CURRICULUM VITÆ
Sandrina Isabel Ribeiro Martins da Silva
Personal details
First name
Sandrina Isabel
Family Name
Ribeiro Martins da Silva
Birth date
11th December 1980
Identity Card
N.º11654441, Arquivo de identificação de Leiria, emission
on 21/02/2000
Civil Status
Single
Nationality:
Portuguese
Home Address
Travassa da Mata n.º1 Arneiro, 2405-005 Maceira – Lis,
Portugal
Telephone number
00351 966 792 623
E-mail:
[email protected]
Education and Qualifications
2010Post doc fellowship (FCT) at Universidade de Aveiro, under supervision of Prof.
José Cavaleiro.
Title: “Síntese de fotossensibilizadores e “nano-aquecedores” hidrossolúveis para
possível aplicação biomédica”.
2008-2009
Post doc fellowship at ETH Zürich, under supervision of Prof. Andrea Vasella.
Title: “Synthesis of paromomycin derived aminoglycoside antibiotics”.
2004-2008
PhD student (FCT grant) at the Faculdade de Ciências da Universidade
de Lisboa (Portugal) and the Université d’Orléans (France) under joint
supervision of Prof. Amélia Pilar Rauter (Dept Chemistry and Biochemistry,
F.C.U.L.) and Prof. Patrick Rollin (ICOA, Institut de Chimie Organique et
Analytique).
Title: “Carbohydrate-based 1,3-oxazoline-2-thiones as original antimicrobial and
insecticidal devices and novel fluorescent probes”.
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1998-2004
Graduation in Education of Physics and Chemistry – variant of Chemistry,
Faculdade de Ciências da Universidade de Lisboa, with a final mark of 17/20.
1995- 1998
Chemistry, Biology and Mathematics with a final mark of 16/20.
Work Experience
2010
Participation in the project:“HybridSolar - Hybrid Si-nanoparticle/polymer
layers for solar cell applications”.
2008
Supervision of Laboratory classes of Organic Chemistry at the University of
Orleans, with active process in planning and evaluation of the discipline.
Participation in the Pessoa project.
2007
Planing of Laboratory Classes of Organic Chemistry at the University of
Orleans.
Supervision of students in Graduation Stage of Organic Chemistry, at the ICOA.
Participation in a Pessoa project (Programmes Hubert Curien) entitled : “Fusion
hétérocycles-carbohydrates : géométries originales à activités biologiques variées”.
2005-2006
Supervision of students in Graduation Stage of Organic Chemistry, at the
University de Lisboa.
2004-2005
Participation in the project “1,3-Oxazolin-2-thiones linked to sugars, molecules
with antimicrobial and insecticidal activity” within the program “Acções Integradas
Luso-Francesas” do Conselho de Reitores de Universidades Portuguesas.
2003-2004
Graduation Pedagogic Stage in Escola Secundária/3 José Cardoso Pires, under
supervision of Professora Doutora Ana Isabel Simões, Dr.ª Maria Conceição Vilela e
Eng.ª Ana Cristina Pedroso, with a final mark of 19/20.
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Publications
1. Aromatic or chiral heterocycle balance between 1,3-oxazoline-2-thione and 1,3oxazolidine-2-thione Leconte, N.; Silva, S.; Tatibouët, A.; Rauter, A. P.; Rollin,
P. Synlett 2006, 2, 301-305.
2. Synthesis and biological evaluation of sugars containing ,- unsaturated lactones; Xavier, N. M.; Silva, S.; Madeira, P.; Florêncio, H.; Silva, F. V. M.;
Justino, J.; Thiem, J.; Rauter, A. P. Eur. J. Org. Chem. 2008, 36, 6134-6143.
3. 1,3- Oxazoline- and 1,3-oxazolidine-2-thiones as substrates in direct modified
Stille and Suzuki cross-coupling; Silva, S.; Tardy, S.; Suzenet, F.; Tatibouet, A.;
Rauter, A. P.; Rollin, P. Tetrahedron Lett. 2008, 49, 5583-5586.
