Alcaloides cheleritrine e sanguinarina são benzofenantridinas com efeito antiproliferativo no
carcinoma epidermóide oral
A SANGUINARINE E A CHELERITRINE ambas benzofenatridinas apresentam efeitos:
antimicrobiano, antifúngico, antiinflamatório, adrenolítico, simpaticolítico, e
anestésico local com citotoxicidade em várias células neoplásicas (câncer) .José
de Felippe Junior
Evaluation of anticancer activities of
benzo[c]phenanthridine alkaloid
sanguinarine in oral squamous cell
carcinoma cell line.
Tsukamoto H, Kondo S, Mukudai Y, Nagumo T, Yasuda A, Kurihara Y, Kamatani T,
Shintani S.
Anticancer Res. 2011 Sep;31(9):2841-6.
Source
Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University,
Ota-ku, Tokyo, Japan.
Abstract
While the effects of benzo[c]phenanthridine alkaloids (QBA), known mainly as
sanguinarine and chelerythrine, on the inhibition of some kinds of cancer cell
proliferation have been established, the effect on oral squamous cell is not known. Here,
the antitumor activity of sanguinarine was demonstrated using in vitro assay systems in
SAS, a human oral squamous cell carcinoma (OSCC) cell line. The anti-proliferative
and -invasive effects were confirmed with IC₅₀ values in the concentration range of
0.75-1.0 μM by MTT assay and invasive assay, respectively. Sanguinarine was also able
to suppress cell anchorage-independent growth, whereas it did not affect the cells'
adhering capabilities. Finally, sanguinarine induced apoptotic cell death by activating
caspase and altering the Bcl-2/Bax ratio. Taken together, these results indicate that
sanguinarine is a potential inhibitor of tumorigenesis and suggest that it may be valuable
in the development of new anticancer drugs for the treatment of OSCC.
PMID:
21868527