Stem cells and materials technologies
Group 16 - Biomaterials and waste treatment
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
th July
E-mail:
[email protected]
Zona Industrial da Gandra
| S. Cláudio
do Barco
Ciência
2009,
29-30
2009, Lisbon
Website: www.stemmatters.com
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
Strategic Intent
To target clinical needs through the integration of advanced
adult stem cell biology and novel biomaterials into
innovative therapeutic products for tissue regeneration
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
History
The workers will bring out all wastes/garbage
with them to deposit at the garbage room before
entering the Undressing room.
All the wastes/garbage will be handled by an
external company.
Garbage
The material will be prepared,
sterilized and packed in the
“Washing room” and transfered
to the near Class C prechamber when needed...
Changing Room

Academic spin-off of the 3B’s Research Group

Created in November, 2007

Installed since September 2008 at the European Institute
of Excellence for Tissue Engineering and Regenerative
Medicine Research, Guimarães, Portugal.

Equipped with a future cGMP compliant facility for the
processing of human tissue and cells (2003/94/EC Directive):
Washing
Room
 300 m2 of clean room (classes B, C and D);
Small Stock Room
Dressing Room
The workers will enter the Facilities through
the “Reception Room” and according to the
sample type, they will pick the necessary
materials from the “Sterile Material Stock”
Room and pass it to the “Material” Room near
the “Dressing Room”.
After changing clothes, they will enter the
“Class C” corridor, if they go to one of the
processing rooms or to the “Class D” corridor,
if they go to the “Centrifugation Room”, taking
the respective and pre-deposited material for
that effect.
Reception
/
Registration
Room
Sample Processing
Room
Centrifuge
Room
Class B
Sample Processing
Room
Changing Clothes Passage
Class C
One-way material/sample
direction
Sample reception
/
Centrifugation
Room
Two-way material/sample
direction
Class B
Sample Processing
Room
Class B
Personal way In through the
control to the Dressing
Room
Personal way In to Class B
Room
 250 m2 of R&D and QC laboratories.
Class B
Sample Expansion
Room

1st funding round estimated to be finished by Sept, 2009

Start of operations estimated by Oct, 2009
Class D
Cryopreservation
Room
Personal way In to Class A
Room
Personal way Out to the
Undressing room / EXIT
Access to the
cryopresevation room
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Team

CSO: Rui L. Reis, CEng., MSc., PhD. (n. 1968) – Founder, President and Chief
Scientific Officer: is an Associated Professor at the Department of Polymer
Engineering and Director 3B’s Research Group. Editor in Chief of the Journal of
Tissue Engineering and Regenerative Medicine, John Wiley and Sons Inc. He
is author or co-author of more than 900 scientific publications.

CEO: Rui A. Sousa, CEng., MBA., PhD. (n. 1974) – Chief Executive Officer: is
a senior researcher at the 3B’s Research Group. Possesses business
experience in several industrial and consultancy domains. He is author or coauthor of more than 90 scientific publications and communications.

Dulce Costa

Luísa Pereira

João Oliveira

Adrian Popa
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Social Context
 The WHO estimates that more than 600 million people are
aged above 60, being estimated that this number reaches
the 2 billion by 2050.
 Growing impact of degenerative or traumatic conditions
due to demographic evolution, more dynamic lifestyles,
and increased physical activities.
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Overall Market
Regenerative Medicine
1
3
5
4
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
Adaptado de Julian H S George et al
http://www.centropede.com/UKSB2006/ePoster
2
E-mail: [email protected]
Website: www.stemmatters.com
Use of stem cells from adipose tissue
 More than 1.6 billion people are overweight, of which 400 million are considered
obese, with treatment costs between 2 and 8% of total health costs.
 Steep increase in aesthetical surgical procedures, being Europe responsible for
about one third of this global market.
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Business Portfolio
Stemmatters
Therapeutics
Stemmatters
Life Banking
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Stemmatters
Biomedical
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Stemmatters Therapeutics
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Current Markets
Stemmatters
Therapeutics
The Market for Cartilage Regeneration
 Prevalence of articular cartilage related lesions in Europe
 Nearly 250.000 traumatic incidents occur;
 About 7 million cases of treatable arthrosis occur each year.
 High market potential for cartilage regeneration
 Among the biggest markets for connective tissues, being estimated between
1 to 5 billion €/year in Europe alone.
 Very high penetration of traditional treatment approaches
 Arthroscopic lavage and debridement, microfracture and mosaicplasty rule
the treatment of cartilage lesions.
 Cell based therapies with reasonable track record in this area
 ACT and MACI procedures are considered market references.
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Product Pipeline
Stemmatters
Therapeutics
Products Under Development
Types of products currently under development:
ATMPs (Advanced Therapy Medicinal Products)
G01AT110C | pre-clinical | RECART Hydrogel/Adipose derived adult stem cells
G01AT300A | research | Hydrogel/Vascular stromal fraction derived cells
MDs (Medical Devices)
G01MD210B | research | Injectable filler for soft tissue applications
G01MD250B | research | Injectable filler system for maxillofacial applications
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Product Pipeline
Stemmatters
Therapeutics
Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells
Combined advanced therapy medicinal product
(1394/2007 Regulation, CBMP EMEA
guideline)