4. Oxazolinethiones and Oxazolidinethiones for the First Copper-Catalyzed
Desulfurative Cross-Coupling Reaction and First Sonogashira Applications;
Silva, S.; Sylla, B.; Suzenet, F.; Tatibouet, A.; Rauter, A. P.; Rollin, P.
Org. Lett. 2008, 10, 853-856.
5. HSCN condensation with ulosides : preferred formation of carbohydrate-fused
hemiaminals of the 4-hydroxy-1,3-oxazolidine-2-thione type; Silva, S.; Simão,
A. C.; Tatibouet, A.; Rollin, P.; Rauter, A. P. Tetrahedron Lett. 2008, 49, 682686.
6. Thyonocarbamates on carbohydrate scaffolds-from synthesis to bioactivity ;
Simão, A. C.; Rousseau, J.; Silva, S.; Rauter, A.P. Tatibouet, A.; Rollin, P.,
Specialist Periodical Reports, Carbohydr. Chem. 2009, 35, 127-172.
7. Controlled Garegg conditions for selective iodination on pyranose templates;
Simão, A.C. ; Silva, S. ; Rauter, A. P. ; Rollin, P. ; Tatibouët, A. Eur. J. Org.
Chem. 2011, 2286-2292.
8. 1,1'-[(5-Hydroxymethyl-1,3-phenylene)bis(methylene)]dipyridin-4(1H)-one
monohydrate; Fernandes, J. A.; Lago, M. E. L.; Silva, S.; Tomé, J. P. C.;
Cavaleiro, J. A. S.; Paz, F. A. A. Acta Cryst. 2011, 67, O1859-U2183.
9. “Decoding and deafness: Two sides of a coin” Akbergenov, R.; Shcherbakov,
D.; Matt, T.; Duscha, S.; Meyer, M.; Fernandez, D. P.; Pathak, R.; Harish, S.;
Kudyba, I.; Dubbaka, S. R.; Silva, S.; Ruiz, M-del C. R.; Salian, S.; Vasella, A.;
Bottger, E. C. in Ribosome Structure, Function and Dynamics,Eds: Rodnina M.
V.; Wintermeyer, W.; Green, R. Springer Verlag Vienna, Austria., 2011, 249261.
10. “Spirocyclic nucleosides in medicinal chemistry: an overview” Soengas, R.;
Silva, S. Mini-reviews in Medicinal Chemistry, accepted
11. “Porphyrin and phthalocyanine glycodendritic conjugates: synthesis,
photophysical and photochemical properties; Silva, S.; Pereira, P. M. R.; Silva,
P.; Paz, F. A. A.; Faustino, M. A. F.; Cavaleiro, J. A. S.; Tome, J. P. C. Chem.
Commun. 2012, 48, 3608-3610.
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Oral Communications
1. Silva, S.; Pereira, P. M. R.; Faustino, M. A. F.; Tomé, J. P. C.; Cavaleiro, J. A.
S.; Functionalization of photosensitizers by dendritic units and their potencial
therapeutic applications, XXII Encontro Nacional SPQ, 2011, Braga (P).
2. Silva, S; Functionalization of photosensitizers by dendritic units for posterior
application in photodynamic therapy, 4as Jornadas da UI QOPNA, 11 de Abril
de 2011, Universidade de Aveiro, Aveiro (P).
3. Silva, S.; Tatibouët, A.; Silva, F.M.V.; Justino, J.; Rauter, A.P.; Rollin, P;
Carbohydrate-heterocycle hybrids: from original geometries to biological
activity, IV Iberian Carbohydrate Meeting, 2008, Santiago de Compostela (Sp).
