COMPLEX WOUNDS DESERVE
INTELLIGENT PROTECTION
A SILVESTRE
ONCE
AGAIN, LABS
SILVESTRE
MAIS UMA
LABS,VEZ
WITH
SURPREENDE
ITS PIONEERING
O MERCADO
SPIRIT,COM
SURPRISES
THE MARKET
WITH AN
UM PRODUTO
INOVADOR.
EMENT of t
AC
he
PL
ing
ess
dr
RE
INNOVATIVE PRODUCT.
Download the QRcode in
your mobile phone.
*Box with 5 or 10 units
of 10 x 10 cm.
www.colzen.com.br
A REVOLUCIONARY PRODUCT THAT HELPS IN THE WOUND HEALING PROCESS.
BENEFÍCIOS
COLZEN
®
BENEFITS OFDO
COLZEN
: :
®
TREATMENT
THE OS
FOLLOWING
WOUND
TRATAMENTOTO
PARA
SEGUINTES
TIPOSTYPES:
DE FERIDAS:
BURNS
PRESSURE ULCERS
CONFORMS TO THE CONTOURS OF THE WOUND;
REDUCES THE BACTERIAL COLONIZATION;
ALLOWS PROPER HUMIDITY EXCHANGE;
LEG ULCERS
DIABETIC FOOT ULCERS
TRAUMATIC AND SURGICAL WOUNDS
GRAFTING AREAS
3 IN 1 DRESSING TO COMPLEX WOUNDS
Unique composition that offers 3 benefits in only one product
OPTIMIZES THE HEALING PROCESS;
(2,2%)
DECREASES PAIN;
EASY APPLICATION.
Promotes
granulation and
epithelialization of
the tissue.
Controls the exudate,
forming a gel that
maintains the optimum
humidity in the wound.
Promotes
immunomodulation
and also has an
antimicrobial effect.
CDM no. 002/15 - 06/2015
COMPLEX WOUNDS DESERVE
INTELLIGENT PROTECTION
Collagen Type I, besides inducing the raise of wound resistance1, provides structural
support for the formation of a new tissue and has an effect over the matrix,
acting as a chemotactic1,2. Additionally, collagen may bind to and inactivate matrix
metalloproteinases, excessively present in chronic ulcers and deleterious to tissue
repair process. It provides granulation and epithelialization of the wound.
The metal cerium has potent antimicrobial activity and low toxicity to mammalian
cells2. Burkes & McCleskey3 demonstrated that cerium salts are toxic in vitro to
bacteria and fungi.
The mechanism of action by which cerium acts seems to be related to a change in
the negatively charged bacterial cell wall, leading to migration and agglutination of
microorganisms, with nucleic acids and formation of insoluble complex, as describes
Monafo et al4.
In addition to the aforementioned shares, cerium nitrate reduces alpha tumoral necrosis factor levels(TNF a), which is usually
present in the fluids of chronic ulcers inhibiting cell proliferation, mainly of fibroblasts. Thus, cerium nitrate acts as an
immunomodulator, promoting chronic ulcers repair.
The addition of cerium nitrate in ColZen® formulation has a considerable local anti-inflammatory and antimicrobial effect that
can help reduce the length of stay and number of visits to hospital to perform dressings in leg ulcers 5.
2,2%
Unlike what was believed in the past, today there is clear evidence that a dried wound will
not heal as well as it will in a wet environment6,7,8. The benefits of a humid environment
include the promotion of re-epithelialization, dermal repair and angiogenesis. However,
excessive humidity can lead to maceration and hinder the wound healing process. The
addition of humidity control agents with debriding action, as in the case of calcium
alginate, adds the described properties to ColZen®.
REFERENCES:
1- Hart J, Silcock D, Gunnigle S, Cullen B, Light ND, Watt PW: The role of oxidised regenerated cellulose/collagen in wound repair: effects in vitro on fibroblast
biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002 (34): 1557-1570.
2- Monafo L. The use of topical cerium nitrate-silver sulfadiazine in major burn Injuries. 1983; Panminerva Medica - v. 25: 151-154.
3- Burkes S & McCleskey CS. The bacteriostatic activity of cerium, lanthanum, and thalium. J Bacteriology 1947. 54: 417-425.
4- Monafo WW, Tandon SN, Ayvazian VH, Tuchshmidt J, Skinner AM, Deitz F. Cerium nitrate: A new topical antiseptic for extensive burns. Surgery 1976; 80, p. 465-473.
5- Herberger K, Rustembach SJ, Grams L, Munter KC, Schafer E, Augustin M. Quality-of-care for leg ulcers in the metropolitan area of Hamburg – a communitybased study. J European Acad Dermatol 2012; 26: 495-502.
6- Frade MAC, Assis RVC, Coutinho-Netto J, Andrade TAM, Foss NT. Biomembrana vegetal na cicatrização de úlceras venosas crônicas. An Bras Dermatol 2012; 87 (1): 45-51.
7- Mendez MV, Raffeto JD, Phillips TJ, Menzonian JO, Park HY. The proliferative capacity of neonatal skin fibroblasts is reduced after exposure to venous ulcer
wound fluid: A potential mechanism for senescence in venous ulcers. J Vasc Surg 1999; 30: 734-43.
8- Deveci et al: Effects of cerium nitrate bathing and prompt burn wound excision on Il-6 and TNFa Levels in Burned Rats. Burns 2000, 26:41-5.
Silvestre Labs Química e Farmacêutica Ltda. Av. Carlos Chagas Filho, 791, Bio-Rio, Cidade Universitária – Ilha do Fundão
CEP: 21.941-904 - Rio de Janeiro - RJ – Brazil – Phone: +55 21 2142-7777 – Fax: +55 21 2142-7734 – CNPJ 33.019.548/0001-32
www.silvestrelabs.com.br | www.colzen.com.br | Contact us: [email protected]