Polysaccharide hydrogel as an active implantable device
 Exopolysaccharide produced by microbial fermentation:
• Straight chain of repeating glucose, rhamnose and glucuronic acid units;
• Potential injectable system for minimally invasive surgeries;
• Processing under physiogical conditions without any reagents;
• Used in vivo for human ophthalmic applications and oral veterinary drug delivery.

Adipose derived adult stem cells
 Isolated from harvested adipose tissue:
• Dedicated or non-dedicated harvest procedure;
• Subpopulation isolated from the stromal vascular fraction;
• Good cell yield avoids previous cell expansion.
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Product Pipeline
Stemmatters
Therapeutics
Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells
 Novel hydrogel system for TE applications
10000
100
10
1
70
60
50
40
30
20
10
0
0,1
0,01
0,001
Temperature (ºC)
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
J.T. Oliveira et al, Patent Application
80
Viscosity (Pa s)
1000
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Product Pipeline
Stemmatters
Therapeutics
Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells
 Good performance upon subcutaneous implantation
1 WEEK
2 WEEKS
3 WEEKS
 No clear macroscopic change after 3 weeks of implantation.
 Extremely good integration with the surrounding tissues with a residual and thin fibrotic capsule.
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Product Pipeline
Stemmatters
Therapeutics
Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells
550
 Human chondrocytes form hyaline-like
cartilage in vitro
500
8 WEEKS
w2
w8
Normalized Expression Ratio
450
400
350
300
70
60
50
40
30
20
10
0
col 1
col 2
aggrecan
sox 9
• Col1 was not detected after 8 weeks
 Col2 increased ≈ 400 fold from 2-8 weeks
 Aggrecan increased ≈ 35 fold from 2-8 weeks
 Sox9 decreased close to zero from 2-8 weeks
house-keeping gene: GAPDH
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Product Pipeline
Stemmatters
Therapeutics
Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells
ADIPOSE TISSUE FROM
THE INTRASCAPULAR
REGION
CHONDROGENIC PRE ≠ MEDIUM BASIC MEDIUM
WITH TGF-Β1 + BMP-2
WITH NO PRE ≠
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
ARTICULAR CARTILAGE
FROM THE JOINTS
PROLIFERATION INDUCING
MEDIUM WITH FGF-2
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Product Pipeline
Stemmatters
Therapeutics
Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells
Rabbit articular cartilage
Implantation site
Subchondral drill
Articular cartilage
full-thickness defect
(Ø 1 mm)
(4 mm x 2-3 mm thickness)
Study groups
A. Gellan + adipose tissue derived cells with pre differentiation period (ASC + GF*)
+
B. Gellan + adipose tissue derived cells with no pre differentiation period (ASC)
+
C. Gellan + articular chondrocytes (AC)
+
D. Gellan alone (GELLAN)
*TGF-Β1 + BMP-2
Autologous approach
E. Empty defect (EMPTY)
Total implantation time: 8 weeks
Characterization
[Cells]=10x106 cells/ml
 Macroscopic observation
 Histology (H&E for cell morphology and tissue formation and alcian blue for cartilage ECM formation)
 Histological scoring (Pineda score)
 Real-time PCR analysis (Sox9, Collagen type I, Collagen type II, and Aggrecan)
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
J.T. Oliveira et al,
Patent Application
E-mail: [email protected]
Website: www.stemmatters.com
Product Pipeline
Stemmatters
Therapeutics
Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells
0 weeks
4 weeks
8 weeks
 Combination of hydrogel with ASCs is able to regenerate focal cartilage lesions
J.T. Oliveira et al, Patent Application
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Patent Application/Priority date: 01.2008
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Product Pipeline
Stemmatters
Therapeutics
Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells
340
COL II
4 WEEKS
315
8 WEEKS
290
240
215
EMPTY
GELLAN
AC
ASC
ASC + GF
EMPTY
AC
GELLAN
ASC
ASC + GF
EMPTY
GELLAN
AC
ASC
ASC + GF
EMPTY
GELLAN
40
AC
165
45
ASC
190
ASC + GF
Normalised expression ratio
265
35
30
AGGRECAN
25
20
15
10
COL I
SOX9
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
EMPTY
GELLAN
AC
ASC
ASC + GF
EMPTY
AC
GELLAN
ASC
ASC + GF
EMPTY
GELLAN
AC
ASC
ASC + GF
EMPTY
GELLAN
AC
ASC
0
ASC + GF
5
E-mail: [email protected]
Website: www.stemmatters.com
Product Pipeline
Stemmatters
Therapeutics
Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells
Advantages of the cartilage repair strategy include:

Potential therapeutic performance

Minimally invasive system to be administered arthroscopically

Avoids the need for a cartilage biopsy

Shorter time to therapy (TTT)

Competitive cost as compared to traditional ACT and MACI procedures
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Competition
Stemmatters
Therapeutics
Tissue Engineering
Products
Cartilage application
Arthro Kinetics, BioTissue Technologies,
Cellgenix, co.don, Curasan, Educell, Fidia
Advanced Biopolymers, Geistlich Surgery,
Genzyme Biosurgery, Histogenics, Interface
Biotech, Karocell Tissue Engineering, Orthogen,
TIGenix, TETEC, Verigen Transplantation Service
International
Cartilage: application
Stemmatters (Autologous)
Bone application
Aastrom Biosciences (Autologous),
Osiris Therapeutics (Allogeneic)
Skin application
Organogenesis, BioTissue Technologies,
Advanced BioHealing, Inc., Genzyme Biosurgery,
Fidia Advanced Biopolymers, Intercytex, Celltran,
Forticell Bioscience, Cambrex
Primary cells
Progenitor cells
Cartilage application
Osiris Therapeutics (Allogeneic)
Several applications:
Cartilage application
co.don, Educell, Geistlich Surgery, Genzyme
Biosurgery, Interface Biotech, TIGenix, TETEC
Advanced Cell Technologies, Geron, ES Cell
International, Stem Cell Sciences, Aastrom
Biosciences, Aldagen, Angioblast Systems, Athersys
, BrainStorm Cell Therapeutics, Cardio3, Cellerant
Therapeutics, Cognate Therapeutics , Gamida-Cell,
Mesoblast , Neuronyx, Osiris Therapeutics,
AdiStem, Bioheart, Cellerix, Cognate Therapeutics,
Cytori Therapeutics , ReNeuron Group Plc, Tengion,
PharmaFrontiers , Tissue Genesis, Inc , GamidaCell, Saneron CCEL Therapeutics, ViaCell
Other Cell
Based Therapies
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Product Pipeline
Stemmatters
Therapeutics
RECART Hydrogel/Adipose derived adult stem cells
R&D and non-clinical
development
Biomaterial R&D
In vitro testing
MA
Applic.
Clinical development
Marketing
Authorization
Phase I
Phase II
Phase III
In VivoTesting
GMP grade
2007-2010
Phase IV
2010-2018
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
2019
2020
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Product Pipeline
Stemmatters
Therapeutics
RECART Hydrogel/Adipose derived adult stem cells
R&D and non-clinical
development
Biomaterial R&D
MA
Applic.
Clinical development
Marketing
Authorization
Phase I
Phase II
In vitro testing
Phase III
In VivoTesting
GMP grade
Phase IV
Stemmatters Life Banking
Stem cell isolation and storage services
Stemmatters Biomedical
Products and services for R&D
2007-2010
2010-2018
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
2019
2020
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Contacts
Rui A. Sousa
CEO
Tel. +351-253-540100
Fax. +351-253-540199
E-mail: [email protected]
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Stemmatters Life Banking
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Current Markets
Stemmatters
Life Banking
Main application markets for stem cells
Current uses of stem cells are made in 3 distinct medical related markets:

Cell banking;

Therapeutic development;

Cell therapies.
(source: Frost & Sullivan).
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Current Offering
Stemmatters
Life Banking
Stemmatters Life Banking | Stem cell isolation and storage services

Bone marrow (onstem service – B2C);

