Volume 4
Supplement 2
September 2010
BMC
Proceedings
Abstracts of the 16th International
Charles Heidelberger Symposium on
Cancer Research
Coimbra, Portugal
26-28 September 2010
BMC-Proceedings-ICHSCR-ofc.indd 1
14/09/2010 15:23:05
Volume 4
Supplement 2
September 2010
BMC
Proceedings
Abstracts of the 16th International Charles Heidelberger
Symposium on Cancer Research
Coimbra, Portugal
26-28 September 2010
Committees
Symposium Chairs
Carlos Freire de Oliveira (Portugal)
Eli Huberman (USA)
International Advisory Committee
Joseph Landolph (USA)
Maria Carmen Alpoim (Portugal)
Local Organizing Committee
Ana Castro Jardim (FMUC)
Ana Daniela Sampaio (FCTUC)
Ana Margarida Urbano (FCTUC)
António Jorge Guiomar (FCTUC)
Armando Cristovão (FCTUC)
Carlos Freire de Oliveira (FMUC)
Isabel Maria Abrantes (FCTUC)
Isabel Marques Carreira (FMUC)
Joana Felício Cerveira (FCTUC)
Leonardo Manuel Ferreira (FCTUC)
Luís Miguel Pires (FMUC)
Maria Carmen Alpoim (FCTUC)
Maria Filomena Botelho (FMUC)
Marta Pinto Coelho (FMUC)
Paula Vasconcelos Morais (FCTUC)
Local Programme Committee
Ana Margarida Urbano (FCTUC)
Carlos Freire de Oliveira (FMUC)
Isabel Marques Carreira (FMUC)
Eli Huberman (USA)
Johan Lillehaug (Norway)
Joseph Landolph (USA)
Karl Heinrich Link (Germany)
Robert Langenbach (USA)
Toshio Kuroki (Japan)
Symposium Executive Committee
Eli Huberman (USA)
Johan Lillehaug (Norway)
Joseph Landolph (USA)
Karl Heinrich Link (Germany)
Secretariat
Maria Carmen Alpoim (FCTUC)
Maria Filomena Botelho (FMUC)
Paula Vasconcelos Morais (FCTUC)
Ana Paula Parreira
The Organization of the 16th International Charles Heidelberger Symposium on Cancer Research acknowledges the support of:
• FCTUC (Faculdade de Ciências e Tecnologia da Universidade de Coimbra)
• CIUC (Centro de Informática da Universidade de Coimbra)
• DIIC-UC (Divisão de Identidade, Imagem e Comunicação da Universidade de Coimbra)
• Turismo de Coimbra
• Turismo Centro de Portugal
• Bentham Science Publishers
Editor-in-Chief
Melissa Norton, MD (UK)
Editorial Board
Dan Benhamou (France)
Sally Blower (USA)
Itzhak Brook (USA)
Max Bulsara (Australia)
Roger Bumgarner (USA)
Rita Casadio (Italy)
Kevin Coombes (USA)
Julia Critchley (UK)
Lalit Dandona (India)
Chris Del Mar (Australia)
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Volume 4
Supplement 2
September 2010
BMC
Proceedings
Contents
Opening Lecture
O1 Inflammation, senescence and cancer: interweaving microRNA, inflammatory cytokines and p53 networks
Curtis C. Harris
Session 1 - Cancer Etiology and Epidemiology
O2 Gene-environment in the induction of cancer
Herman Autrup
O3 Gene variants and lung cancer risk
Nina E Landvik, Shanbeh Zienolddiny, Vidar Skaug, Aage Haugen
O4 Polychlorinated biphenyls (PCB), UV radiation, and cutaneous malignant melanoma
Richard P Gallagher, Tim K Lee, Jean-Philippe Weber, Alain Leblanc, Marilyn Borugian, J Mark Elwood, Amy C MacArthur, Zenaida Abanto,
John J Spinelli
P1
Abstract not submitted for publishing
P2
Association between night shift work, melatonin and estradiol in nurses
Beata Peplonska, Agnieszka Bukowska, Jolanta Gromadzinska, Wojciech Sobala, Edyta Reszka, Jenny A S Lie
P3
Mastermind-like 1 (MAML-1) as a new metastatic marker in esophageal squamous cell carcinoma
Mohammad M Forghanifard, Moein Farshchian, Reza Raeisossadati, Mohammad N Forghani, Meysam Moghbeli, Hussein Naseh,
Mohammad R Abbaszadegan
P4
Polymorphisms of GSTM1, GSTT1, GSTP1 and CYP1A1 genes and susceptibility to lung cancer
Paula Mota, Michelle Horta, Luis Mesquita, Henriqueta Silva
P5
Obesity and breast cancer: inflammatory and adipocytokine correlations
Paulo C Matafome, Ana L Gomes, Manuel Gomes, Lélita C Santos, Ana B Sarmento, Raquel F Seiça
P6
Polymorphisms of estrogen receptors, ERα and GPR30: association with breast cancer susceptibility and prognosis
Susana M Alves, Luís Mesquita, Rita Sousa, Fátima Peralta, Henriqueta C Silva
P7
Breast cancer and environmental factors
J Vicente Paulo, Lélita Santos, Graça Fernandes
P8
Primary bone lymphoma
C Pissarro C Azevedo, P José A F F Tavares, M Isabel P Portela, A José L C P Santos, J Manuel P S Casanova
Session 2 - Molecular Carcinogenesis
O5 Regulation of DNA damage responses by mismatch repair
Anatoly Zhitkovich
O6 Insoluble Ni compound-induced gene amplification/gene silencing causes over-expression of microtubules/microfilaments, cell
shape changes, and de-regulation of global gene expression/Ca+2 gradients, inducing morphological/ neoplastic transformation of
10T1/2 mouse embryo cells
Joseph Landolph, Aruni DeSilva, Duy Mai, Jim K. Lin, Jimmy Zheng
Volume 4
Supplement 2
September 2010
BMC
Proceedings
Contents
O7 The bioenergetic signature of cancer
José M. Cuezva
O8 Roles of beta-arrestin1/2 in prostaglandin-mediated signaling and tumor development
Robert Langenbach, Huei-Chen Lao, Kyung-Soo Chun
O9 PINK1/BRPK inhibits apoptotic cell death and enahances cellular invasiveness through an activation of mTORC2 pathway
Hitoshi Murata, Masakiyo Sakaguchi, Ken Kataoka, Nam-ho Huh
O10 Receptor for activated C-kinase (RACK1) plays a central role in Ras-mediated signal transduction
Johan R Lillehaug, Line M Myklebust, Arnt Raae, Bodil Bjørndal
P9
The role of CD26 and CD40 expression in therapeutic response - experimental study in oral cancer lines
Joana P N Batista, Sílvia S Neves, A Cristina Gonçalves, Vera Alves, Ana Sarmento-Ribeiro, Marília Dourado
P10 Abstract not submitted for publishing
P11 Evaluation of the role of miR-34b in modulation of radioresistance in non-small cell lung cancer
Joana B Silva, Sílvia S Neves, A Cristina Gonçalves, Margarida Marques, Luís Mesquita, Filomena Botelho, A Bela Sarmento-Ribeiro,
Henriqueta C Silva
P12 P-cadherin expression in feline mammary tissues
A Catarina Figueira, Júlio Carvalheira, M Manuela Lacerda, M Fátima Gärtner
P13 Regucalcin, a calcium-binding protein, is a new target gene in human prostate cancer?
