Curriculum Vitae
PERSONAL INFORMATION
Luis Filipe Vicente Constantino
WORK EXPERIENCE
September 1985–November
1994
Assistente
University of Lisbon, (Portugal)
Teaching practical classes and doing research in the areas of pharmaceutical technology and
medicinal chemistry
November 1994–Present
Professor Auxiliar
University of Lisbon, (Portugal)
Lecturer in The Medicinal Chemistry Department of the Faculty of Pharmacy of the University of
Lisbon. Has thatched theoretical classes of several subjects in the area of Medicinal Chemistry,
focusing in Organic Chemistry, Quality Control, Pharmaceutical Technology and Drug Metabolism.
EDUCATION AND TRAINING
January 1980–June 1985
Degree in Industrial Pharmacy (Licenciatura five and half years)
Faculty of Pharmacy, University of Lisbon , (Portugal)
Industrial Pharmacy, Pharmacy
September 1989–November
1994
PhD in Medicinal Chemistry
Faculty of Pharmacy, University of Lisbon , (Portugal)
Pharmaceutical and Medicinal Chemistry
ADDITIONAL INFORMATION
Expertise
Medicinal Chemistry
Drug Metabolism
Quality of Pharmaceutical Substances.
Pharmaceutical Technology
Drug Synthesis
Development of New Drugs
Publications
Books
L. Constantino. Metabolismo de xenobióticos, reacções de fase I e reacções de fase II. Metacriações,
Lisbon 2004. ISBN 9729044473
Papers
M. Prigol, C.W. Nogueira, G Zeni, M.R. Bronze and L Constantino (2013) Physicochemical and
biochemical profiling of diphenyl diselenide. Appl Biochem Biotechnol 169, 885-93 DOI:
10.1007/s12010-012-0042-9
M, Prigol. C. W. Nogueira, G. Zeni, M. R. Bronze, , L. Constantino (2012) In vitro metabolism of
diphenyl diselenide in rat liver fractions. Reaction with GSH and binding to thiol groups. Chem Biol
Interact. 200:65-72. DOI: 10.1016/j.cbi.2012.09.007.
C. Dias, B. Testa; G. Soveral; M. Dias; L. Constantino, (2012) Development of a screening method to
assess the effect of drugs on alcohol metabolism. Toxicolol in vitro. 26, 1177-1180. DOI : 10.1016/
j.tiv.2012.06.011
G. Mata, V. E. do Rosário, J. Iley, L. Constantino, and R. Moreira (2012) A carbamate-based approach
to primaquine prodrugs: antimalarial activity, chemical stability and enzymatic activation Bioorg. Med.
Chem. 20:886-92
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Curriculum Vitae
Luis Filipe Vicente Constantino
E. Valente, M.F. Simões, B. Testa, L. Constantino (2011). Development of a method to investigate the
hydrolysis of xenobiotic esters by a Mycobacterium smegmatis homogenate. J Microbiol Methods 85:
98-102
M. F. Simões, E. Valente, E. Anes E L. Constantino (2009) Lipophilic POA Amide and Ester Prodrugs.
Stability, Activation and activity against M. tuberculosis. European Journal of Pharmaceutical Sciences
28: 257-63
P. Gu, L. Constantino, Y. Zhang (2008) Enhancement of the antituberculosis activity of weak acids by
inhibitors of energy metabolism but not by anaerobiosis suggests that weak acids act differently from
the front-line tuberculosis drug pyrazinamide, J. Med. Microbiol. 57:1129-34.
L. Constantino, J. Iley, (2004) Oxidation of tertiary benzamides by 5,10,15,20tetraphenylporphyrinatoiron III chloride–tert-butylhydroperoxide, Org. Biomolec. Chem., 13: 18941900.
Jim Iley, Roberto Tolando Luís Constantino, (2001) Chemical and microssomal oxidation of terciary
amides: regio and stereoselective aspects, J. Chem. Soc. Perkin Trans. 2, , 1299-1305.
