1
A 6-Month Study of the Effects of a 0.3%
Triclosan/Copolymer Dentifrice on Dental Implants
PK Sreenivasan1, Y Vered2, A Zini2, J Mann2, H Kolog2,
D Steinberg2, JJ Zambon3, VI Haraszthy3, MP da Silva3,
W DeVizio1
J Clin Periodontol: In Press
1
Clinical Dental Research, Colgate-Palmolive Company, Piscataway, NJ, USA
2
Hadassah School of Dental Medicine, Hebrew University, Jerusalem, Israel
3
School of Dental Medicine, University at Buffalo, Buffalo, NY, USA
Study objective
The objective of this study was to evaluate the clinical and microbiological effects of
routine oral hygiene with a triclosan/copolymer toothpaste on dental implants and natural
teeth compared with a fluoride control toothpaste.
Trial conditions and methods
Products under investigation
Test dentifrices: 0.3% triclosan/2% copolymer, 1100 ppm fluoride as NaF
(Colgate-Palmolive Company, New York, NY).
Control dentifrice: 1450 ppm fluoride as MFP (Colgate-Palmolive Company, New York, NY).
Study subjects
120 adult subjects (56 males and 64 females) in good oral and general health, 18 years of age
or over, with at least 20 teeth and at least one dental implant were included in this study.
Methods
In this 6-month, double-blind, two-treatment, parallel group study, 60 subjects were
randomly assigned to a triclosan/copolymer dentifrice group, and 60 subjects to a
fluoride dentifrice control group. Subjects were provided a soft-bristled toothbrush and
instructed to brush twice daily with their assigned toothpaste for the next 6 months. At
baseline, 3, and 6 months, a calibrated dentist examined subjects for dental plaque,
gingival index, and bleeding on probing and collected supragingival plaque from both
the dental implants and contra-lateral natural teeth for laboratory testing. Analysis of the
clinical variables was conducted on an ‘‘intention-to-treat’’ (ITT) basis with the subject as
the statistical unit. ITT included all measured sites from all 120 subjects enrolled in the
study with analyses conducted in accordance with randomized treatment assignment and
statistical significance reported at p<0.05. Primary outcomes were clinical measures of
plaque and gingival inflammation and secondary outcomes were microbiological changes.
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plaque scores
onplaque
naturalscores
teeth and
dental implants
theimplants
durationover
of the
study.
Dental
on natural
teeth andover
dental
the
duration of the study.
Results and discussion
2
Results
Dental
plaque scores on natural teeth and dental implants over the duration of the study.
al plaque scores
on natural
teeth
over the duration
of group
the study.
105 subjects
completed
theand
study.dental
Subjectsimplants
in the triclosan/copolymer
dentifrice
demonstrated
significantly
lower
levels
of dental
plaque and
gingival
inflammation
3the study.
al plaque scores
on
natural
teeth
and
dental
implants
over
the
duration
ofthe
Dental
plaque
scores
on
natural
teeth
and dental
implants
overat
duration of the study.
and 6 months for both the dental implants and contra-lateral natural teeth compared with
the fluoride dentifrice group (p<0.05), as shown in the following charts:
Plaque Scores Control Teeth
Plaque Scores Dental Implants
2.5
Dental plaque scores on natural
teeth and dental implants over the duration of the study.
Dental plaque scores on natural teeth and dental implants over the duration of the study.
2.5
Plaque Index (Mombelli Index)
Plaque Index (Silness and Loe)
Dental plaque scores on natural teeth and dental implants over the duration of the study
2
2
1.5
l index scores
on natural
teeth and
dental implants
over
theimplants
durationover
of the
study.
Gingival
index scores
on natural
teeth and
dental
the
duration of the study.
1
1.5
1
.5
0
Baseline
3 months
Baseline
3 months
6 months
Gingival
scores
on6 months
natural
teeth andover
dental
over
duration of the study.
ival index scores
on index
natural
teeth and
dental implants
the implants
duration of
thethe
study.