4. Silva, S.; Tatibouët, A.; Rauter, A. P.; Rollin, P.; Thionocarbamates Cycliques:
Ancrages et reactivites sur charpentes saccharidiques, GFG, 2008, Piranées (F)
5. Silva, S.; Tatibouët, A.; Silva, F. M. V.; Justino, J.; Rauter, A. P.; Rollin, P.;
Carbohydrate backbones and small heterocycles-a panel of new molecular
hybrids, Eurocarb XIV, 2007, Lübeck (D)
6. Silva, S.; Rauter, A. P.; Tatibouët, A.; Rollin, P.; Silva, F. M. V.; Justino, J.
Synthetic Strategy Towards New 1,3-Oxazoline- and 1,3-Oxazolidine-2-thiones
Anchored on Carbohydrate Templates, 4th Eurasian Meeting on Heterocyclic
Chemistry, 2006, Thessaloniki (GR)
7. Silva, S.; Xavier, N.; Rauter, A. P.; Tatibouët, A., Rollin, P. Nouvelles 1,3Oxazoline- et 1,3-Oxazolidine-2-thiones sur Charpentes Saccharidique , Sycocal
IV- Symposium de chimie Organique et Analitique en Centre-AuvergneLimousin, 2006, Tours (F)
8. Silva, S.; Tatibouet, A.; Rauter, A. P.; Rollin, P. 1,3-oxazoline-e-thiones on
carbohydrate templates towards new pseudo-C-nucleosides, Glupor VI – III
Iberian Carbohydrate Meeting, 2005, Coimbra (P)
Poster Communications
1. Patrícia M R Pereira, Sandrina Silva, Maria A. F. Faustino, José A. S. Cavaleiro,
Rosa Fernandes, João P. C. Tomé. “Glycodendritic-phthalocyanines as potential
photosensitizers”, IBILI Meeting 2011, December 06-07, 2011, Coimbra,
Portugal.
2. Gomes, C. F. A. C.; Silva, S.; Pereira, P. M. R.; Cavaleiro, J. A. S.; Almeida, A.;
Cunha, A.; Tomé, J. P. C. Glycosilated porphyrinoids for PDT applications, 4th
International Symposium on Advances in Synthetic and Medicinal Chemistry
(ASMC11), 2011, São Petersburgo (R).
3. Gomes, C. F. A. C.; Silva, S.; Neves, M. G. P. M. S.; Cavaleiro, J. A. S.;
Almeida, A.; Cunha, A.; Tomé, J. P. C. Cationic galactoporphyrins for the
photoinactivation of microorganisms, XXII Encontro Nacional SPQ, 2011,
Braga (P).
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4. Pereira, P. M. R.; Silva, S.; Faustino, M. A. F.; Cavaleiro, J. A. S.; Fernandes,
R.; Tomé, J. P. C. Water soluble glycodendritic-phthalocyanines for bladder
câncer treatment, XXII Encontro Nacional SPQ, 2011, Braga (P).
5. Silva, S.; Tomé, J.; Cavaleiro, J. Synthesis and characterization of novel water
soluble photosensitizer for biomedical application, Sixth International
Conference on Porphyrins and Phtalocyanines (ICPP-6), 2010, New Mexico
(USA).
6. Silva, F.V.M.; Justino, J.; Silva, S.; Tatibouët, A.; Rollin, P.; Rauter, A.P. New
antifungal and antibacterial compounds: 1,3-oxazoline- and 1,3-oxazolidine-2thiones, CORM V - Carbohydrates as Organic Raw Materials, Building a
Sustainable Future, 2009, Lisboa (P).
7. Fernandes, A.; Silva, S.; Tatibouët, A.; Rauter, A. P.; Rollin, P.
Phenylsulfonylethylidene (PSE) acetals : a versatile protecting group in organic
glycochemistry , Glupor VII, 2007, Oeiras (P)
8. Silva, S.; Tatibouët, A.; Silva, F. M. V.; Justino, J.; Rauter, A. P.; Rollin, P.
Carbohydrates-heterocycle hybrids : novel thio-functionalized structures, ibid.