Cláudio J Maia, Cátia V Vaz, Carina G Peres, Cecília R A Santos, Sílvia Socorro
P14 MicroRNA-21 in lung cancer: overexpression in metastasis of pulmonary adenocarcinomas and squamous cell carcinomas
Maria R Silva, Paulo Santos, Isabel Velada, Catarina Gomes, M João d’Aguiar, Lia Teixeira, João Dinis, Susana Carmona, Luisa Cortes,
Lina Carvalho
P15 Involvement of mitochondrial and survival signaling in berberine-induced apoptosis in melanoma cells
Ana Burgeiro, Consuelo Gajate, El H Dakir, Paulo J Oliveira, Faustino Mollinedo
P16 Metabolic changes in human bronchial epithelial cells upon chronic exposure to hexavalent chromium
Leonardo M R Ferreira, Maria S Santos, M Carmen Alpoim, Ana M Urbano
P17 Cr(VI)-induced malignant transformation of a bronchial epithelial cell line association with altered mitochondria and bioenergetic
phenotypes
Ana Sampaio, Luís Mendes, Ana C Gonçalves, Margarida Abrantes, Ana B Sarmento, Filomena Botelho, Paulo Oliveira, Vilma Sardão,
Rui Carvalho, Ana M Urbano and M Carmen Alpoim
Session 3 - Tumor Microenvironment and Tumor Cell Biology
O11 Tumor Microenvironment Controls the Rate of Cancer Progression and Metastasis
Raghu Kalluri
O12 Metabolism and metastasis: in the bone marrow and beyond
Sérgio Dias
O13 The Immune Biology of Microsatellite Unstable Cancer
Magnus von Knebel-Doeberitz
O14 Targeting secreted heat shock protein-90alpha (Hsp90α) to prevent breast cancer progression
Zhengwei Zhao, Chieh-Fang Cheng, Rosie Kim, Mei Chen, David T Woodley, Wei Li
Volume 4
Supplement 2
September 2010
BMC
Proceedings
Contents
O15 JAKs and STATs in Chemoresistance
Ana Costa-Pereira
O16 Autophagy turns specific: the discovery of p62 and NBR1 as autophagy cargo receptors
Geir Bjørkøy
P18 Abstract not submitted for publishing
P19 Abstract not submitted for publishing
P20 Relation between autophagy and the resistence of glioblastoma cells to temozolomide
Anália Carmo, Helena Carvalheiro, Maria C Lopes
P21 GLUT expression and 18F-FDG uptake in breast cancer cell lines
Ana M Abrantes, Mónica Martins, Ana C Gonçalves, Maria C Rodrigues, Ana C Mamede, Sónia D Tavares, José M Lima, Adriano Rodrigues,
Ana B Sarmento-Ribeiro, Maria F Botelho
P22 MDR modulation in colorectal adenocarcinoma cell lines: kinetic studies using 99mTc-sestamibi
João Casalta-Lopes, A Margarida Abrantes, Joana Rio, Mafalda Laranjo, Bárbara Oliveiros, A Cristina Gonçalves, Ana B. Sarmento-Ribeiro,
M. Filomena Botelho
P23 Phenotypic analysis of breast cell lines – triple negative cells vs expressing hormonal receptors
Mafalda Laranjo, Maria J Carvalho, Artur Paiva, A Margarida Abrantes, Isabel Torgal, Carlos F Oliveira, M Filomena Botelho
P24 Abstract not submitted for publishing
P25 A nonconjugated naphthalene derivative of meso-tetra-(3-hydroxy)-phenyl-porphyrin as a sensitizer for photodynamic therapy
Abílio J F N Sobral, Ana M Urbano, Pedro Silva, Sofia M Fonseca, Cláudia T Arranja, Hugh D Burrows
P26 Polyaromatic hydrocarbons accentuate malignant phenotype of the PC3 prostate cancer cell line
Mariana O Freitas, José Oliveira, Ana M Fernandes, Maria I Coutinho, Vera Alves, Anabela Mota-Pinto, Ana B Sarmento-Ribeiro
P27 MGBG–cisplatin combination chemotherapy against breast cancer
Raquel F Gonsalves, Maria P M Marques
P28 Melanoma skin cancer: could chromone derivatives be efficient chemopreventors?
