BIOGRAPHICAL SKETCH
NAME
Catarina Resende Oliveira
POSITION TITLE
Full Professor
EDUCATION/TRAINING
INSTITUTION AND LOCATION
DEGREE
YEAR(s)
FIELD OF STUDY
Faculty of Medicine, University of Coimbra
Aggregation
1998
Medicine/ Biochemistry
Faculty of Medicine, University of Coimbra
MD /Ph. D
1984
Medicine/ Neurology
Faculty of Medicine, University of Coimbra
B.A./M.D
1970
Medicine
Research and Professional Experience
Positions and Employment
1971-1984
Assistant at Faculty of Medicine - University of Coimbra
1976-1981
Intern of Neurology at Coimbra University Hospital
1981-1989
Junior Consultant of Neurology at Coimbra University Hospital
1984-1991
Assistant Professor at Faculty of Medicine
1991-1998
Associate Professor at Faculty of Medicine - University of Coimbra
1999-Present
Full Professor at Faculty of Medicine - University of Coimbra
1989-Present
Consultant of Neurology at Coimbra University Hospital
Other Experience
and Professional Memberships
1991-1999
President of Portuguese Society of Neurochemistry
1992-1995
Vice-President of Portuguese Society of Neurology.
Vice-President of Portuguese Society of Neuroscience
1992-Present
Investigator - Center for Neuroscience and Cell Biology University of Coimbra
2003-2005
President of “Instituto de Investigação Interdisciplinar” – University of Coimbra
2003- Present
President of the Center for Neuroscience and Cell Biology of Coimbra University of Coimbra
2004-2008
President of Scientific Counsil of the Faculty Medicine - University of Coimbra
2004-2012
Member of the Scientific Comission for Life and Health Sciences at FCT
2012-2013
President of the Scientific Comission for Life and Health Sciences at FCT
2006-2008
Associate Editor of the Journal Alzheimer Disease
2009-Present
Coordinator of the PhD Programme in Health Sciences, Faculty of Medicine, University of Coimbra
2009-Present
Coordinator of the Inter-University PhD Programme in Aging and Chronic Diseases
Academic Honors and Awards
1964
- National Prize, The best student at high school (DR, 2ªserie,27 Jan.1964)
1966
- D.Dinis Prize, The best student at Faculty of Medicine, University of Coimbra
1968
- Boerhinger Prize, The best student in Medical Pathology at Faculty of Medicine/ University of Coimbra
2006
- “Estímulo à Excelência” Prize, Fundação para a Ciência e a Tecnologia (FCT)
2007
- “Homenagem à Mulher Portuguesa – A Mulher Portuguesa saída da Universidade de Coimbra”, Associação
dos Antigos Estudantes de Coimbra
2008
“Nunes Correia Verdades de Faria” Prize, Santa Casa da Misericórdia de Lisboa
Area of Research
Neuroscience: Neurodegenerative disorders are multifactorial complex disorders of unknown etiopathogenesis. Oxidative stress,
excitotoxicity, calcium dyshomeostasis and mitochondrial dysfunction have been suggested to play a key role in cell death occurring in
these disorders. The study of these parameters and the evaluation of antioxidant defenses and neuronal reparing mechanisms during
the process of ageing and in neurodegenerative diseases such as Parkinson’s, Alzheimer’s and Huntington’s diseases are our main
interests of research. The effect of amyloidogenic peptides, beta-amyloid peptide and prion peptide, and alfa-synuclein in neuronal
death and glial reactivity are also investigated. The genetics of neurodegenerative diseases is another focus of interest.
B. Participation in Research Projects
“BIOMARKAPD: Biomarkers for Alzheimer's disease and Parkinson's disease” (JPND/0005/2011) European consortium (Team
Member);
“DEMTEST: Biomarker based diagnosis of rapid progressive dementias -optimisation of diagnostic protocols” (JPND/0001/2011)
European consortium (National coordinator);
“Localização e Metabolismo da APP e Relação com o controlo da Degeneração sináptica em modelos animais da Doença de
Alzheimer”. (PTDC/SAU-MMC/114810/2009) (Principal Investigator);
“Caracterização de alterações genéticas em gliomas humanos por arrays de polimorfismos de nucleótido único: Correlação com as
características clínicas e biológicas e citognéticas da doença.” (PIC/IC/83108/2007) (Principal Investigator);
“Estudo do Perfil do Envelhecimento da População Portuguesa” (EPEPP/Saude XXI) (Principal Investigator);
"Neuroprotecção por receptores de adenosina: acoplar o aumento da formação de adenosina com o bloqueio de receptores A2A"
(POCI/SAU-FCF/59215/2004) (Principal Investigator);
"Biochemical and Behavioural Study of Opioid - Cocaine Interactions" (POCTI/SAU-FCT/58330/2004) (Principal Investigator);
"Neuroprotective effect of neuropeptide Y in excitotoxicity and in temporal lobe epilepsy” (POCTI/NSE/46848/2002) (Principal
Investigator);
“A comparative study of the neurotoxic mechanisms of prion and amyloid-beta peptides. Potential neuroprotective strategies.”