Triclosan/copolymer
Control
Gingival index scores on natural teeth and dental implants over the duration of the study.
Gingival
Inflammation
Control
Teeth
Gingival
Inflammation
Dental Implants
Gingival
index
scores
on
natural
andon
dental
implants
over
the duration
the study.
2
Dental
plaqueteeth
scores
natural
teeth and
dental
implantsofover
the duration of the study.
Dental plaque scores on natural teeth and dental implants over the duration of the study.
Gingival Index ( Loe Silness Index)
Gingival Index (Loe Silness Index)
Gingivalon
index
scores
onteeth
natural
teeth
and
dental
implants
the duration
of the study
Gingival
index
scores
on
natural
teeth
andover
dental
implants
overofthe
val index scores
natural
and
dental
implants
over
the
duration
theduration
study. of the study.
2
1.6
1.2
1.6
1.2
.8
.8
g on probing
scores
on
natural
teeth and
dental implants
over
the
duration
of the
study.
Baseline
3 months
6 months
Bleeding
onBaseline
probing
scores
natural
teeth
and
dental
implants
over
the
duration of the study
3 months
6on
months
Triclosan/copolymer
Control
Bleeding on probing scoresBleeding
on natural
andscores
dental on
implants
theand
duration
the study
onteeth
probing
naturalover
teeth
dentalof
implants
over the duration of the study.
index
scores
on and
natural
teeth
and dental
overofthe
Bleeding on probingGingival
scores on
natural
teeth
dental
implants
overimplants
the duration
theduration
study. of the study.
Bleeding
onnatural
Probing
Control
Teeth
Bleeding
onover
Probing
Dental
Implants
Gingival
index
scoresscores
on
natural
teeth
and dental
implants
thethe
duration
of the study.
ding on probing
scores
teeth
and
dental
implants
over
duration
of
thethe
study.
Bleeding
onon
probing
on
natural
teeth
and
dental
implants
over
duration
Dental
plaque
scores
on1.2
natural
teeth
and
dental
implants
over the
duration
of
the study. of the s
1.2
Dental plaque scores on natural teeth and dental implants over the duration of the study.
BOP Scores
BOP Scores
Bleeding
on probing scores on natural
.8 teeth and dental implants over the duration of the s
.8
ding on probing
scores on natural teeth and dental
implants over the duration of the study.
.4
.4
0
Baseline
Triclosan/copolymer
3 months
6 months
0
Baseline
3 months
6 months
Control
Bleeding on probing
scores
ondemonstrated
natural teeth and
dental implants over the duration of the study.
Furthermore,
the triclosan/copolymer
dentifrice
group
significant
Bleeding on probingGingival
scores on
natural
teeth
dental
implants
overimplants
the duration
the
study. of the study.
index
scores
on and
natural
teeth
and dental
overof
the
duration
reductions
in the
number
of on
anaerobic
and aerobic
bacteria
on over
boththe
theduration
dental of the study.
Gingival
index
scores
natural teeth
and dental
implants
implants and the contra-lateral natural teeth at both 3 and 6 months (p<0.05). There
were significantly fewer Gram-negative anaerobes in the triclosan/copolymer dentifrice
group (p<0.05) including >90% reductions in Aggregatibacter actinomycetemcomitans,
Campylobacter rectus, Eubacterium saburreum, Fusobacterium nucleatum,
Porphyromonas gingivalis, Prevotella melaninogenica, Solobacterium moorei, and
Tannerella forsythia versus a fluoride control toothpaste
Conclusions
Twice daily use of a 0.3% triclosan/2% copolymer toothpaste may enhance dental implant
maintenance by reducing dental plaque and gingival inflammation.
Bleeding on probing scores on natural teeth and dental implants over the duration of the study.
Bleeding on probing scores on natural teeth and dental implants over the duration of the study.
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