Mafalda M Dias, Maria P M Marques
P29 Exosomes from human ovarian carcinoma SKOV3 cells are enriched in glycosylated proteins
Cristina Escrevente, Peter Altevogt, Júlia Costa
P30 Delocalized lipophilic cations as a new therapeutic approach in cancer
A Barbosa Ribeiro, A Luísa Ferreira, A Cristina Gonçalves, Sílvia Neves, A Maria Araújo, Filipa Carvalho, João Carvalho, Rui M Santos, Vera
Alves, Teresa Silva, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P31 Cytotoxic effect induced by combination of polyamines metabolites and endocannabinoid, anandamide, on human cancer cells: a
new anticancer strategy
A Lúcia M Batista-de-Carvalho, G Tempera, N Viceconte, S Saccoccio, E Bidollari, M Nalli, Enrico Morera, Giorgio Ortar, Enzo Agostinelli
P32 An in vitro tumor-fibroblast interaction model of human oral squamous cell carcinoma
Jozséf Dudás, M Bitsche, V Schartinger, G M Sprinzl, H Riechelmann
P33 Physiologic parameters variation in ICR mice during a chemical induced liver carcinogenesis experiment
Ivo Conceição-Pereira, Nuno M Paula-Santos, Filipa O Pereira, Maria J Pires, Luis F Palomino, Aura A Colaço, Paula A Oliveira
P34 Role of VEGF signalling in the regulation of KDR expression in endothelial and tumoral microenvironment
Jacinta Serpa, Cheila Torre, Francisco Caiado, Sérgio Dias
Volume 4
Supplement 2
September 2010
BMC
Proceedings
Contents
P35 EP4-mediated prostanoid signalling promotes oral cancer progression
Karen Sapienza, Stewart Sale, Angela Hague, Ian.R. Hart, J.ohn F. Marshall, Gareth.J. Thomas
P36 Role of notch pathway and HNF1 in cell death induced by HDACs inhibitors in ovarian cancer cell lines, serous and clear cells
Fernanda Silva, Jacinta Serpa, Germana Domingues, Gabriela Silva, António Almeida, Ana Félix
P37 TRAP1 and SORCIN cooperate in a survival pathway responsible for inducing drug-resistance in human colorectal carcinoma (CRC)
Matteo Landriscina, Francesca Maddalena, Gabriella Laudiero, Maria R Amoroso, Annamaria Piscazzi, Valentina Lombardi, Alberto Fersini,
Franca Esposito
P38 Dll4 blockade interferes with the bone marrow vascular niche and perturbs hematopoietic recovery following myeloablation
Leonor Remédio, Tânia Carvalho, Sérgio Dias
P39 Short-chain sphingolipids for enhanced cellular uptake of liposome-encapsulated amphiphilic anti-cancer drugs
Lília R C Pedrosa, Albert van Hell, Wim van Blitterswijk, Ann L B Seynhaeve, Alexander M M Eggermont, Timo L M ten Hagen, Marcel Verheij,
Gerben A Koning
P40 Osteosarcoma contains a subpopulation of cancer stem-like cells that are highly resistant to radiotherapy
Sara R M Neves, Aurio O G Lopes, Anália do Carmo, Antero J Abrunhosa, Paulo C P S Simões, Artur A Paiva, M Filomena Botelho,
Célia M F Gomes
P41 Indentification of cancer stem-like cells in osteosarcoma and their implications in response to chemotherapy
Áurio O Lopes, Sara R Neves, Anália do Carmo, Artur A Paiva, Maria Botelho, Célia M Gomes
P42 Metabolic responses of A549 lung cells to cisplatin and radiation exposure studied by 1H NMR spectroscopy
Ana F Ladeirinha, Inês D Lamego, Ana M Gil, Joana B Melo, Isabel M Carreira, Iola F Duarte
P43 In vivo pulmonary metastatic profile of breast cancer cell lines expressing hormonal receptors versus triple negative
M João Carvalho, A Margarida Abrantes, Mafalda Laranjo, Francisco Falcão, Sofia Cabrita, M Filomena Botelho, Carlos F de Oliveira,
Isabel Torgal
P44 New targeted therapies in myelodysplastic syndrome: the role of farnesyltransferase and proteasome inhibitors
A Cristina Gonçalves, Ana Oliveira, Diana Moreira, Silvia Neves, Vera Alves, Teresa Silva, Luís Mesquita, Henriqueta Coimbra,
Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P45 Targeted gene silencing for cancer treatment
Lígia C G da Silva, José S Ramalho, M Conceição P de Lima, Sérgio Simões, João N Moreira
P46 Recombinant trail: a synergistic effect in myeloid leukemias
Filipa Carvalho, A Sofia Coelho, Cátia Domingues, João A Carvalho, André Ribeiro, Rui M Santos, A Cristina Gonçalves , Vera Alves,
Teresa Silva, Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P47 Co-expression of E- and P-cadherin in breast cancer: role as an invasion suppressor or as an invasion promoter?
Ana S Ribeiro, Laura C Carreto, André Albergaria, Bárbara Sousa, Sara Ricardo, Fernanda Milanezi, Raquel Seruca, Manuel A Santos,
Fernando Schmitt, J oanaParedes
P48 Contribution of Thomsen-Friedenreich antigens to bladder cancer malignancy: Characterization of cell line models
Paulo F Severino, Mylène A Carrascal, Helena Gouveia, M Guadalupe Cabral, Manuela Correia, Nadia Malagolini, Mariella Chiricolo,
Fabio Dall’Olio, Paula AVideira
P49 Antitumoral effect of farnesiltransferase and mtor inhibitors in hepatocellular carcinoma: in vitro studies
Ana M Araújo, Sílvia S Neves, Ana L Ferreira, Diogo Branco, Ana B Sarmento-Ribeiro, José M Nascimento-Costa
Volume 4
Supplement 2
September 2010
BMC
Proceedings
Contents
P50 Metalloproteinase inhibitors as a potential therapeutic approach in multiple myeloma: a preliminary study
A Sofia Pais, A Cristina Gonçalves, Catarina Geraldes, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P51 Novel antitumor DNA monoalkylating agents: Synthesis and biological evaluation
Ana F Brito, M Isabel Soares, Mafalda Laranjo, A Margarida Abrantes, José A Paixão, Ana M Beja, Manuela R Silva, Teresa P Melo, M Filomena
Botelho
P52 The effect of cisplatin in 5637 bladder cancer cell line
Rosário Pinto-Leite, Regina Arantes-Rodrigues, M Luís Cardoso, Lúcio Santos, Paula A Oliveira
Session 4 - Cancer Genetics and Epigenetics
O17 CDH3/P-cadherin overexpression in breast carcinomas: its regulatory mechanisms, the role in cell invasion, and the association with
cancer stem cell properties
Joana Paredes
O18 Spontaneous development of lung adenocarcinoma in the CADM1 gene-deficient mice