(POCTI/36101/NSE/2000) (Principal Investigator);
“Postreceptor events in glutamate neurotoxicity in retina cells.” (PRAXIS/P/SAU/14 120/98) (Principal Investigator);
“Development of excitable cells in culture and adaptation to oxidative stress” (PRAXIS XXI, 2/2.1/BIA/126/94) (Principal Investigator);
“Oxidative Damage of Retina. Relationship with aging and diabetes” (JNICT, PMCT/C/SAU/217/90) (Principal Investigator);
“Membrane changes and senescence” (JNICT, PMCT/C/IMU/583/87) (Principal Investigator)
C.Supervisor and co-supervisor of the following PhD thesis (Concluded):
C. Research Supervision
Supervisor of several BSc thesis (Biology and Biochemistry)
Supervisor of 17 Master thesis (concluded)
Supervisor of 19 PhD thesis (concluded)
Arduíno D. – “ A “Cross talk” entre o retículo endoplásmico e a mitocôndria na doença de Parkinson: O papel na indução da Morte
Celular por autofagia. 2012 (Co- Supervisor)
Esteves R. – “Envolvimento da disfunção mitocondrial e da desorganização do citosqueleto na Doença de Parkinson: Contribuição da
via da cdk5. 2011 (Co- Supervisor) Job position – Posdoc CNC
Guerreiro R. – “Genetics of tauopathies: the role of MAPT” 2010 (Supervisor)(Co- Supervisor – John Hardy – NIH/USA) Job position –
Posdoc UCL, UK
Brás J. - "Genetics of parkinsonism" 2010 (Supervisor) (Co- Supervisor – Andrew Single-fom – NIH/USA) Job position – Posdoc
UCL, UK
Diogo L. – “ Caracterização clínica e Bioquímica das doenças mitocondriais na criança. Contribuição para o estudo epidemiológico na
região centro de Portugal.” 2010 (Supervisor) Job position – MD Pediatric Hospital Coimbra – Invited Assistant Professor FMUC
Teixeira S. H. V. - "Estudos Funcionais em Artrite Reumatoide" 2009 (Co- Supervisor) (Supervisor – Elisabeth Petit-Teixeira- EVRY
University – France) Job position – Posdoc
Almeida S.- "Análise do processo degenerativo em modelos da doença de Huntington - acção protectora de factores neurotróficos"
2009 (Co- Supervisor) Job position – Posdoc
Resende R.- "Disfunção sináptica induzida pelo peptídeo beta-amilóide" 2009 (Supervisor) Job position – Posdoc CNC
Sardão V. – “H9c2 Myoblasts as a Tool to Study Doxorubicin-induced Cardiomyopathy: Mechanisms of Cell Death and Relevance of
Differentiation State” – 2008 (Supervisor) Job position – Posdoc CNC
Oliveira T.- "Neurodegenerescência induzida por drogas de abuso. Um estudo comparativo com terapêuticas de substituição"
(Supervisor) Job position – Posdoc CNC
Moreira P.- Efeito do Peptídeo Ab25-35 no poro de permeabilidade transitória da mitocôndria. (Um estudo comparativo)" - 2005
(Supervisor) (Co- Supervisor – George Perry- Case Western Reserve University, USA)) - Job position – Assistant Professor FMUC
Grazina M.-"Genoma Mitocondrial e Défice Energético no diagnóstico das doenças da Cadeia Respiratória Mitocondrial - 2004
(Supervisor) Job position – Assistant Professor FMUC
Cardoso S.- "Molecular Mechanisms of cell death in Alzheimer´s didease: the role of mitochondria" - 2004 (Supervisor) Job position –
Assistant Professor FMUC
Sarmento A.- "Alterações Fenotípicas na células tumoral e a sua relação com a resistência à Quimioterapia" - 2002 (Supervisor) Job
position – Assistant Professor FMUC
Ambrósio A.- "Estudo de genes candidatos na abordagem molécular de esquizófrenia e na doença bipolar - Análise de linkage e
associação - 2002 (Supervisor) Job position – Researcher National Institute of Forensic Medicine
Pereira C.- "Mecanismos de Degenerescência celular em dois modelos de "stress" oxidativo induzido por glumato e pela proteina betaamiloide. Implicações para a etiopatogenia da doença de Alzheimer" - 2000 (Supervisor) Job position – Researcher FMUC
