Effect of oleic and linoleic acids on the inflammatory phase of wound ...
http://onlinelibrary.wiley.com/doi/10.1002/cbf.1432/abstract;jsessioni...
Research Article
1. Leonardo M. Pereira1,4,
2. Elaine Hatanaka1,*,
3. Edgair F. Martins1,
4. Flávia Oliveira1,
5. Edson A. Liberti2,
6. Sandra H. Farsky3,
7. Rui Curi1 and
8. Tania C. Pithon-Curi1,5
Article first published online: 4 OCT 2007
DOI: 10.1002/cbf.1432
Copyright © 2007 John Wiley & Sons, Ltd.
Issue
Volume 26, Issue 2, (/doi/10.1002/cbf.v26:2/issuetoc) pages 197–204, March 2008
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doi=10.1002
/cbf.1432)
Additional Information
How to Cite
Pereira, L. M., Hatanaka, E., Martins, E. F., Oliveira, F., Liberti, E. A., Farsky, S. H., Curi, R. and Pithon-Curi, T.
C. (2008), Effect of oleic and linoleic acids on the inflammatory phase of wound healing in rats. Cell Biochem.
1 de 3
16/09/2015 17:59
Effect of oleic and linoleic acids on the inflammatory phase of wound ...
http://onlinelibrary.wiley.com/doi/10.1002/cbf.1432/abstract;jsessioni...
Funct., 26: 197–204. doi: 10.1002/cbf.1432
Author Information
1
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
2
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
3
Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of Sao
Paulo, Brazil
4
Faculty of Health Sciences, Methodist University of Piracicaba, SP, Brazil
5
Cruzeiro do Sul University, Sao Paulo, Brazil
Email: Elaine Hatanaka ([email protected])
*Departamento
de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo, Avenida
Prof. Lineu Prestes, 1524, 05508-900, Butantã, São Paulo, SP, Brasil.
Publication History
1. Issue published online: 18 FEB 2008
2. Article first published online: 4 OCT 2007
3. Manuscript Accepted: 1 JUN 2007
4. Manuscript Revised: 23 MAY 2007
5. Manuscript Received: 12 MAR 2007
Funded by
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Abstract
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Keywords:
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fatty acids; oleic acid; linoleic acid; wound healing; neutrophils; inflammation
16/09/2015 17:59
Effect of oleic and linoleic acids on the inflammatory phase of wound ...
http://onlinelibrary.wiley.com/doi/10.1002/cbf.1432/abstract;jsessioni...
Inflammation is a crucial step for the wound healing process. The effect of linoleic and oleic acids on the inflammatory response of the skin during the
healing process and on the release of pro-inflammatory cytokines by rat neutrophils in vitro was investigated. A wound in the dorsal surface of adult rats
was performed and fatty acids were then topically administered. Both oleic and linoleic acids increased the wound healing tissue mass. The total protein
and DNA contents of the wounds were increased by the treatment with linoleic acid. The treatments with oleic and linoleic acids did not affect vascular
permeability. However, the number of neutrophils in the wounded area and air pouches was increased and the thickness of the necrotic cell layer edge
around the wound was decreased. A dose-dependent increase in vascular endothelial growth factor-alpha (VEGF-α) and interleukin-1beta (IL-1β) by
neutrophils incubated in the presence of oleic and linoleic acid was observed. Oleic acid was able to stimulate also the production of cytokine-induced
neutrophil chemoattractant in inflammation 2 alpha/beta (CINC-2α/β). This pro-inflammatory effect of oleic and linoleic acids may speed up the wound
healing process. Copyright © 2007 John Wiley & Sons, Ltd.
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