Masayoshi Nagata, Mika Sakurai-Yageta, Daisuke Yamada, Taketo Kawai, Yumi Tsuboi, Takeshi Ito, Akihiko Ito, Midori Yoshida,
Yoshinori Murakami
O19 The FRAGILOME project, a strategy for the discovery of new gene biomarkers in cancer
Manfred Schwab
O20 Gene amplification in breast cancer – looking for the molecular mechanisms
Sergei Kovalenko
O21 Molecular Genetic Study of Female Cancers in Novosibirsk, Russia
Lyudmila F Gulyaeva
O22 E-cadherin mediated cellular effects and molecular partners. Gastric cancer as an invasive model
Joana Figueiredo, Joana Simões-Correia, Joana Fernandes, Ana R Mateus, Gianpaolo Suriano, Joana Paredes, Carla Oliveira, Raquel Seruca
P53 Identification of copy number variations of chromosomes 7, 9 and 10 in human glioblastomas by SNP-arrays
Inês Crespo, Maria D Tabernero, Ana B Nieto, Olinda Rebelo, Hermínio Tão, Fernando Gomes, Catarina R Oliveira, Maria C Lopes,
Alberto Orfao
P54 Circadian gene variants and MT6s level in nurses under different work shifts – preliminary results
Edyta Reszka, Beata Peplonska, Edyta Wieczorek, Jolanta Gromadzinska, Wojciech Sobala, Wojciech Wasowicz, Agnieszka Bukowska,
Jenny A Lie
P55 MFSD2A is a novel lung tumour suppressor gene whose expression is modulated by a 5’-region polymorphism
Francesca Colombo, Monica Spinola, Felicia S Falvella, James P Sullivan, David S Shames, Luc Girard, Paola Spessotto, John D Minna,
Tommaso A Dragani
P56 FGFR4 GLY388ARG polymorphism modulates cancer patients’ survival in pooled analysis
Elisa Frullanti, Tommaso A Dragani
P57 KRAS and EGFR mutations coexisting in lung adenocarcinoma
Vitor Sousa, Ana Alarcão, Patricia Couceiro, Maria R Silva, Maria J d’Aguiar, Lia Teixeira, Lina Carvalho
P58 Modulation of DNA damage prevention and signaling pathways in diet induced colon cancer prevention
Dalila F N Pedro, Alice A Ramos, Cristóvão F Lima, Fátima Baltazar, Cristina Pereira-Wilson
Volume 4
Supplement 2
September 2010
BMC
Proceedings
Contents
P59 MIR-143 over-expression reduces the growth of xenograft tumors from colon carcinoma cells
Pedro M Borralho, Sofia Gomes, Raquel T Lima, Rui E Castro, Maria H Vasconcelos, Cecília M P Rodrigues
P60 Histone deacetylation - a new epigenetic target in cancer
João A Carvalho, Emília Cortesão, José D Branco, Ana C Gonçalves, Sílvia Neves, Filipa Carvalho, André Ribeiro, Vera Alves, Teresa Silva,
Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P61 EGFR unusual mutation status in lung adenocarcinomas
Ana Alarcão, Vitor Sousa, Patrícia Couceiro, Maria Silva, Maria J. d’Aguiar, Lia Teixeira, Lina Carvalho
P62 Identification of a common deletion region in 10q26 associated with human gliomas
Margarida Alves, Paulo Liberato, Ana Rita Conde, Manuela Mafra, Alexandra Inverno, Ana Teresa Maia, Denise Bagrel, Isabel Carreira,
Miguel Brito, Carolino Monteiro
P63 STEAP1 expression in prostate cancer and its regulation by androgens
Inês Gomes, Cecília R A Santos, Sílvia Socorro, Carlos Lopes, Cláudio J Maia
P64 EGFR/erb-1, HER2/erb-2, CK7, LP34, Ki67 and p53 expression in preneoplastic lesions of bronchial epithelium
Lina Carvalho, Joana E Santo, Ana Alarcão, Patricia Couceiro, Maria R Silva, Ana Gomes, Maria J d’Aguiar, Lia Teixeira, Vitor Sousa
Session 5 - Translational Cancer Medicine
O23 Quality control in colon and rectal cancer surgery
Karl-Heinrich Link
O24 Detecting tumor responses to treatment using hyperpolarized 13C magnetic resonance spectroscopic imaging
Kevin M Brindle
O25 Tumor-tailored treatment of colorectal cancer: from bench to bedside?
Marko Kornmann
O26 Targeting non-viral vectors to tumor cells and the tumor microenvironment
Vera Moura, Manuela Lacerda, Paulo Figueiredo, M Luísa Corvo, M Eugénia M Cruz, M Conceição P. de Lima, Sérgio Simões, João N Moreira
O27 Adjuvant therapy in colorectal cancer – studies of the FOGT group
Ludger Staib, Marko Kornmann, Karl-Heinrich Link
O28 “Omic” landscapes of breast cancer - the end of the beginning
Carlos Caldas
O29 Bacterial anticancer weapons: a promising tool to fight cancer
Ananda M Chakrabarty
P65 Improving the classification of brain tumors in mice with perturbation enhanced (PE)-MRSI
Rui V Simões, Sandra Ortega-Martorell, Teresa Delgado-Goñi, Yann le Fur, Marti Pumarola, Ana P Candiota, Patrick J Cozzone,
Margarida Juliá-Sapè, Carles Arús
P66 NMR metabonomic study of lung cancer: metabolic profiling of tissues
Cláudia M Rocha, António S Barros, Ana M Gil, Brian J Goodfellow, Isabel M Carreira, João Bernardo, Ana Gomes, Vítor Sousa, Lina Carvalho,
Iola F Duarte
P67 NMR metabonomic study of lung cancer: metabolic profiling of urine and blood plasma
Joana Carrola, Cláudia M Rocha, António S Barros, Ana M Gil, Brian J Goodfellow, Isabel M Carreira, João Bernardo, Ana Gomes, Vitor Sousa,
Lina Carvalho, Iola F Duarte
http://www.uc.pt/en/congressos/16ICHSCR | [email protected]
SCIENTIFIC PROGRAM
DAY 1
Sunday, 26 September 2010
09H00−09H30
Opening Ceremony
Joseph Landolph (USA), Eliezer Huberman (USA), Maria Carmen Alpoim (Portugal) and Carlos de Oliveira (Portugal)
Opening Lecture
09H30−10H30
Curtis Harris, Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD, USA
Interweaving p53, Innate Immune and MicroRNA Networks in Human Carcinogenesis and
Molecular Epidemiology
10H30−11H00
Coffee Break
Session 1 – Cancer Etiology and Epidemiology
11H00−11H30
Herman Autrup
School of Public Health, University of Aarhus, Aarhus, Denmark
Gene-environment Interaction in
Cancer Development
Aage Haugen
11H30−12H00
Section of Toxicology, National Institute of Occupational Health, Oslo,
Norway
Institute of Biotechnology, Norwegian University of Science and
Technology, Trondheim, Norway
Gene Variants and Lung Cancer
Risk
Richard Gallagher
12H00−12H30
12H30−14H00
Cancer Control Research, British Columbia Cancer Agency,
Vancouver, BC, Canada
School of Population and Public Health, University of British Columbia,
Vancouver, BC, Canada
Polychlorinated Biphenyls