Rego A. C.- "Efeito das espécies reactivas de oxigénio e do glumato na cititoxicidade das células da retina em cultura. Um modelo de
isquemia neuronal." - 1998 (Supervisor) Job position – Assistant Professor FMUC
Santana I.- "A doença de Alzheimer" - 1998 (Supervisor) Job position – MD, Consultant of Neurology CHUC – Invited Assistant
Professor FMUC
Agostinho P.- "Efeito do "stress" oxidativo nos mecanismos que regulam a libertação de neurotransmissores nas células da retina em
cultura" - 1997 (Supervisor) Job position – Researcher FMUC
Pereira P.- "Catarata e lesão oxidativa do cristalino. Uma abordagem à toxicidade da glicose na Diabetes" - 1996 (Supervisor) Job
position – Invited Full Professor FMUC, Vice –President of FCT
C. Organization scientific events
2012
“V SPB Clinical Biochemistry Workshop”- Coimbra
2007
“2
nd
International meeting of Portuguese Society for Stem Cells and Cellular Therapy” (SPCE-TC) - Coimbra
“SFRR Europe 2007 Meeting” Meeting of the “Society for free Radical Research - Europe”, organized by the Portuguese and Spanish
groups of Free Radicals. - Vilamoura
2005
“The Sixth Keele meeting on Aluminium”- Buçaco
“Implantes neurosensoriais: desafios éticos na era do Homem Biónico” –Coimbra
“III Encontro anual do Centro de Neurociências e Biologia Celular de Coimbra” - Coimbra
2004
th
“7 International Neuropeptide Y Meeting” – Coimbra
“New Molecular strategies to treat neurodegenerative diseases” – Esposende
“II Encontro anual do Centro de Neurociências e Biologia Celular de Coimbra” – Luso
“Workshop on Ageing” – Coimbra
th
“14 Meeting of the Portuguese Biochemical Society” - Vilamoura
D. Peer-reviewed publications in the last 3 years (in inverse chronological order with indication of impact factor> 4).
2012
1.
Laço M. L., Oliveira, C. R. Henry L. Paulson, H. L., Rego, A. C. (2012) Compromised mitochondrial complex II in models of
Machado–Joseph disease. Biochimica et Biophysica Acta, 1822,139–149.
2.
Costa, R.O., Ferreiro, E., Martins, I., Santana, I., Cardoso, S.M., Oliveira, C.R., Pereira, C.M. (2012) Amyloid β-induced ER
stress is enhanced under mitochondrial dysfunction conditions. Neurobiol Aging 33(4):824.e5-824.e16.
3.
Ferreira, I.L., Bajouco, L.M., Mota, S.I., Auberson, Y.P., Oliveira, C.R., Rego, A.C. (2012) Amyloid beta peptide 1-42 disturbs
intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures.
Cell Calcium 51(2):95-106.
4.
Correia, S. C., Santos, R. X., Carvalho, C., Cardoso, S., Candeias, E., Santos, M. S., Oliveira, C. R. (2012) Insulin signaling,
glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation. Review. Brain Research
1441: 64–78.
5.
Sarmento-Ribeiro AB, Dourado M, Paiva A, Freitas A, Silva T, Regateiro F, Oliveira CR. (2012) Apoptosis Deregulation
Influences Chemoresistance to Azaguanine in Human Leukemic Cell Lines. Cancer Invest. 30(5):331-42.
6.
Carvalho, C., Cardoso, S., Correia, S., Santos, R., Santos, M.S., Baldeiras, I., Oliveira, C.R., and Moreira, P.I. (2012) Metabolic
Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities. Diabetes.
61(5):1234-42
7.
Ribeiro M, Rosenstock TR, Cunha-Oliveira T, Ferreira IL, Oliveira CR, Rego AC. (2012) Glutathione redox cycle dysregulation in
Huntington's disease knock-in striatal cells. Free Radic Biol Med. 53(10):1857-1867. doi: 10.1016/j.freeradbiomed.2012.09.004.
8.
Martins-Branco D, Esteves AR, Santos D, Arduino DM, Swerdlow RH, Oliveira CR, Januario C, Cardoso SM. (2012) Ubiquitin
proteasome system in Parkinson's disease: A keeper or a witness? Exp Neurol. 238(2):89-99. doi:
10.1016/j.expneurol.2012.08.008.
