Curriculum vitae
PERSONAL INFORMATION
Bruno Sepodes
WORK EXPERIENCE
2013–Present
Member of the Committee for Advanced Therapies (CAT)
European Medicines Agency (United Kingdom)
2012–Present
Member of the Committee for Medicinal Products for Human Use (CHMP)
European Medicines Agency (United Kingdom)
Member for PORTUGAL (PT)
2008–Present
Member of the Committee of Orphan Medicinal Product (COMP), since 2008.
European Medicines Agency (United Kingdom)
Chairperson, since September 2012
Member nominated by the EC under EMA recommendation
March 2003–Present
Professor of Pharmacology and Pharmacotherapy
University of Lisbon - Faculty of Pharmacy (Portugal)
2005–Present
Non-Clinical Assessor
INFARMED I.P. (Portugal)
Portuguese National Authority for Medicines and Medical Devices
2010–Present
Member of the Evaluation Board of Medicines
INFARMED I.P. (Portugal)
Portuguese National Authority for Medicines and Medical Devices
2005–Present
Portuguese National Formulary of Medicines Working Group
INFARMED I.P. and Ministry of Health (Portugal)
Co-Author of all editions published since 2005
2011–Present
Non-clinical and Pharmaceutical Expert
Portuguese National Authority for Animal Health (Direção Geral de Veterinária, DGV) (Portugal)
2012–Present
Member of the Scientific Coordination Board
European Medicines Agency (United Kingdom)
Since 2012, Chairmanship of the COMP
EDUCATION AND TRAINING
May 2014–
Habilitation
University of Lisbon (Portugal)
Professorship of Pharmacology and Pharmacotherapy
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Curriculum vitae
2008–
Bruno Sepodes
PhD
University of Lisbon (Portugal)
Pharmacy (Pharmacology)
2006–
MSc
University of Lisbon (Portugal)
Master degree in Regulation and Evaluation of Medicines and Health Products
2001–
PharmD
Faculty of Pharmacy - University of Lisbon (Portugal)
Pharmaceutical Sciences degree by the Faculty of Pharmacy at the University of Lisbon, Portugal
ADDITIONAL INFORMATION
Expertise
• Orphan medicinal products development and evaluation • Pharmacology of inflammation
• Ischemia-reperfusion injury
• Human medicines evaluation
• Pharmacodinamics and non-clinical pharmacokinetics • Pharmacology in laboratory and target
animals
• General and special toxicology
• Non-clinical drug development
Publications
SELECTION OF FULL PAPERS:
1. Helder Mota-Filipe, Bruno Sepodes, Michelle McDonald, Salvatore Cuzzocrea, Rui Pinto, Christoph
Thiemermann. The novel PARP-inhibitor 5-aminoisoquinolinone reduces the liver injury caused by
ischemia and reperfusion in the rat, Medical Science Monitor. 2002; 8 (11): BR444-53
2. Bruno Sepodes, Rui Maio, Rui Pinto, Cristina Marques, José Mendes-do-Vale, Christoph
Thiemermann, Helder Mota-Filipe. Efeito do tempol, um captador de radicais livres, na lesão hepática
associada à isquémia-reperfusão do fígado de rato. Jornal Brasileiro de Transplantes. 2003 Aug; 6
(3): 5-10
3. Bruno Sepodes, Rui Maio, Rui Pinto, Cristina Marques, José Mendes-do-Vale, Christoph
Thiemermann, Helder Mota-Filipe. Tempol, an intracellular free radical scavenger, reduces the liver
injury in hepatic ischemia-reperfusion in the rat. Transplantation Proceedings. 2004; 36 (4): 849-853
4. Oliver Murch, Marika Collin, Bruno Sepodes, Simon J. Foster, Helder Mota-Filipe, Christoph
Thiemermann. Lysophosphatidylcholine reduces the organ injury and dysfunction in rodent models of
Gram-negative and Gram-positive shock. British Journal of Pharmacology. 2006; 148 (6):769-77
5. Bruno Sepodes, Rui Maio, Rui Pinto, Edward Sharples, Muhammad Yaqoob, Michelle McDonald,
Christoph Thiemermann, Helder Mota-Filipe. Recombinant human erythropoietin protects the liver
from hepatic ischemia-reperfusion injury in the rat. Transplant International. 2006; 19 (11): 919-26
6. Maio R, Sepodes B, Figueiredo N, Pinto R, McDonald M, Thiermermann C, Costa P, Mota-Filipe H.
Effects of diethyldithiocarbamate (DETC) on liver injury induced by ischemia-reperfusion in rats.