9. Silva, S.; Tatibouët, A.; Silva, F. M. V.; Justino, J.; Rauter, A. P.; Rollin, P. 1,3Oxazoline-2-thiones ancrées sur charpentes saccharidiques : voies de synthèse
et potentiel chimique, SyCOCAL V, 2007, La Rochelle (F)
10. Silva, S.; Tatibouët, A.; Silva, F. M. V.; Justino, J.; Rauter, A. P.; Rollin, P. 1,3Oxazoline-2-thiones sur charpentes sacharidiques : synthèses et applications
biologiques, Journée Jeunes Chercheurs, 2007, Paris (F)
11. Silva, S.; Rauter, A. P.; Tatibouët, A.; Rollin, P.; Silva, F. M. V.; Justino, J.
Synthetic Strategy Towards New 1,3-Oxazoline- and 1,3-Oxazolidine-2-thiones
Anchored on Carbohydrate Templates, XXIIIrd International Carbohydrate
Symposium, 2006, Whistler (Canada)
12. Silva, S.; Tatibouët, A.; Rauter, A. P.; Rollin, P. Nouveaux pseudo-nucleosides :
1,3-oxazoline-2-thiones à visée anti-bactérienne et insecticide, Sciences en
Sologne, 2005, Orléans (F)
Acquired competences
Synthesis :
Elaboration of pseudo-C-nucleosides using heterofunctional groups (namely
oxazoline-2-thiones) anchored on carbohydrate templates with a view to devising and
developing promising bioorganic drugs. Development of new palladium-catalysed cross
coupling reactions, involving thionocarbamate-type moieties anchored on carbohydrate
templates.
Synthesis of pseudo-iminosugars and their biological evaluation.
Synthesis of paromomycin derived amonoglycoside antibiotics in large scale (25
g after 8 or more steps).
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Synthesis of water soluble photosensitizers for photodynamic therapy
applications.
Analysis :
NMR spectroscopy (graphical interpretation 1D – 1H RMN and 13C RMN – and
2D – COSY, NOESY, HMBC, HMQC), UV-Visible, FT-IR spectroscopies and mass
spectrometry, HPLC and MPLC.
Data processing :
Windows (all versions), Excel, Word, Powerpoint, as well as the main chemistry
softwares (ChemDraw, Isis Draw, SciFinder, Beilstein, Topspin, MestreC).
Relevant scientific /pedagogic activities
2005-2006
Participation in the Image Commitee of the University of Lisbon, in the area of
Chemistry : interface between University and high schools / workshops and lectures
about “Chemistry, what it is ?”
Organization at the University of Lisbon of Chemistry Olympiads for high
school students.
2003-2004
Participation on the national competition for “Fotovoltaic cars construction”
with students of Escola Secundária/3 José Cardoso Pires, project coordinated by Ciência
Viva (Agência Nacional para a Cultura Cientifica e Tecnológica).
(http://www.cienciaviva.pt/rede/himalaya/home/inscritos3.asp)
Pedagogic communications
1. Silva, S.; Vidigal, A, A Química do Ferro. 2002
(http://saberes.no.sapo.pt/ferro-a.htm)
2. Silva, S, Coelho, C. Utilização de PowerPoint no Ensino, Work-shop
Universidade de Lisboa, 2004
3. Silva, S., Coelho, C. Um ano de um núcleo de estágio, Universidade de Lisboa
(oral comunication, 2004).
Professional memberships
Member of the Sociedade Portuguesa de Química (Portuguese Society of
Chemistry).
Member of the French Society of Chemistry
Member of the Carbohydrate Group of the Portuguese Society of Chemistry.
Languages
Portuguese – mother tongue, French – Fluent, English – Fluent.
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References
 Professor Andrea Vasella
ETH, Zürich
 : +41 446325130
 :[email protected]
 Professor Patrick Rollin
ICOA, University of Orleans -Orleans- France.
 : +33(0) 238417370
 :[email protected]
 Professora Amélia Pilar Rauter
FCUL, Universidade de Lisboa- Portugal.
 : +351 217500000 ext ( 28560)
 : [email protected]
 Doutor Arnaud Tatibouët
ICOA, University of Orleans -Orleans- France.
 : +33(0) 2 38 49 48 54
 [email protected]
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