9.
Arduíno DM, Raquel Esteves A, Cortes L, Silva DF, Patel B, Grazina M, Swerdlow RH, Oliveira CR, Cardoso SM. (2012)
Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic.
Hum Mol Genet. 21(21):4680-702. doi: 10.1093/hmg/dds309.
10.
Silva DF, Santana I, Esteves AR, Baldeiras I, Arduino DM, Oliveira CR, Cardoso SM. (2012) Prodromal Metabolic Phenotype in
MCI Cybrids: Implications for Alzheimers Disease. Curr Alzheimer Res.
11.
Costa RO, Lacor PN, Ferreira IL, Resende R, Auberson YP, Klein WL, Oliveira CR, Rego AC, Pereira CM. (2012) Endoplasmic
reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated
with amyloid-β oligomers. Aging Cell. 11(5):823-33. doi: 10.1111/j.1474-9726.2012.00848.x.
12.
Ferreiro E, Baldeiras I, Ferreira IL, Costa RO, Rego AC, Pereira CF, Oliveira CR. (2012) Mitochondrial- and endoplasmic
reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers. Int J Cell Biol. 2012:735206.
Epub 2012 Jun 4.
13.
Mota SI, Ferreira IL, Pereira C, Oliveira CR, Rego AC. (2012) Amyloid-Beta Peptide 1-42 Causes Microtubule Deregulation
through N-methyl-D-aspartate Receptors in Mature Hippocampal Cultures. Curr Alzheimer Res. 9(7):844-56.
14.
Duarte AI, Moreira PI, Oliveira CR. (2012) Insulin in central nervous system: more than just a peripheral hormone. J Aging Res.
2012:384017. Epub 2012 Feb 21.
15.
Sarmento-Ribeiro AB, Proença MT, Sousa I, Pereira A, Guedes F, Teixeira A, Oliveira CR. (2012) A possible role for oxidation
stress in lymphoid leukaemias and therapeutic failure. Leuk Res. 36(8):1041-8.
16.
Correia SC, Santos RX, Cardoso SM, Santos MS, Oliveira CR, Moreira PI. (2012) Cyanide preconditioning protects brain
endothelial and NT2 neuron-like cells against glucotoxicity: role of mitochondrial reactive oxygen species and HIF-1α. Neurobiol
Dis. 45(1):206-18.
17.
Guerreiro, R. et al. (2012) TREM2 Variants in Alzheimer’s Disease. N Engl J Med.
2011
18.
Duarte, A.I., Petit, G.H., Ranganathan, S., Li, J.Y., Oliveira, C.R., Brundin P., Björkqvist, M., Rego, A.C. (2011) IGF-1 protects
against diabetic features in an in vivo model of Huntington's disease. Exp Neurol. 231(2):314-9.
IF: 4.699
19.
Ferreira, I.L., Cunha-Oliveira, T., Nascimento, M.V., Ribeiro, M., Proença, M.T., Januário, C., Oliveira, C.R., Rego, A.C. (2011)
Bioenergetic dysfunction in Huntington's disease human cybrids. Exp Neurol. 231(1):127-34.
IF: 4.699
2010
20.
Lopes, J.P., Oliveira, C.R., Agostinho, P. (2010) Neurodegeneration in an A-Beta-induced model of Alzheimer’s disease: the role
of Cdk5. Aging Cell 9(1):64-77.
IF: 7.148
21.
Ferreira, I.L., Nascimento, M.V., Ribeiro, M., Almeida, S., Cardoso, S.M., Grazina, M., Pratas, J., Santos, M.J., Januário, C.,
Oliveira, C.R., Rego, A.C. (2010) Mitochondrial-dependent apoptosis in Huntington's disease human cybrids. Exp Neurol.
222(2):243-55.
IF: 4.436
22.
Costa, R.O., Ferreiro, E., Cardoso, S.M., Oliveira, C.R., Pereira, C.M. (2010) Endoplasmic reticulum stress-mediated apoptotic
pathway induced by Aβ1-40 peptide requires the presence of functional mitochondria. J Alzheimer Dis 20(2):625-36.
IF: 4.261
23.
Guerreiro, R.J., Beck, J., Gibbs, R., Santana, I., Rossor, M.N., Schott, J. M., Nalls, M.A., Ribeiro, H., Santiago, B., Fox, C.,
Oliveira, C., Collinge, J., Mead, S., Singleton, A., Hardy, J. (2010) Genetic Variable in CLU and Its Association with Alzheimer´s
disease. Plos One. 5: 3, e9510.