(PCB), UV Radiation, and
Cutaneous Malignant Melanoma
Lunch
Session 2 − Molecular Carcinogenesis
Anatoly Zhitkovich
14H00−14H30
Department of Pathology and Laboratory Medicine, Division of Biology
and Medicine, Brown University, Providence, RI, USA
Joseph Landolph
14H30−15H00
Keck School of Medicine, University of Southern California, Los
Angeles, CA, USA
School of Pharmacy, University of Southern California, CA, USA
USC/Norris Comprehensive Cancer Center, University of Southern
California, CA, USA
Regulation of DNA Damage
Responses by Mismatch Repair
Insoluble Ni Compound-induced
Gene Amplification/Gene Silencing
Causes Over-expression of
Microtubules/Microfilaments, Cell
Shape Changes, and Deregulation of
Global Gene Expression/Ca2+
Gradients, Inducing
Morphological/Neoplastic
Transformation of 10T1/2 Mouse
Embryo Cells
José Manuel Cuezva
15H00−15H30
15H30−16H00
Centro de Biología Molecular “Severo Ochoa”, Universidad Autónoma
de Madrid, Spain
CIBER de Enfermedades Raras, Instituto de Salud Carlos III,
Universidad Autónoma de Madrid, Madrid, Spain
Coffee Break
Robert Langenbach
16H00−16H30
Laboratory of Toxicology and Pharmacology, National Institute of
Environmental Health Sciences, National Institutes of Health,
Research Triangle Park, NC, USA
Nam-ho Huh
16H30−17H00
Department of Cell Biology, Okayama University Graduate School of
Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Johan Lillehaug
17H00−17H30
The Bioenergetic Signature of
Cancer
Department of Molecular Biology, University of Bergen, Bergen,
Norway
Roles of Beta-arrestin1/2 in
Prostaglandin-mediated
Signaling and Tumor
Development
PINK1/BRPK Inhibits Apoptotic
Cell Death and Enhances
Cellular Invasiveness Through
an Activation of mTORC2
Pathway
Receptor for Activated C-Kinase
(RACK1) Plays a Central Role in
Ras-mediated Signal
Transduction
DAY 2
Monday, 27 September 2010
Session 3 − Tumor Microenvironment and Tumor Cell Biology
Raghu Kalluri
09H00−09H30
Harvard Medical School, Harvard University, Boston, MA, USA
Beth Israel Deaconess Medical Center, Boston, MA, USA
The Role of Fibroblasts and
Pericytes in Cancer Progression
and Metastasis
Sérgio Dias
09H30−10H00
Centro de Investigação em Patobiologia Molecular (CIPM),
Portuguese Institute of Oncology (IPOFG), Lisbon, Portugal
Instituto Gulbenkian de Ciência, Oeiras, Portugal
Metabolism and Metastasis: In
the Bone Marrow and Beyond
Magnus von Knebel Doeberitz
10H00−10H30
10H30−11H00
Department of Applied Tumor Biology, Institute of Pathology,
University of Heidelberg, Heidelberg, Germany
Clinical Cooperation Unit, Applied Tumor Biology (G105), German
Cancer Research Center (DKFZ), Heidelberg, Germany
Coffee Break
Wei Li
11H00−11H30
The Immune Biology of
Microsatellite Unstable Cancer
Department of Dermatology, University of Southern California Keck
School of Medicine, Los Angeles, CA, USA
USC-Norris Comprehensive Cancer Center, University of Southern
California, Los Angeles, CA, USA
Targeting Secreted Heat Shock
Protein-90alpha (Hsp90α) to
Prevent Breast Cancer
Progression
Ana Costa-Pereira
11H30−12H00
12H00−12H30
12H30−14H00
Division of Cancer, Department of Surgery and Cancer, Faculty of
Medicine, Imperial College, London, UK
Hammersmith Hospital, London, UK
Geir Bjørkøy
AFT, Sør-Trøndelag University College (HiST), Trondheim, Norway
JAKs and STATs in
Chemoresistance
Autophagy Turns Specific: The
Discovery of p62 and NBR1 as
Autophagy Cargo Receptors
Lunch
Session 4 − Cancer Genetics and Epigenetics
Joana Paredes
14H00−14H30
Cancer Genetics Group, Institute of Molecular Pathology and
Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Yoshinori Murakami
14H30−15H00
15H00−15H30
15H30−16H00
Division of Molecular Pathology, Institute of Medical Science,
University of Tokyo, Tokyo, Japan
Manfred Schwab
German Cancer Research Center (DKFZ), Heidelberg, Germany
Coffee Break
Sergei Kovalenko
16H00−16H30
CDH3/P-Cadherin
Overexpression in Breast
Carcinomas: Its Regulatory
Mechanisms, the Role in Cell
Invasion, and the Association
With Cancer Stem Cell
Properties
Spontaneous Development of
Lung Adenocarcinoma in the
Cadm1 Gene-Deficient Mice
The FRAGILOME Project, a
Strategy for the Discovery of
New Gene Biomarkers in Cancer
Laboratory of Gene Engineering, Institute of Molecular Biology and
Biophysics, Academy of Medical Sciences, Siberian Branch,
Novosibirsk, Russia
Novosibirsk State University, Novosibirsk, Russia
Gene Amplification in Breast
Cancer Cells: Molecular
Mechanisms and
Possible Prognostic Value
Lyudmila Gulyaeva
16H30−17H00
Laboratory of Molecular Carcinogenesis, Institute of Molecular Biology
and Biophysics, Russian Academy of Medical Sciences, Siberian
Division, Novosibirsk, Russia
Medical Department, Novosibirsk State University, Novosibirsk, Russia
Raquel Seruca
17H00−17H30
Cancer Genetics Group, Institute of Molecular Pathology and
Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Molecular Genetic Study of
Female Cancers in Novosibirsk,
Russia
E-Cadherin Mediated Cellular
Effects and Molecular Partners.
Gastric Cancer as an Invasive
Model
DAY 3
Tuesday, 28 September 2010
Session 5 − Translational Cancer Medicine
Karl-Heinrich Link
09H00−09H30
Surgical Center and Asklepios Tumor Treatment Center Rhein-Main
(ATC), Asklepios Paulinen Klinik (APK), Wiesbaden, Germany
Kevin Brindle
09H30−10H00
Department of Biochemistry, University of Cambridge, UK
Cancer Research UK, Cambridge Research Institute, Cambridge, UK
Marko Kornmann
10H00−10H30
10H30−11H00
Hospital for General, Visceral and Transplantation Surgery, Ulm
University, Ulm, Germany
Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal
Centre for Neurosciences and Cell Biology, Coimbra, Portugal
Ludger Staib
11H30−12H00
Detecting Tumour Responses to
Treatment Using Hyperpolarized
13
C Magnetic Resonance
Spectroscopic Imaging
Tumor-tailored Treatment of
Colorectal Cancer: From Bench
to Bedside?
