Bernardo‑Gusmão
Graphical Abstract
Metallocene was heterogenized on spherical ZSM-5 zeolite and employed
in ethylene polymerization reactions
1411
SI online
Characterization of the Volatile Profile of Brazilian Moscatel
Sparkling Wines Through Solid Phase Microextraction and
Gas Chromatography
Karine P. Nicolli, Juliane E. Welke, Mayara Closs,
Elina B. Caramão, Gustavo Costa, Vitor Manfroi and
Claudia A. Zini
Graphical Abstract
Two-dimensional gas chromatography showed superior potential
compared to one-dimensional gas chromatography for the
characterization of Brazilian Moscatel sparkling wines, which showed a
homogeneous volatile signature
1431
Simple Methods via Mid-IR or 1H NMR Spectroscopy for the
Determination of the Iodine Value of Vegetable Oils
Gustavo G. Shimamoto, Martha M. A. Favaro and
Matthieu Tubino
Graphical Abstract
Two methods for determining the iodine value in vegetable oils are
described. One employs mid-infrared spectroscopy and the other uses
hydrogen nuclear magnetic resonance
1438
Polycyclic Aromatic Hydrocarbons in Superficial Sediments
of the Negro River in the Amazon Region of Brazil
Hilton M. L. Souza, Satie Taniguchi, Márcia C. Bícego,
Luiz A. Oliveira, Tereza C. S. Oliveira, Hiléia S. Barroso and
Sandra P. Zanotto
Graphical Abstract
The profile and the concentration of the polycyclic aromatic
hydrocarbons (PAHs) were determined in samples of superficial sediments
of the Rio Negro in the Amazon region of Brazil
Vol. 26, No. 7, 2015
1450
SI online
Ursane Saponins from the Stems of Firmiana simplex and
their Cytotoxic Activity
Kyeong Wan Woo, Sang Un Choi, Ki Hyun Kim and
Kang Ro Lee
Graphical Abstract
Several ursane triterpene derivatives were isolated from the stems of
Firmiana simplex. Their cytotoxic activity was evaluated against lung
adenocarcinoma (A549), ovarian cancer (SK-OV-3), skin melanoma
(SK‑MEL-2), and colon cancer (HCT-15) cell lines using the sulforhodamine
(SRB) bioassay
1457
SI online
Microwave-Assisted Synthesis of β-1,2,3-Triazolyl-α-amino
Esters
Amna N. Khan, Stanley N. S. Vasconcelos, Gonzalo Carrau and
Hélio A. Stefani
Graphical Abstract
A method for obtaining triazole units from alkynyl amino esters via click
chemistry using a variety organic azides
1466
Poly(vinyl alcohol)-hyaluronic Acid Membranes for Wound
Dressing Applications: Synthesis and in vitro Bio-Evaluations
Alaa Fahmy, Elbadawy A. Kamoun, Raafat El-Eisawy, Esmail
M. El-Fakharany, Tarek H. Taha, Basem K. El-Damhougy and
Farag Abdelhai
Graphical Abstract
Stepwise design and discussed bio-evaluations of poly(vinyl alcohol)hyaluronic acid (PVA-HA) hydrogel membranes for wound dressing
applications
1475
SI online
Application of Ultrasound-Assisted Emulsification
Microextraction Based on Applying Low Density
Organic Solvents to the Extraction and Determination of
Mononitrotoluenes in Water Samples
Manoochehr Bahmaei, Hossein Ali Mashayekhi and
Faezeh Khalilian
Graphical Abstract
In this study, simple and efficient ultrasound-assisted emulsification
microextraction based on applying low density organic solvents
combined was developed for the preconcentration and determination of
mononitrotoluenes in water samples
1482
Polytetrafluorethylene Membrane-Based Liquid ThreePhase Micro Extraction Combined with in situ Differential
Pulse Anodic Stripping Voltammetry for the Determination
of Cadmium Ions Using Au-Nanoparticles Sol-Gel Modified
Pt-Wire
Aliasghar Ensafi, Ali R. Allafchian and Behzad Rezaei
Graphical Abstract
In situ pulse anodic stripping voltamettry and polytetrafluorethylene
membrane-based liquid three-phase micro extraction is presented for the
micro extraction and quantification of cadmium(II) ions in trace levels.
The obtained calibration curve was in the range of 1.0-250 nmol L-1 CdII
with a limit of detection of 0.1 nmol L-1
vii
viii
J. Braz. Chem. Soc.
1491
Determination of Cellulose Crystallinity of Banana Residues
Using Near Infrared Spectroscopy and Multivariate Analysis
Magale K. D. Rambo and Márcia M. C. Ferreira
Graphical Abstract
Two different methods using diffractograms were used to calculate
the crystalline content using near-infrared spectroscopy (NIRS) and
chemometrics
1500
SI online
Synthesis of Dithiocarbamates by Markovnikov Addition
Reaction in PEG and Their Application in Amidoalkylation
of Naphthols and Indoles
Azim Ziyaei Halimehjani, Arefeh Dadras, Meraj Ramezani,
Elham V. Shamiri, Seyyed E. Hooshmand and
Mohammad M. Hashemi
Graphical Abstract
Synthesis of dithiocarbamates by Markovnikov addition reaction in
polyethylene glycol (PEG) and their application in amidoalkylation of
naphthols and indoles is reported in this manuscript
1509
Catalytic Ozonation Using Fe2+ in the Treatment of Dairy
Effluent in a Semi-Batch Process with Recycle
Raquel A. Messias, Hélcio J. I. Filho, Guilherme A. Ferreira,
Otávio A. Silva, Adriano F. Siqueira and Marco A. K. Alcântara
Graphical Abstract
Dairy effluent treatment through the catalytic ozonation using Fe2+ in a
semi-batch process with recycle, proposed new reactor
1520
Surfactant-Assisted Preparation of FeCu Catalyst for FischerTropsch Synthesis
Cailian Ma, Yilong Chen and Jiangang Chen
Graphical Abstract
Different surfactants have a significant effect on the morphology of
catalysts and their active phase. Addition of polyvinyl alcohol (PVA) in
catalyst preparation is favorable for the formation of a loosely packed
microstructure and more iron carbide. Therefore, the catalyst prepared
with PVA exhibits high performance of Fischer-Tropsch synthesis
Short Report
1527
SI online
A New Biflavonoid from Schinopsis brasiliensis (Anacardiaceae)
Manuela P. Cardoso, Luciano S. Lima, Juceni P. David,
Bruno O. Moreira, Edlene O. Santos, Jorge M. David and
Clayton Q. Alves
Graphical Abstract
The new biflavanone (2R*,3R*,2’’R*,3’’R*)-7-hydroxy-4’-methoxyflavanone-(3→3’’)-3’’’,7’’-dihydroxy-4’’’-methoxy-flavanone was isolated
from the stems of Schinopsis brasiliensis (Anacardiaceae), and showed
weak inhibition of acetyl and butyrylcholinesterase enzymes