XXVI Annual Meeting of the Brazilian Federation of Experimental Biology Societies (FeSBE, Federação de Sociedades de Biologia Experimental) August 24th through 27th, 2011 Rio de Janeiro | RJ | Brazil 47 Dear Participants, On behalf of all the members of the Scientific and Organizing Committee, it is our pleasure to welcome scientists from all over the world to the XXVI Annual Meeting of the Brazilian Federation of Experimental Biology Societies (FeSBE, Federação de Sociedades de Biologia Experimental). We are grateful to the organizers of plenary lectures and symposia for their considerable efforts in contributing to the success of the conferences. We have received 2,880 abstracts for oral and poster presentation. The reviewing process involved recognized scientists. The organizers are grateful to the authors for their enthusiasm and to all the reviewers for their effort and time given to evaluate the submissions in detail. We are thankful to the Brazilian funding agencies for support. Luiz Eugênio Araujo de Moraes Mello President of FeSBE Catarina Segreti Porto Chair of Organizing Committee 48 Wednesday, August 24th 09h00 – 12h00 Meeting of the Deliberative Council of the SBFTE (Room 7) 13h00 – 15h00 Meeting of the Boards of the Scientific Societies 15h00 – 16h00 Meeting of the Deliberative Councils of the Scientific Societies Room D SBBf Room A SBFis Room 6 SBIC Room C SBNeC Room B BRAVO Room 5 SBCAL 16h00 – 18h00 Poster Session I – Exhibition Hall 18h00 – 18h30Coffee-Break Grand Ballroom 18h30 – 19h00 Opening Session – Grand Ballroom 19h00 – 20h00 Presidential Plenary Lecture Why and how do we breath? Göran Hedenstierna, (University Hospital Uppsala, Sweden) Chair: Walter Araújo Zin (UFRJ) Foyer 20h10 Social Activity: O Rio Dança no Salão 49 Thursday, August 25th 08h00 – 09h00Courses Room B1 and Room B8 Inflammation. Chair: Niels Olsen Câmara (ICB-USP) and Patrícia Bozza (FIOCRUZ) •1st. Class: Cellular and molecular mechanisms of inflammation. Patrícia Bozza (FIOCRUZ) Room B2 Post-tranductional modifications: much further of the genetic code. Chair: Heraldo Possolo de Souza (FM-USP) •1st. Class: Nitrosylation of the proteins. Heraldo Possolo de Souza (FM-USP) Room B3 Physiological mechanisms governing the autoregulation of acetylcholine release in the somatic motor nerve ending (SMNE). Chair: Alexandre Pinto Corrado (FMRP-USP) •1st. Class: Molecular basis of physiological modulation of neurotransmission. José Eduardo Moreira (FMRP-USP) Room B4 Stem cells and cell therapy. Chair: Regina Coeli dos Santos Goldenberg (UFRJ) •1st. Class: Cell therapy in cardiovascular diseases: preclinical and clinical results. Adriana Bastos Carvalho (UFRJ) Room B5 How to write a Scientific Paper. Chair: Walter Araújo Zin and Dalton Valentim Vassallo •1st. Class: How to write a Scientific Paper. Walter A. Zin (UFRJ) Room B6 Introduction to Biostatistics. Chair: Marcus Vinicius Baldo (ICB-USP) •1st. Class: Basic statistics concepts in Biological Sciences. Marcus Vinicius Baldo (ICB-USP) Room B7 Heart rate variability and autonomic modulation of cardiovascular system. Chair: Rubens Fazan Jr (FMRP-USP) •1st. Class: Heart rate variability as a tool to evaluate autonomic modulation of cardiovascular system. Rubens Fazan Jr (FMRP-USP) Rooms 1 to 6 Cell signaling: from membrane to nucleus. Chair: Rosely Godinho (EPM-UNIFESP) •1st. Class: Cell signaling mediated by tyrosine-kinase and adhesion receptors. Miriam Galvonas Jasiulionis (EPM-UNIFESP) 50 Room 7 Good practices in laboratory animals. Chair: Marcel Frajblat (UFRJ) and Valderez B. Valero Lapchik (EPM-UNIFESP) •1st. Class: Law, CEUAS and normatives of the CONCEA. Marcel Frajblat (UFRJ) •Health status of laboratory animals. Valderez B. Valero Lapchik (EPM-UNIFESP) 09h00 – 09h15Coffee-Break 09h15 – 11h15Symposia Room B1 Cell-cell interaction. Chair: Marimélia Porcionatto (EPM-UNIFESP) C: New perspectives on cell coupling during development, adaptation and degeneration of the nervous system. Alexandre Hiroaki Kihara (Unversidade Federal do ABC) MC:Mesenchymal stem cells transplanted in central nervous system injury modulate local cellular response. Marimélia Porcionatto (EPM-UNIFESP) OC:29.031- Functional study of the P2X7 receptor pore formation in regions rafts and non-rafts. Simões, A. P. S. ; Faria, R. X. ; Alves, L. A. Laboratório de Comunicação Celular - Fiocruz, LCC OC:12.039 - Biflorin induces down-regulation of N-Cadherin and inhibits in vitro melanoma cancer cell invasion. Montenegro, R. C. 1; Barbosa, G. S. 2; Souza, L. G. S. 4; Lemos, T. L. 4; Moraes, M. O. 3; CostaLotufo, L. V. 3; Vasconcellos, M. C. 2 3 Departamento de Fisiologia e Farmacologia, Medicina, UFC; Instituto de Ciências Biológicas, Faculdade de Biotecnologia, UFPA; Faculdade de Ciências Farmacêuticas, UFAM; Departamento de Química, UFC Room B2 Atherosclerosis. Chair: Raul Cavalcante Maranhão (INCor) C: Exploring defects in the pathway of HDL biogenesis caused by mutations using adenovirus mediated gene transfer. Vassilis Zannis (Boston University School of Medicine, Boston, MA) MC:Von Willebrand Factor in Coronary Artery Disease. Sergio Paulo Bydlowski (FM-USP) OC:16.033 - Inhibition of endoplasmic reticulum stress recovers ABCA-1 Expression and APO-AI-mediated cholesterol efflux in macrophages submitted to glycoxidation. Castilho, G.; Okuda, L. S.; Nakandakare, E. R.; Santos, C. X. D. C. D.; Laurindo, F. R. M.; Passarelli, M. Laboratório de Biologia Vascular, InCor, InCor 3 Clínica Médica, Laboratório de Lípides (LIM10), FMUSP Thursday, August 25th OC:02.030 - Oxidative, inflammatory and isquemic biomarkers to the metabolic syndrome. Gottlieb, M. G. V.; Bodanese, L. C.; Duarte, M. F.; Moresco, R. N.; Wiehe, M.; Cruz, I. B. M. D. Faculdade de Medicina, PUCRS; Centro de Ciências da Saúde, UFSM; Ambulatório de Risco Cardiometabólico, ARC Room B3 New aspects of Renin-Angiotensin system. Chair: Dulce Elena Cassarini (EPM-UNIFESP) • Haemodynamic factors and the control of RAS. José Eduardo Krieger (INCor) • ACE as a biomarker in hypertension and diabetes mellitus. Dulce Elena Cassarini (EPM-UNIFESP) • Diabetes and Renin-Angiotensin system: importance of experimental models in the studies of physiopatologic mechanism. Tatiana Souza Cunha (UNIFESP-S.J.dos Campos) Room B4 Respiratory system and the environment. Chair: Walter Zin (UFRJ) C: Enviroment and Health: The challenge of large Cities. Paulo Hilário Nascimento Saldiva (FM-USP) MC:Pollution and lung function. Walter Zin (UFRJ) OC:08.003 - LASSBio 596 per os avoids pulmonary and hepatic inflammation induced by Microcistin-LR. Casquilho, N. V.; Carvalho, G. M. C.; Alves, J. L. C. R.; Machado, M. N.; Soares, R. M. ; Azevedo, S. M. F. D. O. ; Lima, L. M.; Barreiro, E. J. D. L.; Valença, S. S.; Carvalho, A. R. S.; Faffe, D. S.; Zin, W. A. -Universidade Federal do Rio de