Coffee Break
João Nuno Moreira
11H00−11H30
Quality Control in Colon and
Rectal Cancer Surgery
Department of General and Visceral Surgery, Klinikum Esslingen,
Esslingen, Germany
Targeting Non-viral Vectors to
Tumor Cells and the Tumor
Microenvironment
Adjuvant Therapy in Colorectal
Cancer – Studies of the FOGT
Group
Carlos Caldas
12H00−12H30
Department of Oncology, University of Cambridge, Cambridge, UK
Cambridge Experimental Cancer Medicine Centre, Cambridge, UK
Cancer Research UK, Cambridge Research Institute, Cambridge
Breast Cancer Research Unit, Cambridge, UK
NIHR Cambridge Biomedical Research Centre, Cambridge, UK
Ananda M. Chakrabarty
12H30−13H00
13H00−14H30
Afternoon
Department of Microbiology & Immunology, University of Illinois
College of Medicine, Chicago, IL, USA
Lunch
Half-day Tour
'Omic' Landscapes of Breast
Cancer – The End of the
Beginning
Bacterial Anticancer Weapons:
A Promising Tool to Fight
Cancer
Committees
Symposium Chairs
Carlos Freire de Oliveira (Portugal), Eli Huberman (USA), Joseph Landolph (USA), Maria
Carmen Alpoim (Portugal)
Local Organizing Committtee
Ana Castro Jardim (FMUC), Ana Daniela Sampaio (FCTUC), Ana Margarida Urbano
(FCTUC), António Jorge Guiomar (FCTUC), Armando Cristovão (FCTUC), Carlos Freire de
Oliveira (FMUC), Isabel Maria Abrantes (FCTUC), Isabel Marques Carreira (FMUC), Joana
Felício Cerveira (FCTUC), Leonardo Manuel Ferreira (FCTUC), Luís Miguel Pires (FMUC),
Maria Carmen Alpoim (FCTUC), Maria Filomena Botelho (FMUC), Marta Pinto Coelho
(FMUC), Paula Vasconcelos Morais (FCTUC)
Local Programme Committee
Ana Margarida Urbano (FCTUC), Carlos Freire de Oliveira (FMUC), Isabel Marques Carreira
(FMUC), Maria Carmen Alpoim (FCTUC), Maria Filomena Botelho (FMUC), Paula
Vasconcelos Morais (FCTUC)
International Advisory Committee
Eli Huberman (USA), Johan Lillehaug (Norway), Joseph Landolph (USA), Karl Heinrich Link
(Germany), Robert Langenbach (USA), Toshio Kuroki (Japan)
Symposium Executive Committee
Eli Huberman (USA), Johan Lillehaug (Norway), Joseph Landolph (USA), Karl Heinrich Link
(Germany)
Secretariat
Ana Paula Parreira
Acknowledgements
The Organization of the 16th International Charles Heidelberger Symposium on Cancer
Research acknowledges the support of:
• FCTUC (Faculdade de Ciências e Tecnologia da Universidade de Coimbra)
• CIUC (Centro de Informática da Universidade de Coimbra)
• DIIC-UC (Divisão de Identidade, Imagem e Comunicação da Universidade de Coimbra)
• Turismo de Coimbra
• Turismo Centro de Portugal
• Bentham Science Publishers
LIST OF PARTICIPANTS
AUSTRALIA
Stewart, Bernard W.
SE Sydney Public Health Unit, Sidney, Australia
[email protected]
AUSTRIA
Dudás, Jozséf
Medical University Innsbruck, ENT-Clinic, Innsbruck, Austria
[email protected]
CANADA
Gallagher, Richard P.
Cancer Control Research Program, British Columbia Cancer Agency, Vancouver, BC, Canada; School of
Population and Public Health, University of British Columbia; Vancouver, BC, Canada
[email protected]
CZECH REPUBLIC
Mejsnar, George A.
Cytolab Ltd, Praha, Czech Republic
[email protected]
DENMARK
Autrup, Herman
School of Public Health, University of Aarhus, Aarhus, Denmark
[email protected]
GERMANY
von Knebel Doeberitz, Magnus
Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany, and
Clinical Cooperation Unit, Applied Tumor Biology (G105), German Cancer Research Center (DKFZ), Heidelberg,
Germany
[email protected]
Kornmann, Marko
Department of General, Visceral, and Transplantation Surgery, University of Ulm, Ulm, Germany
[email protected]
Link, Karl-Heinrich
Surgical Center and Asklepios Tumortreatment Center Rhein-Main (ATC),
Asklepios Paulinen Klinik (APK), Wiesbaden, Germany
[email protected]
Schwab, Manfred
German Cancer Research Center (DKFZ), Heidelberg, Germany
[email protected]
Staib, Ludger
Department of General and Visceral Surgery, Klinikum Esslingen, Esslingen, Germany
[email protected]
IRAN
Forghanifard, Mohammad M.
Islamic Azad University, Damghan, Iran
[email protected]
ITALY
Colombo, Francesca
Fondazione IRCCS Istitito Nazionale Tumori, Milan, Italy
[email protected]
Frullanti, Elisa
Fondazione IRCCS Istitito Nazionale Tumori, Milan, Italy
[email protected]
Landriscina, Matteo
University of Foggia, Department of Medical Sciences, Clinical Oncology Unit, Foggia, Italy
[email protected]
JAPAN
Huh, Nam-ho
Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical
Sciences, Okayama, Japan
[email protected]
Kuroki, Toshio
University of Tokyo,
Research Center for Science Systems
[email protected]
Murakami, Yoshinori
Division of Molecular Pathology, Institute of Medical Science, University of Tokyo,Tokyo, Japan
[email protected]
NORWAY
Bjørkøy, Geir
AFT, Sør-Trøndelag University College (HiST), Trondheim, Norway
University College of Sør-Trøndelag; University of Tromsø, Norway
[email protected]
Haugen, Aage
Section of Toxicology, National Institute of Occupational Health, Oslo Norway; Institute of Biotechnology,
Norwegian University of Science and Technology, Trondheim, Norway
[email protected]
Lillehaug, Johan R.
