EUROPE MOUSE SOPF EUROPE Charles River Laboratories France Location CRL France M6 Mice Health Status SOPF Past 18 Months Most Recent Summary Item Method Primary Lab Test Date Positive / Tested Positive / Tested Viruses Minute Virus of Mouse (MVM) ae MFIA RADS EU -- -- -- Mouse Parvovirus (MPV) ae MFIA RADS EU -- -- -- Mouse Hepatitis Virus (MHV) ae MFIA RADS EU -- -- -- Mouse NoroVirus (MNV) ae MFIA RADS EU -- -- -- Theiler Virus (TMEV - GDVII) ae MFIA RADS EU -- -- -- Rotavirus (EDIM) ae MFIA RADS EU -- -- -- Sendai (SEND) ae MFIA RADS EU -- -- -- Reovirus 3 (REO3) ae MFIA RADS EU -- -- -- Pneumonia Virus (PVM) ae MFIA RADS EU -- -- -- (Mouse Thymic Virus (MTV) ae MFIA RADS EU -- -- -- Mouse CytomegaloVirus (MCMV) ae MFIA RADS EU -- -- -- Hantaan Virus (HANT) ae MFIA RADS EU -- -- -- Mouse Choriomening (LCMV) ae MFIA RADS EU -- -- -- Mouse Adenovirus (MAV 1&2) ae MFIA RADS EU -- -- -- K Virus (K) ae MFIA RADS EU -- -- -- Ectromelia (ECTRO) ae MFIA RADS EU -- -- -- Polyoma Virus (POLY) ae MFIA RADS EU -- -- -- Lactic Deshydog. Virus (LDV) ae MFIA RADS EU -- -- -- Tyzzer's Disease (CPIL) ae Necropsy Exam RADS EU -- -- -- Bordetella bronchiseptica ae Culture RADS EU -- -- -- Citrobacter rodentium ae Culture RADS EU -- -- -- Corynebacterium kutscheri ad Culture RADS EU -- -- -- Corynebacterium bovis af PCR RADS EU -- -- -- Mycoplasma pulmonis ae MFIA RADS EU -- -- -- Pasteurella pneumotropica ad Culture RADS EU -- -- -- Pasteurella multocida ad Culture RADS EU -- -- -- Salmonella spp ae Culture RADS EU -- -- -- Streptobacillus moniliformis ae Necropsy Exam RADS EU -- -- -- Beta Hemolytic Streptococci ad Culture RADS EU -- -- -- Streptococcus pneumoniae ad Culture RADS EU -- -- -- Helicobacter hepaticus ae PCR RADS EU -- -- -- Helicobacter bilis ae PCR RADS EU -- -- -- Helicobacter, other spp ae PCR RADS EU -- -- -- Staphylococcus aureus ad Culture RADS EU -- -- -- Pseudomonas aeruginosa ad Culture RADS EU -- -- -- Klebsiella pneumoniae ad Culture RADS EU -- -- -- Klebsiella oxytoca ad Culture RADS EU -- -- -- Bacteria Page 1 of 2 Reported on Friday, January 22, 2016 at 6:20 GMT EUROPE MOUSE SOPF EUROPE Charles River Laboratories France Location CRL France M6 Mice Health Status SOPF Past 18 Months Most Recent Summary Item Method Primary Lab Test Date Positive / Tested Positive / Tested Bacteria Proteus mirabilis ad Culture RADS EU -- -- -- CAR Bacillus ae MFIA RADS EU -- -- -- Clinical exam and necropsy RADS EU -- -- -- Ectoparasites ae Direct Exam RADS EU -- -- -- Helminths ae Direct Exam RADS EU -- -- -- Enteric Pathogenic Protozoa ae Direct Exam RADS EU -- -- -- Other protozoa ae Exam EU RADS -- -- -- E. cuniculi ae MFIA RADS EU -- -- -- Pneumocystis spp af PCR RADS EU -- -- -- Lesions observed Gross Exam ae Parasites * dashes indicate not tested during specified period. HOUSED STRAINS Outbred OF1 Legend: RADS EU = Research Animal Diagnostic Services Europe Lyon, France RADS US = Research Animal Diagnostic Services United States Wilmington Massachusetts COLONY POLICY FOR POSITIVE RESULT: a = immediate termination; b = planned future recycle of the colony; c = no action. TESTING SCHEDULE: d = screened every four weeks; e = screened quarterly on 1/4 of isolators; f = screened annually M6 CRLF Mice SOPF Page 2 of 2 Reported on Friday, January 22, 2016 at 6:20 GMT