Janeiro, UFRJ OC:31.031 - Evaluation of oxidative stress on the toxicity of direct exposure to urban particles on the rat brain: in vitro study. Fleck, A. S.; Fagundes, L. S.; Morais, M. C.; Zanchi, A. C.; Saldiva, P. H. N. ; Rhoden, C. R. Laboratory of Oxidative Stress and Atmospheric Pollution., UFCSPA; Laboratory of Experimental Air Pollution, Medical School, USP Room B5 Regulators of inflammation and the search of alternatives for treatment of inflammatory diseases. Chair: Marco Aurélio Martins (FIOCRUZ) and Fernando Cunha (FMRP-USP) C: Neutrophil Paralysis Correlates with Sepsis outcome: critical role of TLR, NOS/NO-cGMP-PKG pathway and Chemokines receptors. Fernando de Queiróz Cunha (FMRP-USP) MC:Screening and pharmacological evaluation of new PDE4 inhibitors. Marco Aurélio Martins (FIOCRUZ) OC:17.146 - Cannabidiol produces a long-term anti- inflammatory effect in a murine model of acute lung injury: role for A2A adenosine receptor. Ribeiro, A.; Ferraz-de-Paula, V.; Pinheiro, M. L. ; Almeida, V. I.; Quinteiro-Filho, W. M.; Akamine, A. T.; Hallak, J. E. C. ; Zuardi, A. W.; Crippa, J. A.; Palermo-Neto, J. Departamento de Patologia, FMVZ-USP, FMVZ-USP; Departamento de Neurociências e Comportamento FMRP-USP, FMRP-USP OC:17.039 - Role of chemokine receptor CCR4 and regulatory T cells in the wound healing of surgicallyinduced skin lesion in mice. Figueiredo, J.B. ; Borges, P. A. ; Brogliato, A. R. ; Benjamim, C. F. Universidade Federal do Rio de Janeiro, UFRJ Room B6 Drugs of abuse: an update. Chair: Reinaldo N. Takahashi (UFSC) C: Neurobiology of addiction: involvement of endocannabinoid system. Reinaldo N.Takahashi (UFSC) MC:Experimental approach of the danger factors involved in the addiction of the psychoactive drugs. Cleópatra S. Planeta (UNESP) OC:23.155 - Rimonabant repeated treatment inhibits C-FOS expression in cocaine-sensitized mice. Yokoyama, T. S.; Marinho, E. A. V.; Oliveira-Lima, A. J.; Santos, R. ; Hollais, A. W.; Ribeiro, L. T. C.; Estebanez, D. N.; Ruiz, A. R.; Longo, B. M.; Frussa-Filho, R.- Área da Saúde, UBC, Farmacologia, UNIFESP, Área da Saúde, FIT, Neurofisiologia, UNIFESP OC:23.103 - Participation of orexin system in the behavioural sensitization induced by ethanol in male mice. Macedo, GC; Kawakami, S. E. ; Vignoli, T.; Sinigaglia-Coimbra, RC. ; Suchecki, D. Universidade Federal de São Paulo, Depto de Psicobiologia, UNIFESP Room B7 Gene therapy. Chair: Rafael Linden (UFRJ) •Curing colorblindness in a primate using gene therapy. Mauren Neitz (University of Washington, USA) •Therapeutic vaccines against tumors induced by HPV16. Luis Carlos de Souza Ferreira (ICB-USP) •Genetic vaccination against parasitic diseases. Maurício Martins Rodrigues (EPM-UNIFESP) •Gene therapy in the treatment of Refractory Angina Pectoris: Clinical assays. Renato Karam Kalil (Instituto de Cardiologia-RGS) Room B8 Fetal programming. Chair: Joel Claudio Heimann (FMUSP) C: Perinatal Programming of obesity: epidemiology, animal model and concept. Thomas Harder (University Medicine Berlin, Germany) MC:Influence of the perinatal salt intake on the offspring phenotype. Joel Claudio Heimann (FMUSP) 51 Thursday, August 25th OC:24.021 - Maternal protein restriction is accompanied by early changes in myocardium of progeny until the F3 generation. Frantz, E. D. C. ; Silva-Junior, G. O. ; Aguila, M. B.; Mandarim-de-Lacerda, C. A. Departamento de Anatomia, UERJ OC:24.128 - L-arginine reduces serum inflammatory marker expression and improves renal dysfunction in intrauterine undernourished rats. Landgraf, M.A.; Correia-Costa, M.; Hirata, A.E.; Landgraf, R.G.; Semedo, P.; Hyane, M. I.; Vieira, D. A. G.; De Marco, D.T.K.; Gil, F. Z.; Camara, N. O. S. - Imunologia/Universidade de São Paulo, USP; Fisiologia, Universidade Federal de São Paulo, UNIFESP; Ciências Biológicas - Universidade Federal de São Paulo, UNIFESP; Nefrologia. Universidade Federal de São Paulo, UNIFESP Rooms 1 to 4 Understanding how the body responds and adapts to exercise. Chair: Patrícia Brum (USP) C: The physiological subacute effects of exercise. Antonio Claudio Nóbrega (UFF) MC:Skeletal myopathy in heart failure: effects of aerobic exercise training. Patricia Brum (USP) OC:03.002 - Effects of a single bout of exercise on circulating endothelial progenitor cells in subjects at increased cardiometabolic risk. Rocha, N.G.; Sales, A.R.K.; Medeiros, R.F.; Silva, J.F.R. ; Silva, B.M.; Neves, F.J.; Silva, M.S.; Santos, A.A.; Nóbrega, A.C.L. Graduate Program in Cardiovascular Sciences, UFF; Laboratory of Exercise Sciences, UFF. OC:03.020 - Endurance exercise training ameliorates insulin resistance and reticulum stress in adipose and hepatic tissue in obese rats. Cesconetto; P. A.; Vitto, M. F. ; Marques, S. O. ; Luciano, T. F. ; Santos, D. Z.; Souza, D. R.; Luz, G. ; Souza, C. T. Universidade do Extremo Sul Catarinese, UNESC 11h15 – 11h30Coffee-Break 11h30 – 13h30Symposia Room B1 Intracellular proteolytic systems and their involvement in critical cellular and pathological processes. Chair: Marcelo Damario Gomes (FMRP-USP) •Proteolysis and skeletal muscle plasticity. Anselmo Moriscot (ICB, USP) •Protein aggregation in the cell nucleus: role of Ubiquitin-Ligase FBXO25. Marcelo Damario (FMRP, USP) •Active biologically intracellular peptides and their functional correlations with the Thimet Oligopeptidase. Lilian Cristina Russo (ICB-USP) Room B2 Epigenetic modifications and diseases. Chair: Miriam Galvonas Jasiulionis (UNIFESP) 52 MC: Epigenomes, non-coding RNAs and diseases. Fabrício Falconi Costa (Northwestern University, USA) MC: Epigenetics and cancer – the blastic evolution of chronic mieloid leukemia. Eliane Saul Furquim Werneck Abdelhay (INCA, RJ) MC:Epigenetics, microenvironment and melanocyte malignant transformation. Miriam Galvonas Jasiulionis (UNIFESP) •OC: 25.067 - DNMT3b overexpression contributes to aberrant methylation in burkitt’s lymphoma cell lines Arruda, V. O.; Robaina, M. C. S.; Klumb, C. E. N. P. Laboratório de Hemato-Oncologia Celular e Molecular, INCA; Programa de Pós-graduação em Oncologia , INCA OC:12.008 - Effect of sulfasalazine and valproic acid on inhibition of human multiform glioblastoma viability. Garcia, C. G.; Alves, TR.; Kahn, SA. ; Moura Neto, V.; Cossenza, M - Dept Fisiologia Farmacologia, Universidade Federal Fluminense, UFF; ICB, Universidade Federal Do Rio De Janeiro, UFRJ Room B3 Neurodegeneration Chair: Débora Foguel (UFRJ) e Jerson Lima e Silva (UFRJ) •Interaction of the prion protein with nucleic acids and glycosaminoglycans: Modulation of the pathogenic conversion. Jerson Lima e Silva (UFRJ) •Alzheimer’s and neurodegeneration - can we use the retina as a window on to the brain? Francesca Cordeiro (Institute of Ophthalmology, London) •Bradykinin-induced neurogenesis and neuroprotection in differentiation and ischemic stroke models. Henning