L. Jordão, L. Constantino., E. Anes (2007). Formulation and activity of liposome encapsulated βlactam antibiotics in macrophages infected with mycobacteria. 8th virtual AIDS congress,
http://www.aidscongress.net/pdf/338.pdf
L. Constantino, P. Paixão , R: Moreira , J. Iley, V. E. do Rosário. (1999) Metabolism of primaquine by
liver homogenate fractions. Evidence for MAO and Cyt P450 involvement in the oxidative deamination
of primaquine to Carboxyprimaquine. Exp. Toxic Pathol.51: 299-303.
L. Constantino, J. Iley, (1999) Metabolism of N,N-diethyl-m-toluamide by rat liver microsomes. The
network of metabolites. Xenobiotica 19: 409-416.
M. J. Portela, R. Moreira, E. Valente, L. Constantino, J. Iley, J. Pinto, R. Rosa, P. Cravo and V. E. do
Rosário (1999) Dipeptide derivatives of primaquine as transmission-blocking antimalarials. Effect of
aliphatic side-chain acylation on the gametocytocidal activity and on the formation of
carboxyprimaquine in rat liver homogenates, Pharm. Res.16: 949-55.
J. Iley, L. Constantino (1994) The microssomal dealkylation of N,N-dialkylbenzamides. Biochem.
Pharmacol. 47: 275-280.
L. Constantino, J. Iley (1994) Oxidative dealkylation of N,N-dialkylbenzamides. In: Cytochrome P 450,
Biochemistry, Biophysics and Molecular Biology pp 677-680 (Ed. Lechner, M. C.) Jonh Libbey
Eurotext, Paris. Citações: 0
L. Constantino, R.T. Mehta, M.E.M. Cruz, G. Lopez Berestein (1993) Formulation and toxicity of
liposomes containing rifampicin. J. Liposs. Research 3: 275-301.
L. Constantino, E. Rosa, J. Iley (1992) The microsomal demethylation of N,N-Dimethylbenzamides:
Substituent and kinetic deuterium isotope effects. Biochem. Pharmacol. 44: 651-658.
J. Illey, L. Constantino, F. Norberto, E.Rosa (1990) Oxidation of the methyl groups of N,Ndimethylbenzamide by a cytochrome p 450 mono-oxigenase model system, Tet. Letters. 431: 49214922.
L. Constantino, M.E.M. Cruz (1989) Liposomes containing rifampicin, Cien. Biol. ( Mol. Cell. Biol ) 14:
1-8.
Projects
Coordinator of financed Projects
•PTDC/SAU-FCF/101950/2008 coordinator of the FCT project “A new life for old antimycobacterial
drugs”
•PBIC/BIA/2047/95. Coordinator of the FCT Project “ study of the biotransformation pathways of
primaquine”
•C0HITEC2007. Coordinator of the C0TEC project “Prodrugs of pyrazinoic acid for treatment of
tuberculosis”
Patents
Vesicular formulations containing organic acid prodrugs, process for their preparation. L. Constantino,
E. Anes, M. Simões e E. Valente
o WO/2007/142548.
o USA Application US/2010/0221315A1
o EU Application 07747764.4
o India application 2733/MUMNP/2008
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Curriculum Vitae
Luis Filipe Vicente Constantino
o China patent CN 101460146 (200780021029.6
o Eurasia patent 200900043
WO/1993/023016 Cruz, M.E.M., Constantino, L., Gaspar, M. M., Mehta, R .T., Lopez Berestein, G.,
(1993) Liposomal Formulations Containing Rifamycins
P100487/INPI Cruz, M.E.M., Constantino, L., Gaspar, M. M., Mehta, R .T., Lopez Berestein, G.,
(1992) Formulações lipossomais de Rifampicina com Elevada Eficácia de Incorporação de Antibiótico
e Processo para a sua Preparação.
P103495/INPI Formulações vesiculares contendo pró-fármacos do ácido pirazinóico ou de outros
ácidos orgânicos, que permitem proteger o pró-fármaco da degradação plasmática e processos para
a sua preparação. L. Constantino, E. Anes, M. Simões e E.Valente.