Department of Molecular Biology, University of Bergen, Bergen, Norway
[email protected]
POLAND
Bukowska, Agnieszka
Noffer Institute of Occupational Medicine, Lodz, Poland
[email protected]
Reszka, Edyta
Noffer Institute of Occupational Medicine, Lodz, Poland
[email protected]
PORTUGAL
Abrantes, Ana M.
Biophysics/Biomathematics Institute, IBILI, Faculdade de Medicina da Universidade de Coimbra, Coimbra,
Portugal
[email protected]
Abrantes, Isabel M.
Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra,
Portugal
[email protected]
Alarcão, Ana
Instituto de Anatomia Patológica - Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
[email protected]
Alpoim, Maria C.
Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra,
Portugal
[email protected]
Alves, Susana M.
Serviço de Genética Médica da Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
[email protected]
Arantes, Regina M.
Department of Veterinary Sciences, CECAV, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
[email protected]
Araújo, Ana M.
Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
[email protected]
Batista, Joana P.
Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal
[email protected]
Batista de Carvalho, Ana
Molecular Physical-Chemistry R&D Unit, Faculty of Sciences and Technology, University of Coimbra, Coimbra,
Portugal
[email protected]
Borralho, Pedro M.
Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy of the University
of Lisbon (FFUL), Lisbon, Portugal
[email protected]
Botelho, Maria F.
Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
[email protected]
Brito, Ana F.
Biophysics/Biomathematics Institute; Faculty of Medicine; University of Coimbra, Coimbra, Portugal.
[email protected]
Burgeiro, Ana A.
CNC - Centro de Neurociências e Biologia Celular, Coimbra, Portugal
[email protected]
Carmo, Anália G.
CNBC - Center for Neuroscience and Cell Biology, Coimbra, Portugal
[email protected]
Carrola, Joana Q.
CICECO, Aveiro, Portugal
[email protected]
Carvalho, Filipa V.
Medicine Faculty of the University of Coimbra, Coimbra, Portugal
[email protected]
Carvalho, João A.
Faculty of Medicine of the University of Coimbra, Coimbra, Portugal
[email protected]
Carvalho, Lina M.
Instituto de Anatomia Patológica, FMUC, Coimbra, Portugal
[email protected]
Carvalho, M. João
CIMAGO, Medicine Faculty of the University of Coimbra /Gynaecology Service, University Hospitals of Coimbra /
Biophysics and Biomathematics Institute, IBILI, Medicine Faculty of Coimbra, Coimbra, Portugal
[email protected]
Carreira, Isabel M.
Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
[email protected]
Cerveira, Joana F.
Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra,
Portugal
[email protected]
Coelho, Marta P.
Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
[email protected]
Cortesão, Emília N.
University Hospitals of Coimbra/ACIMAGO, Coimbra, Portugal
[email protected]
Crespo, Ana I.
Faculdade de Farmácia da Universidade de Coimbra, Coimbra, Portugal
[email protected]
Cristovão, Armando J.
Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra,
Portugal
[email protected]
Cruz, Rui S.
College of Health Technologies of Coimbra, Coimbra, Portugal
[email protected]
Dias, Mafalda M.
Molecular Physical-Chemistry R&D Unit, University of Coimbra, Coimbra, Portugal
[email protected]
Dias, Sérgio
Angiogenesis Laboratory, Centro de Investigação em Patobiologia Molecular (CIPM), Portuguese Institute of
Oncology (IPOFG), and Instituto Gulbenkian de Ciência, Lisbon, Portugal.
[email protected]
Dourado, Marília A.
Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
[email protected]
Escrevente, Cristina I.
Instituto de Tecnologia Química e Biológica, Oeiras, Portugal
[email protected]
Ferreira, Ana L.
Faculty of Medicine, University of Coimbra, Coimbra, Portugal
[email protected]
Ferreira, Leonardo M.
Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra,
Portugal
[email protected]
Figueira, Ana C.
Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto (ICBAS-UP), Porto, Portugal
[email protected]
Freitas, Mariana O.
General Pathology Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
[email protected]
Gomes, Ana I.
Banco de Tumores, Hospitais da Universidade de Coimbra, Coimbra, Portugal
[email protected]
Gomes, Célia M.
Biophysics/Biomathematics Institute, IBILI, Faculdade de Medicina da Universidade de Coimbra, Coimbra,
Portugal
[email protected]
Gonçalves, Ana C.
Medicine Faculty, Coimbra University, Coimbra, Portugal
[email protected]
Gonsalves, Raquel F.
Molecular Physical-Chemistry R&D Unit, University of Coimbra, Coimbra, Portugal
[email protected]
Guiomar, António J.
Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra,
Portugal
[email protected]
Jardim, Ana C.
Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
[email protected]
Ladeirinha, Ana F.
Cytogenetics Laboratory and CNC, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
[email protected]
Laranjo, Mafalda S.
Biophysics/Biomathematics Institute, IBILI, Faculdade de Medicina da Universidade de Coimbra, Coimbra,
Portugal
[email protected]
Lopes, Áurio O.
Institute of Biophysics and Biomathematics - IBILI - FMUC, Coimbra, Portugal
[email protected]
Lopes, João C.
Biophysics/Biomathematics Institute, IBILI, Faculdade de Medicina da Universidade de Coimbra, Coimbra,
Portugal
[email protected]
Lopes, Maria C.
Centro de Neurociências e Biologia Celular; Universidade de Coimbra; CIMAGO/FMUC, Coimbra, Portugal
[email protected]
Maia, Cláudio J.
Universidade da Beira Interior, Covilhã, Portugal
[email protected]
Matafome, Paulo N.
Centro de Investigação em Meio Ambiente, Genética e Oncobiologia (CIMAGO), Faculdade de Medicina da
Universidade de Coimbra, Coimbra, Portugal
[email protected]
Mendes, Luís
Faculdade de Ciências e Tecnologia, Universidade de Coimbra
[email protected]
Monteiro, Carolino J.
Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal
[email protected]
Morais, Paula V.
Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra,
Portugal
[email protected]
Moreira, João N.
Faculty of Pharmacy and Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
[email protected]
Mota, Paula M.
Instituto de Genética Médica, Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal
[email protected]
Mota-Pinto, Anabela
Faculdade de Medicina da Unievsridade de Coimbra, Coimbra, Portugal
[email protected]
Moura, Vera L.
Centro de Neurociências e Biologia Celular, Coimbra, Portugal
[email protected]
Nascimento-Costa, José
Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
[email protected]
Neves, Sara R.
IBILI, Coimbra, Portugal
[email protected]
Neves, Sílvia S.
ACIMAGO, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
[email protected]
Nobre, Rui J.