Ulrich (IQ-USP) Room B4 Stress and Behaviour. Chair: Eliane Volchan(UFRJ) C: Social stress, depression and memory: do animal models agree with these relationships? Roberto Frussa Filho (UNIFESP) MC:Traumatic Stress: immobility reaction in humans. Eliane Volchan(UFRJ) OC:27.002 - Cardiac reactivity to acute social stress in peacekeepers: the influence of vagal tone and resilience. Magalhães, L. N.; Carvalho, N. B. ; da Cruz, T. A. R.; Mendonça-De-Souza, A. C. F. ; Duarte, A. F. A. ; Coutinho, E. S. F. ; Gleiser, S. ; Figueira, I.; Volchan, E. ; Souza, G. G. L. - Departamento de Ciências Biológicas, UFOP; Forebrain Neurotecnologia Ltda, FOREBRAIN; Instituto de Pesquisa da Capacitação Física do Exército, IPCFEx; Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz, FIOCRUZ; Instituto de Psiquiatria, UFRJ; Instituto de Biofísica Carlos Chagas Filho, UFRJ OC:22.010 Involvement of dorsal premammillary nucleus in a psot defeat paradigm and social recognition. Rangel JR, M. J. ; Faturi, C. D. B. ; Canteras, N. S. Instituto de Ciências Biomédicas, Universidade de São Paulo, USP Thursday, August 25th Room B5 Cell therapy and Stem cells. Chair: Marcelo M. Morales •Cell therapies in neurologcal Diseases. Rosalia Mendes-Otero (UFRJ) •Cell therapy in cardiac diseases: factor fiction? Antonio Carlos Campos de Carvalho (UFRJ) •Embryonic Stem Cell in research and therapy: State of the Art Lygia da Veiga Pereira (IB-USP) •Stem cells and ischemic disease. Paulo Brofman (PUC-PR) Room B6 Comparative Biology: adaptations to the environment. Chair: Francisco Tadeu Rantin (UFSCAR) •Biochemical adaptation to freezing environments. Kenneth B. Storey (Carleton University, Canada) •Environmental variables inducing aestivation in reptiles. Denis Otávio Vieira de Andrade (UNESP-Rio Claro) •Anuran aestivation: ecological and physiological diversity. Carlos Arturo Navas Iannini (IB-USP) •Respiratory chemoreceptor function in vertebrates: Comparative, evolutionary and adaptative aspects. Luciane H. Gargaglioni Batalhão (UNESP–Jaboticabal) Room B7 Function e dysfunction of the Sensorial systems. •Satellites Cells and Fractalkine: new mediators of inflammatory pain. Thiago Mattar Cunha (FMRP-USP) Room 1 a 4 Innovation in Health. Chair: Jamil Assreuy (UFSC) •Rio de Janeiro State Policy in Innovation. Ruy Garcia Marques (FAPERJ) •Innovation in health: opportunities and challenges in neglected diseases. Carlos M. Morel (FIOCRUZ) •Innovation: cause or effect of technological development? Ogari de Castro Pacheco (Cristália Produtos Químicos e Farmacêuticos Ltda.) 13h30 – 15h30 Poster Session II - Exhibition Hall 13h30 – 15h30 Meeting of the Deliberative Council of the ABDC/Brazilian Journal of Medical and Biological Research 15h30 – 16h00Coffee-Break 16h00 – 17h00 Plenary lecture Rooms B1-B2-B7-B8 New insights into GPCR pharmacology from the use of fluorescent ligands in single living cells. Stephen John Hill (The University of Nottingham, UK) Chair: Marco Aurélio Martins (FIOCRUZ) Rooms B3-B4-B5-B6 Chair: Dora Fix Ventura (IP-USP) e Solange Rios Salomão (EPM-UNIFESP) •Pupillary responses as an evidence of melanopsin ganglion cells sparing in Leber’s Hereditary Optic Neuropathy Dora Fix Ventura (IP-USP) •Optic Nerve Electrophysiology: usefulness and interpretation Adriana Berezovsky (EPM-UNIFESP) •Retinal dysfunction in patients treated with chloroquine assessed by multifocal ERG. Luiz Carlos de Lima Silveira (UFPA) •Development of motion processing and binocularity: insights from evoked potential measurements. Russell D. Hamer (Smith Kettlewell Eye Research institute, San Francisco/IP-USP) Controlling stress: neurohumoral mechanisms regulating the dynamic range of neuroendocrine responses. Room B8 18h30 - 21h00 General Assembly of the Scientific Societies Sala A - SBFTE Sala B – SBFis Sala C – SBNeC Sala D – SBBf Sala 5 – SBIC Sala 6 - BRAVO Novel mechanisms involved in the neurobiology of pain and its control. Chair: Thiago Mattar Cunha (FMRP-USP) •Neural mobilization as neuropathic pain control. Marucia Chacur (ICB-USP) •Dissociation between endothelin-induced nociception and itch behaviors in the face of mice. Giles A. Rae (UFSC) •Novel agents to control superficial ocular pain. Jayter da Silva Paula (FMRP-USP) John A. Russell (University of Edinburgh, UK) Chair: Jackson Cioni Bittencourt (ICB-USP) Rooms 1 to 4 The príon protein beyond neurodegeneration. Rafael Linden (UFRJ) Chair: Marcelo Marcos Morales (UFRJ) 17h00 – 17h30Coffee-Break 17h30 – 18h30 Presidential Plenary Lecture Grand Ballroom Cancer: A Malady of Genes. Inder Verna (The Salk Institute, USA) Chair: Roger Chammas (FM-USP) 53 Friday, August 26th 08h00 – 09h00 Courses Room B1 and Room B8 Inflammation. Chair: Niels Olsen Câmara (ICB-USP) and Patrícia Bozza (FIOCRUZ) •2nd. Class: New inflammatory mediators. Patrícia Bozza (FIOCRUZ) Room B2 Post-tranductional modifications: much further of the genetic code. Chair: Heraldo Possolo de Souza (FM-USP) •2nd. Class: Glutathionilation of proteins. Marilene Demasi (Instituto Butantan) Room B3 Physiological mechanisms governing the autoregulation of acetylcholine release in the somatic motor nerve ending (SMNE). Chair: Alexandre Pinto Corrado (FMRP-USP) •2nd. Class: Electrophysiological basis of the modulation of cholinergic neurotransmission at the SMNE. Chariston André Dal Belo (UNIPAMPA) Room B4 Stem cells and cell therapy. Chair: Regina Coeli dos Santos Goldenberg (UFRJ) •2nd. Class: Genetic control of the cultivated human stem cells. Spencer Luiz Marques Payão (FAMEMA) Room B5 How to write a Scientific Paper. Chair: Walter Araújo Zin and Dalton Valentim Vassallo •2nd. Class: How to Prepare Research Projects and Grant Applications. Dalton Valentim Vassallo (EMESCAM) Room B6 Introduction to Biostatistics. Chair: Marcus Vinicius Baldo (ICB-USP) •2nd. Class: Practical applications of Biostatistics: What, when and how to do it. Carolina F. da Silva (ICB-USP) Room B7 Heart rate variability and autonomic modulation of cardiovascular system. Chair: Rubens Fazan Jr (FMRP-USP) •2nd. Class: Practical aspects of heart rate variability analysis: demonstration of a freeware computer software. Daniel Penteado Martins Dias (FMRPUSP) Rooms 1 to 6 Cell signaling: from membrane to nucleus. Chair: Rosely Godinho (EPM-UNIFESP) •2nd. Class: Transmembrane signal transduction via G-Protein coupled receptors. Rosely Godinho (EPM-UNIFESP) 54 Room 7 Good practices in laboratory animals. Chair: Marcel Frajblat (UFRJ) and Valderez B. Valero Lapchik (EPM-UNIFESP) •2nd. Class: Interference in the experimental data. Marcel Frajblat (UFRJ) •Colonies management Valderez B. Valero Lapchik (EPM-UNIFESP) 09h00 – 09h15Coffee-Break 09h15 – 11h15Symposia Room B1 Calcium signaling. Chair: Lusiane Bendhack (FMRP-USP) •Mitochondrial Ca2+ overload, oxidative stress and permeability