IF: 4.411
24.
Cardoso, S.M., Pereira, C.F., Moreira, P.I., Arduíno, D.M., Esteves, A.R., Oliveira, C.R. (2010) Mitochondrial control of
autophagic lysosomal pathway in Alzheimer´s disease. Experimental Neurology 223 294-298.
IF: 4.436
25.
Esteves, A.R., Arduíno, D.M., Swerdlow, R.H., Oliveira, C.R., Cardoso, S.M. (2010) Dysfunctional mitochondria uphold calpain
activation: Contribution to Parkinson's disease pathology. Neurobiol Dis. 37(3):723-30.
IF: 5.121
26.
Baldeiras, I., Santana, I., Proença, M.T., Garrucho, M.H., Pascoal, R., Rodrigues, A., Duro, D., Oliveira, C.R. (2010) Oxidative
Damage and Progression to Alzheimer's Disease in Patients with Mild Cognitive Impairment. J Alzheimers Dis. 21(4):1165-77.
IF: 4.261
27.
Marque, S.C., Oliveira, C.R., Outeiro, T.F., Pereira, C.M. (2010) Alzheimer's disease: the quest to understand complexity. J
Alzheimers Dis. 21(2):373-83.
IF: 4.261
28.
Fonseca, A.C., Resende, R., Oliveira, C.R., Pereira, C.M. (2010) Cholesterol and statins in Alzheimer's disease: current
controversies. Exp Neurol. 223(2):282-93.
IF: 4.436
2009
29.
Lopes, J. P., Oliveira, C. R., and Agostinho, P. (2009) Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by
amyloid-â and prion peptides. Cell Cycle, 8:1, 97-104.
IF: 4.087
30.
Lopes, J.P., Oliveira, C.R., Agostinho, P. (2009) Cell Cycle Re-Entry in Alzheimer’s Disease. A major Neuropathological
Characteristic? Curr. Alz Res. 6:3.
IF: 4.971
31.
Almeida, S., Cunha-Oliveira, T., Oliveira, C.R., Rego, A.C. (2009) BDNF regulates BIM expression levels in 3-nitropropionic cortical
neurons. Neurobiol. Dis. 3: 448-56.
IF: 4.518
32.
Teixeira, V.H., Olaso, R., Martin-Magniette, M.L., Lasbleiz, S., Jacq, L., Oliveira, C.R., Hilliquin, P., Gut, I., Cornelis, F., PetitTeixeira, E. (2009)Transcriptome analysis describing new immunity and defense genes in peripheral blood mononuclear cells of
rheumatoid arthritis patients. PLoS One. 4(8):e6803.
IF: 4.351
33.
Sidransky, E., Nalls, M.A., Aasly, J.O., Aharon-Peretz, J., Annesi, G., Barbosa, E.R., Bar-Shira, A., Berg, D., Brás, J., Brice, A.,
Chen, C-M., Clark, L.N., Condroyer, C., De Marco, E.V., Dürr, A., Eblan, M.J., Fahn, S., Farrer, M.J., Fung, H-C., Gan-Or, Z.,
Gasser, T., Gershoni-Baruch, R., Giladi, N., Griffith, A., Gurevich, T., Januário, C., Kropp, P., Lang, A.E., Lee-Chen, G-J.,
Lesage, S., Marder, K., Mata, I.F., Mirelman, A., Mitsui, J., Mizuta, I., Nicoletti, G., Oliveira, C., Ottman, R., Orr-Urtreger, A.,
Pereira, L.V., Quattrone, A., Rogaeva, E., Rolfs, A., Rosenbaum, H., Rozenberg, R., Samii, A., Samaddar, T., Schulte, C.,
Sharma, M., Singleton, A., Spitz, M., Tan, E-K., Tayebi, N., Toda, T., Troiano, A.R., Tsuji, S., Wittstock, M., Wolfsberg, T.G., Wu,
Y-R., Zabetian, C.P., Zhao, Y., and Ziegler, S.G. (2009) Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson’s
Disease. N Engl J Med. 361:1651-61.
IF: 47.050
34.
Canas, P.M., Porciúncula, L.O., Cunha, G.M., Silva, C.G., Machado, N.J., Oliveira, J.M., Oliveira, C.R., Cunha, R.A. (2009)
Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38
mitogen-activated protein kinase pathway. J Neurosci. 29(47):14741-51.
IF: 7.17
Total Number of publications: 325; H-index 41
Citing Articles: 4393
Citing Articles without self-citations: 4213
Average Citations per Item: 17.94