CNBC - Center for Neuroscience and Cell Biology, Coimbra, Portugal
[email protected]
Oliveira, Carlos F.
Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
[email protected]
Oliveira, Paula A.
Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
[email protected]
Pais, Ana S.
Faculty of Medicine of the University of Coimbra, Coimbra, Portugal
[email protected]
Paredes, Joana
Cancer Genetics Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP),
Porto, Portugal
[email protected]
Paulo, Judy V.
Faculdade de Medicina da Universidade de Coimbra / IPO-FG Coimbra, Coimbra, Portugal
[email protected]
Pedro, Dalila F.
CBMA, Department of Biology, Minho University, Braga, Portugal
[email protected]
Pires, Luís M.
Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
[email protected]
Pissarro, Cristina A.
Portuguese Oncology Institute, Coimbra, Portugal
[email protected]
Prazeres, Hugo
IPATIUP, Porto, Portugal
[email protected]
Remédio, Leonor V.
CIPM, IPOLFG, EPE, Lisbon, Portugal
[email protected]
Ribeiro, Ana S.
IPATIMUP, Porto, Portugal
[email protected]
Ribeiro, André B.
Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal
[email protected]
Rocha, Cláudia M.
CICECO, Aveiro, Portugal
[email protected]
Rodrigues, Vítor L.
Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal
[email protected]
Sampaio, Ana D.
Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra,
Portugal
[email protected]
Santos, Ana T.
Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
[email protected]
Santos, Catarina G.
Hospitais da Universidade de Coimbra (HUC), Coimbra, Portugal
[email protected]
Santos, Nuno R.
IBB/CBME, Universidade do Algarve, Faro, Portugal
[email protected]
Santos, Rui C.
Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
[email protected]
Sarmento-Ribeiro, Ana B.
CIMAGO, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
[email protected]
Serpa, Jacinta
Grupo de Angiogénese-CIPM-Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisboa,
Portugal
[email protected]
Seruca, Raquel
Cancer Genetics Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP),
Porto, Portugal
[email protected]
Severino, Paulo F.
Departamento de Imunologia da Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisboa,
Portugal
[email protected]
Silva, Daniela S.
CIMAGO, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
[email protected]
Silva, Fernanda
Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisboa, Portugal
[email protected]
Silva, Henriqueta C.
Genetic Department, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
[email protected]
Silva, Joana B.
Faculty of Medicine of the University of Coimbra, Coimbra, Portugal
[email protected]
Silva, Lígia C.
Center for Neuroscience and Cell Biology, Coimbra, Portugal
[email protected]
Silva, Maria R.
Instituto de Anatomia Patológica, Faculdade de Medicina da Universidade de Coimbra (FMUC), Coimbra,
Portugal
[email protected]
Sobral, Abílio J.
Chemistry Department, Faculty of Sciences and Technology of the University of Coimbra, Coimbra, Portugal
[email protected]
Socorro, Sílvia M.
Universidade da Beira Interior, Covilhã, Portugal
[email protected]
Sousa, Vítor M.
Faculty of Medicine of the University of Coimbra, Coimbra, Portugal
[email protected]
Urbano, Ana M.
Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra,
Portugal
[email protected]
REPUBLIC OF KOREA
Kim, Ji-hyun
Department of Life and Nanopharmaceutical Science, Kyung-hee University, Seoul, Republic of Korea
[email protected]
Yang, Yeong-in
Department of Life and Nanopharmaceutical Science, Kyung-hee University, Seoul, Republic of Korea
[email protected]
RUSSIA
Gulyaeva, Lyudmila M.
Laboratory of Molecular Carcinogenesis, Institute of Molecular Biology and Biophysics, Russian Academy of
Medical Sciences, Siberian Division, Novosibirsk, Russia; Medical Department, Novosibirsk State University,
Novosibirsk, Russia
[email protected]
Kovalenko, Sergei
Laboratory of Gene Engineering, Institute of Molecular Biology and Biophysics, Academy of Medical Sciences,
Siberian Branch, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia
[email protected]
SPAIN
Cuezva, José M.
Centro de Biología Molecular Severo Ochoa, CIBER de Enfermedades Raras, ISCIII
Universidad Autónoma de Madrid, Madrid, Spain
[email protected]
UNITED KINGDOM
Brindle, Kevin M.
Department of Biochemistry, University of Cambridge, UK; Cancer Research UK Cambridge Research Institute,
Cambridge, UK
[email protected]
Caldas, Carlos
Department of Oncology, University of Cambridge, Cambridge, UK; Cambridge Experimental Cancer Medicine
Centre, Cambridge, UK; Cancer Research UK Cambridge Research Institute; Cambridge Breast Cancer
Research Unit; NIHR Cambridge Biomedical Research Centre, Cambridge, UK
[email protected]
Costa-Pereira, Ana
Division of Cancer, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, UK;
Hammersmith Hospital, London, UK
[email protected]
Sapienza, Karen
Institute of Cancer, Department of Tumour Biology, Barts and The London School of Medicine and Dentistry,
Queen Mary University of London, London, UK
[email protected]
THE NETHERLANDS
Pedrosa, Lília R.
Erasmus MC, Rotterdam, The Netherlands
[email protected]
UNITED STATES OF AMERICA
Chakrabarty, Ananda M.
Department of Microbiology & Immunology, University of Illinois College of Medicine, Chicago, IL, USA
[email protected]
Harris, Curtis C.
Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD, USA
curtis@[email protected]
Huberman, Eliezer
NovaDrug, Chicago, IL, USA and School of Pharmacy
University of Illinois in Chicago, IL, USA
[email protected]
Jurka, Elzbieta
Peninsula Pathologists Medical Group, San Francisco, USA
[email protected]
Kalluri, Raghu
Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA
[email protected]
Landolph, Joseph
Cancer Research Laboratory, USC Cancer Center, Departments of Molecular Microbiology/Immunology and
Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
[email protected]
Langenbach, Robert
Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National
Institutes of Health, Research Triangle Park, NC, USA
[email protected]
Li, Wei
Department of Dermatology and the USC-Norris Comprehensive Cancer Center, the University of Southern
California Keck School of Medicine, Los Angeles, CA, USA
[email protected]
Samaniego, Felipe
UT M.D. Anderson Cancer Center, Houston, USA
[email protected]
Simões, Rui V.
Memorial Sloan-Kattering Cancer Center, New York, USA
[email protected]
Zhitkovich, Anatoly
Department of Pathology and Laboratory Medicine, Division of Biology and Medicine,
Brown University, Providence, RI, USA
[email protected]