transition. Anibal Vercesi (FCM-UNICAMP) •Intracellular calcium stores modulate autophagy in cell death and survival. Soraya Smailli (EPM-UNIFESP) •Does intrinsic cardiomyocyte cholinergic machinery modulates Ca2+ handling? Silvia C. Guatimosim Fonseca (UFMG) •Calcium signaling on the vascular relaxation induced by nitric oxide. Lusiane Bendhack (FMRP-USP) Room B2 Cancer: a metabolic view. Chair: Roger Chammas (FMUSP) •New metabolic targets in brain tumors. Alison Colquhoun (ICB-USP) •Antitumoral activities of metformin: new perspectives for an old drug. José Barreto Carvalheira (UNICAMP) •Non-canonical signaling and non-canonical fuction of the vasoactive peptides Cláudio Costa (FMRP-USP) •The importance of Glutaminase C for tumor metabolism. André Ambrosio (Laboratório Nacional Biociências) Room B3 Interactions between metabolism e inflammation. Chair: Mário José Abdalla Saad (FCM-UNICAMP) C: Interactions between metabolism and inflammation through nuclear receptors and co-activators of gene transcription. Ajay Chawla (Stanford School of Medicine, USA) MC:Molecular mechanisms of insulin resistance. Mário José Abdalla Saad (FCM-UNICAMP) Friday, August 26th OC:24.012 - The brown adipose tissue is involved in the weigh loss and thermal effects induced by central injection of C75 in rats. Cassolla, P.; Garófalo, M. A. R.; Guimarães, J. B.; Machado, F. S. M.; Coimbra, C. C.; Brito, N.; Kettelhut, I. C.; Navegantes, L.. 1 - Physiology, University of São Paulo, FMRP-USP; Biochemistry and Immunology, University of São Paulo, FMRP-USP; Physiology and Biophysics, Federal University of Minas Gerais, ICB-UFMG; Physology Sciencies, University of Maringa, CCB-UEM OC:13.030 - Effect of PPAR agonists alpha and gamma on renal glucose transporters expression of insulinopenic diabetic rats. Okamoto, M. M. ; Miyake, G. M. ; David-Silva, A; Marques, M. F. D. S. ; Sabino da Silva R ; Freitas, H. S. ; Machado, U. F. - Departamento de Fisiologia, Instituto de Ciências Biomédicas, ICB-USP Room B4 Hypertension and RAAS (Renin Angiotensin Aldosterone System). Chair: Maria Helena C. Carvalho (ICB-USP) •Immune mechanisms and hypertension. Ernesto Schriffrin (McGILL University Teaching Hospital, Canada) •Interaction of renin-angiotensin and kallikrein-kinin systems in hypertension. Maria Helena C. Carvalho (ICB-USP) •Modulation of autonomic control by angiotensin II: Opposite effects of hypertension and aerobic training. Lisete C. Michelini (ICB-USP) Room B5 Imunology of infect parasitic diseases. Chair: Marcelo Bozza (UFRJ) •Oxidative stress fuels Trypanosoma cruzi infection. Claudia Paiva (UFRJ) •The Kinin System at the interface between the microcirculation and immunity in Chagas Disease: Targeting the Heart. Julio Scharfstein (UFRJ) •Nod-like receptors-dependent innate immune responses to intracellular pathogens. Dario Zamboni (FMRP-USP) •Mechanisms of Dengue Disease: The role of Inflamassome. Mauro Martins Teixeira (UFMG) Room B6 Stress, anxiety and depression. Chair: Marcus Lira Brandão (FFCLRP) •Dopaminergic mechanisms in fear and anxiety. Marcus Lira Brandão (FFCLRP-USP) •Clinical and biological differences between psychotic and non-psychotic unipolar depression. Cristina Marta Del-Ben (FMRP-USP) •Biological rhythms, stress and depression. Roberto Andreatini (UFPR) •Neuropharmacology of the reconsolidation of the memory of fear. Victor Alejandro Molina (Universidad Nacional de Córdoba - Argentina) Room B7 Angiogenesis. Chair: Maurício Maia (UNIFESP) •Inibition of VEGF using Bevacixumab: pharmacological principies and clinical use. Maurício Maia (UNIFESP) •Bevacizumab and Ranibizumab for vitreoretinal and choroidal diseases: anti-angiogeneses or antipermeability effects? Juliana Orefice (UFMG) •Innovations of anti-angiogenises therapy for vitreoretinal diseases: macular function following antiVEGF therapy combined with laser. André Messias (FMRP-USP) Room B8 Neuroendocrine control of energy homeostasis: What is new? Chair: Egberto Gaspar Moura (UERJ) •Regulation of glycemia by hypothalamic leptin signaling. Christian Bjorbaek (Beth Israel Deaconess Medical Center, USA) •Corticotropin-releasing factor and the satiety-related responses. Lucila Leico Kagohara Elias (FMRP-USP) •Neonatal programming of energy homeostasis - the role of leptin. Egberto Gaspar Moura (UERJ) Room 1 to 4 National Council for the Control of Animal Experimentation (CONCEA), Arouca’s Law and the Prospects of use of Animal in Research in Brazil. Chair: Marcelo M. Morales (UFRJ) •Arouca’s Law and National Council for Control of use of Animal in Research (CONCEA). Marcelo M. Morales (UFRJ) •The Laboratory Animal Facilities in Brazil: Current situation and prospects. Luiza Maria Gomes de Macedo Braga (UFRGS) •The importance of laboratory animals for human and animal health research. Valderez Valero Lapchik (EPM-UNIFESP) •The role of Animal Ethics Committees (CEUAs) to biomedical research. Marcel Frajblat (UFRJ) 11h15 – 11h30Coffee-Break 11h30 – 13h30 Symposia Room B1 Ion Transport: physiological and molecular aspects. Chair: Wamberto Varanda (FMRP-USP) •On the Voltage Gating of T-type Calcium Channels. Edward Perez-Reyes (University of Virginia, USA) •T-type calcium channels and secretion in Leydig cells. Wamberto Varanda (FMRP-USP) 55 Friday, August 26th •Na/K-ATPase: Novel roles beyond ion pumping. François Noel (UFRJ) Room B2 Post transcriptional control of the gene expression. Chair: Edna Kimura (ICB-USP) CP: Control of neuronal differentiation by translational regulators. Beatriz Castilho (UNIFESP) MC:MicroRNA regulates signaling pathway related with thyroid cancer. Edna Kimura (ICB-USP) OC:25.092 - miRNAs: general view in murine melanoma model. Cruz, A.T.; Costa, F. F. ; Bischof, J. ; Soares, M. B. ; Jasiulionis, M. G. -Micro, Imuno e Parasitologia, UNIFESP OC:20.011 - The role of micrornas in the control of apoptosis in neurodegeneration – an in silico approach. Sousa, É.; Kihara, A. H. -Universidade Federal do ABC, UFABC Room B3 Tumor immunity and immunology. Sul, Health and Basic Sc, UFRGS OC:27.004 - A selective and competitive nmda receptor antagonist prevents oxidative alterations and synaptic impairment induced by AMYLOID-BETA peptide in mice. Bicca, M. A.; Figueiredo, C. P. ; Piermartiri, T. C.; MEOTTI, F. C.; Medeiros, R.; Tasca, C. I.; Calixto, J. B. Departamento de Farmacologia, UFSC; Departamento de Bioquímica, UFSC Room B5 New frontiers in kidney function. Chair: Gerhard Malnic (ICB-USP) •P2 receptor signing in the kidney with particular emphasis on the renal microvasculature. Eduard Inscho (School of Medicine Medical College of Georgia, USA) •Impact of stem cells in Kidney Diseases. Nestor Schoor (EPM-UNIFESP) •Possible role of albumin on the renal sodium excretion. Celso Caruso Neves (UFRJ) Chair: José Alexandre Marzagão (ICB,USP) CP: Anti-cancer peptides, activities and perspectives. Luiz Travassos (UNIFESP) MC:Dendritic cells: in the immune response and immunotherapy of cancer. José Alexandre Marzagão (ICB, USP) OC:18.049 - Products derived from leukemic cells modulate the generation of dendritic cells in different stages. Motta, J. M. ; Rumjanek, V. M. - Instituto de Bioquímica Médica, UFRJ OC:30.015 - In vitro phototoxicity evaluation of chitosan nanoparticles containing 5-ala or 8-ala on melanoma. Maranho, D. S.; Saga, Y. Y.; Tedesco, A. C.- Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Usp, FcfrpUsp; Faculdade De Filosofia, Ciências e Letras, FFCLRPUSP Room B6 Room B4 Signaling pathways and erectile dysfunction. Neurodegeneration: basic and pathological aspects. Chair: Cristoforo Scavone (ICB-USP) MC: Brain morphology and neurodegeneration: magnetic resonance imaging studies from healthy aging to dementia. Geraldo Bussato Filho (FMUSP) MC:Neuroprotective effects of guanosine in experimental models of brain diseases. Diogo Onofre Gomes de Souza (UFRGS) MC: The influence of Glutamate and NF-kB signaling cascade in Neuroinflammation and Neurodegeneration process. Cristoforo Scavone (ICB-USP) OC:27.023 - Effects of treadmill running in short and LONG-TERM memory and BDNF, PRO-BDNF and TRKB hippocampal immunocontent in adult and MIDDLE-AGED rats. Ardais, A. P. ; Costa, M. S. D. ; Fioreze, G. T. ; Botton, P. H. ; Mioranzza, S. ; Portela, L. V. ; Souza, D. O. G. ; Porciúncula, L. O. Federal University of Rio Grande do 56 Multifaceted regulation of immune response. Chair: Niels Olsen Saraiva Camara (ICB,USP) •Cytoprotection induced by heme oxygenase 1 endproducts. Niels Olsen Saraiva Camara (ICB-USP) •New bioactive products and molecular process involved in inflammation. Moises Clemente Marinho Cavalcante (UFRJ) •Insights into the regulation of adaptive immune responses by catecholamines. Alexandre Salgado Basso (UNIFESP) •Natural Killer T lymphocytes in inflammatory responses: from pathogen resistance to autoimmunity. Alexandre de Castro Keller (UNIFESP) Room B7 Chair: Gilberto de Nucci (ICB-USP/FCM-UNICAMP) •Combination of soluble guanylate cyclase stimulators and phosphodiesterase 5 inhibitors for the treatment of erectile dysfunction. Peter Sandner (Bayer Schering Pharma) •Cytokine-activated signaling pathways in the cavernosal endothelial and smooth muscle cells. Rita C. A. Tostes (FMRP-USP) •Sodium channel as therapeutic target for erectile dysfunction. Gilberto de Nucci (ICB-USP/FCM-UNICAMP) Room B8 The neural basis for motivated behaviors Chair: Antonio Padua Carobrez (UFSC) CP: The defensive hypothalamic system: from rodents to humans. Newton Canteras (ICB-USP) MC:The periaqueductal gray matter circuits: from learning to flight. Friday, August 26th Antonio Padua Carobrez (UFSC) OC:23.057 - Fear expression is reduced after updating a contextual fear memory. Haubrich, J.; DE Oliveira Alvares, L.; Cassini, L.; Santana, F.; Sierra Ordoñez, R. A.; Crestani, A. P. ; Dalmaz, C. ; Quillfeldt, J. A. - UFRGS OC:23.214 - Mother deprivation facilitates and learned helplessness inhibits the defensive behaviors produced by electrical stimulation of the dorsal periaqueductal gray matter (DPAG) of adult rats. Santos, J. W. Q.; Müller, C. T.; Bernabé, C. S.; Rosa, C. A. ; Mendonça, V. A.; Schenberg, L. C. - Depto de Fisiologia, Universidade Federal do Espírito Santo , UFES Rooms 1 to 4 Application of Academic knowledge in Industry: job prospects and success stories. Chair: Luiz Eugênio de Moraes Mello (UNIFESP) •Challenges for innovation in Brasil. José Fernando Perez (Recepta Biopharma) •Chemical Biodiversity and their industrial applications. Antonio Paes de Carvalho (Extracta Moléculas Naturais S A.) •Vale and its new model of cooperation and support for Science, Technology and innovation. Domenica Blundi (Vale) 13h30 – 15h30 Poster Session III - Exhibition Hall 15h30 – 16h00Coffee-Break Rooms B1-B2-B7-B8 Estrogen receptors as selective sensors for structurally diverse ligands. Geoffrey L. Greene (The University of Chicago, USA) Chair: José Antunes Rodrigues (FMRP-USP) e Catarina Segreti Porto (EPM-UNIFESP) Rooms B3-B4-B5-B6 Redox signalling, lipid rafts and vascular (patho) biology. Rhian M. Touyz (University of Ottawa, Canada) Chair: Maria Cristina de Oliveira Salgado (FMRP-USP) Rooms 1 to 4 Muscular dystrophy: cellular therapy and immunotherapy Wilson Savino (FIOCRUZ) Chair: Marimélia Porcionatto (EPM-UNIFESP) 17h00 – 17h30Coffee-Break 17h30 – 18h30 Presidential Plenary Lecture Grand Ballroom Rocha e Silva Memorial Lecture Bradykinin revisited 62 years after its discovery. João Batista Calixto (UFSC) Chair: Jamil Assreuy (UFSC) Room A 18h30 - 21h00 General Assembly of the FeSBE 16h00 – 17h00 Plenary Lecture 57 Saturday, August 27th 08h00 – 09h00Courses Room B1 and Room B8 •3rd. Class: Nuclear Receptors and Cell Signaling. Maria Christina Werneck de Avellar (EPM-UNIFESP) Inflammation. Room 7 Chair: Niels Olsen Câmara (ICB-USP) and Patrícia Bozza (FIOCRUZ) •3rd. Class: Inflammatory diseases, from bench to bed side, Part I. Patrícia Bozza (FIOCRUZ) •Inflammatory diseases, from bench to bed side, Part II. Niels Olsen Câmara (ICB-USP) Good practices in laboratory animals. Room B2 09h15 – 11h15Symposia Post-tranductional modifications: much further of the genetic code. Chair: Heraldo Possolo de Souza (FM-USP) •3rd. Class: Phosphorylation of the proteins. Licio Velloso (UNICAMP) Room B3 Physiological mechanisms governing the autoregulation of acetylcholine release in the somatic motor nerve ending (SMNE). Chair: Alexandre Pinto Corrado (FMRP-USP) •3rd. Class: Physiological role of the cholinergic autoreceptors of the SMNE. Wilson Alves Prado (UEM) Room B4 Stem cells and cell therapy. Chair: Regina Coeli dos Santos Goldenberg (UFRJ) •3rd. Class: Mesenchymal stem cell: challengers in scale up production. Regina Coeli dos Santos Goldenberg (UFRJ) Room B5 How to write a Scientific Paper. Chair: Walter Araújo Zin and Dalton Valentim Vassallo •3rd. Class: How Reviewers and Editors Appraise Scientific Manuscripts Submitted for Publication in Scientific Journals. Lewis J. Greene (FMRP-USP) Room B6 Introduction to Biostatistics. Chair: Marcus Vinicius Baldo (ICB-USP) •3rd. Class: Common errors in applying biostatistics. Carolina F. da Silva (ICB-USP) e Marcus Vinicius Baldo (ICB-USP) Room B7 Heart rate variability and autonomic modulation of cardiovascular system. Chair: Rubens Fazan Jr (FMRP-USP) •3rd. Class: Baroreflex sensitivity and cardiovascular variability. Rubens Fazan Jr (FMRPUSP) Rooms 1 to 6 Cell signaling: from membrane to nucleus. Chair: Rosely Godinho (EPM-UNIFESP) 58 Chair: Marcel Frajblat (UFRJ) and Valderez B. Valero Lapchik (EPM-UNIFESP) •3rd. Class: Routes of administration and collection. Valderez B. Valero Lapchik (EPM-UNIFESP) •Euthanasia and Biosecurity (biological