Adipose tissue (adstem service – B2C):
 The treatment of tissues and biological residues generated in surgical
procedures assures a cell banking opportunity not yet addressed.
 Market potential for the isolation and storage of adipose derived adult stem
cells for autologous application is estimated to worth:
• 75 million €/year for Spain, France, Germany, UK, Italy and Portugal;
• 120 million €/year for EU15.
 Assures a polyvalent platform for regenerative technologies;
 Assures positive cash flow and supports leveraging of R&D pipeline.
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Competition
Stemmatters
Life Banking
Stemmatters Life Banking | Stem cell isolation and storage services
Newborns
Children
Adults
Crioestaminal, Bioteca, Bebé Vida, Criovida, Cytothera (Portugal)
Bioeden (UK)
Stemmatters
USA
Europe
Celvitae, Vidacord, Secuvita, Vidaplus, Stem Cell, CrioCord,
Safetycord (Spain)
Cytothera (Portugal)
ActiVision Life (Poland), Babycord (Cyprus), Babycord (Turkey),
Biohellenica (Greece), Biophylaxis (Greece), BPK (Slovenia),
CopyGene (Denmark), CryoBank (Turkey), Cryo-Save (Belgium),
Cryomedica (Russia), Eticur (Germany), Eurocord (Slovakia),
Floramed (Russia), Gemabank (Russia), GenKord (Turkey),
Hemafund (Ukraine), In Scientia Fides (Italy), Krio (Hungary), Liaison
(Greece), LifeBank (Cyprus), Lifecord (Austria), Lifeline (Cyprus),
LongaVita (Poland), Polish Stem Cell Bank (Poland), Progenis
(Poland), RCB (Switzerland), Seracell (Germany), SmartBank (Italy),
StellaCure (Germany), Stemcare (Denmark), Stem-Health Hellas
(Greece), VITA34 (Germany), Vitacord (Austria), Yasam Bankasi
(Turkey), Cells4Life (UK), Cells Limited (UK), CryoGENESIS (UK),
Future Health Technologies (UK), SmartCells (UK), UK Cord Blood
Bank (UK), UK Health Solutions (UK), Virgin Health Bank (UK)
AlphaCord, CordBancUSA, Cord Blood America, Cord Blood Registry,
Cord Blood Solutions, Cryobanks International, Cryo-Cell
International, DomaniCell, Elie Katz, Family CB Services, Family Link,
Genesis Bank, HemaStem, LifebankUSA, LifeLine, LifeSource, MAZE
Labs, Neocells, Newborn Blood Banking, New England CB Bank, RMI,
Safetycord, Securacell, StemCyte, Stork Medical, Utah Cord Bank,
Viacord, Vista Cord, Xytex
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Cryo-Save (Belgium)
Cytori Therapeutics
Biohellenika (Greece)
Bioeden, StemSave, Baby
Teeth Cell Bank
Cryo-cell
Neostem
Cytori Therapeutics
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Current Offering
Stemmatters
Life Banking
Stemmatters Life Banking | Stem cell isolation and storage services
Acquisition Drivers

Increased value of the surgical procedure;

Potential application in future autologous regenerative therapies;

Allows for off the shelf availability of personalized regenerative products;

Decreases time for clinical delivery of therapy.
Current applications of adipose derived adult stem cells

Radiation Necrosis

Breast Reconstruction

Heart Attack

Chronic Heart Disease

Crohn’s Disease

Tracheal Fistula Healing

Calvarial Repair

Marrow Transplant Complications

Diabetes
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Stemmatters Biomedical
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Current Offering
Stemmatters
Biomedical
Stemmatters Biomedical | Products and services for R&D

Isolation and processing services of human cells:
 Human stromal vascular fraction isolated from adipose tissue
containing human adipose derived stem cells (all samples are
characterized for cell number and viability);
 Human adipose derived stem cells (all samples are characterized
for cell number and viability, as well as multipotent mesenchymal
stem cell markers: CD29, CD105, CD34 and CD45);
• Pre-clinical research in regenerative medicine accounts for a market
volume of about 700 million €/year.

Cell culturing products;
 Hydrogel support systems for 3D cell culturing;
• Very high R&D visibility among the potential buyer community;
• The global market potential for the commercialization of 3D supports
for non-clinical R&D is estimated to worth between 7 and 35 million
€/year.
 Device for dynamic cell seeding and culturing.
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Corporate Strategy
Stemmatters
Life Banking
Trade sale
Spin-off
Stemmatters
Therapeutics
R&D
Licensing
Stemmatters
Biomedical
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Corporate Strategy
Time in
Corporate
Portfolio
Other
Company
Stemmatters
Biomedical
Stemmatters
Therapeutics
R&D
Technology
Stemmatters
Life Banking
Time to Market
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Financial projections
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com
Financial Projections
2009-2016
14.0
12.0
MEuros
10.0
8.0
6.0
4.0
2.0
0.0
2009
2010
2011
2012
2013
2014
2015
2016
-2.0
Operating income
Stemmatters, Biotecnologia e Medicina Regenerativa Lda
AVEPARK - Parque de Ciência e Tecnologia S.A.
EBIT
Net result
Zona Industrial da Gandra | S. Cláudio do Barco
APARTADO 4152 | 4805 CALDAS DAS TAIPAS
E-mail: [email protected]
Website: www.stemmatters.com