CONGRESS PROGRAMME Thursday, 28 April 09.00 Opening Session Symposium Symposium II EARLY CANCER DETECTION TUMOUR IMMUNOLOGY Chairs: Dias Pereira,Demengeot Carla Oliveira Chairs: António José Dinis, Jocelyne Friday, 29 April SymposiumIII Symposium IV CANCER GENES: WHAT DID LEARN FROM THEM?MODEL SIGNALING PATHWAYS: THEWE ANDROGEN RECEPTOR Chair: Sergio Dias, João Nuno Moreira Chairs: Carmen Jerónimo, Nuno Sousa 09.30 Wytske van Weerden . Netherlands The continued role of AR in castration-resistant prostate cancer. 09.30 Bruno Silva Santos . Portugal Gamma-delta T lymphocytes in the tumour environment: from oncoimmunology to adoptive cell immunotherapy. 10.00 Jolanda de Vries . Netherlands 10.00 Tiffany Traina . United States The role of the AR in advanced breast cancer. 10.30 2 selected oral presentations 11.00 Coffee-break Harnessing adaptive immune responses in hereditary cancer. 10.30 11.00 2 selected oral presentations Coffee-break Symposium Symposium IIII NEW RESEARCH APPROACHES FROM ASPIC –ASEICA IMMUNOMODULATION OF CANCER Chairs: Carrato (Spain) Leonor David (Portugal) Chairs: Alfredo Bruno Silva Santos, Júlioand Oliveira 11.30 Frederick Arce Vargas . United Kingdom Symposium V CELL AND TUMOUR BIOLOGY Chairs: Luís Costa, Fátima Baltazar 11.30 Gunther Boysen . United Kingdom Molecular features of SPOP mutant/ CHD1 deleted prostate cancer. 12.00 Joan Seoane . Spain Tackling intratumour heterogeneity in brain tumors. Targeting immune regulation in the tumour site. 12.00 12.30 2 selected oral presentations 13.00 Lunch Jeffrey Weber . United States Novel checkpoint blockade combinations and biomarkers. 12.30 2 selected oral presentations 13.00 Lunch 14.00 Poster Parallel Sessions Symposium III RADIATION BIOLOGY AND RADIOTHERAPY Chairs: Luísa Carvalho, Pedro Almeida MECHANISMS AND IMPLICATIONS OF TUMOUR PLENARY LECTURES HETEROGENEITY Chairs: Manuel Sobrinho Simões, Nuno Miranda, Jorge Soares, Carlos Camps 14.00 14.45 16.00 Rolf Lewensohn . Sweden (title to be announced) 16.30 Marie Dutreix . France Focus on the combination of DNA repair inhibitors with radiotherapy. Alberto Cambrosio . Canada ASPIC lecture Mapping the development of Portuguese clinical research in oncology. Luis Paz Ares . Spain ASEICA lecture Lung cancer precision treatment. 15.30 Richard Marais . United Kingdom 17.00 2 selected oral presentations EACR lecture RAS and RAF signalling in melanoma: from basic biology to clinical responses. 17.30 Coffee-break 16.15 18.00 19:00 ASPIC General Assembly 20.00 Congress Dinner Awards Closing Session