disposal). Valderez B. Valero Lapchik (EPM-UNIFESP) 09h00 – 09h15Coffee-Break Room B1 Signal transduction in sensory, hormone and drug receptors. Chair: Gustavo Ballejo (FMRP-USP) •Opening remarks: some historical aspects on receptors and signal transduction. Gustavo Balejo (FMRP-USP) •Thyroid hormone receptor interaction with coactivators and co-repressors in gene expression. Tania Ortiga (UFRJ) •Vesicle transport on the synaptic ribbon and its role in the recovery from synaptic depression. Christina Joselevitch (IP-USP) •Molecular and cellular aspects of neurotransmitter release from the analog ribbon-type synapses of the retina. David Zenisek (Yale University School of Medicine, USA) Room B2 Cell Cycle, cell death, therapy and resistance. Chair: Heraldo Possolo de Souza (FM-USP). •Mechanisms of cell death and development of tumor chemoresistance. Marisol Soengas (Centro Nacional de Investigaciones Oncológicas, Espanha) •NFAT in Cancer. João Viola (INCA) •PGC-1 β and Melanoma growth Luis Augusto Passos (FM-USP) •Melanoma cell chemosensitization to cisplatin by tunicamycin, an endoplasmatic reticulum stress inducer Renata Saito (FM-USP) Room B3 Reproduction: from basic to clinical aspects. Chair: Luiz Renato França (ICB-UFMG) •Regulation of Sertoli cells proliferation. Luiz Renato França (ICB-UFMG) •Creation of an immune privileged site with testicular Sertoli cells. Jannette Dufour (Texas Tech University Health Sciences Center, USA) •Endometrial signaling pathways: a redundanct system for continuous nest rebuilding. Fernando M. Reis (UFMG) Saturday, August 27th Room B4 OC:13.056 - Increased pancreatic beta cell mass Aging: from lab bench to bedside. induced by insulin resistance is possible attributed to hepatocyte growth factor. Araújo, T. G.; Carvalho, B. M.; Guadagnini, D.; Protzek, A. O. P.; Vanzela, E. C.; Boschero, A. C.; Saad, M. J. A.- Internal Medicine, FCM, UNICAMP; Institute of Biology, UNICAMP OC:13.053 - Taurine (TAU) supplementation enhances insulin secretion and calcium handling in response to depolarization stimulus in isolated islets from malnourished mice submitted to high fat diet (HFD). Vettorazzi, J. F.; Santos-Silva, J. C.; Camargo, R. L. ; Ribeiro, R. A.; Boschero, A. C.; Carneiro, E. M. Instituto de Biologia, UNICAMP; NUPEM, UFRJ Chair: Alicia Kowaltowski (IQUSP) •Aging, mitochondria and dietary interventions. Alicia Kowaltowski (IQUSP) •Study of population cohorts and translational Science: data from the EPIDOSO Project. Luiz Roberto Ramos (EPM-UNIFESP) •Spontaneous physical activity, energy expenditure, and aging. Eduardo Ferrioli (FMRP-USP) •Ophtalmo-geriatry: what we know and what we seek to know about the aging eye Marcela Cypel (EPM-UNIFESP) Room B5 Lung and inflammation: a multidisciplinary analysis. Chair: Patrícia R.M. Rocco (UFRJ) MC:New therapeutic strategies for silicosis. Patricia Machado Rodrigues e Silva Martins (FIOCRUZ) MC:Role of nuclear receptors in lung inflammation. Patrícia T. Bozza (FIOCRUZ) MC:Understanding the mechanisms of action of stem cell therapy in acute lung injury. Patrícia R.M. Rocco (UFRJ) OC:08.069 - Opposite roles of bradykinin receptors in bleomycin-induced pulmonary inflammation and fibrosis in mice. Russo, R. C.; Cordeiro, B. F.; Garcia, C. C.; Tavares, L. P.; Lopes, G. A. O. ; Lima, B. H. F.; Soriani, F. M.; Cassali, G. D.; Teixeira, M. M.- Dep. Fisiologia e Biofísica, Instituto Ciências Biológicas, UFMG; Dep. Bioquimica e Imunologia/Instituto Ciências Biológicas, UFMG; Dep. Patologia Geral, Instituto Ciências Biológicas, UFMG OC:08.062 - Bone marrow-derived mononuclear cell therapy modulates the inflammatory and remodeling processes independent of the administration route in experimental chronic allergic asthma. Abreu, S. C.; Antunes, M. A.; Cruz, F. F.; Maron-Gutierrez, T.; Ornellas, D. S.; Teodoro, W. R.; Capelozzi, V. L.; Morales, M. M.; Rocco, P. R. M. - Laboratório de Investigação Pulmonar - IBCCF, UFRJ, UFRJ; Laboratório de Fisiologia Celular e Molecular - IIBCCF, UFRJ, UFRJ; Departamento de Patologia, Universidade de São Paulo, USP Room B6 Treatment of type 1 diabetes: why and how to get to cell therapy? Chair: Maria Lúcia Corrêa-Giannella (FMUSP) MC:Difficulties and limitations of current therapy of type 1 diabetes mellitus. Daniel Giannella-Neto (HC-FMUSP) MC:Pancreatic islet transplantation. Maria Lúcia Corrêa-Giannella (FMUSP) MC:Advances of NUCEL (Center for Cellular and Molecular Therapy) toward the therapy of diabetes mellitus. Thiago Rennó Mares-Guia (IQ-USP) Room B7 Recent advances in neurobiology of learning and memory. Chair: Cláudio da Cunha (UFPR) •Extinction of aversive memories. Jociane de Carvalho Myskim (PUC-RS) •Working Memory and Episodic Memory: mutual relations. Orlando Francisco Amodeo Bueno (UNIFESP) •Striatal dopaminergic mechanisms for acquisition of aversive memory. Cláudio da Cunha (UFPR) •Building attention from memory. Gilberto Fernando Xavier (IB-USP) Room B8 Natural Products: a multidisciplinary approach. Chair: Roberto Soares de Moura (UERJ) •Licensing of the phytopharmaceutical in Brazil Ana Cecília Carvalho (ANVISA) •Natural Products and The Brazilian Patent System. Fabiane Pereira Ramos Figueiredo (INPI) •Challenges for the use of the Brazilian Biodiversity for development of drugs. João Batista Calixto (UFSC) •Challenges for Industry. Marcio Falci (Biolab) Rooms 1 to 4 Laboratory Animals: development rational and monitored Chair: Valderez B. Valero Lapchik (UNIFESP) •Education: harmonization and prospects. Vania Gomes Moura Mataraia (Butantan) •The Laboratory Animals Research: implications of genetic background. Ana Lucia Brunaldi Godard (UFMG) •Health of genetically modified Animal models: how to monitor them ? Rovilson Gilioli (UNICAMP) •The law 11.794/08 and the Science of Laboratory Animals. Octávio Presgrave (FIOCRUZ) 11h15 – 11h30Coffee-Break 11h30 – 13h30Symposia 59 Saturday, August 27th Room B2 Roberto Alcântara Gomes Award Symposium (SBBf) Scientific Committee: Pietro Ciancaglini (FMRP-USP) Audrey Ivanenko Salgado (UFMG) Christopher Kushmerick (UFMG) •07.001 - Direct action of angiotensin-(1-7) on NA+/ H+ exchanger in in vivo cortical proximal tubule. Branco, R. C. C. ; Aires, M. D. M. - Fisiologia e Biofísica, USP •09.022 - Ion channels in mesenchymal stem cells of wharton´s jelly human umbilical cord: RVD study. Albertim, G. J. B.; MORAES, T. F.; Yuldasheva, L. N; Silva, R. P. ; Rodrigues, C. G.; Silva, M. B. D.; Krasilnicov, O. V. Biophysics and Radiobiology Department, CCB, UFPE,PE, Brazil, UFPE; Physiology and Pharmacology Department, CCB, UFPE,PE, Brazil, UFPE •17.213 - (-)-Carvone activates TRPV1 channels in DRG neurons and TRPV1-expressing HEK cells. Goncalves, J.C.R.; Souza, H. D. N. D.; Nery, A. A.; Ulrich, A. H.; Prado, V. F.; Prado, M. A. M.; Araújo, D. A. M. D. Laboratório de Tecnologia