Electronic Supplementary Material (ESI) for RSC Advances.
This journal is © The Royal Society of Chemistry 2015
Supplementary Material
Synthesis and controlled curcumin supramolecular complex release
from pH-sensitive modified gum-arabic-based hydrogels
Adriana P. Gerola,1,2,* Danielle C. Silva,1,2 Sandra Jesus,3,4 R.A. Carvalho,5 Adley
F. Rubira,2 Edvani C. Muniz,2 Olga Borges,3,4 Artur J. M. Valente1*
1 CQC, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal
2 Grupo de Materiais Poliméricos e Compósitos, GMPC, Chemistry Department,
Maringá State University, 87020-900 Maringá, Paraná, Brazil
3 Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal
4 CNC, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517
Coimbra, Portugal
5 Department of Life Sciences, University of Coimbra, 3004-535 Coimbra, Portugal
M-GA
GA
7
6
5
4
3
2
 (ppm)
Figure S1. 1H NMR spectra of GA and GAm in D2O at 25.0 °C.
1
Cell Viability (%)
150
Hydrogel
Hydrogel+CUR/-CD
100
Viability
50
Figure
0
36
00
0
18
00
90
00
45
00
22
50
11
25
56
3
28
1
14
1
70
35
0
Hydrogel Concentration (g mL-1)
Figure S2. Viability of the Caco-2 cells exposed to hydrogel and
hydrogel/CUR/α-CD for 24 h to various concentrations of hydrogel (0-36000 µg mL1).
The cell viability was determined by MTT assay. Values represent the mean ± M of three
different experiments in triplicate (P <0.05)