Memberships
Other Relevant Information
Portuguese Pharmaceutical Society
Training in Other Institutions
M. D. Anderson Hospital and Cancer Centre Houston USA 1988
National Jewish Centre of Immunology and Respiratory Medicine, Denver,USA.(1988)
Chemistry Dept .Open University Milton Keynes England (1989-1993)
Management Positions (Academic)
Vice-President of the Scientific Council - Faculty of Pharmacy of Lisbon (2001/2003)
Member of the Scientific Council Coordination Committee Faculty of Pharmacy of Lisbon (2001/2003)
Head of Pharmaceutical Chemistry Dept. Faculty of Pharmacy of Lisbon (2001/2003)
Vice-coordinator of Pharmaceutical Chemistry Dept. Faculty of Pharmacy of Lisbon (2003/…)
Coordinator of the masters programme in Pharmaceutical Chemistry Faculty of Pharmacy of Lisbon
(1999/2003).
Member of the coordination committee of the masters programme in Pharmaceutical Chemistry
Faculty of Pharmacy of Lisbon (1999/2003).
Expert in lawsuits related to medicinal products (Court-appointed)
Lawsuit 2723/94 - Merck & Co. Inc. e Merck Sharp & Dolme Lda vs Produtos Farmacêuticos Bioty
Lda. Tribunal Cível da Comarca de Lisboa - 3º Juízo.
Lawsuit 1693/96 - Pentafarma Soc. Técnico-Medicinal S.A. e Farmoz Representações Importações e
Exportações Lda. vs Sanofi. Sarroel e Sanofi Winthorop Produtos Farmacêuticos Lda. Tribunal Cível
da Comarca de Lisboa - 1º Juízo, 3ª Secção.
Lawsuit 1455/97 - Glaxo Wellcome Group limited e Glaxo Wellcome Farmacêutica Lda vs
Pentafarma Soc. Técnico Medicinal S.A. e Farmoz Representações Importações e Exportações Lda.
Tribunal Cível da Comarca de Lisboa - 16º Juízo.
Lawsuit 994/97 - Merck & Co. Inc. e Merck Sharp & Dolme Lda vs Pentafarma – Sociedade Técnico
Medicinal. Tribunal Cível da Comarca de Lisboa - 15ª Vara Cível da Comarca de Lisboa, 3ª Secção.
Lawsuit 473/96 - Merck & Co. Inc. e Merck Sharp & Dolme Lda vs Farmocore S.A.. Tribunal Cível da
Comarca de Lisboa - 9ª Vara Cível da Comarca de Lisboa.
Lawsuit 462/99 - Merck & Co. Inc. e Merck Sharp & Dolme Lda vs Merck Genéricos Produtos
Farmacêuticos Lda. Tribunal Cível da Comarca de Lisboa - 7ª Vara Cível da Comarca de Lisboa, 2ª
Secção.
Lawsuit 332/03.6TYLSB Laboratórios Pfizer Lda vs Alter S.A. Tribunal do Comércio de Lisboa, 2º
Juízo.
Injuction 354/2001. Merck Sharp & Dolme Lda e Merck & Co. Inc. vs Jaba Farmacêutica, SA. Tribunal
do Comércio de Lisboa, 3º Juízo.
Lawsuit 951/96 - Merck & Co. Inc. e Merck Sharp & Dolme Lda vs Companhia Portuguesa de Higiene
S.A. Tribunal Cível da Comarca de Lisboa - 14ª Vara Cível da Comarca de Lisboa, 3ª Secção.
Lawsuit 339/2001 – Tecnimede, Sociedade Técnico-medicinal S.A. vs Merck & Co. Inc. Tribunal do
Comércio de Lisboa, 2º Juízo.
Lawsuit 1469/04.0TYLSB Merck & Co. Inc.. e outros vs Farmoz Sociedade Técnico-Medicinal S.A.
Tribunal do Comércio de Lisboa, 2º Juízo.
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Curriculum Vitae
Luis Filipe Vicente Constantino
Lawsuit 317/2002 - Tecnnimede soc Técnico-medicinal S.A. vs Merk e Co inc. Tribunal do Comércio
de Lisboa, 3º Juízo.
Processo 1258/03.9TYSLSB Merck & Co. Inc.. e outros vs Pentafarma. S..A. Tribunal do Comércio
de Lisboa, 1º Juízo.
3/2/15
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