Farmaceutica, UFPB, Instituto de Química, IQ/USP - Robarts Research Institute, UWO •21.098 - Differential effects of angiotensin 1-7 on the electrical activity of vasopressin and oxytocin neurons of the supraoptic nucleus. Merino, R. M. ; Varanda, W. A. - Departamento de Fisiologia, FMRP-USP. •21.198 - Strusctural studies with the cerebral dopamine neurotrophic factor (CDNF) and its neuroprotective effects against the toxicity of AlphaSynuclein aggregates. Silva, C. L. D. A. ; Brivio, A. M. ; Andrade, G. T. L.C.; Braga, C. A. ; Cabral, K. ; Almeida, M. S.; Foguel, D. Intituto de Bioquímica Médica, IBqM. Room B3 Álvaro Ozório de Almeida Award Symposium (SBFis) Scientific Committee: Armenio Aguiar dos Santos (UFC) José Antunes Rodrigues (USP) Maria José Campagnole-Santos (UFMG) Thiago S. Moreira (USP Valdir A. Braga (UFPB) •24.065 - Norepinephrine attenuates the fastinginduced expression of atrophy- and autophagyrelated genes in skeletal muscles of mice. Silveira, W. A.; Gonçalves, D. A. P.; Graça, F. A.; Zanon, N. M.; Kettelhut, I. C.; Navegantes, L. C. C. Depto. Fisiologia/ Faculdade de Medicina de Ribeirão Preto, FMRP; Depto. Bioquímica, Faculdade de Medicina de Ribeirão Preto, FMRP •13.108 - Estrogen modulates H2O2 production in rat thyroid. Braga, W. M. O.; Souza, E. C. L.; Rodrigues, D. C.; Cardoso, L. C.; Freitas, M. L.; Rondinelli, E.; Ferreira, A. C. F. ; Carvalho, D. P.; Fortunato, R. S. Instituto de Biofísica Carlos Chagas Filho, UFRJ Departamento de Patologia Clínica, Faculdade de Medicina, UFF •11.008 - Modulation and synchronization by light and endothelins: xenopus laevis melanophores as a model of peripheral clock. Moraes, M. N. C. M. ; Castrucci, A. M. L. Instituto de Biociências - Fisiologia, USP •02.077 - Aerobic exercise training induced cardiac hypertrophy involves regulatory microRNAs, decreased ACE-ANG II, and synergistic regulation of ACE2-ANG (1-7). Fernandes, T.; Hashimoto, N. Y.; Magalhães, F. C.; Fernandes, F. B.; Casarini, D. E.; Carmona, A.; Krieger, J. E.; Phillips, M. I.; Oliveira, E. M. Laboratory of Biochemistry of the Motor Activity, USP, EEFE-USP; Laboratory of Genetics and Molecular Cardiology, InCor, FMUSP Nephrology Division, Kidney and Hypertension Hospital , UNIFESP,Laboratory of Stem Cells / Keck Graduate Institute, KGI •16.046 - The increment in nitric oxide modulation in rat coronary arteries post-myocardial infarction is a possible mechanism involved in preventing the onset of heart failure. Couto, G. K. ; Britto, L. R. G.; Mill, J. G.; Rossoni, L. V. Department of Physiology and Biophysics, ICB, USP Department of Physiological Sciences, CCS, UFES Room B4 José Ribeiro de Valle Award Symposium (SBFTE) Chair: Jamil Assreuy (UFSC) Scientific Committee: Lusiane Bendack (USP) (Chair) Newton Gonçalves de Castro (UFRJ) Thereza Christina Monteiro de Lima (UFSC) •17.081 - The antinociceptive effect of crotalphine, an opioid-like analgesic peptide, involves stimulation of peripheral cannabinoid receptors and endogenous opioid release. Machado, F. C. ; Zambelli, V. O. ; Fernandes, A. C. O.; Cury, Y. ; Picolo, G. Special Laboratory of Pain and Signaling, Butantan Institute, IBu •23.154 - Evidence of the role of spinal C-JUN-NH2terminal kinase (JNK) activation in the development of spinal cord injury. Martini, A. C. ; Forner, S. ; Koepp, J. ; Rae, G. A. - Dept. of Pharmacology, Federal University of Santa Catarina, UFSC •16.044 - Role of TLR4 in blood pressure and cardiac hypertrophy of spontaneously hypertensive rats (SHR). Echem, C.; Bomfim, G. F.; Dos Santos, R. A.; Fortes, Z. B.; Carvalho, M. H. C. Farmacologia, USP (ICB1), ICB/USP •12.027 - ATL-1, a synthetic analog of 15-EPI-LIPOXIN A4, modulates key function of tumor-associated macrophage: a potential anti-tumoral tool. De Brito, N. M. ; Simões, R. L. ; Fierro, I. M. ; Barja-Fidalgo, C. Departamento de Farmacologia e Psicobiologia, UERJ •17.026 - Therapeutic attenuation of silica-induced pulmonary fibrosis by immunotoxin chimeric molecule IL-13PE. Ferreira, T. P. T.; Arantes, A. C. S. D.; Rocco, P. R. M.; Puri, R.; Hogaboam, C. M. ; Martins, M. A.; Silva, P. M. R. E. Fundação Oswaldo Cruz, FIOCRUZ; Laboratório de Investigação Pulmonar , LIP Center for Biologics Evaluation and Research, FDA University of Michigan Medical School, UMMS Room B5 Young Investigador Michel Jamra Award Symposium (SBIC) Chair: Heraldo Possolo de Souza (FM-USP) 60 Saturday, August 27th Undergraduate students •12.012 - Evidences for activation of unfolded protein response after axotomy of retinal ganglion cells: analysis of CHOP/GADD153 and JNK. Vieira-barroso, L. ; Gonçalves, B. S. ; Ribas, V. T; Torres, D. N. M. ; Chiarini, L. B. Instituto de Biofísica Carlos Chagas Filho, UFRJ •18.012 - B7-CD28/CTLA-4 pathway in altered in alzheimer and frontotemporal dementia patients Lima, G.S.F..; Torres, K. C. L.; Santos, R. R. D.; Fiamoncini, C.; Ferreira, R. O. S.; Moraris, E. N.; Silva, M. A. R.- Departamento de Saúde Mental, Universidade Federal de Minas , UFMG Graduate students •13.114 - Melatonin-induced activation of hypothalamic insulin signaling activates an interorgan communication leading to suppression of hepatic gluconeogenesis. de Almeida Faria, J. ; Kinote, A. P. B. M. ; Ignácio-souza, L. M. ; Araújo, T. M. F. ; Velloso, L. A. ; Anhê, G. F. - Departamento de Farmacologia, Univ. Estadual de Campinas, UNICAMP •16.064 - Development of chagasic cardiomyopathy model in chimeric mice. Irion, C. I.; Brasil, G. V.; Christie, B. B.; Vitiello, G.; Duran, D. B.; Paredes, B.; Brunsnick, T. H.; Cunha, S. T. D.; Rocha, N.; Rezende, I.; Abreu, M. S. C.; Carvalho, A. B.; Carvalho, A. C. C. D.; Goldenberg, R. C. D. S. Biofísica, Universidade Federal do Rio de Janeiro, IBCCF, UFRJ; Universidade Federal Fluminense , UFF; Instituto Nacional de Cardiologia, INC •09.038 - Effects of nerve growth factor on extracellular levels of glutamate and thiols in the chick retina. Garcia, T. B. ; Grisólia, A. B. A. ; Moraes, E. R. D. S. ; Oliveira, K. R. M. ; Crespo-lopez, M. E. ; Picançodiniz, D. L. W. ; Silva, A. M. H. O. D., Universidade Federal do Pará, Inst. de Ciências Biológicas, UFPA Room B7 SBEM Award Symposium (DEB, SBEM) Chair: Maria Tereza Nunes (ICB-USP) Scientific Committee: Doris Rosenthal (UFRJ) Catarina Segretti Porto (EPM-UNIFESP) Patricia Seraphim (UNESP – Presidente Prudente) Maria Lucia Giannella (FM-USP) Lucila Keico Elias (FMRP-USP) •13.128 - Absence of EIF2 alpha phosphorylation could result in insulin resistance in L6 myotubes treated with palmitate. Silva, P. E. ; Poletto, A. C. ; Anhê, G. F. ; Machado, U. F. Departamento de Fisiologia e Biofísica, ICB/USP •13.110 - HMGCOA reductase and ABCG1 gene expression vary according to the plasma HDL-C concentration and contribute to the intracellular cholesterol homeostasis in human peripheral blood mononuclear