Transplantation Procedings. 2007 Mar;39(2): 365-8
7. de Lemos ET, Reis F, Baptista S, Pinto R, Sepodes B, Vala H, Rocha-Pereira P, Silva AS, Teixeira
F. Exercise training is associated with improved levels of C-reactive protein and adiponectin in ZDF
(type 2) diabetic rats. Medical Science Monitor. 2007 Aug;13(8): BR168-74
8. E Teixeira de Lemos, F Reis, S Baptista, A P Garrido, R Pinto, B Sepodes, H Vala, P RochaPereira, A Santos Silva, F Teixeira. Efeitos do exercício físico aeróbio no perfil metabólico e oxidativo
de ratos diabéticos tipo 2. Boletim SPHM. 2007; 22(1): 16-28
9. R. Maio, N. Figueiredo, I. Santos, B. Sepodes, C. Thiemermann, H. Mota-Filipe, P. Costa. Donors
pre-treatment with erythropoietin – a way to improve the quality of organs donated after cardiac death.
Organ, Tissues & Cells. 2008; 3: 157-165
10. Isabel A. Ribeiro, João Rocha, Bruno Sepodes, Helder Mota-Filipe, Maria H. Ribeiro. Effect of
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Curriculum vitae
Bruno Sepodes
naringin enzymatic hydrolysis towards naringenin on the anti inflammatory activity of both compounds.
Journal of Molecular Catalysis B: Enzymatic. 2008; 52-3:13-18
11. Brines M, Patel NS, Villa P, Brines C, Mennini T, De Paola M, Erbayraktar Z, Erbayraktar S,
Sepodes B, Thiemermann C, Ghezzi P, Yamin M, Hand CC, Xie QW, Coleman T, Cerami A.
Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin. Proc
Natl Acad Sci U S A. 2008 Aug 5; 105(31): 10925-30
12. Lemos ET, Reis F, Baptista S, Pinto R, Sepodes B, Vala H, Rocha-Pereira P, Silva GC, Teixeira N,
Silva AS, Carvalho L, Teixeira F, Das UN. Exercise training decreases proinflammatory profile in
Zucker diabetic (type 2) fatty rats. Nutrition. 2008; 25-3: 330-339
13. Bruno Sepodes, Helder Mota-Filipe. Uma Perspectiva Multidimensional para a Terapêutica da Dor
Crónica. Revista Portuguesa de Farmacoterapia. Julho 2009, Vol.1, Nº1, 22-30
14. Leticia Bignotto, Joao Rocha, Bruno Sepodes, Maria Eduardo-Figueira, Rui Pinto, Marco Chaud,
Joao Carvalho, Heitor Moreno Junior, Helder Mota-Filipe. Anti-inflammatory effect of lycopene on
carrageenan-induced paw edema and hepatic ischemia-reperfusion in the rat. British Journal of
Nutrition. 2009; 102-1:126-133
15. Pinpat Tripatara, Nimesh S Patel, Vincenzo Brancaleone, Derek Renshaw, João Rocha, Bruno
Sepodes, Helder Mota-Filipe, Mauro Perretti, Christoph Thiemermann. Characterisation of
Cystathionine Gamma-Lyase/Hydrogen Sulphide Pathway in Ischaemia/Reperfusion Injury of the
Mouse Kidney: an in vivo Study. European Journal of Pharmacology. 2009; 606 (1-3): 205-209
16. Maria Inês Amaro, João Rocha, Maria Eduardo-Figueira, Helder Mota-Filipe, Bruno Sepodes,
Maria H. Ribeiro. Anti-inflammatory activity of naringin and the biosynthesid naringenin by naringinase
immobilized in microstructured materials in a model of DSS-induced colitis in mice. Food Research
International. 2009; 42-8:1010-1017
17. Amar Kapoor, Yasunori Shintani, Massimo Collino, Lucy K. Bailey, Nimesh S.A. Patel, Bruno
Sepodes, Pinpat Tripatara, Sara Castiglia, Roberto Fantozzi, Helder Mota-Filipe, Ken Suzuki, Jane A.
Mitchell, Christoph Thiemermann. Protective role of PPAR-β/δ in septic shock. American Journal of
Respiratory and Critical Care Medicine 2010. 182(12): 1506-1515
18. Milsom AB, Patel NS, Mazzon E, Tripatara P, Storey A, Mota-Filipe H, Sepodes B, Webb AJ,
Cuzzocrea S, Hobbs AJ, Thiemermann C, Ahluwalia A. Role for endothelial nitric oxide synthase in
nitrite-induced protection against renal ischemia-reperfusion injury in mice. Nitric Oxide: Biology and
Chemistry. 2010 Feb 15;22(2):141-148
19. Rauter AP, Martins A, Borges C, Mota-Filipe H, Pinto R, Sepodes B, Justino J. Antihyperglycaemic
and protective effects of flavonoids on streptozotocin-induced diabetic rats. Phytotherapy Research.
