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Antofagasta
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Biological Activity Aspects
Leishmania amazonensis PH8
Immunological Aspects
Wenner Gren Institute of Immunology
Stockholm University
Our results showed that the
alkaloid extract of Evanta was not
directly stimulating B cells, T cells
or J774 macrophages, but it
interfered with the activation of
both mouse and human T cells, as
seen by the reduction of cellular
proliferation and in vitro induced
production of IFN-γγ.
It was established, as well, that the
effect of CAT on the parasite was
intense at 10 ug/ml and that it was
stronger than the effect of the
purified alkaloid, 2-phenylquinoline.
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Our results suggest that Evanta
can control the chronic
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therefore may contribute to the
reduction of the pathology in the
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ìndice de Lesões (ULI)
ULI (ìndice de Lesões Ulcerativas)
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Contorções abdominais induzidas pelo ácido acético, i.p.
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Programa UMSA-ASDI-SAREC- Período 2004 – 2010
Proyecto: Enfermedades Infecciosas
”Estudios Clínicos Fase II de la Evanta en el
Tratamiento de Leishmaniasis cutanea”
•Universidad Mayor de San Andrés - UMSA
•Facultad de Ciencias Farmacéuticas y Bioquímicas
•CIDME-SELADIS –IIFB
•Universidad de Estocolmo
•Departamento de Inmunología
•Hospital de Palos Blancos
•Centro de Estudios
•Proyecto OSCAR
•Seguimiento de pacientes
•Consejo Indigena de los Pueblos Tacana – CIPTA
•Comunidad de Santa Rosa de Maravilla
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Unidad Proponente: Instituto de Investigaciones Fármaco Bioquímicas:
Unidad de Química Farmacéutica
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