cells. Leança, C. C.; Nunes, V. S.; Panzoldo, N. B.; Parra, E.; Cazita, P. M.; Nakandakare, E. R.; Faria, E. C. D.; Quintão, E. C. R. Disciplina de Endocrinologia, Faculdade de Medicina da USP, FMUSP; Departamento de Patologia Clínica, Fac. Ciências Médicas, UNICAMP •03.089 - Resistance training regulates il-10 and srebp1c expression, size and weight of mesenteric fat mass in ovariectomized rats. Stotzer, U. S. ; Duarte, F. O. ; Gatto, C. D. V. G. ; Silva, G. H. G. D. ; Domingues, M. M. ; Rodrigues, M. F. C. ; Perez, S. E. A. ; Araújo, H. S. S. D. Ciências Fisiológicas, Universidade Federal São Carlos, UFSCar •12.021 - The thyroid hormone antagonist nh3 inhibits thyroid hormone-induction of osteoblast differentiation in human calvaria periosteal mesenchymal stem cell. Costa, C. C.; Fanganiello, R. D.; Scanlan, T. S.; Passosbueno, M. R.; Gouveia, C. H. A. Depto. de Anatomia, Instituto de Ciências Biomédicas, USP Depto. de Genética e Biologia Evolutiva, IB, USP; Depto. de Fisiologia e Farmacologia, OHSU •13.034 - Effect of cinnamon on lipid profile of euthyroid and hypothyroid rats. Lopes, B. P.; Gaique, T. G.; Souza, L. L.; Paula, G. S. M.; Neto, J. F. N.; Pazos-moura, C. C.; Oliveira, K. J. Instituto de Biofísica Carlos Chagas Filho , UFRJ; Departamento de Fisiologia e Farmacologia , UFF; Faculdade de Ciências Médicas , UERJ Room 8 BRAVO/ALLERGAN Award Symposium (BRAVO) Scientific Committee: Eduardo Melani Rocha FRP-USP Jacqueline Lopes de Faria, da FM-UNICAMP Francisco Max Damico, da FMUSP •32.007 - Anti-inflammatory effects and mechanism of action of anxa1 protein and its mimetic peptide in endotoxin-induced uveitis. Girol, A. P.; Gil, C. D.; Oliani, S. M. Depto Biologia, Inst. Biociências, Letras e Ciências Exatas, IBILCE, UNESP; Depto Ciências Básicas/ Faculdades Integradas Padre Albino, FIPA/FAMECA, Depto Morfologia e Genética, Univ. Federal de São Paulo, UNIFESP •32.022 - Effects of chlorin e6 in the p23h rat model of retinitis pigmentosa. Akamine; Balêm, F.; Ioshimoto, G. L.; Ventura, D. F.; Klein-seetharaman, J.; Hamassaki, D. E. Biologia Celular e do Desenvolvimento, ICB/USP Dept. of Structural Biology, Univ. Pittsburgh; Psicologia Experimental, IP/USP •32.017 - Pattern-reversal visually evoked potentials in children with amblyopia. Andrade, E. P. D. ; Sacai, P. Y. ; Pereira, J. M. ; Berezovsky, A. ; Salomão, S. R. Universidade Federal de São Paulo, UNIFESP •32.018 - Therapeutic effect of bone-marrow mononuclear cells in the optic nerve regeneration. Zaverucha-do-valle, C.; Gubert, F.; Mesentier-louro, L.; Bargas-rega, M.; Paredes, B.; Mencalha, A. L.; Abdelhay, E.; Santiago, M. F.; Mende-otero, R. Instituto de Biofísica Carlos Chagas Filho, UFRJ; Instituto Nacional do Câncer, INCa •32.011 - Experimental evidence for cooperation and division of labour between the magnocellular (m) and parvocellular (p) visual pathways. Silveira, V. A.; Souza, G. S.; Gomes, B. D.; Rodrigues, A. R.; Silveira, L. C. L. 61 Saturday, August 27th Instituto de Ciências Biológicas, ICB, UFPA; Núcleo de Medicina Tropical, NMT, UFPA •32.013 - The effects of brimonidine on retinal spreading depression. Oliveira, V. V. P. D.; Dantas, A. M.; Zangalli, C. E. S.; Streit, D. S.; Calixto, N. Instituo de Biofísica Carlos Chagas Filho, UFRJ; Universidade Federal de Minas Gerais, UFMG; Faculdade de Medicina de Petrópolis, FMP •32.020- Decreased functional magnetic resonance imaging response to visual stimuli and pericalcarine cortex volume in patients with glaucoma . Gerente, V. M.; Schor, R. R.; Amaro Jr, E. A.; Felix, M.; Chaim, K. T.; Ventura, D. F.; Lottenberg, C. L.; Teixeira, S. H.; Paranhos Jr. , A. Oftalmologia, Universidade Federal de Sao Paulo, Unifesp; Instituto do Cerebro, Hospital Israelita Albert Einstein, HIAE •32.004 - Visual outcomes and self-reported qualityof-life in cataract operated patients. Mitsuhiro, M. R. K. H. ; Berezovsky, A. ; Belfort Jr, R. ; Salomão, S. R. Oftalmologia, Universidade Federal de São Paulo, UNIFESP. 13h30 – 15h30 Poster Session IV – Exhibition Hall 15h30 – 16h00Coffee-Break 16h00 – 17h00 Plenary Lecture Rooms B1-B2-B7-B8 Stimulated nuclear translocation of signaling proteins – a novel layer of transcriptional regulation. Rony Seger (Weizmann Institute of Science, Israel) Chair: Roger Chammas (FM-USP) Rooms B3-B4-B5-B6 Radicais livres na intoxicação por chumbo. Etelvino José Henriques Bechara (UNIFESP-Diadema) Chair: Hélio César Salgado (FM-USP) Rooms 1 to 4 Regulation of HDL biogenesis by the ABCA1 pathway, its importance as a pharmacological target for anti-atherogenic treatment. Shinji Yokoyama (Nagoya City University) Chair: Marisa Passarelli (FM-USP) 17h00 – 17h30Coffee-Break 17h30 – 18h30 Grand Ballroom Presidential Plenary Lecture Optogenetics: development and application. Karl Deisseroth (Stanford University, USA) Chair: Luiz Eugênio M. Mello (EPM-UNIFESP) 18h30 - 19h30 Closing and Awards Session 62 ON-SITE INFORMATION Registration Desk The meeting registration desk will be located in the Exhibition Hall (Ground floor) of the Convention Center SulAmérica. The information/registration desk will be staffed throughout conference hours for queries and late registrations. For security reasons please ensure that you wear your badge throughout the meeting. Presidential Plenary Lecture, Plenarry Lecture and Symposium Locations The meeting will be held in the 2nd Floor: Grand Ballroom (Rooms B1 to B8) and Rooms 1 to 7), beginning at 18h30 on Wednesday, 24th August. Poster Sessions The poster sessions will take place in the Exhibition Hall (Ground floor). Poster presenters should refer to the information board alongside the registration desk or in the program booklet to check which poster session & board has been allocated to them. The organizers request that poster presenters stand by their boards during their allocated session for queries and discussion. Exhibitors The exhibitors will be present at the meeting in the Exhibition Hall (Ground floor). Invited and oral speakers All presentations must be preloaded onto the PC in the Room 13 at least two hours before the relevant session. Oral presenters are reminded to be in the room no later than 15 minutes before the start of their session in order to meet with the session chair and to finalize the set-up of presentation visuals with the room technician. Certificates of Presentation are available inside the room with the technician. For Invited speakers, the lunch box will be available at the Foyer. Transportation The bus will be available at the Rio Othon Palace Hotel. Please see scheduled times below. Transportation from hotel to Convention Center Wednesday: 16h00 Thursday: 07h00 and 08h00 Friday: 07h00 and 08h00 Saturday: 07:00 and 08h00 Transportation from Convention Center to Hotel Wednesday: 21h30 Thursday: 19h00 and 21h45 Friday: 19h00 and 21h45 Saturday: 18h30 and 19h45 63