SYNTHESIS OF BIOLOGICALY ACTIVE COMPOUNDS BASED
ON NATURAL PRODUCT CORES
Ângelo de Fátima
Department of Chemistry, Universidade Federal de Minas Gerais,
Belo Horizonte, MG, 31270-901, Brazil
Plant-derived natural products (PDNPs) are excellent prototypes for the design of new compounds
capable of improving quality of life. Indeed, the diversity of chemical structures make these PDNPs
attractive for food and agricultural industries, as well as for pharmaceutical purposes [1]. However, in
some cases, natural products supply for industrial and therapeutic uses is a challenge because of the
low yields found in nature and seasonal accumulation variability. In this lecture, I will present the
approaches we have been using to synthesize PDNPs of agricultural and pharmaceutical interests. In
this context, it will be presented examples of modified natural products [2,3] and synthetic compounds
bearing a natural product pharmacophore [4,5]. (This work is supported by CAPES, CNPq and
FAPEMIG)
References
[1] Cragg, G.M., Newman, D.J. 2013. Natural products: a continuing source of novel drug leads.
Biochim. Biophys. Acta. 1830: 3670-3695.
[2] Euzébio, F.P.G., dos Santos, F.J.L., Piló-Veloso, D., Ruiz, A.L.T.G., de Carvalho, J.E.,
Ferreira-Alves, D.L., de Fátima, Â. 2009. Bioorg. Chem. 37:96-100.
[3] Euzébio, F.P.G., dos Santos, F.J.L., Piló-Veloso, D., Alcântara, A.F.C., Ruiz, A.L.T.G., de Carvalho,
J.E., Foglio, M.A., Ferreira-Alves, D.L., de Fátima, Â. 2010. Bioorg. Med. Chem. 18:8172-8177.
[4] Simões, J.B., de Fátima, Â., Sabino, A.A., Barbosa, L.C.A., Fernandes, S.A. 2014. RSC Adv.
4:18612-18615.
[5] da Silva, D.L., Terra, B.S., Lage, M.R., Ruiz, A.L.T.G., da Silva, C.C., de Carvalho, J.E., Carneiro,
J.W.M., Martins, F.T., Fernandes, S.A., de Fátima, Â. 2015. Org. Biomol. Chem. 13:3280-3287.