Table S7. BRCA1 classification results of lumB BRCA1 (n =9) and lumB sporadic (n = 48) tumors obtained using
leave-one-out cross-validation. See Materials and methods section for more details. Mutations are all known
pathogenic mutation described using HGVS nomenclature.
SampleID
Group
Age
Prediction
WHO
Grade Mutation
A086
A016
A120
A129
A133
A007
A125
A170
BRCA1
BRCA1
BRCA1
BRCA1
BRCA1
BRCA1
BRCA1
BRCA1
28
39
46
52
57
57
62
72
Sporadic
BRCA1
Sporadic
Sporadic
BRCA1
Sporadic
BRCA1
Sporadic
IDC
IDC
NA
IDC
IDC
IDC
IDC
IDC
1
1
NA
1
3
2
3
3
A174
BRCA1
74
BRCA1
IDC
3
K058
K046
K083
K079
K011
K123
K088
K074
K021
K056
K113
K114
K057
K064
K089
K055
K052
K148
K082
K155
K043
K031
K086
K108
K147
K179
K013
K175
K120
K151
K142
K091
K003
K150
K062
K133
K027
K019
K128
K054
K171
K165
K038
K101
K080
K066
K154
K045
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
36
43
43
43
44
44
47
48
49
50
50
50
51
51
53
54
58
60
60
61
63
64
64
64
65
66
69
71
72
72
74
74
75
75
75
76
77
78
81
82
83
85
85
85
86
87
88
89
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
BRCA1
Sporadic
Sporadic
Sporadic
BRCA1
BRCA1
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
Sporadic
BRCA1
BRCA1
Sporadic
Sporadic
BRCA1
Sporadic
Sporadic
Sporadic
BRCA1
Sporadic
Sporadic
BRCA1
Sporadic
Sporadic
Sporadic
BRCA1
Sporadic
Sporadic
BRCA1
Sporadic
Sporadic
IDC
IDC
IDC
IDC
IDC
IDC
IDC
ILC
IDC
IDC
IDC
IDC
IDC
IDC
IDC
Medullary
IDC
IDC
IDC
IDC
IDC
IDC
IDC
ILC
IDC
IDC
Other
IDC
IDC
IDC
NA
IDC
IDC
IDC
IDC
Other
IDC
IDC
IDC
IDC
IDC
IDC
IDC
ILC
Tubular
Mucinous
IDC
IDC
3
3
3
3
3
2
2
2
2
1
1
2
2
2
2
NA
3
3
2
2
2
2
2
NA
2
2
NA
3
2
2
NA
3
2
2
2
NA
2
2
2
3
1
1
2
NA
NA
NA
3
2
BRCA1 c.2475delC, Exon11, p.(Asp825Glufs*21)
BRCA1 c.2476delA, Exon11, p.(Thr826Glnfs*20)
BRCA1 c.2475delC, Exon11, p.(Asp825Glufs*21)
BRCA1 c.115T>G, Exon3, p.(Cys39Gly)
BRCA1 c.5266dupC, Exon20, p.(Gln1756Profs*74)
BRCA1 c.5503C>T, Exon24, p.(Arg1835*)
BRCA1 c.2475delC, Exon11, p.(Asp825Glufs*21)
BRCA1 c.4987-?_5193+?del, Exon17-19,
p.(Met1663_Glu1731del)
BRCA1 c.4987-?_5193+?del, Exon17-19,
p.(Met1663_Glu1731del)
-
Functional
effects
FS
FS
FS
MS
FS
NS
FS
Exon del (IF)
Exon del (IF)
Abbreviations: MS, missense mutation; FS, frameshift mutation; NS, nonsense mutation; IF, in-frame mutation