The place:
Instituto de Tecnologia Química e Biológica
Universidade Nova de Lisboa
The place:
OEIRAS
The place:
Instituto de Tecnologia Química e Biológica
Universidade Nova de Lisboa
Research divisons:
- Chemistry
- Biology
- Biological chemistry
- Technology
Supercritical fluid
processes
The people: Prof. Dr. Manuel Nunes da Ponte
Prof. Ana Aguiar Ricardo*
Prof. Pedro Simões*
Dr. Catarina Duarte
Post Doc:
Anna Banet
Joana Fonseca
Rui Ruivo
Teresa Casimiro*
Ph D students:
Vesna Najdanovic-Visak
Rita Duarte
Ana Serbanovic
Junior researchers:
Raquel Sousa
Ana Matias
Ana Nunes
*REQUIMTE – Research
Center of Excellence
The people:
Versailles 2003
Biarritz 2003
The work – Supercritical Fluid Processes
- Extraction from solids
- Fraccionation of complex liquid mixtures (liquid – liquid
extraction)
- Emulsions for protein transport
-Chemical Reaction: hydrogenation, oxidation with air,
polymerization
- Impregnation of polymeric matrixes with pharmaceuticals
- Phase Behavior Studies: solubility, VLE, polymer sorption
and swelling
The work – Supercritical Fluid Processes
Extraction from solids
Pilot plant
Laboratory scale
P
P
P
*
*
P
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T
P
The work – Supercritical Fluid Processes
Fraccionation of complex liquid mixtures
Emulsions for protein transport
Pilot plant
The work – Supercritical Fluid Processes
Liquid – liquid extraction
The work – Supercritical Fluid Processes
Chemical Reaction
Hydrogenation/Oxidation
Polymerization
The work – Supercritical Fluid Processes
Impregnation of polymeric matrixes with pharmaceuticals
Liquid
pump
CO2 pump
P
P
TC
P
Vac
CO2
Metering
valve
T
c
Extraction
cell
V1
Impregnation cell
The work – Supercritical Fluid Processes
Phase Behaviour Studies: Solubility measurements
CO2 Pump
5
P
Atm
Vac
CO2
2
P
TC
1
TC
4
3
T
B
C
The work – Supercritical Fluid Processes
Phase Behaviour Studies: vapour-liquid
equilibria
2
PT
PT
Atm
Vac
4
TC
5
T
B
C
3
CO2 pump
1
(1) CO2 compressor; (2) rupture disk; (3) thermostatic water bath; (4) six port sampling HPLC-valve; (5) HPLC-valve; (PT) pressure
transducer; (TC) temperature controller; (C) equilibrium cell with sapphire windows; (T) glass trap; (B) expansion calibrated cylinder.
The work – Supercritical Fluid Processes
Phase Behaviour Studies: polymer sorption and swelling
CO2 pump
Vac
TC
P
Atm
High pressure
cell
The work – Supercritical Fluid Processes
Relevant recent publications:
- “Production
of
phytosqualene
and
phytosqualane
compounds,
useful
for
e.g.
pharmaceutical/cosmetic industries, comprises integral carbon dioxide extraction, purification and
optional hydrogenation of saponified and dried residues”, DE Patent 19934834 (2001). Inventors:
Bus, A. Mueller, P. Swidersky, P. Bondioli, P. Simões, J.A.C. Fernandes
- "An apparatus for high-pressure VLE measurements using a static mixer. Results for (CO2 +
limonene + citral) and (CO2 + limonene + linalool)" J. Fonseca, P.Simoes, M. Nunes da Ponte J.
Supercritical Fluids, 2003, 25, 7-17
-- “Supercritical CO2 - induced Phase Changes in Ionic Liquid + Water + Ethanol Solutions:
Application to Biphasic Catalysis” V. Najdanovic-Visak, A. Serbanovic, J. M.S.S. Esperança, H. J.R.
Guedes,L.P.N. Rebelo, M. Nunes da Ponte ChemPhysChem 2003, 4, 1-6
-- “Fractionation of Edible Oil Model Mixtures by Supercritical Carbon Dioxide in a Packed Column –
Part II: A Mass Transfer Study”, R. Ruivo, M.J. Cebola, P.C. Simões, M. Nunes da Ponte,
Ind.Eng.Chem.Res., 2002, 41(9), 2305-2315 .
- “Phase Equilibrium for Capsaicin + Water + Ethanol + Supercritical Carbon Dioxide.” C. M. M.
Duarte, M. Crew, T. Casimiro, A. Aguiar Ricardo, M. Nunes da Ponte J. Supercritical Fluids, 2002,
22, 87-92
The work – Supercritical Fluid Processes
On-going projects:
- “EXTEN-Extraction and encapsulation of natural products” Program FAIR-ST8009 (Contract
nºCT96-1075; c/ DG XII - UE)
- ”Preparation of controlled release systems for ophthalmic applications”, Program Sapiens 2001
(Contract nºPOCTI/FCB/38213/2001)
- “Natural antioxidants” (POE –Medida 3.1,Contract: 03/2003/00068/192).
-………
The place:
Instituto de Tecnologia Química e Biológica
Universidade Nova de Lisboa