Name: Paulo J. Oliveira
Position:
1) Assistant Researcher, Center for Neurosciences and
Cell Biology, University of Coimbra, Portugal, 2006present (Leader: “Mitochondrial Toxicology Group”)
2) Visiting Research Associate, University of MinnesotaMedical School, Duluth, USA, 2003-present
E-mail address: [email protected]
Research areas:
1) Mitochondrial Physiology and Toxicology
Education:
1) University of Coimbra, 1999: Graduation in Biochemistry
2) University of Coimbra, 2003: Ph.D. in Cellular Biology
3) University of Minnesota, Duluth, USA, 2003, 2004, 2005: Post-Doc in
Toxicology
4) University of Minnesota, Duluth, USA, 2006: Post-Doc in Molecular and
Cellular Biology
Previous positions
1) Ph.D. Research Fellow (2001-2003)
2) Post-Doc Research Fellow (2003-2006)
Research activities:
1) Design and characterization of mitochondrial toxicity of synthetic polyphenols:
relevance for the discovery of novel anti-cancer
2) Strategies for protection of cardiac mitochondria during ischemia and
reperfusion
3) Mitochondrial toxicity of phytochemicals used in alternative medicine
4) Mitochondrial involvement in the cardiotoxicity of doxorubicin
Teaching activities
1) Invited lecturer of Cell Biology classes for Master degree students and
Biomembranes and Laboratorial Biochemistry II for undergraduated students
Selected publications
Editorship of Publications
1. Co-editor: Mitochondrial Pharmacology and Toxicology, Antonio J. Moreno
ed., Research Signpost, Kerala, India
Book Chapters
1. Paulo J. Oliveira, Edward Perkins, Jon Holy (2006) Vital Imaging of
Multicellular Spheroids. In Confocal Microscopy: Methods and Protocols,
(tentative title), Stephen W. Paddock ed., Humana Press, Totowa, N.J., USA
2. Vilma A. Sardão, Dario L. Santos, Paulo J. Oliveira (2006) Cardiac
Mitochondrial Dysfunction Induced by Doxorubicin: Role of Calcium and
Oxidative Stress. In Mitochondrial Pharmacology and Toxicology, Antonio J.
Moreno ed., Research Signpost, Kerala, India
3. Paulo J. Oliveira, António J. M. Moreno (2006) Carvedilol, an Hypertensive
Drug, Protects Heart Mitochondria From Oxidative Damage. In Mitochondrial
Pharmacology and Toxicology, Antonio J. Moreno ed., Research Signpost,
Kerala, India
Selected papers in peer-reviewed journals (from a total of 45)
1. Timothy M. O’Brien, Robert M. Carlson, Paulo J. Oliveira, Kendall B.
Wallace (2006) Esterification Prevents Induction of the MPT by N-Acetyl
Perfluorooctane Sulfonamides, Chem. Res. Toxicol. 19(10):1305-12
2. Paulo J. Oliveira, Kendall B. Wallace (2006) Depletion of Adenine
Nucleotide Translocator Protein in Heart Mitochondria From Doxorubicintreated Rats – Relevance for Mitochondrial Dysfunction, Toxicology, 220:
160-168.
3. João Teodoro, Anabela P. Rolo, Paulo J. Oliveira, Carlos M. Palmeira
(2006) Decreased ANT Content in Zucker Fatty Rats: Relevance for Altered
Hepatic Mitochondrial Bioenergetic in Steatosis, FEBS Lett. 580(8):2153-7.
4. António Ascenção, José Magalhães, José Soares, Rita Ferreira, Maria J.
Neuparth, Franklim Marques, Paulo J. Oliveira, José Duarte (2005)
Moderate Endurance Training Prevents Doxorubicin-induced in vivo
Mitochondriopathy and Reduces the Development of Cardiac Apoptosis,
Am. J. Physiol. Heart Circ. Physiol. 289 (2): H722 – H731.
5. Paulo J. Oliveira (2005) Cardiac Mitochondrial Alterations Observed in
Hyperglycaemic Rats – What Can We Learn From Cell Biology? Curr.
Diabetes Rev., 1 (1): 11 – 21.
6. Paulo J. Oliveira, James A. Bjork, Maria S. Santos, Richard L. Leino, M.
Kent Froberg, António J. Moreno and Kendall B. Wallace (2004)
Carvedilol-Mediated Antioxidant Protection Against Doxorubicin-Induced
Cardiac Mitochondrial Toxicity, Tox. Appl. Pharmacol. 200(2):159-68.
7. Paulo J. Oliveira, Raquel Seiça, Pedro M. Coxito, Anabela P. Rolo, Carlos
M. Palmeira, Maria S. Santos and António J. M. Moreno (2003), Enhanced
Permeability Transition Explains the Reduced Calcium Uptake in Cardiac
Mitochondria From Streptozotocin-Induced Diabetic Rats, FEBS Lett. 554:
511 – 514
Honors and awards
1. Prize for Merit from the University of Coimbra (1999)
2. PhD. fellowship Praxis XXI\BD\21494\99 from the Portuguese Foundation for
Science and Technology (2000-2003)
3. Pos-Doc Fellowship SFRH\BPD\ 8359\2002 from the Fundação Portuguesa
Para a Ciência e Tecnologia (2003-2008)
4. Best Young Researcher in Basic Investigation Prize, endorsed by the
Portuguese Cardiology Society, 2003 (co-author)Communication “Valsartan
Ameliorates the Rate of Phosphorylation During Acute Myocardial Ischemia”
5. Prize Aventis for Scientific Research 2003 “Toxicity of Caffeine on the Cardiac
Mitochondrial Function – Deregulation of Calcium Homeostasis and
Interactions with the Respiratory Chain” (co-author)
6. Prize for Best Young Researcher in Basic Investigation, endorsed by the
Portuguese Cardiology Society, 2004 (first author). Title of communication:
Advantages of the Use of Carvedilol Against Propranolol in the Protection of
Cardiac Mitochondrial Function