2010 Jun;24 Suppl 2:S133-138. Erratum in: Phytother Res. 2010 Jun;24 Suppl 2:S233-234
20. Maio R, Sepodes B, Patel NS, Thiemermann C, Mota-Filipe H, Costa P. Erythropoietin preserves
the integrity and quality of organs for transplantation after cardiac death. Shock. 2011 Feb;35(2):12633
21. da Silva G, Taniça M, Rocha J, Serrano R, Gomes ET, Sepodes B, Silva O. In vivo antiinflammatory effect and toxicological screening of Maytenus heterophylla and Maytenus senegalensis
extracts. Human & Experimental Toxicology. 2011 Jul;30(7):693-700
22. Westermark K, Holm BB, Söderholm M, Llinares-Garcia J, Rivière F, Aarum S, Butlen-Ducuing F,
Tsigkos S, Wilk-Kachlicka A, N'Diamoi C, Borvendég J, Lyons D, Sepodes B, Bloechl-Daum B, Lhoir
A, Todorova M, Kkolos I, Kubáčková K, Bosch-Traberg H, Tillmann V, Saano V, Héron E, Elbers R,
Siouti M, Eggenhofer J, Salmon P, Clementi M, Krieviņš D, Matulevičiene A, Metz H, Vincenti AC,
Voordouw A, Dembowska-Bagińska B, Nunes AC, Saleh FM, Foltánová T, Možina M, Torrent i Farnell
J, Beerman B, Mariz S, Evers MP, Greene L, Thorsteinsson S, Gramstad L, Mavris M, Bignami F,
Lorence A, Belorgey C. European regulation on orphan medicinal products: 10 years of experience
and future perspectives. Nature Reviews Drug Discovery. 2011; 10(5):341-349
23. Brachkova MI, Marques P, Rocha J, Sepodes B, Duarte MA, Pinto JF. Alginate films containing
Lactobacillus plantarum as wound dressing for prevention of burn infection. Journal of Hospital
Infection. 2011 Dec;79(4):375-377
24. Serra AT, Rocha J, Sepodes B, Matias AA, Feliciano RP, de Carvalho A, Bronze MR, Duarte CM,
Figueira ME. Evaluation of cardiovascular protective effect of different apple varieties - Correlation of
response with composition. Food Chemistry. 2012; 135(4): 2378-2386
25. Paula Ferreira, Marta Repolho, Maria Joana Ribeiro, Bruno Sepodes. Diagnóstico e Abordagem
Terapêutica da Osteoartrite. Revista Portuguesa de Farmacoterapia. Janeiro 2012, Vol.4, Nº1, 15-28
26. Tânia Faia, Sílvia Morais, Andreia Rosa, Joana Santos, Bruno Sepodes. Uma Perspectiva
Multidimensional do Tratamento da Enxaqueca. Revista Portuguesa de Farmacoterapia. Julho 2012,
Vol.4, Nº3, 198-216
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Curriculum vitae
Bruno Sepodes
27. Bruno Sepodes, Helder Mota-Filipe. Doenças Raras e Medicamentos Órfãos. Acta Farmacêutica
Portuguesa – Ciência Farmacêutica. 2012, Vol.1, Nº2, 73-78.
28. Ângela Sequeira Silva, Bruno Rosa, João Soares, Bruno Sepodes. Desafios e Oportunidades na
Abordagem Terapêutica da Artrite Reumatóide. Revista Portuguesa de Farmacoterapia. Abril 2013,
Vol.5, Nº2, 118-127
29. Vaquer G, Riviere F, Mavris M, Bignami F, Llinares-Garcia J, Westermark K, Sepodes B. Animal
models for metabolic, neuromuscular and ophthalmological rare diseases. Nature Reviews Drug
Discovery. 2013; 12(4):287-305
30. Meisel ML, Sepodes B, Pena A. Environmental Risk Assessment for Human Medicinal Products:
Old-marketed / Generic Medicinal Products. Ecotoxicology. (in press)
31. Ratilal BO, Arroja MMC, Rocha JPF, Fernandes AMA, Barateiro AP, Brites DMTO, Pinto RMA,
Sepodes BMN, Mota-Filipe HD. Neuroprotective effects of erythropoietin pretreatment in a rodent
model of transient middle cerebral artery occlusion. Journal of Neurosurgery. (in press)
32. Tsigkos S, Llinares-Garcia J, Mariz S, Aarum S, Fregonese L, Dembowska-Baginska B, Elbers R,
Evers P, Foltanova T, Lhoir A, Corrêa-Nunes A, O'Connor D, Voordouw A, Westermark K, Sepodes B.
Use of biomarkers in the context of Orphan Medicines Designation in the European Union. Orphanet
Journal of Rare Diseases (in press)
Projects
Memberships
Other Relevant Information
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